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  1. Article ; Online: BEST3-Mediated MEKK2/3 Activation: A Novel Therapeutic Target in Aortopathies.

    Sawada, Hisashi / Daugherty, Alan

    Circulation

    2023  Volume 148, Issue 7, Page(s) 607–609

    MeSH term(s) Humans ; Muscle, Smooth, Vascular/metabolism ; Aortic Dissection ; Aorta ; MAP Kinase Signaling System ; Bestrophins/metabolism ; Muscle Proteins/metabolism
    Chemical Substances BEST3 protein, human ; Bestrophins ; Muscle Proteins
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.065946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
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  2. Article ; Online: Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.

    Daugherty, Alan / Sawada, Hisashi / Sheppard, Mary B / Lu, Hong S

    Arteriosclerosis, thrombosis, and vascular biology

    2024  Volume 44, Issue 5, Page(s) 1021–1030

    Abstract: AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased ... ...

    Abstract AGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased recently, particularly with the evolution of drugs to target the synthesis of the protein. AGT is a noninhibitory serpin that has several conserved domains in addition to the angiotensin II sequences at the N terminus. Increased study is needed on the structure-function relationship to resolve many unknowns regarding AGT metabolism. Constitutive whole-body genetic deletion of
    MeSH term(s) Animals ; Humans ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/genetics ; Angiotensinogen/metabolism ; Angiotensinogen/genetics ; Metabolic Diseases/drug therapy ; Metabolic Diseases/metabolism ; Metabolic Diseases/genetics ; Renin-Angiotensin System/drug effects ; Molecular Targeted Therapy
    Chemical Substances Angiotensinogen (11002-13-4)
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.124.318374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Abdominal aortic aneurysms: insights into mechanical and extracellular matrix effects from mouse models.

    Lu, Hong S / Sawada, Hisashi / Daugherty, Alan

    JVS-vascular science

    2023  Volume 4, Page(s) 100099

    Language English
    Publishing date 2023-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3503
    ISSN (online) 2666-3503
    DOI 10.1016/j.jvssci.2023.100099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metformin ameliorates established abdominal aortic aneurysms induced by elastase in mice.

    Lu, Hong S / Sawada, Hisashi / Daugherty, Alan

    JVS-vascular science

    2023  Volume 4, Page(s) 100103

    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3503
    ISSN (online) 2666-3503
    DOI 10.1016/j.jvssci.2023.100103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Divergent Roles of Matrix Metalloproteinase 12 in Abdominal Aortic Aneurysms.

    Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Circulation research

    2023  Volume 132, Issue 4, Page(s) 449–451

    MeSH term(s) Humans ; Matrix Metalloproteinase 12 ; Aortic Aneurysm, Abdominal ; Matrix Metalloproteinase 9 ; Angiotensin II ; Aorta, Abdominal
    Chemical Substances Matrix Metalloproteinase 12 (EC 3.4.24.65) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.123.322511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.70: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Ui IV Zs.60: Show issues Location:
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  6. Article ; Online: Expression of a PCSK9 Gain-of-Function Mutation in C57BL/6J Mice to Facilitate Angiotensin II-Induced AAAs.

    Sawada, Hisashi / Daugherty, Alan / Lu, Hong S

    Biomolecules

    2022  Volume 12, Issue 7

    Abstract: Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein ...

    Abstract Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein receptor (LDLR) or apolipoprotein E deficiency have been used as a hypercholesterolemic background. However, it is a time-consuming and expensive process to generate compound deficient strains that have either an LDLR or apolipoprotein E deficient background. Proprotein convertase subtilisin/kexin type 9 (PCSK9) facilitates the degradation of LDL receptors. Previous studies demonstrated profound increases of plasma cholesterol concentrations after a single intraperitoneal injection of adeno-associated viruses (AAV) expressing a gain-of-function mutation of mouse PCSK9 (AAV.mPCSK9
    MeSH term(s) Angiotensin II/metabolism ; Animals ; Dependovirus/genetics ; Gain of Function Mutation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proprotein Convertase 9/genetics
    Chemical Substances Angiotensin II (11128-99-7) ; PCSK9 protein, human (EC 3.4.21.-) ; Pcsk9 protein, mouse (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12070915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Aortic Aneurysm and Dissection: Heterogeneity and Molecular Mechanisms.

    Lu, Hong S / Sawada, Hisashi / Wu, Congqing

    Biomolecules

    2022  Volume 12, Issue 10

    Abstract: Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [ ... ]. ...

    Abstract Aortic aneurysms and dissections (AAD) are devastating aortic diseases with high risks for aortic rupture, leading to uncontrolled bleeding and death [...].
    MeSH term(s) Humans ; Aortic Aneurysm, Thoracic/genetics ; Aneurysm, Dissecting ; Aortic Aneurysm
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Annexin A1: a promising target for preventing aortic dissections.

    Sawada, Hisashi / Lu, Hong S / Daugherty, Alan

    Cardiovascular research

    2022  Volume 118, Issue 6, Page(s) 1383–1384

    MeSH term(s) Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/prevention & control ; Annexin A1 ; Humans ; Myocytes, Smooth Muscle
    Chemical Substances Annexin A1
    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Imaging Techniques for Aortic Aneurysms and Dissections in Mice: Comparisons of Ex Vivo, In Situ, and Ultrasound Approaches.

    Ito, Sohei / Lu, Hong S / Daugherty, Alan / Sawada, Hisashi

    Biomolecules

    2022  Volume 12, Issue 2

    Abstract: Aortic aneurysms and dissections are life-threatening conditions that have a high risk for lethal bleeding and organ malperfusion. Many studies have investigated the molecular basis of these diseases using mouse models. In mice, ex vivo, in situ, and ... ...

    Abstract Aortic aneurysms and dissections are life-threatening conditions that have a high risk for lethal bleeding and organ malperfusion. Many studies have investigated the molecular basis of these diseases using mouse models. In mice, ex vivo, in situ, and ultrasound imaging are major approaches to evaluate aortic diameters, a common parameter to determine the severity of aortic aneurysms. However, accurate evaluations of aortic dimensions by these imaging approaches could be challenging due to pathological features of aortic aneurysms. Currently, there is no standardized mode to assess aortic dissections in mice. It is important to understand the characteristics of each approach for reliable evaluation of aortic dilatations. In this review, we summarize imaging techniques used for aortic visualization in recent mouse studies and discuss their pros and cons. We also provide suggestions to facilitate the visualization of mouse aortas.
    MeSH term(s) Aneurysm, Dissecting/diagnostic imaging ; Animals ; Aorta/diagnostic imaging ; Aorta/pathology ; Aortic Aneurysm/diagnostic imaging ; Disease Models, Animal ; Mice ; Ultrasonography
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12020339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms.

    Ito, Sohei / Lu, Hong S / Daugherty, Alan / Sawada, Hisashi

    Genes

    2022  Volume 13, Issue 9

    Abstract: Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this ... ...

    Abstract Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
    MeSH term(s) Aortic Aneurysm, Thoracic/genetics ; Aortic Aneurysm, Thoracic/metabolism ; Humans ; Muscle, Smooth, Vascular/metabolism ; Myocytes, Smooth Muscle/metabolism ; Neural Crest/metabolism
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13091618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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