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Article ; Online: Facteurs pronostiques et survie des leucémies aiguës de l'adulte au Burkina Faso.

Traoré, Catherine / Nebié, Koumpingnin / Sawadogo, Salam / Sanou, Adjaratou Fabienne / Héma, Arsène / Kafando, Éléonore

Medecine tropicale et sante internationale

2023 Volume 3, Issue 3

Abstract: Introduction: Acute leukemia is both a diagnostic and therapeutic emergency. Our study aimed to describe the prognostic factors and survival of adults with acute leukemia in Burkina Faso.: Patients and methods: Cross-sectional descriptive study with ... ...

Title translation	Prognostic factors and survival in adult acute leukemia in Burkina Faso.
Abstract	Introduction: Acute leukemia is both a diagnostic and therapeutic emergency. Our study aimed to describe the prognostic factors and survival of adults with acute leukemia in Burkina Faso. Patients and methods: Cross-sectional descriptive study with retrospective data collection covering a period of 4.5 years (2018-2022) in two university hospitals in Burkina Faso. Were included all patients over 18 years hospitalized for acute leukemia in these sites with a usable medical record. Results: A total of 42 cases were collected, of which 45% suffered from acute lymphoblastic leukemia and 43% from acute myeloid leukemia. In 12% of cases, acute leukemia was not classified. The average age was 35 ± 15 years, with extremes of 19 and 72 years. 12% of the patients presented an age of poor prognosis. Comorbidities were present in 14% of patients. The deterioration in general condition was fairly constant with 95% of patients at WHO stages 3 and 4. All patients presented with bone marrow failure syndrome and tumor syndrome was found in 45%. Anemia and thrombocytopenia were present in almost all cases. Hyperleukocytosis at diagnosis was present in 28 patients (67%); among them 18 patients (64%) had leukocytes greater than 50 G/L. Death in hospital was found in 38% of patients and loss of sight in 31%. The median survival was 3 months. Survival was 30% at 6 months and 0% at 12 months. Conclusion: Acute leukemias are in our practice conditions of poor prognosis with a fairly short survival.
MeSH term(s)	Adult ; Humans ; Young Adult ; Middle Aged ; Prognosis ; Burkina Faso/epidemiology ; Cross-Sectional Studies ; Retrospective Studies ; Leukemia, Myeloid, Acute/diagnosis ; Anemia
Language	French
Publishing date	2023-08-19
Publishing country	France
Document type	English Abstract ; Journal Article
ISSN	2778-2034
ISSN (online)	2778-2034
DOI	10.48327/mtsi.v3i3.2023.409
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Article ; Online: Blood transfusion requirements among children with severe malarial anemia: a cross-sectional study in a second level reference hospital in Burkina Faso.

Sawadogo, Salam / Nébié, Koumpingnin / Millogo, Tieba / Kafando, Eléonore

The Pan African medical journal

2020 Volume 37, Page(s) 108

Abstract: Introduction: blood transfusion (BT) is an important part of pediatrics healthcare in sub-Saharan Africa because of anemia due to malaria, malnutrition and hereditary anomalies of red blood cells. However, BT services experienced chronic blood shortage, ...

Abstract	Introduction: blood transfusion (BT) is an important part of pediatrics healthcare in sub-Saharan Africa because of anemia due to malaria, malnutrition and hereditary anomalies of red blood cells. However, BT services experienced chronic blood shortage, unsafe blood products and poor procedures of clinical use of blood. This results in inadequate management of severe anemia. Methods: to assess the quality of BT requirements in severe malarial anemia at the regional hospital center of Koudougou in Burkina Faso, we carried out a cross-sectional study including 402 children with severe malaria (WHO 2000 criteria). Results: over the study period, severe malaria represented 45.6% (402/882) of pediatric admissions. Anemia was observed in 97.5% (392/402) of cases and BT was required for 78.4% (315/402). The median age was 16 months (IQR 9-27) and the average hemoglobin was 51.4±22.2 g/L. The prescriptions were in accordance with WHO and national guidelines respectively in 63.8% and 92.7%. Blood units were issued in 99.4% (350/352) of blood orderings. Out of 350 blood units delivered, blood was administered in 98% (343/350). The median actual time to transfusion was 65 minutes (IQR: 45-100) and median transfusion duration was 73.8 minutes (IQR: 47.5-110). The signs of intolerance to anemia disappeared in 134/138 cases (97.1%) and the average haemoglobin increased of 37.9±17.6 g/L. Death occurred in 23 cases (5.7%). Conclusion: the management of severe malaria requires blood transfusion in almost half of cases. Blood was available to meet most requests. However, efforts are still required for proper use of the blood.
MeSH term(s)	Adolescent ; Anemia/parasitology ; Anemia/therapy ; Blood Transfusion/statistics & numerical data ; Burkina Faso ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Infant ; Malaria/complications ; Male ; Severity of Illness Index ; Time Factors
Language	English
Publishing date	2020-10-01
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2020.37.108.22384
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Article ; Online: Allo-immunisation chez les patients polytransfusés avec des concentrés de globules rouges non phénotypés au Centre Hospitalier Universitaire Souro Sanou de Bobo Dioulasso (Burkina Faso).

Yonli, Yétéma Dieudonné / Nébié, Koumpingnin / Yacouba, Sourabié / Kiba, Alice / Sawadogo, Salam / Sawadogo, Serges Mamadou / Traore, Yves

The Pan African medical journal

2022 Volume 41, Page(s) 244

Abstract: Introduction: in Burkina Faso, blood transfusion is carried out with only ABO and RHD compatibility between the donor and the recipient. Such a practice carries risks of alloimmunisation, which can lead to clinical complications especially in ... ...

Title translation	Alloimmunisation in polytransfused patients with non-phenotyped red blood cells at the University Hospital Souro Sanou of Bobo Dioulasso (Burkina Faso).
Abstract	Introduction: in Burkina Faso, blood transfusion is carried out with only ABO and RHD compatibility between the donor and the recipient. Such a practice carries risks of alloimmunisation, which can lead to clinical complications especially in polytransfused patients. The objective is to determine the prevalence and factors associated with alloimmunisation in polytransfused patients with non-phenotyped red blood cells at Souro Sanou University Hospital. Methods: we conducted a cross-sectional study in polytransfused patients in the clinical departments of the University Hospital Souro Sanou over a 3-month period (March to May 2019). In each of the 141 patients included, 5 ml of whole blood was collected in an ethylenediaminetetraacetic acid (EDTA) tube for testing for irregular antibodies. Irregular antibody testing was performed using the indirect Coombs gel filtration technical. Results: in total, the frequency of alloimmunisation obtained was 5.67%. The majority of the antibodies identified belonged to the Rhesus systems and Kell. We found no statistically significant relationship between age, sex, disease history, number of bags transfused and the positivity of the Irregular Antibody test (p = 0.37, p = 0, 75, p = 0.96). Conclusion: we found that the risk of alloimmunisation is major. Additional measures should be taken to strengthen the immunological safety of transfusions in Burkina Faso. We propose that in Burkina Faso, anti-globulin compatibility testing should be performed systematically in patients with a high risk of immunisation.
MeSH term(s)	Burkina Faso/epidemiology ; Cross-Sectional Studies ; Erythrocytes ; Hospitals, University ; Humans
Language	French
Publishing date	2022-03-24
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2022.41.244.30952
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Article ; Online: Establishment of reference values for prothrombin time, activated partial thromboplastin time and fibrinogen in adults in Burkina Faso.

Nebie, Koumpingnin / Sawadogo, Salam / Traore, Catherine / Koulidiati, Jerome / Kima, Donatien / Ouedraogo, Florence Alida Wendyam / Minoungou, Myriam Wendkuni Nikiema / Sawadogo, Salifo / Toure, Awa Oumar / Kafando, Eleonore

Annales de biologie clinique

2023

Abstract: The ordering of clinical haemostasis tests is increasing in Burkina Faso due to the newly emergence of cardiovascular and metabolic diseases. However, appropriate local reference values (RV) are lacking. Our study aimed to establish RV for prothrombin ... ...

Abstract	The ordering of clinical haemostasis tests is increasing in Burkina Faso due to the newly emergence of cardiovascular and metabolic diseases. However, appropriate local reference values (RV) are lacking. Our study aimed to establish RV for prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen assays. In 2020, we carried out a cross-sectional study at the transfusion centre of Ouagadougou and included 280 healthy blood donors (140 males and 140 females) as reference subjects (RS) according to CLSI guidelines (C28 A3). From each RS a 5 mL blood sample had been withdrawn in citrated tubes. We performed PT, aPTT and fibrinogen assays using the Sysmex™ CA660 coagulometer and Siemens™ reagents. RV were calculated using the "central 95 percentile" method. Reference values of PT, aPTT and Fibrinogen were respectively [73.84%-117.50%], [20,01-29.45] seconds and [2.04-3.83] g/L for females and [58.81%-112,31%] seconds, [20,9-29,98] seconds and [1.58-3.35] g/L for males. We report for the first time locally appropriate haemostasis RV for the Burkina Faso adult's population. They will be of clinical use to our health care professionals.
Language	English
Publishing date	2023-11-01
Publishing country	France
Document type	Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2023.1835
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Article ; Online: Prevalence and specificity of red blood cell antibodies in patients transfused in tertiary hospitals in Burkina Faso.

Sawadogo, Salam / Nébié, Koumpingnin / Traoré, Catherine / Bonzi, Yérémadé Juste / Boro, Mariam / Yonli, Dieudonné / Yaméogo, Joseph / Ouédraogo, Paul / Coulibaly, Catherine / Zala, Jedida / Deneys, Véronique / Kafando, Eléonore

Transfusion medicine (Oxford, England)

2023 Volume 33, Issue 4, Page(s) 306–314

Abstract: Background: Sub-Saharan African countries face the challenge of immunological transfusion safety that puts many patients at risk of post-transfusion hemolytic reactions. This is because pre-transfusion testing for irregular/unexpected antibodies that ... ...

Abstract	Background: Sub-Saharan African countries face the challenge of immunological transfusion safety that puts many patients at risk of post-transfusion hemolytic reactions. This is because pre-transfusion testing for irregular/unexpected antibodies that helps to prevent these risks are neither universally available nor accessible. The aim of our study was to determine the prevalence of red blood cell alloantibodies and their specificity in patients transfused in Burkina Faso. Materials and methods: This was a cross-sectional study including patients who had received at least one blood transfusion. Indirect antiglobulin testing using LISS-enhanced medium gel column agglutination technique was used for antibodies screening and identification. Enzymatic technique with papain-treated red cell reagent was performed in attempt to solve some difficulties if necessary as well as auto-control test and RH-KEL phenotyping when possible to help antibodies identification. Results: A total of 832 patients were included, 51.6% of whom were female, and the median (IQR) age was 34 (20-49) years. Of these, 43.7% had chronic kidney disease and 20.4% were sickle cell patients. The median (IQR) number of immunisation episodes (blood transfusion and pregnancies) was 3 (2-6) with the median (IQR) number of blood units received per patient of 2 (1-5). The proportion of patients with RBCs antibodies was 6.4% (53/832), with mainly anti-Rh antibodies. A combination of 2 antibodies was found in 7 patients and a combination of 3 antibodies in one patient. Antibodies of unknown specificity (AUS) were encountered in 29%. Independent factors associated with antibody positivity were age (OR = 1.02; p = 0.026), sickle cell disease (OR = 3.23; p = 0.017) and receiving more than 10 blood units (OR = 7.33; p = 0.01). Conclusion: In this study, the proportion of patients with RBC antibodies was quite similar to that observed in Sub-Saharan African countries. However, the availability and accessibility of pre-transfusion compatibility tests as well as the quality of methods used should be improved to ensure the safety of blood transfusions.
MeSH term(s)	Pregnancy ; Humans ; Female ; Adult ; Middle Aged ; Male ; Prevalence ; Cross-Sectional Studies ; Tertiary Care Centers ; Burkina Faso/epidemiology ; Transfusion Reaction/epidemiology ; Isoantibodies ; Erythrocytes
Chemical Substances	Isoantibodies
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12970
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Article ; Online: Characterization of Plasmodium Falciparum Resistance Genes to Common Antimalarial Drugs in Semi-urban Areas of Burkina Faso.

Zida, Adama / Tchekounou, Chanolle / Soulama, Issiaka / Zongo, Cheikna / Sombié, Salif / Nikiema, Seni / Yanogo, Nassandba J / Sawadogo, Salam / Kaboré, Farida C A / Zoure, Oumou A Z D / Sawadogo, Haffsatou / Sawadogo, Patindoilba M / Tibiri, Yssimini N G / Guiguemde, Kiswendsida T / Ily, Raissa P / Ouedraogo-Traoré, Rasmata / Ouedraogo, Youssoufou / Savadogo, Aly

Acta parasitologica

2024 Volume 69, Issue 1, Page(s) 910–921

Abstract: Introduction: Malaria still remains the most frequent parasitic disease on the world with, in 2022, 249 million cases and 608,000 deaths worldwide. Malaria control is compromised by the spread of the parasite's resistance to available antimalarials. The ...

Abstract	Introduction: Malaria still remains the most frequent parasitic disease on the world with, in 2022, 249 million cases and 608,000 deaths worldwide. Malaria control is compromised by the spread of the parasite's resistance to available antimalarials. The objective of our study is to characterize the Plasmodium falciparum resistance genes to common antimalarial drugs in semi-urban areas of Burkina Faso. Materials and methods: This is a prospective cross-sectional study whose collection took place from June to October 2021 and from June to October 2022 in five health facilities in Burkina Faso. The molecular analysis based on PCR-RFLP took place from January to June 2023 at Centre National de Recherche et de Formation (CNRFP) to determine resistance genes such as Pfcrt, Pfmdr1, Pfdhps, and Pfdhfr. Results: A total of 150 samples were analyzed giving a prevalence of 46.67, 1.33, 0.67, 20, 82, and 4.67%, for Pfcrt 76 T, Pfmdr1 86Y, Pfdhps 437G, Pfdhfr 51I, Pfdhfr 59R, and Pfdhfr 108N mutations, respectively. There are no mutations observed Pfdhps 540E and Pfdhfr 164L positions. However, mutation on Pfdhfr 59R position was the most common. In addition, triple mutation (Pfdhps 437G + Pfdhfr 59R + Pfdhfr 108N) was found with a low frequency which is 0.67%. Conclusion: Surveillance of Plasmodium falciparum resistance markers to antimalarial drugs, remains one of the priorities in the context of the control or malaria elimination.
MeSH term(s)	Plasmodium falciparum/genetics ; Plasmodium falciparum/drug effects ; Burkina Faso/epidemiology ; Antimalarials/pharmacology ; Cross-Sectional Studies ; Drug Resistance/genetics ; Malaria, Falciparum/parasitology ; Malaria, Falciparum/epidemiology ; Humans ; Protozoan Proteins/genetics ; Prospective Studies ; Multidrug Resistance-Associated Proteins/genetics ; Mutation ; Membrane Transport Proteins/genetics ; Prevalence
Chemical Substances	Antimalarials ; Protozoan Proteins ; Multidrug Resistance-Associated Proteins ; PfCRT protein, Plasmodium falciparum ; Mdr1 protein, Plasmodium falciparum ; Membrane Transport Proteins
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1132735-2
ISSN	1896-1851 ; 0065-1478 ; 1230-2821
ISSN (online)	1896-1851
ISSN	0065-1478 ; 1230-2821
DOI	10.1007/s11686-024-00826-x
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Article: Plasmodium falciparum

Sawadogo, Haffsatou / Soulama, Issiaka / Zida, Adama / Zongo, Cheikna / Sawadogo, Patindoilba Marcel / Guiguemde, Kiswendsida Thierry / Nikiema, Seni / Badoum, Salimata Emilie / Sawadogo, Salam / Tou, Aïcha / Sombié, Salif / Tchekounou, Chanolle / Sermé, Sindié Samuel / Ouedraogo-Traoré, Rasmata / Guiguemdé, Tinga Robert / Savadogo, Aly

Infection and drug resistance

2023 Volume 16, Page(s) 6673–6680

Abstract: Purpose: Intermittent preventive treatment with sulfadoxine-pyrimethamine is widely used for the prevention of malaria in pregnant women in Africa. Known resistance cases of sulfadoxine-pyrimethamine during pregnancy need to be follow up to support IPTp ...

Abstract	Purpose: Intermittent preventive treatment with sulfadoxine-pyrimethamine is widely used for the prevention of malaria in pregnant women in Africa. Known resistance cases of sulfadoxine-pyrimethamine during pregnancy need to be follow up to support IPTp implementation in Burkina Faso. However, data on the development and spread of resistance to this molecule are lacking. This study aimed to investigating the genetic diversity of Patients and methods: This was a prospective and cross-sectional study conducted between April 2019 and March 2020 in four health districts of Ouagadougou capital city. From the placentas collected after delivery, Results: PCR-positive samples were estimated at 96% for Conclusion: The results showed that
Language	English
Publishing date	2023-10-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S420004
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Article: Red blood cell alloimmunisation in multi-transfused patients from an haemodialysis service in Burkina Faso.

Nebie, Koumpingnin / Sawadogo, Salam / Sawadogo, Salifo / Koulidiati, Jérôme / Lengani, Habi Y A / Sawadogo, Abdoul G / Babinet, Jérôme / Khalloufi, Mohammed / Diop, Saliou / Kafando, Eléonore

African journal of laboratory medicine

2022 Volume 11, Issue 1, Page(s) 1625

Abstract: Background: In Burkina Faso, red blood cell (RBC) transfusion remains the crucial anaemia treatment following chronic renal failure (CRF) as erythropoietin and its analogues are unavailable. However, blood group matching beyond the ABO and Rhesus is not ...

Abstract	Background: In Burkina Faso, red blood cell (RBC) transfusion remains the crucial anaemia treatment following chronic renal failure (CRF) as erythropoietin and its analogues are unavailable. However, blood group matching beyond the ABO and Rhesus is not common in Burkina Faso. Thus, alloimmunisation is a potential issue for transfused patients. Objective: Our study aimed to identify anti-erythrocyte antibodies in multi-transfused CRF patients at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou, Burkina Faso. Methods: This cross-sectional study, conducted from October 2018 to November 2019, included CRF patients who had received at least two RBC units. We screened patients for the presence of RBC antibodies using three commercial Cells panels and identified antibody specificities for positive screenings using 11 Cells panels for an indirect antiglobulin test (IAT) in a low ionic strength microcolumn gel-card system. Results: Two hundred and thirty-five patients (45.1% female; average age: 41.5 years) were included. The median number of blood units received per patient was 10 (interquartile range: 5-20). The overall alloimmunisation rate was 5.9% (14/235). Antibodies identified included: anti-D (1 case), anti-C (1 case), anti-D+C (4 cases), anti-C Conclusion: In Burkina Faso, screening for RBC alloantibodies should be mandated for patients at risk. The high rate of indeterminate antibodies suggests the need to develop a local RBC antibody panel adapted to the local population.
Language	English
Publishing date	2022-09-26
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	2708535-1
ISSN	2225-2010 ; 2225-2002
ISSN (online)	2225-2010
ISSN	2225-2002
DOI	10.4102/ajlm.v11i1.1625
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Article ; Online: Distribution and Incidence of Blood-Borne Infection among Blood Donors from Regional Transfusion Centers in Burkina Faso: A Comprehensive Study.

Wongjarupong, Nicha / Oli, Sharad / Sanou, Mahamoudou / Djigma, Florencia / Kiba Koumare, Alice / Yonli, Albert T / Hassan, Mohamed A / Mara, Kristin / Harmsen, William S / Therneau, Terry / Barro, Oumar / Vodounhessi, Ghislaine / Sawadogo, Salam / Chamcheu, Jean Christopher / Simpore, Jacques / Roberts, Lewis R / Nagalo, Bolni M

The American journal of tropical medicine and hygiene

2021 Volume 104, Issue 4, Page(s) 1577–1581

Abstract: There is a high prevalence of blood-borne infections in West Africa. This study sought to determine the seroprevalence of blood-borne infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), HIV, and syphilis, in blood donors in Burkina ... ...

Abstract	There is a high prevalence of blood-borne infections in West Africa. This study sought to determine the seroprevalence of blood-borne infections, including hepatitis B virus (HBV), hepatitis C virus (HCV), HIV, and syphilis, in blood donors in Burkina Faso. Blood donors were recruited from 2009 to 2013 in four major cities in Burkina Faso of urban area (Ouagadougou) and rural area (Bobo Dioulasso, Fada N'Gourma, and Ouahigouya). Serology tests including hepatitis B surface antigen, anti-HCV, anti-HIV, and rapid plasma reagin test were used for screening and were confirmed with ELISA. Disease prevalence was calculated among first-time donors. Incidence and residual risk were calculated from repeat donors. There were 166,681 donors; 43,084 had ≥ 2 donations. The overall seroprevalence of HBV, HCV, HIV, and syphilis were 13.4%, 6.9%, 2.1%, and 2.4%, respectively. The incidence rates (IRs) of HBV, HCV, HIV, and syphilis infection were 2,433, 3,056, 1,121, and 1,287 per 100,000 person-years. There was lower seroprevalence of HBV and HCV in urban area than in rural area (12.9% versus 14.0%, P < 0.001; and 5.9% versus 8.0%, P < 0.001), and no difference in HIV (2.1% versus 2.1%, P = 0.25). The IRs of new HBV, HCV, HIV, and syphilis were 2.43, 3.06, 1.12, and 1.29 per 100,000 person-years, respectively. The residual risk was one per 268 donations for HBV, one per 181 donations for HCV, and one per 1,480 donations for HIV, respectively. In conclusion, this comprehensive study from four blood donation sites in Burkina Faso showed high HBV and HCV seroprevalence and incidence with high residual risk from blood donation.
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0601
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Article ; Online: Seroprevalence and factors associated with IgG anti-DENV positivity in blood donors in Burkina Faso during the 2016 dengue outbreak and implications for blood supply.

Sawadogo, Salam / Baguiya, Adama / Yougbare, Fiffou / Bicaba, Brice Wilfried / Nebie, Koumpingnin / Millogo, Tieba / Kamba, Ibrahim / Kaba, Losseni / Sangare, Lassana / Kafando, Eléonore / Deneys, Véronique

Transfusion medicine (Oxford, England)

2019 Volume 30, Issue 1, Page(s) 37–45

Abstract: Objectives: Our study aimed to update the seroprevalence and factors associated with anti-dengue virus (DENV) antibody positivity among blood donors and to discuss their implications for blood supply.: Background: Questions on the potential ... ...

Abstract	Objectives: Our study aimed to update the seroprevalence and factors associated with anti-dengue virus (DENV) antibody positivity among blood donors and to discuss their implications for blood supply. Background: Questions on the potential transmission of DENV by transfusion increased after the documentation of the risk of transmission of the West Nile virus. This risk was estimated after transfusion of DENV RNA-positive blood units of up to 37.5%. In Burkina Faso, very few studies on DENV in blood donors have been conducted. As a result, there were no reliable data on DENV to allow the implementation of appropriate measures to control the risk of transmission of the dengue virus by blood transfusion. Methods: We conducted a 4-week cross-sectional study from December 4 to 30, 2016. Blood donors of both genders, aged 18-60 years, accepted for blood donation after medical selection were consecutively enrolled. Results: Our study included a total of 1007 blood donors, in which donors living in urban areas represented 78.2%. The mean age was 26.1 ± 8.1 years. After adjustment in a multiple regression logistic model, the odds of having IgG anti-DENV increased as age increased. The odds of DENV was 53% lower in rural areas (OR = 0.47; P = .000) compared to urban settings and 42% lower in mobile sites (OR = 0.58; P = .03) compared to fixed ones. Conclusion: Our study provides new and useful insights for future research on the risk of TT-DENV throughout blood transfusion.
MeSH term(s)	Adolescent ; Adult ; Antibodies, Viral/blood ; Blood Donors ; Blood Safety ; Burkina Faso ; Cross-Sectional Studies ; Dengue/blood ; Dengue/epidemiology ; Dengue Virus/metabolism ; Disease Outbreaks ; Female ; Humans ; Male ; Middle Aged ; Seroepidemiologic Studies
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2019-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12646
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