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  1. AU="Savona, Steven"
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  1. Article ; Online: Tracheostomy during SARS-CoV-2 pandemic: Recommendations from the New York Head and Neck Society.

    Miles, Brett A / Schiff, Bradley / Ganly, Ian / Ow, Thomas / Cohen, Erik / Genden, Eric / Culliney, Bruce / Mehrotra, Bhoomi / Savona, Steven / Wong, Richard J / Haigentz, Missak / Caruana, Salvatore / Givi, Babak / Patel, Kepal / Hu, Kenneth

    Head & neck

    2020  Volume 42, Issue 6, Page(s) 1282–1290

    Abstract: The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients ... ...

    Abstract The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients requiring endotracheal intubation and prolonged ventilator support. The rapid rise in endotracheal intubations coupled with prolonged ventilation requirements will certainly lead to an increase in tracheostomy procedures in the coming weeks and months. Performing tracheostomy in the setting of active SARS-CoV-2, when necessary, poses a unique situation, with unique risks and benefits for both the patient and the health care providers. The New York Head and Neck Society has collaborated on this document to provide guidance on the performance of tracheostomies during the SARS-CoV-2 pandemic.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Intubation, Intratracheal ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Practice Guidelines as Topic ; SARS-CoV-2 ; Tracheostomy
    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26166
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1493: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Ibrutinib penetrates the blood brain barrier and shows efficacy in the therapy of Bing Neel syndrome.

    Mason, Christopher / Savona, Steven / Rini, Josephine N / Castillo, Jorge J / Xu, Lian / Hunter, Zachary R / Treon, Steven P / Allen, Steven L

    British journal of haematology

    2016  Volume 179, Issue 2, Page(s) 339–341

    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Biomarkers ; Blood-Brain Barrier/metabolism ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/secondary ; Humans ; Immunophenotyping ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrazoles/administration & dosage ; Pyrazoles/pharmacokinetics ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacokinetics ; Tomography, X-Ray Computed ; Treatment Outcome ; Waldenstrom Macroglobulinemia/complications ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy
    Chemical Substances Antineoplastic Agents ; Biomarkers ; Protein Kinase Inhibitors ; Pyrazoles ; Pyrimidines ; ibrutinib (1X70OSD4VX)
    Language English
    Publishing date 2016-07-13
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.14218
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    Uh III Zs.182: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Metastatic medullary carcinoma of thyroid presenting as a dural-based mass: case report and review of literature.

    Rishi, Arvind / Savona, Steven / Black, Karen / Schulder, Michael / Li, Jian Yi

    Endocrine pathology

    2013  Volume 24, Issue 1, Page(s) 40–44

    Abstract: Dural metastasis from medullary thyroid carcinoma (MTC) is not well established in English literature. We present the case report of MTC with unusual clinical presentation as a dural-based mass in a 39-year-old male with no family history of multiple ... ...

    Abstract Dural metastasis from medullary thyroid carcinoma (MTC) is not well established in English literature. We present the case report of MTC with unusual clinical presentation as a dural-based mass in a 39-year-old male with no family history of multiple endocrine neoplasia syndrome. Magnetic resonance imaging showed an extra-axial dural-based mass in right frontal lobe with calvarium and soft tissue extension to the right superior orbit. Histopathology showed MTC with variegated morphology and various patterns. Thyroid mass and widespread metastases from medullary thyroid carcinoma were subsequently identified.
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/blood ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Carcinoma, Medullary/pathology ; Carcinoma, Medullary/secondary ; Dura Mater/pathology ; Exophthalmos/etiology ; Fatal Outcome ; Humans ; Immunohistochemistry ; Magnetic Resonance Imaging ; Male ; Meningeal Neoplasms/pathology ; Meningeal Neoplasms/secondary ; Thyroid Neoplasms/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2013-01-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1033267-4
    ISSN 1559-0097 ; 1046-3976
    ISSN (online) 1559-0097
    ISSN 1046-3976
    DOI 10.1007/s12022-013-9233-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2956: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Tracheostomy during SARS-CoV-2 pandemic: Recommendations from the New York Head and Neck Society

    Miles, Brett A / Schiff, Bradley / Ganly, Ian / Ow, Thomas / Cohen, Erik / Genden, Eric / Culliney, Bruce / Mehrotra, Bhoomi / Savona, Steven / Wong, Richard J / Haigentz, Missak / Caruana, Salvatore / Givi, Babak / Patel, Kepal / Hu, Kenneth

    Head Neck

    Abstract: The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients ... ...

    Abstract The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients requiring endotracheal intubation and prolonged ventilator support. The rapid rise in endotracheal intubations coupled with prolonged ventilation requirements will certainly lead to an increase in tracheostomy procedures in the coming weeks and months. Performing tracheostomy in the setting of active SARS-CoV-2, when necessary, poses a unique situation, with unique risks and benefits for both the patient and the health care providers. The New York Head and Neck Society has collaborated on this document to provide guidance on the performance of tracheostomies during the SARS-CoV-2 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #72234
    Database COVID19

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  5. Article ; Online: Tracheostomy during SARS‐CoV ‐2 pandemic

    Miles, Brett A. / Schiff, Bradley / Ganly, Ian / Ow, Thomas / Cohen, Erik / Genden, Eric / Culliney, Bruce / Mehrotra, Bhoomi / Savona, Steven / Wong, Richard J. / Haigentz, Missak / Caruana, Salvatore / Givi, Babak / Patel, Kepal / Hu, Kenneth

    Head & Neck

    Recommendations from the New York Head and Neck Society

    2020  Volume 42, Issue 6, Page(s) 1282–1290

    Keywords Otorhinolaryngology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ISSN 1043-3074
    DOI 10.1002/hed.26166
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature.

    Yancoskie, Aaron E / Frank, Douglas K / Fantasia, John E / Savona, Steven / Eiseler, Nicole / Reder, Ilan / Kahn, Leonard B

    Head and neck pathology

    2015  Volume 9, Issue 4, Page(s) 447–452

    Abstract: Giant cell tumor of the larynx (GCTL) is a rare entity; only 34 cases have been reported in the literature. We report a case of GCTL in a 46 year-old male presenting clinical, radiographic, histological and therapeutic features. Previously reported cases ...

    Abstract Giant cell tumor of the larynx (GCTL) is a rare entity; only 34 cases have been reported in the literature. We report a case of GCTL in a 46 year-old male presenting clinical, radiographic, histological and therapeutic features. Previously reported cases are also reviewed.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Chemotherapy, Adjuvant ; Denosumab/therapeutic use ; Giant Cell Tumors/pathology ; Giant Cell Tumors/therapy ; Humans ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Male ; Middle Aged ; Otorhinolaryngologic Surgical Procedures
    Chemical Substances Antineoplastic Agents ; Denosumab (4EQZ6YO2HI)
    Language English
    Publishing date 2015-03-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-015-0622-4
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  7. Article ; Online: Phase II double-blind placebo-controlled randomized study of armodafinil for brain radiation-induced fatigue.

    Page, Brandi R / Shaw, Edward G / Lu, Lingyi / Bryant, David / Grisell, David / Lesser, Glenn J / Monitto, Drew C / Naughton, Michelle J / Rapp, Stephen R / Savona, Steven R / Shah, Sunjay / Case, Doug / Chan, Michael D

    Neuro-oncology

    2015  Volume 17, Issue 10, Page(s) 1393–1401

    Abstract: Background: Common acute-term side effects of brain radiotherapy (RT) include fatigue, drowsiness, decreased physical functioning, and decreased quality of life (QOL). We hypothesized that armodafinil (a wakefulness-promoting drug known to reduce ... ...

    Abstract Background: Common acute-term side effects of brain radiotherapy (RT) include fatigue, drowsiness, decreased physical functioning, and decreased quality of life (QOL). We hypothesized that armodafinil (a wakefulness-promoting drug known to reduce fatigue and increase cognitive function in breast cancer patients receiving chemotherapy) would result in reduced fatigue and sleepiness for patients receiving brain RT.
    Methods: A phase II, multi-institutional, placebo-controlled randomized trial assessed feasibility of armodafinil 150 mg/day in participants receiving brain RT, from whom we obtained estimates of variability for fatigue, sleepiness, QOL, cognitive function, and treatment effect.
    Results: From September 20, 2010, to October 20, 2012, 54 participants enrolled with 80% retention and 94% self-reported compliance. There were no grade 4-5 toxicities, and the incidence of grade 2-3 toxicities was similar between treatment arms, the most common of which were anxiety and nausea (15%), headaches (19%), and insomnia (20%). There were no statistically significant differences in end-RT or 4 week post-RT outcomes between armodafinil and placebo in any outcomes (Functional Assessment of Chronic Illness Therapy [FACIT]-Fatigue, Brief Fatigue Inventory, Epworth Sleepiness Scale, FACT-Brain, and FACIT-cognitive function). However, in participants with more baseline fatigue, those treated with armodafinil did better than those who received the placebo on the end-RT assessments for several outcomes.
    Conclusion: Armodafinil 150 mg/day was well tolerated in primary brain tumor patients undergoing RT with good compliance. While there was no overall significant effect on fatigue, those with greater baseline fatigue experienced improved QOL and reduced fatigue when using armodafinil. These data suggest that a prospective, phase III randomized trial is warranted for patients with greater baseline fatigue.
    MeSH term(s) Adult ; Aged ; Benzhydryl Compounds/administration & dosage ; Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/therapeutic use ; Brain Neoplasms/radiotherapy ; Double-Blind Method ; Fatigue/etiology ; Fatigue/prevention & control ; Female ; Glioblastoma/complications ; Glioblastoma/radiotherapy ; Humans ; Male ; Meningioma/complications ; Meningioma/radiotherapy ; Middle Aged ; Modafinil ; Quality of Life ; Radiotherapy/adverse effects ; Treatment Outcome ; Wakefulness-Promoting Agents/therapeutic use
    Chemical Substances Benzhydryl Compounds ; Wakefulness-Promoting Agents ; Modafinil (R3UK8X3U3D)
    Language English
    Publishing date 2015-05-12
    Publishing country England
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/nov084
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    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Randomized trial of influenza vaccine with granulocyte-macrophage colony-stimulating factor or placebo in cancer patients.

    Ramanathan, Ramesh K / Potter, Douglas M / Belani, Chandra P / Jacobs, Samuel A / Gravenstein, Stefan / Lim, Felix / Kim, Hyoung / Savona, Steven / Evans, Terry / Buchbarker, Dianne / Simon, Mary B / Depee, Jane K / Trump, Donald L

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2002  Volume 20, Issue 21, Page(s) 4313–4318

    Abstract: Purpose: To determine whether granulocyte-macrophage colony-stimulating factor (GM-CSF) would improve response to influenza vaccination in cancer patients.: Patients and methods: In a randomized, patient-blinded, placebo-controlled trial carried out ... ...

    Abstract Purpose: To determine whether granulocyte-macrophage colony-stimulating factor (GM-CSF) would improve response to influenza vaccination in cancer patients.
    Patients and methods: In a randomized, patient-blinded, placebo-controlled trial carried out in 1997 to 2000, 133 patients were stratified into five groups of treatment and disease. Single doses of standard split trivalent influenza vaccine and either placebo or 250 micro g of GM-CSF were administered at the same time. Hemagglutination inhibition assay titers were measured before and 4 weeks after vaccination.
    Results: Standard analyses, which define response as at least a four-fold increase in titers, detect no effect of GM-CSF for any of the three influenza subtypes in the trivalent vaccines (P >or=.12). Analysis that includes the magnitude of the change in titers and combines responses of the subtypes suggests that the placebo group had the greater response (P =.051), thus indicating that GM-CSF does not improve response. Ancillary analyses show that response declines both with increasing age and with higher initial titers. The fraction of patients with at least a four-fold increase in titers was 0.36 (95% confidence interval, 0.29 to 0.42)
    Conclusion: A single 250- micro g dose of GM-CSF administered with the influenza vaccine does not improve response to vaccination. Response in cancer patients is low and declines as age and initial titer increase.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antibody Formation ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Humans ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Neoplasms/complications ; Single-Blind Method
    Chemical Substances Influenza Vaccines ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2002-11-01
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2002.02.041
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    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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