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  1. AU="Sava, Alexandru"
  2. AU="Strandwitz, Philip"
  3. AU="Modrau, Boris"
  4. AU="Sallese, Anthony"
  5. AU="T Kennedy, Patrick"
  6. AU="Cheng, XiaoQing"
  7. AU="Onwuteaka-Philipsen, Bregje D"
  8. AU="Robert D. Welch"
  9. AU="Forget, Francois"

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  1. Artikel: Synthesis of novel series of 3,5-disubstituted imidazo[1,2-d] [1,2,4]thiadiazoles involving SNAr and Suzuki–Miyaura cross-coupling reactions

    Pescheteau, Clémentine / Place, Matthieu / Sava, Alexandru / Nunes, Lea / Profire, Lenuta / Routier, Sylvain / Buron, Frédéric

    RSC advances. 2022 Feb. 23, v. 12, no. 10

    2022  

    Abstract: The first access to 3,5-disubstituted imidazo[1,2-d][1,2,4]thiadiazole derivatives is reported. The series were generated from 2-mercaptoimidazole, which afforded the key intermediate bearing two functional positions. The SNAr reactivity toward tosyl ... ...

    Abstract The first access to 3,5-disubstituted imidazo[1,2-d][1,2,4]thiadiazole derivatives is reported. The series were generated from 2-mercaptoimidazole, which afforded the key intermediate bearing two functional positions. The SNAr reactivity toward tosyl release at the C-3 position was investigated and a regioselective electrophilic iodination in C-5 position was performed to allow a novel C–C bond using Suzuki–Miyaura reaction. Palladium-catalyzed cross-coupling conditions were optimized. A representative library of various boronic acids was employed to establish the scope and limitations of the method. To complete this methodological study, the influence of the nature of the C-3 imidazo[1,2-d][1,2,4]thiadiazole substitutions on the arylation in C-5 was investigated.
    Schlagwörter Lewis acids ; Suzuki reaction ; arylation ; iodination ; regioselectivity
    Sprache Englisch
    Erscheinungsverlauf 2022-0223
    Umfang p. 6303-6313.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ISSN 2046-2069
    DOI 10.1039/d1ra07208k
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  2. Artikel ; Online: Synthesis of novel series of 3,5-disubstituted imidazo[1,2-

    Pescheteau, Clémentine / Place, Matthieu / Sava, Alexandru / Nunes, Lea / Profire, Lenuta / Routier, Sylvain / Buron, Frédéric

    RSC advances

    2022  Band 12, Heft 10, Seite(n) 6303–6313

    Abstract: The first access to 3,5-disubstituted imidazo[1,2- ...

    Abstract The first access to 3,5-disubstituted imidazo[1,2-
    Sprache Englisch
    Erscheinungsdatum 2022-02-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra07208k
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  3. Artikel ; Online: The Impact of the Storage Conditions and Type of Clearomizers on the Increase of Heavy Metal Levels in Electronic Cigarette Liquids Retailed in Romania.

    Jităreanu, Alexandra / Cara, Irina Gabriela / Sava, Alexandru / Mârțu, Ioana / Caba, Ioana-Cezara / Agoroaei, Luminița

    Toxics

    2022  Band 10, Heft 3

    Abstract: The growing popularity of electronic cigarettes has raised several public health concerns, including the risks associated with heavy metals exposure via e-liquids and vapors. The purpose of this study was to determine, using atomic absorption ... ...

    Abstract The growing popularity of electronic cigarettes has raised several public health concerns, including the risks associated with heavy metals exposure via e-liquids and vapors. The purpose of this study was to determine, using atomic absorption spectrometry, the concentrations of Pb, Ni, Zn, and Co in some commercially available e-liquid samples from Romania immediately after purchase and after storage in clearomizers. Lead and zinc were found in all investigated samples before storage. The initial concentrations of Pb ranged from 0.13 to 0.26 mg L
    Sprache Englisch
    Erscheinungsdatum 2022-03-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10030126
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  4. Artikel ; Online: THE CRISIS OF EFFICIENCY IN RESOURCE ALLOCATION IN ROMANIAS AGRICULTURE

    Sava Alexandru Davidovici

    Ekonomika Poljoprivrede (1979), Vol 59, Iss Special nu (2012)

    2012  

    Abstract: The present paper highlights the peripheral position of Romanian farmers position in the European context. It reveals the causes of efficiency crisis that derives from the ownership structures, competition environment situation, the deficiencies of the ... ...

    Abstract The present paper highlights the peripheral position of Romanian farmers position in the European context. It reveals the causes of efficiency crisis that derives from the ownership structures, competition environment situation, the deficiencies of the institutional environment and the inconsistencies of the agricultural policies.
    Schlagwörter agrarian crisis ; causes ; solutions ; Agriculture ; S
    Sprache Englisch
    Erscheinungsdatum 2012-04-01T00:00:00Z
    Verlag Naučno društvo agrarnih ekonomista Balkana, Beograd; Institut za ekonomiku poljoprivrede, Beograd i Akademija ekonomskih nauka, Bukurešt
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies.

    Sava, Alexandru / Buron, Frederic / Routier, Sylvain / Panainte, Alina / Bibire, Nela / Profire, Lenuţa

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Band 139, Seite(n) 111678

    Abstract: In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a-s), as a new safer and efficient multi-targets strategy for inflammatory diseases. The ... ...

    Abstract In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a-s), as a new safer and efficient multi-targets strategy for inflammatory diseases. The chemical structure of all synthesized derivatives (intermediaries and finals) was proved by NMR and mass spectroscopic analysis. In order to study the selectivity of NO-IND-TZDs for COX isoenzymes (COX-1 and COX-2) a molecular docking study was performed using AutoDock 4.2.6 software. Based on docking results, COX-2 inhibitors were designed and 6o appears as the most selective derivative which showed an improved selective index compared with indomethacin (IND) and diclofenac (DCF), used as reference drugs. The biological evaluation of 6a-s, using in vitro assays has included the anti-inflammatory and antioxidant effects as well as the nitric oxide (NO) release. Referring to the anti-inflammatory effects, the most active compound was 6i, which was more active than IND and aspirin (ASP) in term of denaturation effect, on bovine serum albumin (BSA), as indirect assay to predict the anti-inflammatory effect. An appreciable anti-inflammatory effect, in reference with IND and ASP, was also showed by 6k, 6c, 6q, 6o, 6j, 6d. The antioxidant assay revealed the compound 6n as the most active, being 100 times more active than IND. The compound 6n showed also the most increase capacity to release NO, which means is safer in terms of gastro-intestinal side effects. The ADME-Tox study revealed also that the NO-IND-TZDs are generally proper for oral administration, having optimal physico-chemical and ADME properties. We can conclude that the compounds 6i and 6n are promising agents and could be included in further investigations to study in more detail their pharmaco-toxicological profile.
    Mesh-Begriff(e) Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/pharmacology ; Aspirin/pharmacology ; Computer Simulation ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/metabolism ; Diclofenac/pharmacology ; Drug Design ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; Humans ; Indomethacin/analogs & derivatives ; Indomethacin/chemistry ; Indomethacin/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Docking Simulation ; Nitric Oxide Donors/chemistry ; Nitric Oxide Donors/pharmacology ; Nitric Oxide Donors/toxicity ; Serum Albumin, Bovine/chemistry ; Structure-Activity Relationship ; Thiazolidines/pharmacology
    Chemische Substanzen Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants ; Free Radical Scavengers ; Nitric Oxide Donors ; Thiazolidines ; Diclofenac (144O8QL0L1) ; Serum Albumin, Bovine (27432CM55Q) ; Cyclooxygenase 1 (EC 1.14.99.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Aspirin (R16CO5Y76E) ; Indomethacin (XXE1CET956)
    Sprache Englisch
    Erscheinungsdatum 2021-05-06
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111678
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: PAHs, Physicochemical and Microbiological Analyses of Trout Processed by Traditional Smoking, in Different Types of Packaging

    Sava, Alexandru / Uiuiu, Paul / Lațiu, Călin / Cocan, Daniel / Muntean, George-Cătălin / Papuc, Tudor / Ihuț, Andrada / Răducu, Camelia / Becze, Anca / Craioveanu, Cristina / Munteanu, Camelia / Constantinescu, Radu / Mireșan, Vioara

    Fishes. 2023 Aug. 19, v. 8, no. 8

    2023  

    Abstract: Smoking represents one of the oldest thermic processing methods of fish, and it was originally used to preserve fish for later meals, delaying spoiling. The objective of this study was to analyze the physicochemical and microbiological safety and quality ...

    Abstract Smoking represents one of the oldest thermic processing methods of fish, and it was originally used to preserve fish for later meals, delaying spoiling. The objective of this study was to analyze the physicochemical and microbiological safety and quality of two traditionally smoked trout species (Oncorhynchus mykiss and Salvelinus fontinalis). We analyzed the effect of trout processed by traditional smoking, characterizing the samples according to the relationships existing between classical microbial analysis, physicochemical parameters, and the content of polycyclic aromatic hydrocarbons (PAHs). The microbial activity of the smoked fish was very low. Although traditional smoking implies high temperatures and direct exposure to the smoke, Benzo[a]pyrene, Benzo[b]fluoranthene, Benzo[k]fluoranthene, Dibenzo[a,h]anthracene, Benzo[g,h,i]perylene, and Indeno [1,2,3-cd]pyrene compounds had undetectable levels in the samples. The products obtained in this study did not exceed the maximum values imposed by EU legislation regarding the TVB-N values during the 30 days of the experiment. We conclude that traditionally smoked trout has many advantages in terms of quality and safety of the products. Thus, the obtained products are safe for consumption for at least 30 days after processing.
    Schlagwörter Oncorhynchus mykiss ; Salvelinus fontinalis ; anthracenes ; direct contact ; laws and regulations ; microbial activity ; microbiological quality ; smoke ; total volatile basic nitrogen ; trout
    Sprache Englisch
    Erscheinungsverlauf 2023-0819
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ISSN 2410-3888
    DOI 10.3390/fishes8080424
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  7. Artikel: New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management.

    Tatarusanu, Simona-Maria / Sava, Alexandru / Profire, Bianca-Stefania / Pinteala, Tudor / Jitareanu, Alexandra / Iacob, Andreea-Teodora / Lupascu, Florentina / Simionescu, Natalia / Rosca, Irina / Profire, Lenuta

    Pharmaceutics

    2023  Band 15, Heft 3

    Abstract: Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are ... ...

    Abstract Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are considered viable options since they mimic the skin structure and promote autolysis and growth factor synthesis. Unfortunately, hydrogels are associated with several drawbacks, such as low mechanical strength and the potential toxicity of byproducts released after crosslinking reactions. To overcome these aspects, in this study new smart chitosan (CS)-based hydrogels were developed, using oxidized chitosan (oxCS) and hyaluronic acid (oxHA) as nontoxic crosslinkers. Three active product ingredients (APIs) (fusidic acid, allantoin, and coenzyme Q10), with proven biological effects, were considered for inclusion in the 3D polymer matrix. Therefore, six API-CS-oxCS/oxHA hydrogels were obtained. The presence of dynamic imino bonds in the hydrogels' structure, which supports their self-healing and self-adapting properties, was confirmed by spectral methods. The hydrogels were characterized by SEM, swelling degree, pH, and the internal organization of the 3D matrix was studied by rheological behavior. Moreover, the cytotoxicity degree and the antimicrobial effects were also investigated. In conclusion, the developed API-CS-oxCS/oxHA hydrogels have real potential as smart materials in wound management, based on their self-healing and self-adapting properties, as well as on the benefits of APIs.
    Sprache Englisch
    Erscheinungsdatum 2023-03-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15030975
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  8. Artikel ; Online: Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-oxadiazole-2-thiol Scaffold.

    Sava, Alexandru / Buron, Frederic / Routier, Sylvain / Panainte, Alina / Bibire, Nela / Constantin, Sandra Mădălina / Lupașcu, Florentina Geanina / Focșa, Alin Viorel / Profire, Lenuţa

    International journal of molecular sciences

    2021  Band 22, Heft 13

    Abstract: Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, ...

    Abstract Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs,
    Mesh-Begriff(e) Cyclooxygenase 2/chemistry ; Humans ; Indomethacin/chemical synthesis ; Indomethacin/chemistry ; Molecular Docking Simulation ; Nitric Oxide/chemistry ; Oxadiazoles/chemical synthesis ; Oxadiazoles/chemistry
    Chemische Substanzen Oxadiazoles ; 1,3,4-oxadiazole (20O2F20OUR) ; Nitric Oxide (31C4KY9ESH) ; Cyclooxygenase 2 (EC 1.14.99.1) ; PTGS2 protein, human (EC 1.14.99.1) ; Indomethacin (XXE1CET956)
    Sprache Englisch
    Erscheinungsdatum 2021-06-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22137079
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  9. Artikel ; Online: Bulky Polyfluorinated Terphenyldiphenylboranes: Water Tolerant Lewis Acids.

    Stoian, Corina / Olaru, Marian / Cucuiet, Teodor A / Kegyes, Krisztina T / Sava, Alexandru / Timoshkin, Alexey Y / Raţ, Ciprian I / Beckmann, Jens

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Band 27, Heft 13, Seite(n) 4327–4331

    Abstract: Protocols for the synthesis of the bulky polyfluorinated triarylboranes 2,6-( ... ...

    Abstract Protocols for the synthesis of the bulky polyfluorinated triarylboranes 2,6-(C
    Sprache Englisch
    Erscheinungsdatum 2021-02-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202005367
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  10. Artikel: Multi-Approach Assessment for Stress Evaluation in Rainbow Trout Females, Oncorhynchus mykiss (Walbaum, 1792) from Three Different Farms during the Summer Season

    Uiuiu, Paul / Lațiu, Călin / Păpuc, Tudor / Craioveanu, Cristina / Ihuț, Andrada / Sava, Alexandru / Răducu, Camelia / Șonea, Cosmin / Constantinescu, Radu / Cocan, Daniel / Mireșan, Vioara

    Animals. 2021 June 17, v. 11, no. 6

    2021  

    Abstract: Blood biochemistry parameters are valuable tools for monitoring fish health. Their baseline values are still undefined for a multitude of farmed fish species. In this study, changes in the blood profile of rainbow trout females (Oncorhynchus mykiss) from ...

    Abstract Blood biochemistry parameters are valuable tools for monitoring fish health. Their baseline values are still undefined for a multitude of farmed fish species. In this study, changes in the blood profile of rainbow trout females (Oncorhynchus mykiss) from three farms were investigated using different biomarkers during the summer season. In the given context, the main water physicochemical parameters were investigated and twelve biochemical parameters were measured from blood samples of rainbow trout reared in the Fiad, Șoimul de Jos, and Strâmba farms. We selected these farms because the genetic background of the rainbow trout is the same, with all studied specimens coming from the Fiad farm, which has an incubation station. Forty-five samples were collected monthly (May to August) throughout summer to observe the changes in the blood profile of rainbow trout. Principal component analysis showed a clear separation both among the studied farms and months. Furthermore, significant correlations (p < 0.05) between the majority of the biochemical parameters were found, indicating that the environmental parameters can influence several blood parameters at the same time. The present study provides several useful norms for assessing the welfare of rainbow trout, indicating that the relationships among different parameters are important factors in interpreting the blood biochemical profiles.
    Schlagwörter Oncorhynchus mykiss ; biomarkers ; blood ; blood chemistry ; farmed fish ; farms ; fish health ; genetic background ; principal component analysis ; summer
    Sprache Englisch
    Erscheinungsverlauf 2021-0617
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11061810
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