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  1. Article ; Online: Behavioral profile alterations and predation susceptibility of Japanese medaka fish exposed to phenytoin, an antiepileptic drug.

    Sawada, Ayaka / Dorcas, Uaciquete / Horie, Yoshifumi

    Environmental toxicology and pharmacology

    2024  , Page(s) 104474

    Abstract: Antiepileptic drugs, such as phenytoin, are often leaked into aquatic systems through sewage facilities due to their low metabolic rate. Fish, such as the Japanese medaka (Oryzias latipes), demonstrate abnormal swimming behavior such as equilibrium ... ...

    Abstract Antiepileptic drugs, such as phenytoin, are often leaked into aquatic systems through sewage facilities due to their low metabolic rate. Fish, such as the Japanese medaka (Oryzias latipes), demonstrate abnormal swimming behavior such as equilibrium abnormalities, rotational behavior, and vertical swimming, when exposed to phenytoin. Therefore, it is hypothesized that predator avoidance may be hindered. This study aimed to investigate the effects of phenytoin exposure-induced behavioral abnormalities in predator avoidance in Japanese medaka. The results showed that individuals with behavioral abnormalities had a reduced ability to avoid danger. Furthermore, the fish demonstrated a delayed recognition reaction to approaching predators. Additionally, predatory fish, such as silver pike characin (Ctenolucius hujeta), were more likely to prey upon abnormal individuals. In conclusion, the fish exposed to phenytoin demonstrated behavioral changes that increased its predation risk. This study is the first to determine the effects of behavioral abnormalities in Japanese medaka which was induced after phenytoin exposure on predator risk avoidance.
    Language English
    Publishing date 2024-05-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2024.104474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Iopanoic acid alters thyroid hormone-related gene expression, thyroid hormone levels, swim bladder inflation, and swimming performance in Japanese medaka.

    Horie, Yoshifumi / Sawada, Ayaka / Dorcas, Uaciquete / Ramaswamy, Babu Rajendran / Iguchi, Taisen

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2024  Volume 281, Page(s) 109930

    Abstract: Disruption of the thyroid hormone system by synthetic chemicals is gaining attention owing to its potential negative effects on organisms. In this study, the effects of the dio-inhibitor iopanoic acid (IOP) on the levels of thyroid hormone and related ... ...

    Abstract Disruption of the thyroid hormone system by synthetic chemicals is gaining attention owing to its potential negative effects on organisms. In this study, the effects of the dio-inhibitor iopanoic acid (IOP) on the levels of thyroid hormone and related gene expression, swim bladder inflation, and swimming performance were investigated in Japanese medaka. Iopanoic acid exposure suppressed thyroid-stimulating hormone β (tshβ), tshβ-like, iodotyronin deiodinase 1 (dio1), and dio2 expression, and increased T4 and T3 levels. In addition, IOP exposure inhibited swim bladder inflation, reducing swimming performance. Although adverse outcome pathways of thyroid hormone disruption have been developed using zebrafish, no adverse outcome pathways have been developed using Japanese medaka. This study confirmed that IOP inhibits dio expression (a molecular initiating event), affects T3 and T4 levels (a key event), and reduces swim bladder inflation (a key event) and swimming performance (an adverse outcome) in Japanese medaka.
    MeSH term(s) Animals ; Oryzias/physiology ; Swimming ; Air Sacs/drug effects ; Air Sacs/metabolism ; Thyroid Hormones/metabolism ; Thyroid Hormones/blood ; Iopanoic Acid/toxicity ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Gene Expression Regulation/drug effects ; Thyroxine/blood ; Triiodothyronine/blood ; Iodide Peroxidase/genetics ; Iodide Peroxidase/metabolism
    Chemical Substances Thyroid Hormones ; Iopanoic Acid (FE9794P71J) ; Fish Proteins ; Thyroxine (Q51BO43MG4) ; Triiodothyronine (06LU7C9H1V) ; Iodide Peroxidase (EC 1.11.1.8)
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2024.109930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 44/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Evidence for Introgressive Hybridization between Native Dolly Varden (

    Fukui, Sho / Kasugai, Kiyoshi / Sawada, Ayaka / Koizumi, Itsuro

    Zoological science

    2021  Volume 38, Issue 3, Page(s) 247–251

    Abstract: Hybridization is one of the negative outcomes for the introduction of non-native species, which can lead to rapid displacement and genetic extinction of native species. Salmonid fishes have been widely introduced outside of their native ranges for food ... ...

    Abstract Hybridization is one of the negative outcomes for the introduction of non-native species, which can lead to rapid displacement and genetic extinction of native species. Salmonid fishes have been widely introduced outside of their native ranges for food supply and recreational fishing. Here, we investigate the occurrence of introgressive hybridization among native Dolly Varden (
    MeSH term(s) Animals ; Hybridization, Genetic ; Introduced Species ; Japan ; Microsatellite Instability ; Rivers ; Trout/genetics
    Language English
    Publishing date 2021-05-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038883-4
    ISSN 2212-3830 ; 0289-0003
    ISSN (online) 2212-3830
    ISSN 0289-0003
    DOI 10.2108/zs200041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gram-Scale Syntheses and Conductivities of [10]Cycloparaphenylene and Its Tetraalkoxy Derivatives.

    Kayahara, Eiichi / Sun, Liansheng / Onishi, Hiroaki / Suzuki, Katsuaki / Fukushima, Tatsuya / Sawada, Ayaka / Kaji, Hironori / Yamago, Shigeru

    Journal of the American Chemical Society

    2017  Volume 139, Issue 51, Page(s) 18480–18483

    Abstract: 10]Cycloparaphenylene ([10]CPP) and its tetraalkoxy derivatives were synthesized on the gram scale in 7 steps starting from 1,4-benzoquinone or 2,5-dialkoxy-1,4-benzoquinone. The key steps involve the highly cis-selective bis-addition of 4-bromo-4'- ... ...

    Abstract [10]Cycloparaphenylene ([10]CPP) and its tetraalkoxy derivatives were synthesized on the gram scale in 7 steps starting from 1,4-benzoquinone or 2,5-dialkoxy-1,4-benzoquinone. The key steps involve the highly cis-selective bis-addition of 4-bromo-4'-lithiobiphenyl to the quinones to produce a five-ring unit containing cyclohexa-1,4-diene-3,6-diol moiety, the platinum-mediated dimerization of the five-ring unit, and the H
    Language English
    Publishing date 2017--27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.7b11526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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