Article ; Online: Associations between affective factors and high-frequency heart rate variability in primary care patients with depression.
Journal of psychosomatic research
2022 Volume 161, Page(s) 110992
Abstract: Objective: Depression is a risk factor for cardiovascular disease (CVD), and subgroups of people with depression may be at particularly elevated CVD risk. Lower high-frequency heart rate variability (HF HRV), which reflects diminished parasympathetic ... ...
| Abstract | Objective: Depression is a risk factor for cardiovascular disease (CVD), and subgroups of people with depression may be at particularly elevated CVD risk. Lower high-frequency heart rate variability (HF HRV), which reflects diminished parasympathetic activation, is a candidate mechanism underlying the depression-CVD relationship and predicts cardiovascular events. Few studies have examined whether certain depression subgroups - such as those with co-occurring affective factors - exhibit lower HF HRV. The present study sought to assess associations between co-occurring affective factors and HF HRV in people with depression. Methods: Utilizing baseline data from the 216 primary care patients with depression in the eIMPACT trial, we examined cross-sectional associations of depression's co-occurring affective factors (i.e., anxiety symptoms, hostility/anger, and trait positive affect) with HF HRV. HF HRV estimates were derived by spectral analysis from electrocardiographic data obtained during a supine rest period. Results: Individual regression models adjusted for demographics and depressive symptoms revealed that anxiety symptoms (standardized regression coefficient β = -0.24, p = .002) were negatively associated with HF HRV; however, hostility/anger (β = 0.02, p = .78) and trait positive affect (β = -0.05, p = .49) were not. In a model further adjusted for hypercholesterolemia, hypertension, diabetes, body mass index, current smoking, CVD prevention medication use, and antidepressant medication use, anxiety symptoms remained negatively associated with HF HRV (β = -0.19, p = .02). Conclusion: Our findings suggest that, in adults with depression, those with comorbid anxiety symptoms have lower HF HRV than those without. Co-occurring anxiety may indicate a depression subgroup at elevated CVD risk on account of diminished parasympathetic activation. |
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| MeSH term(s) | Adult ; Cardiovascular Diseases ; Clinical Trials as Topic ; Cross-Sectional Studies ; Depression/psychology ; Heart Rate/physiology ; Humans ; Primary Health Care |
| Language | English |
| Publishing date | 2022-07-22 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 80166-5 |
| ISSN | 1879-1360 ; 0022-3999 |
| ISSN (online) | 1879-1360 |
| ISSN | 0022-3999 |
| DOI | 10.1016/j.jpsychores.2022.110992 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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