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  1. Article ; Online: Glimepiride: an old antidiabetic medication with potential as a new cardiovascular therapeutic?

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    European journal of preventive cardiology

    2023  Volume 30, Issue 8, Page(s) e46–e47

    MeSH term(s) Humans ; Hypoglycemic Agents/adverse effects ; Sulfonylurea Compounds/adverse effects ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Blood Glucose
    Chemical Substances glimepiride (6KY687524K) ; Hypoglycemic Agents ; Sulfonylurea Compounds ; Blood Glucose
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwad084
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    Zs.A 4686: Show issues Location:
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  2. Article ; Online: Letter by Sawami et al Regarding Article, "Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)".

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    Circulation

    2023  Volume 147, Issue 6, Page(s) e73–e74

    MeSH term(s) Humans ; Diuresis ; Heart Failure/drug therapy ; Benzhydryl Compounds/adverse effects ; Kidney ; Stroke Volume ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances empagliflozin (HDC1R2M35U) ; Benzhydryl Compounds
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.062333
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  3. Article ; Online: Are There Any "Tips" for Better Joint Risk Factor Control in Patients With Diabetes?

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    JACC. Heart failure

    2023  Volume 11, Issue 10, Page(s) 1470

    MeSH term(s) Humans ; Heart Failure/etiology ; Diabetes Mellitus/epidemiology ; Risk Factors ; Treatment Outcome ; Retrospective Studies ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.07.024
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  4. Article ; Online: How to Measure DELIVERed Benefits of Dapagliflozin in the Management of HFmrEF/HFpEF?

    Tanaka, Atsushi / Sawami, Kosuke / Node, Koichi

    JACC. Heart failure

    2023  Volume 11, Issue 2, Page(s) 261

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure ; Ventricular Function, Left ; Benzhydryl Compounds/therapeutic use ; Prognosis
    Chemical Substances dapagliflozin (1ULL0QJ8UC) ; Benzhydryl Compounds
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2022.11.027
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  5. Article ; Online: Recent understandings about hypertension management in type 2 diabetes: What are the roles of SGLT2 inhibitor, GLP-1 receptor agonist, and finerenone?

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 8, Page(s) 1892–1899

    Abstract: Diabetes and hypertension often coexist, with about half of patients with diabetes also having hypertension. The risk of cardiovascular disease increases by three to six-fold with the coexistence of diabetes and hypertension; therefore, the management of ...

    Abstract Diabetes and hypertension often coexist, with about half of patients with diabetes also having hypertension. The risk of cardiovascular disease increases by three to six-fold with the coexistence of diabetes and hypertension; therefore, the management of blood pressure to prevent cardiovascular disease is a particularly important issue in patients with diabetes. Clinical trial findings have resulted in recommendations to control blood pressure to <130/80 mmHg in Japanese patients with diabetes. However, the target blood pressure and selection of anti-hypertensive medications should vary depending on the duration of diabetes and comorbidities, and guidelines and clinical trial results should be interpreted flexibly to provide anti-hypertensive treatment tailored to individual patients. In recent years, a number of drugs have emerged that have significant cardio-renal protective effects in patients with diabetes, and a typical example is sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like peptide-1 receptor agonist (GLP-1RA), and nonsteroidal mineralocorticoid receptor antagonist, finerenone. They have also shown modest but significant blood pressure-lowering effects. In the future, beyond considering the thresholds for how far to lower blood pressure, blood pressure management in patients with diabetes will require understanding the additive cardioprotective value of drugs aimed at lowering blood pressure and the quality of blood pressure lowering. Clinical questions of blood pressure lowering in patients with diabetes GLP-1RA, glucagon-like peptide-1 receptor agonist; SGLT2i, sodium-glucose cotransporter 2 inhibitor.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; Cardiovascular Diseases/prevention & control ; Antihypertensive Agents/therapeutic use ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/chemically induced ; Glucose/therapeutic use ; Sodium
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor ; finerenone ; Antihypertensive Agents ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01324-9
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    Zs.A 3898: Show issues Location:
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  6. Article ; Online: Appropriate mineralocorticoid receptor antagonism and salt restriction are essential for primary aldosteronism therapy.

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 3, Page(s) 794–796

    MeSH term(s) Humans ; Mineralocorticoid Receptor Antagonists ; Sodium Chloride, Dietary ; Renin ; Receptors, Mineralocorticoid ; Hyperaldosteronism ; Sodium Chloride
    Chemical Substances Mineralocorticoid Receptor Antagonists ; Sodium Chloride, Dietary ; Renin (EC 3.4.23.15) ; Receptors, Mineralocorticoid ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-022-01155-0
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    Zs.A 3898: Show issues Location:
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  7. Article ; Online: Anti-obesity therapy for cardiovascular disease prevention: potential expected roles of glucagon-like peptide-1 receptor agonists.

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    Cardiovascular diabetology

    2022  Volume 21, Issue 1, Page(s) 176

    Abstract: Obesity is characterized by visceral fat accumulation and various metabolic disturbances that cause metabolic syndrome and obesity-related cardiovascular diseases (ORCVDs). Hence, treatments targeting obesity should also prevent ORCVDs. Nonetheless, ... ...

    Abstract Obesity is characterized by visceral fat accumulation and various metabolic disturbances that cause metabolic syndrome and obesity-related cardiovascular diseases (ORCVDs). Hence, treatments targeting obesity should also prevent ORCVDs. Nonetheless, lifestyle modification therapy alone is still insufficient to reduce the risk of ORCVDs, although most cardiovascular guidelines still list it as the only treatment for obesity. Additionally, conventional anti-obesity drugs, such as orlistat, phentermine-topiramate, and naltrexone-bupropion, can reduce body weight but have not demonstrated a clear reduction in the risk of ORCVDs. To overcome this unmet clinical need, newer anti-obesity drugs must exhibit not only sufficient and long-lasting weight loss but also obvious cardiovascular benefits. Given recent clinical findings and evidences, in this context glucagon-like peptide-1 receptor agonist is currently available as a candidate that is clinically positioned as a first-line anti-obesity agent for the effective prevention of ORCVDs in people with obesity.
    MeSH term(s) Anti-Obesity Agents/adverse effects ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Glucagon-Like Peptide-1 Receptor/agonists ; Humans ; Liraglutide/therapeutic use ; Obesity/diagnosis ; Obesity/drug therapy ; Obesity/epidemiology ; Orlistat/therapeutic use
    Chemical Substances Anti-Obesity Agents ; Glucagon-Like Peptide-1 Receptor ; Liraglutide (839I73S42A) ; Orlistat (95M8R751W8)
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-022-01611-8
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  8. Article ; Online: Clinical roles of vascular function assessment in cancer care.

    Sawami, Kosuke / Tanaka, Atsushi / Node, Koichi

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2021  Volume 30, Issue 2, Page(s) 985–987

    Abstract: Atherosclerotic cardiovascular disease and cancer often share risk factors and influence each other's pathological features. In addition to the unfavorable effects of cancer on the cardiovascular system, the adverse effects of cancer therapies, such as ... ...

    Abstract Atherosclerotic cardiovascular disease and cancer often share risk factors and influence each other's pathological features. In addition to the unfavorable effects of cancer on the cardiovascular system, the adverse effects of cancer therapies, such as chemotherapy and radiation, have also been determined. In particular, vascular toxic effects associated with cancer therapy (vasospasm, thrombosis formation, and promotion of arteriosclerosis), which are the second most common complications after myocardial adverse effects, are usually managed after the onset of vascular diseases, because screening and predictive methods are yet to be fully established. However, the onset of these vascular complications has a major influence on the implementation of cancer therapy, resulting in worsening of the quality of cancer care and prognosis of patients with cancer. It is therefore necessary to establish clinical strategies for detecting the vascular adverse effects of cancer therapy and evaluating vascular function during cancer care. In this article, we discuss the expected role of vascular function assessment using physiological testing tools for early detection of vascular adverse effects caused by cancer therapy and also preemptive assessment of vascular function prior to this treatment being initiated.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/epidemiology ; Cardiovascular System ; Humans ; Neoplasms/drug therapy ; Risk Factors ; Vascular Diseases/diagnosis ; Vascular Diseases/epidemiology ; Vascular Diseases/etiology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-021-06465-6
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    Zs.A 3697: Show issues Location:
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  9. Article ; Online: An evidence review project for food with function claims ~Challenges of the Japan society for vascular failure for the promotion of adequate evidences for food with function claims.

    Matsumoto, Chisa / Tomiyama, Hirofumi / Takahashi, Osamu / Maruhashi, Tatsuya / Matsuzawa, Yasushi / Masaki, Nobuyuki / Muraki, Isao / Yano, Yuichiro / Sugimoto, Tadafumi / Kabutoya, Tomoyuki / Sawami, Kosuke / Tanaka, Atsushi / Arima, Hisatomi / Sata, Masataka / Node, Koichi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 47, Issue 2, Page(s) 533–536

    MeSH term(s) Japan ; Food ; Health Promotion ; Food Labeling
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Editorial
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01485-7
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  10. Article: Multiple potency of ezetimibe in a patient with macroproteinuric chronic kidney disease and statin-intolerant dyslipidemia.

    Sawami, Kosuke / Tanaka, Atsushi / Nakamura, Tsukasa / Sato, Eiichi / Ueda, Yoshihiko / Node, Koichi

    Journal of cardiology cases

    2018  Volume 17, Issue 6, Page(s) 204–207

    Abstract: Dyslipidemia is often complicated by chronic kidney disease (CKD). Lipid-lowering medications may be effective, in part, for inhibiting development and progression of CKD. Ezetimibe, a cholesterol absorption inhibitor, has pleiotropic actions, including ... ...

    Abstract Dyslipidemia is often complicated by chronic kidney disease (CKD). Lipid-lowering medications may be effective, in part, for inhibiting development and progression of CKD. Ezetimibe, a cholesterol absorption inhibitor, has pleiotropic actions, including anti-inflammatory and anti-oxidant effects, contributing to a decreased risk of cardiovascular diseases. A 40-year-old woman was admitted with dyslipidemia and macroproteinuria, whose samples of renal biopsy showed exudative lesions, but without glomerular basement membrane thickening or nodular lesions, in some glomeruli. Blood glycemic parameters were normal. After initiation of atorvastatin, she developed muscle pain and an increase in serum creatine kinase. Twelve months after switching to ezetimibe, serum levels of low-density lipoprotein cholesterol and triglyceride reduced from 170 mg/dL to 116 mg/dL and from 320 mg/dL to 160 mg/dL, respectively. Although serum creatinine levels remained unchanged after 12 months, urinary protein excretion and urinary liver-type fatty acid binding protein were reduced. Flow-mediated dilatation also increased from 4.9% to 5.5% after 12 months, associated with a slight decrease in mean intima-media thickness in the common carotid artery from 0.722 mm to 0.718 mm. These results suggest that ezetimibe protects against renal and vascular damage in patients with CKD and statin-intolerant dyslipidemia. <
    Language English
    Publishing date 2018-03-19
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN 1878-5409
    DOI 10.1016/j.jccase.2018.02.003
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