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  1. Article: Korrektsiya nevrologicheskikh posleoperatsionnykh narushenii u bol'nykh s opukholyami golovy i shei s ispol'zovaniem nizkointensivnogo lazernogo izlucheniya.

    Gorchak, Yu Yu / Stakhanov, M L / Savin, A A / Gens, G P / Reshetov, D N

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2023  Volume 123, Issue 1, Page(s) 75–80

    Abstract: Objective: To evaluate the efficacy of low-intensity laser radiation in rehabilitation treatment of patients undergoing radical treatment for head and neck tumors.: Material and methods: The study included 134 patients (39 (29.1%) men, 95 (70, 9%) ... ...

    Title translation Treatment of neurological postoperative disorders after surgical intervention for head and neck tumors using low-intensity laser radiation.
    Abstract Objective: To evaluate the efficacy of low-intensity laser radiation in rehabilitation treatment of patients undergoing radical treatment for head and neck tumors.
    Material and methods: The study included 134 patients (39 (29.1%) men, 95 (70, 9%) women), aged from 23 to 78 years old, with an average age of 54.24±12.7 years. Three groups were formed: Group 1 - 45 patients who received the traditional complex of rehabilitation treatment, which includes physical exercise, massage, and drug therapy, without using low-intensity laser radiation; Group 2 - 45 patients who received the traditional complex of rehabilitation treatment in combination with low-intensity laser radiation; Group 3 - 44 patients who underwent only a few low-intensity laser irradiation courses as a rehabilitation treatment. The impact on the tissues of the shoulder joint and cervico-supraclavicular region was carried out by radiation with a wavelength of 660 nm and 970 nm using a matrix radiation source. The course of treatment was 10 treatment sessions lasting 10 minutes. During the first year after radical treatment, the course of laser therapy was repeated every 3 months. In the course of the study, indicators of the patient's subjective assessment of changes occurring with them were studied, depending on the method of rehabilitation used, as well as the restoration of range of motion in the shoulder joint on the side of the operation and the function of soft tissues in the shoulder joint on the radical treatment side.
    Results: Against the background of the treatment, an improvement in the condition of patients was recorded in the form of a decrease in the severity of motor and sensory disorders.
    Conclusion: Complex rehabilitation treatment with the obligatory use of low-intensity laser radiation provides an improvement in the function of the peripheral nervous system and blood circulation, which, in turn, allows not only to restore the function of these organs, but also to generally improve the quality of life of patients.
    MeSH term(s) Male ; Humans ; Female ; Adult ; Middle Aged ; Aged ; Young Adult ; Quality of Life ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/surgery ; Shoulder Joint ; Laser Therapy ; Nervous System Diseases ; Lasers
    Language Russian
    Publishing date 2023-01-31
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro202312301175
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  2. Article: Sindrom Giiena—Barre u bol'noi tuberkulezom.

    Savin, A A / Bugun, A V / Tsomaeva, E B / Sergeeva, S P / Sirotinskaya, A Yu / Savin, L A / Khomenko, N Z

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2023  Volume 123, Issue 8, Page(s) 129–133

    Abstract: The article reports on the rarest case of Guillain-Barré syndrome in the form of acute motor-sensory polyneuropathy in a female patient with tuberculous meningitis, disseminated pulmonary tuberculosis, and tuberculous pleurisy. In the neurological status ...

    Title translation Guillain-Bare syndrome in a patient with tuberculous.
    Abstract The article reports on the rarest case of Guillain-Barré syndrome in the form of acute motor-sensory polyneuropathy in a female patient with tuberculous meningitis, disseminated pulmonary tuberculosis, and tuberculous pleurisy. In the neurological status at the exit from the coma, the patient was diagnosed with tetraplegia, bulbar syndrome, and respiratory disorders. Further, within a week, pronounced muscle atrophy appeared. Active etiotropic, pathogenetic therapy, including plasmapheresis, gave a dramatic effect with a significant improvement in the condition and a gradual regression of neurological disorders. The differential diagnosis was carried out primarily with critical illness polyneuropathy. The authors emphasize the rarity of the presented case: to date, such a combination of pathologies has never been described in the literature.
    MeSH term(s) Female ; Humans ; Coma ; Diagnosis, Differential ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/therapy ; Patients ; Plasmapheresis ; Polyneuropathies
    Language Russian
    Publishing date 2023-08-17
    Publishing country Russia (Federation)
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro2023123081129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [The experience of application of test system "TB-Biochip" in the Tambov oblast].

    Manaenkova, E V / Savin, A A

    Klinicheskaia laboratornaia diagnostika

    2015  Volume 60, Issue 2, Page(s) 59–62

    Abstract: The analysis was implemented concerning application of biological chips technique developed by the V A. Engelgardt institute of molecular biology--"TB-Biochip" designed for detecting DNA agent of tuberculosis in diagnostic samples of human respiratory ... ...

    Abstract The analysis was implemented concerning application of biological chips technique developed by the V A. Engelgardt institute of molecular biology--"TB-Biochip" designed for detecting DNA agent of tuberculosis in diagnostic samples of human respiratory organs and establishing its medicinal sensitivity to rifampicin and isoniazid. It is demonstrated that "TB-Biochip" is a sensitive and highly specific method of detecting medicinal sensitivity to main anti-tuberculosis pharmaceuticals. At that, analysis time amount to less than 72 hours. The comparative analysis was carried out concerning results of detection of medicinal sensitivity of mycobacteria by two express techniques--TB-Biochip (Biochip-IMB) and BACTECTM MGITTM 960 ("Becton Dickonson"). The data obtained by two techniques matched in 97.6%for rifampicin and in 92.1% for isoniazid.
    MeSH term(s) DNA, Bacterial/drug effects ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Humans ; Isoniazid/pharmacology ; Microarray Analysis/methods ; Microbial Sensitivity Tests ; Mutation/drug effects ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Rifampin/pharmacology ; Russia ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/genetics ; Tuberculosis, Pulmonary/microbiology
    Chemical Substances DNA, Bacterial ; Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR)
    Language Russian
    Publishing date 2015-05-31
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1155086-7
    ISSN 0869-2084
    ISSN 0869-2084
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  4. Article: Golovnoĭ mozg posle ishemicheskogo insul'ta: kliniko-gistologicheskoe issledovanie.

    Sergeeva, S P / Savin, A A / Shishkina, L V / Vinogradov, E V

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2018  Volume 117, Issue 3. Vyp. 2, Page(s) 66–70

    Abstract: Aim: To analyze the histological features of changes in the brain tissue after ischemic stroke.: Material and methods: Brain tissue samples obtained in autopsy from 9 people died as a result of a left middle cerebral artery ischemic stroke from 3 to ... ...

    Title translation The brain after ischemic stroke: a clinical/histological study.
    Abstract Aim: To analyze the histological features of changes in the brain tissue after ischemic stroke.
    Material and methods: Brain tissue samples obtained in autopsy from 9 people died as a result of a left middle cerebral artery ischemic stroke from 3 to 7 days after admission were studied. Tissue samples were taken from 3 areas of the brain: 1) contiguous to the tissue necrotic damage site zone, 2) 5-10 cm distant from the previous one, 3) the contralateral hemisphere zone symmetrical to damage site. Samples were Nissl and hematoxylin-eosin stained. Detection of p53 protein, NSE, GFAP was performed by indirect immunoperoxidase immunohistochemistry.
    Results: A decrease in the total number of neurons and glial elements, their spatial redistribution, change in cell structure and their functional activity was found. The changes of the artery wall and impaired regional blood flow were detected. The more intense NSE reactivity; p53-positive neurons, reduced neuron-astrocytes distance were identified in zones 2 and 3.
    Conclusion: Ischemic stroke is accompanied by severe histological changes. These changes with varying degrees of severity occur both in the areas adjacent to necrotic core, and in remote areas, and it is a substrate for neuroplasticity.
    MeSH term(s) Astrocytes ; Brain/pathology ; Brain Ischemia/complications ; Humans ; Neurons ; Stroke/complications
    Language Russian
    Publishing date 2018-02-05
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro20171173266-70
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Zhestkost' arterial'noi stenki u bol'nykh s ishemicheskimi narusheniyami mozgovogo krovoobrashcheniya.

    Trush, E Yu / Ivanova, S V / Savin, A A / Yushchuk, E N / Teltevskaya, I I / Melehina, I V / Dobrovolskaya, L E

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2021  Volume 120, Issue 12. Vyp. 2, Page(s) 16–21

    Abstract: Objective: To identify correlations between parameters of vascular stiffness and characteristics of the clinical course of acute cerebrovascular accident (stroke).: Material and methods: Two hundred and seven patients with stroke (mean age 64.6±10.9 ... ...

    Title translation Arterial stiffness in patients with acute cerebrovascular accident.
    Abstract Objective: To identify correlations between parameters of vascular stiffness and characteristics of the clinical course of acute cerebrovascular accident (stroke).
    Material and methods: Two hundred and seven patients with stroke (mean age 64.6±10.9 years; 115 men) treated in a neurological department of «Municipal Clinical Hospital Br. Bakhrushins of the Health Care Department of Moscow» were studied. All patients underwent a standard neurological and clinical-instrumental examination, including assessment of arterial stiffness by sphygmography. Analysis of the data was carried out depending on the severity of stroke and the pathogenetic subtype of stroke.
    Results: The pathological value of the CAVI was detected in all patients with cerebral infarction. The highest values were noted in patients with an atherothrombotic subtype of stroke. A positive correlation was revealed between CAVI and the age of patients (
    Conclusions: The factors determining the severity of stroke are age, arterial hypertension, type 2 diabetes, carotid atherosclerosis, left ventricular remodeling, and decreased glomerular filtration rate. The CAV and the toe-brachial index, rather than the ankle-brachial index, significantly distinguished patients with ischemic stroke from patients with transient ischemic attack.
    MeSH term(s) Aged ; Ankle Brachial Index ; Diabetes Mellitus, Type 2 ; Humans ; Male ; Middle Aged ; Moscow ; Stroke/diagnostic imaging ; Vascular Stiffness
    Language Russian
    Publishing date 2021-01-15
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro202012012216
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  6. Article: Rol' sistemy Fas v patogeneze ishemicheskogo insul'ta.

    Sergeeva, S P / Savin, A A / Litvitskiy, P F

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2016  Volume 116, Issue 3 Pt 2, Page(s) 3–8

    Abstract: The Fas system can promote several biological effects due to their activation after ischemic stroke: apoptosis, inflammation, proliferation, differentiation. Fas interacts with adapter proteins activating a number of signaling pathways, including MAPK, ... ...

    Title translation A role of the Fas system in the pathogenesis of ischemic stroke.
    Abstract The Fas system can promote several biological effects due to their activation after ischemic stroke: apoptosis, inflammation, proliferation, differentiation. Fas interacts with adapter proteins activating a number of signaling pathways, including MAPK, NFKB, JNK, ERK, phosphorylation of cytoskeletal proteins, and caspase-dependent apoptosis. Fas expressed by neuronal progenitor cells from the subventricular zone does not induce apoptosis in healthy adult humans. During motion and differentiation of these cells, Fas regulates their morphological structure by the phosphorylation/dephosphorylation of cytoskeletal elements. An increase in the Fas and Fas ligand expression is observed in response to stroke injury. Fas responsible not only for cell death and inflammation but also for neuronal plasticity which occupies a central place in the processes of sanogenesis.
    MeSH term(s) Apoptosis ; Brain Ischemia/physiopathology ; Fas Ligand Protein/physiology ; Humans ; Phosphorylation ; Signal Transduction ; Stroke/physiopathology ; fas Receptor/physiology
    Chemical Substances FASLG protein, human ; Fas Ligand Protein ; fas Receptor
    Language Russian
    Publishing date 2016-06-13
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro2016116323-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [The role of surrogate alcoholic beverages in the development of hemorrhage in the patients presenting with Mallory-Weiss syndrome].

    Pavlov, A L / Bogomolov, D V / Savin, A A

    Sudebno-meditsinskaia ekspertiza

    2015  Volume 58, Issue 1, Page(s) 22–25

    Abstract: The objective of the present work was to study the pathological changes in various organs and tanatogenesis associated with Mallory-Weiss syndrome making use of the forensic medical and clinical materials. It was shown that the main cause of unrestrained ...

    Abstract The objective of the present work was to study the pathological changes in various organs and tanatogenesis associated with Mallory-Weiss syndrome making use of the forensic medical and clinical materials. It was shown that the main cause of unrestrained vomiting resulting from alcoholic intoxication and leading to perfusive bleeding is not only the direct action of ethanol and surrogate alcohol on gastroesophageal mucosa and induced thrombocytopenia. Another cause may be brain oedema with subsequent cerebral herniation and irritation of the pseudobulbar centres responsible for the initiation of the vomiting reflex. The authors propose recommendations for forensic medical diagnostics of the cases of such hemorrhage.
    MeSH term(s) Adult ; Aged ; Alcoholic Beverages/adverse effects ; Alcoholic Beverages/classification ; Alcoholism/complications ; Alcoholism/diagnosis ; Alcoholism/mortality ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/drug therapy ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/mortality ; Humans ; Mallory-Weiss Syndrome/complications ; Mallory-Weiss Syndrome/diagnosis ; Mallory-Weiss Syndrome/mortality ; Middle Aged ; Povidone/administration & dosage ; Povidone/therapeutic use ; Treatment Outcome ; Vomiting/complications ; Vomiting/diagnosis ; Vomiting/mortality
    Chemical Substances Povidone (FZ989GH94E)
    Language Russian
    Publishing date 2015-01
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 41012-3
    ISSN 0039-4521
    ISSN 0039-4521
    DOI 10.17116/sudmed201558122-25
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  8. Article: Neirogumoral'nyi otvet i aktivnost' Fas-liganda perifericheskoi krovi v ostrom periode ishemicheskogo insul'ta.

    Sergeeva, S P / Savin, A A / Litvitsky, P F / Lyundup, A V / Breslavich, I D / Manasova, Z Sh

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2020  Volume 120, Issue 6, Page(s) 57–63

    Abstract: Objective: To identify an effect of the neurohumoral response on the severity and orientation of Fas-ligand-initiated processes in the acute period of IS.: Material and methods: The study included 155 patients with IS in the territory of the left and ...

    Title translation Neurohumoral response and Fas-ligand-induced apoptosis in peripheral blood of patients with acute ischemic stroke.
    Abstract Objective: To identify an effect of the neurohumoral response on the severity and orientation of Fas-ligand-initiated processes in the acute period of IS.
    Material and methods: The study included 155 patients with IS in the territory of the left and right middle cerebral arteries, the control group consisted of 28 people. The National Institutes of Health Stroke Scale (NIHSS), the Hospital Anxiety and Depression Scale (HADS), and the Daily Life Stress scale were used. Concentrations of sFas, sFasL, cortisol (K), adrenaline (A), norepinephrine (NE), adrenocorticotropic hormone (ACTH) in the blood plasma of patients with IS were measured by enzyme-linked immunosorbent assay on days 1, 7 and 21 and once in the control group. CD3CD95+ lymphocytes phenotyping was performed using flow cytometry.
    Results and conclusion: The hypothalamic-pituitary-adrenal axis dominance is associated with the activation of the apoptosis-inducing properties of peripheral blood in the first week after the IS onset and their decrease towards the end of the acute period, which is clinically represented by the increased levels of anxiety and depression, an unfavorable outcome of the acute period of IS.
    MeSH term(s) Apoptosis ; Brain Ischemia ; Enzyme-Linked Immunosorbent Assay ; Humans ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Stroke
    Language Russian
    Publishing date 2020-07-17
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro202012006157
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  9. Article: Klinicheskaia patomorfologiia i tanatogenez razlichnykh form alkogol'noĭ intoksikatsii.

    Pavlov, A L / Savin, A A / Bogomolov, D V / Pavlova, A Z / Larev, Z V

    Sudebno-meditsinskaia ekspertiza

    2018  Volume 61, Issue 3, Page(s) 11–14

    Abstract: The objective of the present study was to identify the clinical and pathomorphological changes in the internal organs for the elucidation of the cause of death associated with various forms of alcoholic intoxication (chronic alcoholic intoxication, ... ...

    Title translation Clinical pathomorphology and tanatogenesis of various forms of alcoholic intoxication.
    Abstract The objective of the present study was to identify the clinical and pathomorphological changes in the internal organs for the elucidation of the cause of death associated with various forms of alcoholic intoxication (chronic alcoholic intoxication, poisoning with surrogate alcohols, etc.). The analysis of the clinical conditions resulting from alcohol abuse has demonstrated that the principal pathology underlying the fatal outcome is complemented by a variety of non-lethal somatic disorders aggravating the patients' condition and enhancing its severity. The clinicians are known to give more attention to the accompanying somatic complications than to the cause underlying the main pathology (alcoholism). Such attitude in the absence of the adequate treatment of the alcohol dependency is neither clinically efficient nor economically appropriate. Poisoning with surrogate alcohols is characterized by the pulmonary-cerebral variant of tanatogenesis in the combination with hypercoagulation and the erosive processes in the gastrointestinal tract whereas death from alcoholic intoxication is usually associated with heart tanatogenesis.
    MeSH term(s) Alcoholic Intoxication/etiology ; Alcoholic Intoxication/mortality ; Alcoholic Intoxication/pathology ; Brain/pathology ; Cause of Death ; Ethanol/chemistry ; Ethanol/toxicity ; Forensic Pathology/methods ; Gastrointestinal Tract/pathology ; Humans ; Lung/pathology
    Chemical Substances Ethanol (3K9958V90M)
    Language Russian
    Publishing date 2018-05-15
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 41012-3
    ISSN 0039-4521
    ISSN 0039-4521
    DOI 10.17116/sudmed201861311-14
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  10. Article: Znachenie komp'iuternoĭ tomografii v otsenke rasprostranennosti zlokachestvennykh opukholeĭ verkhnikh dykhatel'nykh puteĭ.

    Savin, A A

    Vestnik rentgenologii i radiologii

    1999  , Issue 2, Page(s) 22–24

    Abstract: In the work there are summarized the results of the examination of the 112 patients with the malignant neoplasms of larynx (70), pharynx (24), rhinopharynx with spreading to the cells of ethmoidal labyrinth and maxillary sinus (18), aged from 14 till 69. ...

    Title translation Significance of computed tomography in the assessment of invasiveness of malignant tumors of upper respiratory tract.
    Abstract In the work there are summarized the results of the examination of the 112 patients with the malignant neoplasms of larynx (70), pharynx (24), rhinopharynx with spreading to the cells of ethmoidal labyrinth and maxillary sinus (18), aged from 14 till 69. There are described the methods of computed tomography. There are show the possibilities computed tomography in estimation of the localization specification, prevalence, structure, degree of invasion into the neoplasms gathering round the cells, as well as the definition of the bony destruction.
    MeSH term(s) Adolescent ; Adult ; Aged ; Female ; Humans ; Laryngeal Neoplasms/diagnostic imaging ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/diagnostic imaging ; Neoplasm Invasiveness ; Neoplasm Staging ; Tomography, X-Ray Computed
    Language Russian
    Publishing date 1999-03
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 128671-7
    ISSN 0042-4676
    ISSN 0042-4676
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