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Article ; Online: Delayed PET/CT of Pericardial Synovial Sarcoma.

Stefanelli, Antonella / Savelli, Giordano / Bonacina, Mattia / Zaniboni, Alberto

2021 Volume 46, Issue 9, Page(s) e451–e453

Abstract: Abstract: Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside ... ...

Abstract	Abstract: Pericardial synovial sarcoma is a rare malignancy. We report the case of a patient who was referred to our institution for a large pericardial effusion requiring pericardiocentesis. CT imaging revealed an inhomogeneous pericardial mass beside the right atrium, and then a PET/CT scan was performed. Standard images were inconclusive whether delayed images showed an FDG-avid pericardial lesion that was surgically removed with histological diagnosis of a poorly differentiated biphasic synovial sarcoma. When considering mediastinal or pericardial mass, a delayed PET/CT may improve lesion-to-background contrast by reducing blood pool activity.
MeSH term(s)	Heart Neoplasms/diagnostic imaging ; Humans ; Mediastinal Neoplasms ; Pericardial Effusion ; Positron Emission Tomography Computed Tomography ; Sarcoma, Synovial/diagnostic imaging
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003603
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Article: Dural Metastases of Advanced Prostate Cancer Detected by

Morassi, Mauro / Bonacina, Mattia / Bnà, Claudio / Zaniboni, Alberto / Savelli, Giordano

Diagnostics (Basel, Switzerland)

2020 Volume 10, Issue 6

Abstract: Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned ... ...

Abstract	Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (
Language	English
Publishing date	2020-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics10060385
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Article ; Online: Penile Metastasis From Prostate Cancer Detected by 18F-Fluorocholine PET/CT.

Bianchi, Denise / Rizzo, Alessio / Bonacina, Mattia / Zaniboni, Alberto / Savelli, Giordano

Clinical nuclear medicine

2020 Volume 46, Issue 1, Page(s) e38–e39

Abstract: F-Fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. F-FCH PET/CT is suitable for the detection of pelvic and abdominal nodal and skeletal metastases. Indeed, F-FCH PET/CT sensitivity for other organs, such as the ... ...

Abstract	F-Fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. F-FCH PET/CT is suitable for the detection of pelvic and abdominal nodal and skeletal metastases. Indeed, F-FCH PET/CT sensitivity for other organs, such as the liver and the urinary tract, is lowered by the radiopharmaceutical urinary washout and intense liver uptake. Herein, we report the case of a patient affected by oligometastatic prostate cancer in good clinical condition treated with total androgen blockade. F-FCH PET/CT showed a diffuse and intense uptake in the shaft of the penis, which was an evidence of a rare penile metastasis.
MeSH term(s)	Aged ; Choline/analogs & derivatives ; Humans ; Male ; Middle Aged ; Penile Neoplasms/diagnostic imaging ; Penile Neoplasms/secondary ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/pathology
Chemical Substances	fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2020-09-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003249
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Article ; Online: Re: Clinical and molecular features of treatment-related neuroendocrine prostate cancer.

Savelli, Giordano / Zaniboni, Alberto / Stefanelli, Antonella

International journal of urology : official journal of the Japanese Urological Association

2018 Volume 26, Issue 1, Page(s) 142

MeSH term(s)	Humans ; Male ; Neoplasms, Second Primary ; Prostatic Neoplasms
Language	English
Publishing date	2018-10-24
Publishing country	Australia
Document type	Letter ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.13832
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Somatostatin Receptors in an Anaplastic Oligodendroglioma Relapse Evidenced By 68Ga DOTANOC PET/CT.

Savelli, Giordano / Muni, Alfredo

Clinical nuclear medicine

2015 Volume 40, Issue 7, Page(s) e363–5

Abstract: Six years ago, a right frontal lobe anaplastic oligodendroglioma negative for AE1/AE3 and HBM-45, positive for 1p/19q deletion, EMA, GFAP, and synaptophysin was excised from a 50-year-old woman. Treatments that followed were radiation therapy, and ... ...

Abstract	Six years ago, a right frontal lobe anaplastic oligodendroglioma negative for AE1/AE3 and HBM-45, positive for 1p/19q deletion, EMA, GFAP, and synaptophysin was excised from a 50-year-old woman. Treatments that followed were radiation therapy, and surgery plus radiation therapy and temozolomide for a relapse with an early partial response, followed by disease progression. In the middle of last year, ⁶⁸Ga-DOTANOC PET/CT was carried out to evaluate the possibility of treatment with peptide receptor radionuclide therapy. The examination revealed a grossly round-shaped uptake corresponding to the surgical wall, with some smaller uptakes disseminated in different parts of the brain.
MeSH term(s)	Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Female ; Gene Deletion ; Humans ; Middle Aged ; Multimodal Imaging ; Oligodendroglioma/diagnostic imaging ; Oligodendroglioma/genetics ; Organometallic Compounds ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed
Chemical Substances	68Ga-DOTANOC ; Organometallic Compounds ; Radiopharmaceuticals
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000000816
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Article ; Online: Big data, observational research and P-value: a recipe for false-positive findings? A study of simulated and real prospective cohorts.

Veronesi, Giovanni / Grassi, Guido / Savelli, Giordano / Quatto, Piero / Zambon, Antonella

International journal of epidemiology

2019 Volume 49, Issue 3, Page(s) 876–884

Abstract: Background: An increasing number of observational studies combine large sample sizes with low participation rates, which could lead to standard inference failing to control the false-discovery rate. We investigated if the 'empirical calibration of P- ... ...

Abstract	Background: An increasing number of observational studies combine large sample sizes with low participation rates, which could lead to standard inference failing to control the false-discovery rate. We investigated if the 'empirical calibration of P-value' method (EPCV), reliant on negative controls, can preserve type I error in the context of survival analysis. Methods: We used simulated cohort studies with 50% participation rate and two different selection bias mechanisms, and a real-life application on predictors of cancer mortality using data from four population-based cohorts in Northern Italy (n = 6976 men and women aged 25-74 years at baseline and 17 years of median follow-up). Results: Type I error for the standard Cox model was above the 5% nominal level in 15 out of 16 simulated settings; for n = 10 000, the chances of a null association with hazard ratio = 1.05 having a P-value < 0.05 were 42.5%. Conversely, EPCV with 10 negative controls preserved the 5% nominal level in all the simulation settings, reducing bias in the point estimate by 80-90% when its main assumption was verified. In the real case, 15 out of 21 (71%) blood markers with no association with cancer mortality according to literature had a P-value < 0.05 in age- and gender-adjusted Cox models. After calibration, only 1 (4.8%) remained statistically significant. Conclusions: In the analyses of large observational studies prone to selection bias, the use of empirical distribution to calibrate P-values can substantially reduce the number of trivial results needing further screening for relevance and external validity.
MeSH term(s)	Adult ; Aged ; Bias ; Big Data ; Computer Simulation ; Data Interpretation, Statistical ; Female ; Humans ; Italy ; Male ; Middle Aged ; Observational Studies as Topic ; Prospective Studies
Language	English
Publishing date	2019-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyz206
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Zs.A 893: Show issues

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Article ; Online: 18F-Fluorocholine Uptake by a Head and Neck Meningeal Inflammatory Pseudotumor.

Savelli, Giordano / Morassi, Mauro / Cobelli, Milena / Stefanelli, Antonella / Zaniboni, Alberto

Clinical nuclear medicine

2019 Volume 44, Issue 8, Page(s) 657–659

Abstract: F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an ... ...

Abstract	F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an opportunity to study different diseases, on the other hand, this condition brings with it the source of error in the evaluation of the images. Here we present the case of a meningeal inflammatory pseudotumor evidenced by F-FCH.
MeSH term(s)	Choline/analogs & derivatives ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Male ; Meninges/diagnostic imaging ; Meninges/pathology ; Middle Aged ; Neck/diagnostic imaging ; Neck/pathology ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals ; fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2019-07-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002635
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article: Cutaneous Adnexal Carcinoma with Apocrine Differentiation: A Challenging Diagnosis and Personalized Treatment with mTOR Inhibitor in a Very Rare Disease.

Libertini, Michela / Oneda, Ester / Di Biasi, Brunella / Savelli, Giordano / Zaniboni, Alberto

Case reports in oncology

2020 Volume 13, Issue 3, Page(s) 1091–1096

Abstract: Cutaneous adnexal carcinoma with apocrine differentiation is a rare neoplasm arising from cutaneous adnexa, especially of the head and neck and trunk region. Because of its rarity, the diagnosis is challenging and often impossible to distinguish from ... ...

Abstract	Cutaneous adnexal carcinoma with apocrine differentiation is a rare neoplasm arising from cutaneous adnexa, especially of the head and neck and trunk region. Because of its rarity, the diagnosis is challenging and often impossible to distinguish from metastatic cutaneous adenocarcinoma of the breast. The standard of care remains surgery for resectable disease. To date, univocal guidelines for metastatic disease are lacking, particularly regarding systemic therapy. We report a clinical case of a patient diagnosed with cutaneous adnexal adenocarcinoma with apocrine differentiation of the left axilla with lymph node and bone metastasis. We started with carboplatin and paclitaxel chemotherapy regimen, with good response. After progression, we performed a next-generation sequencing analysis (by the Foundation One CDx test) to identify genomic alteration in cancer-related genes. We found PIK3CA and KRAS mutations. Due to this result, the patient started a second-line treatment with a personalized therapy including an mTOR inhibitor, everolimus, and, to date, he is still under treatment. To our knowledge, this is the first case of a patient responding both to chemotherapy and to a personalized treatment with an mTOR inhibitor. It is important to support the value of genomic screening in this rare neoplasm.
Language	English
Publishing date	2020-09-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000510097
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Article: Drug-Related Pneumonitis in Cancer Treatment during the COVID-19 Era.

Cherri, Sara / Noventa, Silvia / Fanelli, Martina / Calandra, Giulio / Prochilo, Tiziana / Bnà, Claudio / Savelli, Giordano / Zaniboni, Alberto

Cancers

2021 Volume 13, Issue 5

Abstract: Interstitial lung disease is recognized as a group of diseases with a different etiopathogenesis characterized by chronic lung inflammation with the accumulation of inflammatory cells, lymphocytes and macrophages, and the consequent release of ... ...

Abstract	Interstitial lung disease is recognized as a group of diseases with a different etiopathogenesis characterized by chronic lung inflammation with the accumulation of inflammatory cells, lymphocytes and macrophages, and the consequent release of proinflammatory cytokines. Various degrees of pulmonary fibrosis can be associated with this inflammatory condition. Interstitial lung disease related to oncological drugs is a relevant problem in clinical practice. The etiopathogenetic mechanisms underlying this adverse event are not completely known but can be partly explained by the mechanism of action of the drug involved. Therefore, knowledge of the relevance of this potentially fatal adverse event supported by the reported safety data of pivotal studies becomes fundamental in the management of patients. The prompt diagnosis of drug-related pneumonia and the consequent differential diagnosis with other forms of pneumonia allow a rapid suspension of treatment and the establishment of an immunosuppressive treatment if necessary. In the context of the health emergency related to SARS CoV2 infection and COVID-19-related interstitial lung disease, such knowledge holds decisive relevance in the conscious choice of cancer treatments. Our intent was to describe the oncological drugs most correlated with this adverse event by reporting, where possible, the percentages of insurgency in pivotal studies to provide an overview and therefore promote greater awareness of this important toxicity related to oncological treatment.
Language	English
Publishing date	2021-03-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13051052
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Article ; Online: Clinical and prognostic

Albano, Domenico / Bonacina, Mattia / Savelli, Giordano / Ferro, Paola / Busnardo, Elena / Gianolli, Luigi / Camoni, Luca / Giubbini, Raffaele / Bertagna, Francesco

Japanese journal of radiology

2021 Volume 40, Issue 1, Page(s) 66–74

Abstract: Purpose: The aim of this retrospective multicentric study was to investigate the diagnostic performance, the prognostic value and the impact of : Materials and methods: Sixty-three patients affected by VC performed : Results: Fifty-two (82.5%) PET/ ...

Abstract	Purpose: The aim of this retrospective multicentric study was to investigate the diagnostic performance, the prognostic value and the impact of Materials and methods: Sixty-three patients affected by VC performed Results: Fifty-two (82.5%) PET/CT showed the presence of recurrence, while the remaining 11 (17.5%) were negative. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT were 100% (95%CI 93-100%), 92% (95%CI 62-100%), 98% (95%CI 89-99%), 100% and 98% (95%CI 92-100%). A relevant impact of Conclusions: 18
MeSH term(s)	Female ; Fluorodeoxyglucose F18 ; Humans ; Neoplasm Recurrence, Local/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Prognosis ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Vulvar Neoplasms/diagnostic imaging
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-07-17
Publishing country	Japan
Document type	Journal Article ; Multicenter Study
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-021-01173-x
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