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  1. Article: Autopsy findings of fatal retroperitoneal hemorrhage after traumatic rupture of bilateral renal angiomyolipoma.

    Dominicis, Enrico De / Marella, Gian Luca / Giuga, Gabriele / Ceccobelli, Giulia / Savino, Luca / Tavone, Alessandro Mauro

    Autopsy & case reports

    2024  Volume 14, Page(s) e2024482

    Abstract: The present work reports the autopsy findings of a unique case characterized by fatal retroperitoneal hemorrhage following the traumatic rupture of bilateral renal angiomyolipomas. Renal angiomyolipomas are generally benign tumors with an unpredictable ... ...

    Abstract The present work reports the autopsy findings of a unique case characterized by fatal retroperitoneal hemorrhage following the traumatic rupture of bilateral renal angiomyolipomas. Renal angiomyolipomas are generally benign tumors with an unpredictable clinical course, ranging from asymptomatic to sudden rupture and hemorrhagic shock. They may be associated with genetic disorders such as tuberous sclerosis complex. The case under investigation is unprecedented in the medical literature due to its bilateral nature and fatal outcome. Autopsy analysis revealed an extensive retroperitoneal hemorrhage originating from bilateral ruptured tumors. Microscopic examination found features consistent with bilateral renal angiomyolipoma. Circumstantial information identified a traffic accident before the death, considering it as the cause of the tumors' traumatic rupture. In this case, due to the severity of the situation, immediate medical measures-such as fluid resuscitation, coagulopathy correction, and surgical treatment, which are usually lifesaving-could not be performed. This led to the patient being declared dead at the scene of the crash.
    Language English
    Publishing date 2024-03-15
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2024.482
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  2. Article ; Online: A high-performance xylene-free tissue-clearing agent for routine histology: Preliminary histomorphological results.

    Scioli, Maria Giovanna / Fabbri, Giulia / Cappelli, Sabrina / Savino, Luca / Ferlosio, Amedeo / Orlandi, Augusto

    Annals of diagnostic pathology

    2023  Volume 66, Page(s) 152163

    Abstract: After the discovery of the hazardous effects of xylene, less toxic substitutes were proposed for routine histology in the last years. However, the introduction of new xylene-free substitutes in histological processes requires a careful evaluation of ... ...

    Abstract After the discovery of the hazardous effects of xylene, less toxic substitutes were proposed for routine histology in the last years. However, the introduction of new xylene-free substitutes in histological processes requires a careful evaluation of their performance in terms of morphological and microscopic details to permit a solid diagnosis as well as good quality immunohistochemical and biomolecular analyses. In this study, we analyzed the performance of a new commercially available xylene-free Tissue-Tek® Tissue-Clear® agent in comparison with another routine xylene-free solvent yet available and employed in routine histological process. Serial histological tissue samples (n = 300) were selected and processed with the two clearing agents. Comparison and evaluation were also performed on slides obtained 6 months after paraffin embedding and archive storage. Blinded semiquantitative analysis of technical performance and morphological details, including tissue architecture and nuclear and cytoplasmic details, was performed on Haematoxylin-Eosin stained sections by two technicians and two pathologists, respectively. Evaluation of tissue slides documented a good overall histological performance in slides obtained after processing with the two different clearing agents. Slides obtained with Tissue-Tek® Tissue-Clear® displayed a higher score in some quality parameters, further supporting its use as a valid alternative to the other commercial routine xylene-free solvents.
    MeSH term(s) Humans ; Xylenes/chemistry ; Indicators and Reagents ; Eosine Yellowish-(YS)
    Chemical Substances Xylenes ; Indicators and Reagents ; Eosine Yellowish-(YS) (TDQ283MPCW)
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2023.152163
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5463: Show issues Location:
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  3. Article ; Conference proceedings: EUS-guided Fine-Needle Biopsy for Diagnosis and Molecular Profiling of Extrahepatic Cholangiocarcinoma: a Single-Center Retrospective Study

    Troncone, E. / Gadaleta, F. / Savino, L. / Amendola, R. / Moscardelli, A. / Santangelo, P. / De Cristofaro, E. / De Vico, P. / Monteleone, G. / Del Vecchio Blanco, G.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1782951
    Database Thieme publisher's database

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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  4. Article: Colo-colic intussusception in an adult caused by lipoma: Case report of a rare condition.

    Di Stefano, Carla / Salvatori, Eva / Savino, Luca / Forte, Valentina / Paoletti, Stefano / Ricciardi, Federica / Floris, Roberto / Garaci, Francesco

    Radiology case reports

    2023  Volume 19, Issue 2, Page(s) 665–670

    Abstract: This report describes the case of a 56-year-old woman who presented at the emergency room with a 3-week history of severe, intermittent abdominal pain. A CT scan revealed colo-colic intussusception caused by a large, substenosing mass with predominant ... ...

    Abstract This report describes the case of a 56-year-old woman who presented at the emergency room with a 3-week history of severe, intermittent abdominal pain. A CT scan revealed colo-colic intussusception caused by a large, substenosing mass with predominant adipose density. Subsequent endoscopic examination with biopsy revealed a necrotic tissue covering the mass, without definitive histological characterization. A second biopsy led to the extremely rare diagnosis of colo-colic lipoma. While intussusception is rare in adults, it's important to consider it as a differential diagnosis, especially when presenting with abdominal pain and signs of bowel obstruction. Timely diagnosis and appropriate treatment are essential to prevent complications.
    Language English
    Publishing date 2023-11-25
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.10.080
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  5. Article ; Online: Giant Aneurysm of Aortic Arch: When Coughing Can Save A Life.

    Giovannico, Lorenzo / Fischetti, Giuseppe / Parigino, Domenico / Savino, Luca / Santeramo, Vincenzo / Scrascia, Giuseppe / Di Bari, Nicola / Milano, Aldo Domenico / Bottio, Tomaso

    Heart, lung & circulation

    2023  Volume 33, Issue 1, Page(s) e1–e2

    MeSH term(s) Humans ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aneurysm/complications ; Aneurysm/diagnosis ; Aneurysm/surgery ; Aortic Aneurysm, Thoracic/complications ; Aortic Aneurysm, Thoracic/diagnosis ; Aortic Aneurysm, Thoracic/surgery ; Thorax
    Language English
    Publishing date 2023-12-29
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2020980-0
    ISSN 1444-2892 ; 1443-9506
    ISSN (online) 1444-2892
    ISSN 1443-9506
    DOI 10.1016/j.hlc.2023.11.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4988: Show issues Location:
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  6. Article ; Online: World's oldest heart transplant donor: age is just a number.

    Giovannico, Lorenzo / Parigino, Domenico / Ramirez, Antonio D'Errico / Fischetti, Giuseppe / Santeramo, Vincenzo / Savino, Luca / Fiore, Giuseppe / Bottio, Tomaso / Musajo Somma, Chiara / Gesualdo, Loreto / Milano, Aldo Domenico

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2024  Volume 25, Issue 3, Page(s) 243–245

    MeSH term(s) Humans ; Heart ; Tissue Donors ; Thorax ; Heart Transplantation/adverse effects
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001585
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    Zs.A 5210: Show issues Location:
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    Zs.MO 559: Show issues

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  7. Article ; Online: Can a "broken heart" successfully be transplanted? A brief report.

    Giovannico, Lorenzo / Fischetti, Giuseppe / Mazzone, Federica / Parigino, Domenico / Savino, Luca / Santeramo, Vincenzo / Silva, Aline Maria / di Bari, Nicola / Acquaviva, Tommaso / Fiore, Giuseppe / Milano, Aldo Domenico / Bottio, Tomaso

    Clinical transplantation

    2024  Volume 38, Issue 4, Page(s) e15303

    Abstract: A 59-year-old woman, with dilated ischemic cardiomyopathy, was urgently admitted to our Intensive Care Unit for cardiogenic shock. ECMO VA was implanted and placed on the national emergency waitlist for transplantation. A potential donation was ... ...

    Abstract A 59-year-old woman, with dilated ischemic cardiomyopathy, was urgently admitted to our Intensive Care Unit for cardiogenic shock. ECMO VA was implanted and placed on the national emergency waitlist for transplantation. A potential donation was identified ten days later. The donor was a 58-year-old woman, with no cardiovascular risk factors, had died of a rupture of a cerebral aneurysm with left ventricle dysfunction due to Takotsubo syndrome. Brain injuries such as hemorrhage, trauma and stroke have been extensively documented in literature to cause a surge in stress hormones, such as catecholamines. Such a surge can have a direct effect on the heart, resulting in a transient myocardial dysfunction commonly referred to as "Takotsubo cardiomyopathy" or "broken heart syndrome". Many studies have shown that hearts that are dysfunctional at the start of transplant screening, with normal contractile function at the time of organ retrieval, have similar outcomes to hearts that do not have dysfunction. In our case, the transplanted heart, at the time of sampling, still had moderate dysfunction (EF 40%) which completely disappeared after the transplant.
    MeSH term(s) Female ; Humans ; Middle Aged ; Heart ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/etiology ; Shock, Cardiogenic ; Tissue Donors
    Language English
    Publishing date 2024-03-29
    Publishing country Denmark
    Document type Case Reports ; Letter
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15303
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    Zs.A 2204: Show issues Location:
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  8. Article ; Online: Psychological assessment of patients on the heart transplant waiting list: A single center experience.

    De Santis, Simona / Ladisa, Valeria / Giovannico, Lorenzo / Fischetti, Giuseppe / Parigino, Domenico / Savino, Luca / Silva, Aline Maria / Bari, Nicola Di / Taurisano, Paolo / De Caro, Maria Fara / Bottio, Tomaso

    Clinical transplantation

    2024  Volume 38, Issue 5, Page(s) e15328

    Abstract: Objective: To analyze the data of the psychological assessment, focusing attention on the quality of life and the psychological status of patients who are listed for heart transplant.: Methods: All heart failure patients listed for heart transplant ... ...

    Abstract Objective: To analyze the data of the psychological assessment, focusing attention on the quality of life and the psychological status of patients who are listed for heart transplant.
    Methods: All heart failure patients listed for heart transplant at the Cardiac Surgery Unit of Bari University, Italy, were evaluated from September to November 2023, by administering the Symptom Checklist-90-R (SCL-90-R) and the Short Form Health Survey 36 (SF-36).
    Results: Overall, 27 patients were studied. Mean age was 60 years, 88% were males. One third of the patients showed a clinically significant overall mental distress. The symptoms leading to domains such as somatization (55.55%), anxiety (40.74%) and depression (33.33%) were frequently observed. The majority of the population studied (96.30%) showed low levels of perceived physical health status, while 59,62% of them presented levels of perceived physical health status below normal ranges.
    Conclusions: Heart transplant candidates show elements of overall mental distress and low quality of life related to physical health status.
    MeSH term(s) Humans ; Heart Transplantation/psychology ; Male ; Female ; Middle Aged ; Quality of Life ; Waiting Lists ; Follow-Up Studies ; Prognosis ; Heart Failure/psychology ; Heart Failure/surgery ; Stress, Psychological ; Adult ; Anxiety/psychology ; Anxiety/etiology ; Anxiety/diagnosis ; Depression/psychology ; Depression/etiology ; Aged ; Italy ; Surveys and Questionnaires
    Language English
    Publishing date 2024-04-30
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15328
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    In stock of ZB MED Cologne/Königswinter

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  9. Article: Effects of H

    Savino, Luca / Di Marcantonio, Maria Carmela / Moscatello, Carmelo / Cotellese, Roberto / Centurione, Lucia / Muraro, Raffaella / Aceto, Gitana Maria / Mincione, Gabriella

    Frontiers in oncology

    2022  Volume 12, Page(s) 860760

    Abstract: Gastric cancer is worldwide the fifth and third cancer for incidence and mortality, respectively. Stomach wall is daily exposed to oxidative stress and BER system has a key role in the defense from oxidation-induced DNA damage, whilst ErbB receptors have ...

    Abstract Gastric cancer is worldwide the fifth and third cancer for incidence and mortality, respectively. Stomach wall is daily exposed to oxidative stress and BER system has a key role in the defense from oxidation-induced DNA damage, whilst ErbB receptors have important roles in the pathogenesis of cancer. We used AGS cells as an aggressive gastric carcinoma cell model, treated with H
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.860760
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  10. Article ; Online: Fatal acute graft-versus-host disease in Sézary Syndrome treated with Mogamulizumab and hematopoietic cell transplantation.

    Trotta, Gentiana Elena / Ciangola, Giulia / Cerroni, Ilaria / Mezzanotte, Valeria / Nunzi, Andrea / Anemona, Lucia / Savino, Luca / De Angelis, Gottardo / Mariotti, Benedetta / Bonanni, Fabrizio / Meddi, Elisa / Zizzari, Annagiulia / Rapisarda, Vito Mario / Mangione, Ilaria / Bruno, Antonio / Cantonetti, Maria / Venditti, Adriano / Cerretti, Raffaella

    Current research in translational medicine

    2024  Volume 72, Issue 3, Page(s) 103452

    Abstract: Sézary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. Allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graft-versus-host disease (GvHD) remain a ... ...

    Abstract Sézary syndrome (SS) is a rare and aggressive T-cell lymphoma with a poor prognosis in advanced stages. Allogeneic hematopoietic cell transplantation (allo-HCT) offers a potential cure, but complications such as graft-versus-host disease (GvHD) remain a clinical challenge. Mogamulizumab, a humanized anti-CC chemokine receptor 4 (CCR4) antibody, is sometimes used as a bridge to transplantation, but its potential interactions with allo-HCT are unclear. This report describes the case of a 37-year-old man with advanced SS who received mogamulizumab therapy followed by allo-HCT from an HLA-identical sibling donor. The patient developed severe gastrointestinal acute GvHD, which was treated with steroids and infliximab. However, the condition rapidly progressed to severe intestinal symptoms and life-threatening haemorrhagic shock, ultimately resulting in the patient's death. This case highlights a potential link between mogamulizumab and severe acute GvHD promoted by drug-induced suppression of regulatory T cells. Further research is required to fully understand the interaction between mogamulizumab and allo-HCT and to determine whether it is an optimal approach as a bridge to transplant therapy. This paradigmatic case suggests the need of personalizing transplant strategies by selecting appropriate conditioning therapy and GvHD prophylaxis to minimize potential toxicity.
    Language English
    Publishing date 2024-04-24
    Publishing country France
    Document type Letter
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2024.103452
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