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  1. AU="Sawyer, Thomas K"
  2. AU="Ana Lydia Vasco de Albuquerque Peixoto"

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  1. Article: Human Saposin B Ligand Binding and Presentation to α-Galactosidase A.

    Sawyer, Thomas K / Aral, Efecan / Staros, James V / Bobst, Cedric E / Garman, Scott C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular ...

    Abstract Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular mechanism of SapB presenting Gb3 to α-galactosidase A, we subjected the fluorescent substrate globotriaosylceramide-nitrobenzoxidazole (Gb3-NBD) to a series of biochemical and structural assays involving SapB. First, we showed that SapB stably binds Gb3-NBD using a fluorescence equilibrium binding assay, isolates Gb3-NBD from micelles, and facilitates α-galactosidase A cleavage of Gb3-NBD
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.04.584535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  2. Book: The scientist as consultant

    Sindermann, Carl J. / Sawyer, Thomas K.

    building new career opportunities

    1997  

    Author's details Carl J. Sindermann and Thomas K. Sawyer
    Keywords Wissenschaftler ; Unternehmensberatung ; Berufsplanung
    Subject Beruf ; Betriebsberatung ; Unternehmen ; Managementberatung ; Management ; Wirtschaftsberatung ; Consulting ; Forscher ; Wissenschaftler ; Wissenschaftliche Elite
    Language English
    Size XIV, 341 S.
    Publisher Plenum Trade
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008743039
    ISBN 0-306-45637-0 ; 978-0-306-45637-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 8537 order for loan Magazin

    Order via subito

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  3. Article ; Online: The integrin-growth factor receptor duet.

    Alam, Naved / Goel, Hira Lal / Zarif, Matthew J / Butterfield, Julie E / Perkins, Hillary M / Sansoucy, Brian G / Sawyer, Thomas K / Languino, Lucia R

    Journal of cellular physiology

    2007  Volume 213, Issue 3, Page(s) 649–653

    Abstract: Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli ... ...

    Abstract Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.
    MeSH term(s) Animals ; Forecasting ; Humans ; Integrins/metabolism ; Ligands ; Models, Biological ; Receptors, Growth Factor/metabolism
    Chemical Substances Integrins ; Ligands ; Receptors, Growth Factor
    Language English
    Publishing date 2007-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.21278
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Book: Marine Flora and fauna of the northeastern United States

    Bovee, Eugene C / Sawyer, Thomas K

    Protozoa: Sarcodina: Amoebae

    (NOAA Technical Report : NMFS Circular ; 419)

    1979  

    Author's details Eugene C. Bovee and Thomas K. Sawyer
    Series title NOAA Technical Report : NMFS Circular ; 419
    Language English
    Size III, 56 S
    Publisher U.S. Department of Commerce
    Publishing place Seattle
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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