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  1. Book ; Online ; Thesis: Neural crest-derived sympathoadrenergic-like progenitors of the postnatal murine adrenal gland

    Saxena, Shobhit [Verfasser]

    2013  

    Author's details Shobhit Saxena
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität Ulm. Medizinische Fakultät
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: Study of Tidal Volume and Positive End-Expiratory Pressure on Alveolar Recruitment Using Spiro Dynamics in Mechanically Ventilated Patients.

    Saxena, Shobhit / Tripathi, Manoj / Kumar, Virendra / Malviya, Deepak / Harjai, Mamta / Rai, Sujeet

    Anesthesia, essays and researches

    2020  Volume 14, Issue 1, Page(s) 154–159

    Abstract: Background and aims: Ventilator setting in the intensive care unit patients is a topic of debate and setting of tidal volume (TV) should be patient-specific based on lung mechanics. In this study, we have evaluated to develop optimal ventilator ... ...

    Abstract Background and aims: Ventilator setting in the intensive care unit patients is a topic of debate and setting of tidal volume (TV) should be patient-specific based on lung mechanics. In this study, we have evaluated to develop optimal ventilator strategies through continuous and thorough monitoring of respiratory mechanics during ongoing ventilator support to prevent alveolar collapse and alveolar injury in mechanically ventilated patients.
    Methods: In our monocentric, randomized, observational study, we had recruited 60 patients and divided them into two groups of 30 each. In Group 1 patients, TV and positive end-expiratory pressure (PEEP) were set according to pressure-volume (P/V) curve obtained by the mechanical ventilator in a conventional manner (control group), and in Group 2, TV and PEEP were set according to P/V curve obtained by the mechanical ventilator using intratracheal catheter. PEEP and TV were set accordingly. TV, PEEP, and PaO
    Results: We found a significant difference between PEEP and P/F ratio in both groups while intragroup comparison at days 1, 3, and 7. After the intergroup comparison of Group 1 and 2, we observed a significant difference of PEEP and P/F ratio between the groups at day 7 and not on day 1 or 3.
    Conclusion: This study concludes that optimal PEEP is more accurate using an intratracheal catheter than the conventional method of deciding ventilator setting. Hence, it is recommended to use intratracheal catheter to obtain more accurate ventilator settings.
    Language English
    Publishing date 2020-06-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 2626233-2
    ISSN 2229-7685 ; 0259-1162
    ISSN (online) 2229-7685
    ISSN 0259-1162
    DOI 10.4103/aer.AER_10_20
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  3. Article: Association of Selected Fitness Variables with Perceived Performance Levels in Lawn Tennis Players

    Manchanda, Sukriti / Saxena, Shobhit / Sharma, Pooja / Rizvi, Moattar Raza / Sharma, Ankita / Ahmad, Irshad / Kachanathu, Shaji John

    Journal of Health and Allied Sciences NU

    2023  Volume 13, Issue 04, Page(s) 535–542

    Abstract: Objectives: Lawn tennis is an explosive sport that involves various fitness parameters such as explosive strength, endurance, power, and agility. Improved physical fitness leads to superior athletic performance. The coach's perception is contingent upon ...

    Abstract Objectives: Lawn tennis is an explosive sport that involves various fitness parameters such as explosive strength, endurance, power, and agility. Improved physical fitness leads to superior athletic performance. The coach's perception is contingent upon his perception of the player at the time the athlete is comparing himself to the coach. Thus, this study aimed to determine the association between chosen fitness factors and perceived performance by coach in lawn tennis players. Thus, the study aims to detect the relationship between different fitness variables and perceived level of performance in lawn tennis player.
    Materials and Methods: Fifty-two lawn tennis players from two sports academies were measured for various parameters of fitness and perceived performance level as rated by the coach.
    Statistical Analysis: The association between selected fitness metrics and perceived performance in lawn tennis players was investigated using Pearson's correlation test. Furthermore, the data were analyzed with paired t -test for male and female group, and ANOVA was used to analyze the difference between the levels of performance.
    Results: Fatigue index, closed kinetic chain upper extremity stability (CKCUEST) test, and peak power and energy expenditure taken by metabolic equivalent (MET) calculation was found to be statistically different between males and females. While comparing BMI with the peak power, there was a weak positive correlation for males, while for female there was no correlation. Metabolic equivalent, energy expenditure, and peak power were positively correlated with the level of performance; however, fatigue index and level of performance had a negative nonsignificant correlation.
    Conclusion: Peak power, fatigue index, energy expenditure, and BMI were found to be associated in males, but not in females. Peak power and energy expenditure were connected to performance in both genders.
    Keywords energy expenditure ; fatigue index ; peak power ; upper limb stability ; perceived performance
    Language English
    Publishing date 2023-03-17
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2582-4953 ; 2582-4287
    ISSN (online) 2582-4953
    ISSN 2582-4287
    DOI 10.1055/s-0042-1760438
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  4. Article ; Online: Evaluation of penalty and enforcement strategies to combat speeding offences among professional drivers: A Hong Kong stated preference experiment.

    Chen, Tiantian / Sze, N N / Saxena, Shobhit / Pinjari, Abdul Rawoof / Bhat, Chandra R / Bai, Lu

    Accident; analysis and prevention

    2019  Volume 135, Page(s) 105366

    Abstract: Speeding has been a great concern around the world due to the occurrence and severity of road crashes. This paper presents an evaluation of the effectiveness of different penalty and camera-based enforcement strategies in curbing speeding offences by ... ...

    Abstract Speeding has been a great concern around the world due to the occurrence and severity of road crashes. This paper presents an evaluation of the effectiveness of different penalty and camera-based enforcement strategies in curbing speeding offences by professional drivers in Hong Kong. A stated preference survey approach is employed to measure the association between penalty and enforcement strategies and drivers' speed choices. Data suggest that almost all drivers comply with speed limits when they reach a camera housing section of the road. For other road sections, a panel mixed logit model is estimated and applied to understand the effectiveness of penalties and enforcement strategies on driver's speeding behaviors. Driving-offence points (DOPs) are found to be more effective than monetary fines in deterring speeding offences, albeit there is significant heterogeneity in how drivers respond to these strategies. Warning drivers of an upcoming camera-based enforcement section increased speed compliance. Several demographic and employment characteristics, driving history and perception variables also influence drivers' choices of speed compliance. Finally, besides penalty and enforcement strategies, driver education and training programs aimed at addressing aggressiveness/risk-taking traits might help reduce repeated speeding offences among drivers.
    MeSH term(s) Accidents, Traffic/prevention & control ; Accidents, Traffic/statistics & numerical data ; Automobile Driving/legislation & jurisprudence ; Automobile Driving/statistics & numerical data ; Female ; Hong Kong ; Humans ; Logistic Models ; Male ; Safety ; Social Control, Formal/methods
    Language English
    Publishing date 2019-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 210223-7
    ISSN 1879-2057 ; 0001-4575
    ISSN (online) 1879-2057
    ISSN 0001-4575
    DOI 10.1016/j.aap.2019.105366
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Patient experience of sentinel lymph node biopsy for melanoma.

    Sadideen, Hazim / Saxena, Shobhit / Dobbs, Thomas D / Adams, Titus S

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2017  Volume 70, Issue 5, Page(s) 712–713

    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2017.01.011
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  6. Article ; Online: Reactive Oxygen Species Impair the Function of CD90

    Rönn, Roger E / Guibentif, Carolina / Saxena, Shobhit / Woods, Niels-Bjarne

    Stem cells (Dayton, Ohio)

    2017  Volume 35, Issue 1, Page(s) 197–206

    Abstract: Cell stressors, such as elevated levels of reactive oxygen species (ROS), adversely affect hematopoietic stem cell (HSC) reconstituting ability. However, the effects of ROS have not been evaluated in the context of hematopoietic development from human ... ...

    Abstract Cell stressors, such as elevated levels of reactive oxygen species (ROS), adversely affect hematopoietic stem cell (HSC) reconstituting ability. However, the effects of ROS have not been evaluated in the context of hematopoietic development from human pluripotent stem cells (hPSCs). Using our previously described in vitro system for efficient derivation of hematopoietic cells from hPSCs, we show that the vast majority of generated hematopoietic cells display supraphysiological levels of ROS compared to fresh cord blood cells. Elevated ROS resulted in DNA damage of the CD34
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1002/stem.2503
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The effect of intercalated degrees on student involvement in academic medicine.

    Phillips, Alexandra / Saxena, Shobhit / Lingham, Aranghan / Zoubir, Imen / Graham, Helen

    Medical teacher

    2014  Volume 36, Issue 1, Page(s) 87

    MeSH term(s) Biomedical Research/education ; Biomedical Research/manpower ; Biomedical Research/trends ; Career Choice ; Clinical Medicine/standards ; Clinical Medicine/trends ; Education, Medical, Undergraduate/organization & administration ; Education, Medical, Undergraduate/trends ; Humans ; Interdisciplinary Studies/standards ; Interdisciplinary Studies/trends ; Students, Medical/psychology ; Teaching/trends ; United Kingdom
    Language English
    Publishing date 2014-01
    Publishing country England
    Document type Letter
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.3109/0142159X.2014.856513
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  8. Article ; Online: Response to letter regarding "The effect of intercalated degrees on student involvement in academic medicine".

    Phillips, Alexandra / Saxena, Shobhit / Lingham, Aranghan / Zoubir, Imen / Graham, Helen

    Medical teacher

    2014  Volume 36, Issue 7, Page(s) 645

    MeSH term(s) Biomedical Research/manpower ; Career Choice ; Clinical Medicine/standards ; Education, Medical, Undergraduate/organization & administration ; Humans ; Interdisciplinary Studies/standards ; Students, Medical/psychology
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.3109/0142159X.2014.917291
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  9. Article ; Online: Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation.

    Saxena, Shobhit / Rönn, Roger E / Guibentif, Carolina / Moraghebi, Roksana / Woods, Niels-Bjarne

    Stem cell reports

    2016  Volume 6, Issue 5, Page(s) 692–703

    Abstract: Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic ... ...

    Abstract Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic AMP (cAMP) induction dramatically increases HSC-like cell frequencies. We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis; Epac signaling inhibition decreased both hemogenic and non-hemogenic endothelium, and abrogated hematopoietic cell generation. Furthermore, in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4) expression, benefiting the maintenance of these primitive cells. Collectively, our study provides insights and mechanistic details on the previously unrecognized role of cAMP signaling in regulating human hematopoietic development. These findings advance the mechanistic understanding of hematopoietic development toward the development of transplantable human hematopoietic cells for therapeutic needs.
    Language English
    Publishing date 2016-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2016.03.006
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  10. Article ; Online: Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition.

    Guibentif, Carolina / Rönn, Roger Emanuel / Böiers, Charlotta / Lang, Stefan / Saxena, Shobhit / Soneji, Shamit / Enver, Tariq / Karlsson, Göran / Woods, Niels-Bjarne

    Cell reports

    2017  Volume 19, Issue 1, Page(s) 10–19

    Abstract: During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell- ... ...

    Abstract During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34
    MeSH term(s) Antigens, CD34/metabolism ; Cell Lineage ; Cells, Cultured ; Down-Regulation ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Endothelium/metabolism ; Flow Cytometry ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Leukosialin/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-ets/metabolism ; Repressor Proteins/metabolism ; Single-Cell Analysis ; Wiskott-Aldrich Syndrome Protein/metabolism ; ETS Translocation Variant 6 Protein
    Chemical Substances Antigens, CD34 ; GFI1B protein, human ; Leukosialin ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-ets ; Repressor Proteins ; WAS protein, human ; Wiskott-Aldrich Syndrome Protein
    Language English
    Publishing date 2017-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2017.03.023
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