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  1. Article: Association of fibromyalgia with cancerous and non-cancerous gastrointestinal comorbidities: a cross-sectional study.

    Savin, Einat / Tsur, Avishai M / Watad, Abdulla / Gendelman, Omer / Kopylov, Uri / Cohen, Arnon D / Amital, Howard

    Clinical and experimental rheumatology

    2023  Volume 41, Issue 6, Page(s) 1248–1253

    Abstract: Objectives: Several studies have shown a higher prevalence of irritable bowel syndrome (IBS) among patients with fibromyalgia yet, data regarding association between fibromyalgia and other gastrointestinal disorders have been relatively overlooked. Our ... ...

    Abstract Objectives: Several studies have shown a higher prevalence of irritable bowel syndrome (IBS) among patients with fibromyalgia yet, data regarding association between fibromyalgia and other gastrointestinal disorders have been relatively overlooked. Our aim was to investigate the association between fibromyalgia and gastrointestinal disorders including both benign and malignant conditions.
    Methods: We conducted a retrospective cross-sectional study based on the comprehensive electronic database of the largest health maintenance organisation in Israel. All subjects with a diagnosis of fibromyalgia in their medical records and age- and sex-matched controls were included in the study. We investigated the association of fibromyalgia with benign gastrointestinal disorders including IBS, gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), celiac disease, Crohn's disease, ulcerative colitis, and with gastrointestinal malignancies including colorectal, pancreatic, stomach, liver, and bile duct cancers.
    Results: The study enrolled 18,598 patients with fibromyalgia and 36,985 controls. The mean age was 56.5 years (standard deviation=14) with a female predominance (91%). Fibromyalgia was significantly associated with IBS (OR 4.61, 95% CI 4.09-5.2, p<0.001), GERD (OR 2.62, 95% CI 2.5-2.75, p<0.001), PUD (OR 2.13, 95% CI 1.98-2.3, p<0.001), celiac disease (OR 2.08, 95% CI 1.63-2.65, p<0.001), Crohn's disease (OR 1.85, 95% CI 1.408-2.32, p<0.001) and ulcerative colitis (OR 1.81, 95%CI 1.4-2.33, p<0.001). Nonetheless, no significant differences were found regarding the prevalence of gastrointestinal malignancies between the fibromyalgia patients and controls.
    Conclusions: Our findings suggest that FM is positively associated with various benign but not malignant GI disorders.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Fibromyalgia/complications ; Crohn Disease/complications ; Crohn Disease/epidemiology ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/epidemiology ; Colitis, Ulcerative/complications ; Cross-Sectional Studies ; Irritable Bowel Syndrome/epidemiology ; Irritable Bowel Syndrome/complications ; Celiac Disease/complications ; Retrospective Studies ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/complications ; Neoplasms/epidemiology ; Neoplasms/complications ; Prevalence
    Language English
    Publishing date 2023-04-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/rp5lkn
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The association between psoriasis, psoriasis severity, and inflammatory bowel disease: a population-based analysis.

    Shani, Uria / Ben-Shabat, Niv / Qassem, Roula / Lahat, Adi / Omar, Mahmud / Savin, Einat / Dotan, Arad / Patt, Yonatan Shneor / Fisher, Lior / Zacay, Galia / Amital, Howard / Watad, Abdulla / Sharif, Kassem

    Therapeutic advances in gastroenterology

    2024  Volume 17, Page(s) 17562848241227037

    Abstract: Background: The skin-gut axis, characterized by bidirectional communication between the skin and gut, plays a crucial role in the pathogenesis of psoriasis and inflammatory bowel diseases (IBD).: Objectives: We aimed to explore the association ... ...

    Abstract Background: The skin-gut axis, characterized by bidirectional communication between the skin and gut, plays a crucial role in the pathogenesis of psoriasis and inflammatory bowel diseases (IBD).
    Objectives: We aimed to explore the association between psoriasis and IBD and identify predictors associated with IBD development among patients with psoriasis.
    Design: Retrospective cohort study.
    Methods: A retrospective study which utilized an electronic database from the Meuhedet Health Maintenance Organization (MHMO) in Israel. Psoriasis was categorized as severe if any systemic agent or phototherapy was administered. Univariate and multivariate logistic regressions were used to identify specific predictors for IBD, with adjustments made for potential confounders. The study received approval from the Ethical Committee of the MHMO.
    Results: In total, 61,003 adult patients who were diagnosed with psoriasis between 2000 and 2022 were included. Among them, 1495/61,003 patients (2.4%) were diagnosed with IBD, as compared to 3834/244,012 patients (1.6%) in the non-psoriasis group [adjusted odds ratio (OR): 1.47; 95% confidence interval (CI): 1.37-1.56;
    Conclusion: A significant association between psoriasis and IBD was demonstrated, including its subtypes: Crohn's disease and ulcerative colitis. Moreover, such association may depend on psoriasis severity as determined by the treatment used. This association warrants further investigation and implies a potential need for closer monitoring of patients with severe psoriasis.
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848241227037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The possible onset of fibromyalgia following acute COVID-19 infection.

    Savin, Einat / Rosenn, Gali / Tsur, Avishai M / Hen, Or / Ehrenberg, Scott / Gendelman, Omer / Buskila, Dan / Halpert, Gilad / Amital, Daniela / Amital, Howard

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0281593

    Abstract: Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced ... ...

    Abstract Introduction: The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among convalesced individuals following hospitalization for Acute Coronavirus Disease-2019 (COVID-19).
    Methods: We performed a cross-sectional study on patients who were discharged after COVID-19 hospitalization from the Sheba Medical Center, Israel, between July 2020 to November 2020. A phone interview was performed consisting of the following questionnaires: the Fibromyalgia Survey Diagnostic Criteria Questionnaire, Sense of Coherence Questionnaire to evaluate resilience, and the Subjective Traumatic Outlook Questionnaire to assess the associated psychological aspects of the trauma. The incidence of post-COVID FM was calculated and regression models were performed to identify predictors.
    Results: The study population consisted of 198 eligible patients who completed the phone interview. The median age was 64 (52-72) and 37% were women. The median follow-up was 5.2 months (IQR 4.4-5.8). The incidence of FM was 15% (30 patients) and 87% (172 patients) had at least one FM-related symptom. Female gender was significantly associated with post-COVID FM (OR 3.65, p = 0.002). In addition, high median Subjective Traumatic Outlook scores and low median Sense of Coherence scores were both significantly associated with post-COVID FM (OR 1.19, p<0.001 and OR 0.92, p<0.001, respectively).
    Conclusions: FM is highly prevalent among COVID-19 convalescent patients. Our finding suggests that a significant subjective traumatic experience and a low resilience are highly associated with post-COVID FM.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Fibromyalgia/complications ; Fibromyalgia/epidemiology ; Fibromyalgia/diagnosis ; Cross-Sectional Studies ; COVID-19/complications ; COVID-19/epidemiology ; Surveys and Questionnaires ; Israel/epidemiology
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Biologic Treatment Modification Efficacy in Concurrent Inflammatory Bowel Disease and Ankylosing Spondylitis: A Retrospective Cohort Study at a Single Tertiary Center.

    Savin, Einat / Ben-Shabat, Niv / Levartovsky, Asaf / Lahat, Adi / Omar, Mahmud / Gendelman, Omer / Lidar, Merav / Watad, Abdulla / Ben-Horin, Shomron / Kopylov, Uri / Sharif, Kassem

    Journal of clinical medicine

    2023  Volume 12, Issue 22

    Abstract: Background: The link between ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) is well-established, with concurrent prevalence estimates ranging from 5-10%. However, there are still significant gaps in our understanding, and a ... ...

    Abstract Background: The link between ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) is well-established, with concurrent prevalence estimates ranging from 5-10%. However, there are still significant gaps in our understanding, and a comprehensive treatment guideline for these co-diagnosed patients has yet to be established. Our objective was to explore patterns of treatment alterations following the diagnosis of AS in patients previously diagnosed with IBD, and vice versa. Additionally, we sought to determine how these modifications influence clinical outcomes in both conditions.
    Methods: This retrospective data-based cohort study included patients with coexisting IBD and AS that were diagnosed between the years 2009-2022 and were followed by the gastroenterology and the rheumatology units of the Sheba Medical Center, Israel. The data were extracted from the electronic health record and included demographic information, medication history, treatment modification at the time of second diagnosis, and the characteristics and activity of both IBD and AS at the index time and at the 3-month mark.
    Results: The study included a total of 68 patients, with a male predominance (40 patients, 59%). The median age was 43 years (IQR 31-55) and 78% had Crohn's disease (CD). The median duration between the diagnosis of the first disease to the second one was 4 years (IQR 1-9.5). A significant proportion of patients (85%) underwent treatment modification at their second diagnosis. Out of the total cohort, 28% initiated biological therapy, 17.6% switched their biologic regimen, and 16.2% discontinued NSAIDS. Patients who underwent biologic modifications at time of the second diagnosis (the initiation/switch/augmentation of a concurrent regimen) experienced significantly higher rates of clinical improvement in either IBD or AS at the 90-day follow-up compared to patients who did not (68% vs. 32%,
    Conclusions: Our findings suggest that biologic therapy modification at the time of the second diagnosis was associated with a higher rate of improvement in AS/IBD at the 90-day follow-up.
    Language English
    Publishing date 2023-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12227151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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