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  1. AU="Sayan Chatterjee"
  2. AU="Köstler, Josef"
  3. AU="Conboy, Erin"
  4. AU=Martinot Martin
  5. AU="Heller, R."
  6. AU="Mo, Jinping"
  7. AU="Lui, Wen"
  8. AU="Strati, V."
  9. AU="Dixon, Matthew W.A"
  10. AU=da Mata Kanzaki Elida C G
  11. AU="ElenaTourkina"
  12. AU="Chu, Yaojuan"
  13. AU="Bakker, Michiel A."
  14. AU=Hill W Cary AU=Hill W Cary
  15. AU="Hand, Marissa"
  16. AU="Guerra, Giselle"
  17. AU="Allouch, Asma"

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  1. Artikel ; Online: Effects of Perinatally Acquired Cytomegalovirus Infection on Growth Hormone Axis

    Sayan Chatterjee / Shreya Ray Chaudhuri / Subhasish Bhattacharya

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 1, Pp SR01-SR

    2023  Band 03

    Abstract: Cytomegalovirus (CMV) is one of the most common causes of perinatally acquired infection worldwide. It affects almost every organ system with varied type of clinical manifestation. In this case series, effect of perinatally acquired cytomegalovirus ... ...

    Abstract Cytomegalovirus (CMV) is one of the most common causes of perinatally acquired infection worldwide. It affects almost every organ system with varied type of clinical manifestation. In this case series, effect of perinatally acquired cytomegalovirus infection was studied on relatively unexplored area i.e, on growth hormone axis. Effect of standard antiviral treatment was also studied in these children. Five children were diagnosed to have perinatally acquired cytomegalovirus infection and it was found that all of these children were suffering from growth hormone deficiency (as evidenced by low insulin-like growth factor 1 and insulin-like growth factor binding protein 3 level as well). Some of the children were also found to have other endocrine manifestations like hypothyroidism and hypoglycaemia. They were treated with intravenous Ganciclovir followed by oral Valganciclovir and most of them responded well.
    Schlagwörter endocrine manifestation ; hepatosplenomegaly ; insulin growth factor ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Comparison of Efficacy and Safety of Cefpodoxime and Amoxicillin-Clavulanate Potassium in Paediatric Acute Otitis Media in Children below Two Years

    Arijit Ghosh / Sayan Chatterjee

    Journal of Clinical and Diagnostic Research, Vol 11, Iss 6, Pp FC01-FC

    A Prospective Longitudinal Study

    2017  Band 04

    Abstract: Introduction: Acute Otitis Media (AOM) is one of the frequently diagnosed diseases in children below two years. Amoxicillinclavulanate potassium is the first line drug in treatment of Paediatric AOM (PAOM). Cefpodoxime has good antimicrobial activity ... ...

    Abstract Introduction: Acute Otitis Media (AOM) is one of the frequently diagnosed diseases in children below two years. Amoxicillinclavulanate potassium is the first line drug in treatment of Paediatric AOM (PAOM). Cefpodoxime has good antimicrobial activity against various types of microorganisms that include causative microorganisms of PAOM. Aim: To compare the efficacy and safety of cefpodoxime and amoxicillin-clavulanate potassium for the treatment of PAOM in children below two years. Materials and Methods: A prospective longitudinal study was conducted on children diagnosed with PAOM. Thirty-six children were included in the study: 17 in the Group A (amoxicillinclavulanate potassium) and 19 in the Group B (cefpodoxime). Primary outcome of this study was clinical success rate at day 10 visit and secondary outcome was incidence of Adverse Events (AEs). Results: The clinical success rates were 93.8% in Group A and 88.2 % in Group B. These rates are comparable and no statistically significant difference was observed between the groups. Few mild and self-limiting AEs were observed and both the drugs were well tolerated. Conclusion: The results of this prospective study showed that a 10-day course of cefpodoxime is therapeutically comparable to amoxicillin-clavulanate potassium in terms of both efficacy and safety for the treatment of PAOM in children below two years.
    Schlagwörter adverse events ; antimicrobial agents ; aom-sos score ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2017-06-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01)

    Nandana Das / Shripad Banavali / Sameer Bakhshi / Amita Trehan / Venkatraman Radhakrishnan / Rachna Seth / Brijesh Arora / Gaurav Narula / Subir Sinha / Prakriti Roy / Manash Pratim Gogoi / Sayan Chatterjee / Bindhu Abraham / Parag Das / Vaskar Saha / Shekhar Krishnan

    Trials, Vol 23, Iss 1, Pp 1-

    a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India

    2022  Band 20

    Abstract: Abstract Background In the west, survival following treatment of childhood acute lymphoblastic leukaemia (ALL) approaches 90%. Outcomes in India do not exceed 70%. To address this disparity, the Indian Collaborative Childhood Leukaemia group (ICiCLe) ... ...

    Abstract Abstract Background In the west, survival following treatment of childhood acute lymphoblastic leukaemia (ALL) approaches 90%. Outcomes in India do not exceed 70%. To address this disparity, the Indian Collaborative Childhood Leukaemia group (ICiCLe) developed in 2013 a contemporary treatment protocol for uniform risk-stratified management of first presentation ALL based on cytogenetics and minimal residual disease levels (MRD). A multicentre randomised clinical trial opened in 2016 (ICiCLe-ALL-14) and examines the benefit of randomised interventions to decrease toxicity and improve outcomes. Methods Patients 1–18 years with newly diagnosed ALL are categorised into four risk groups based on presentation features, tumour genetics and treatment response. Standard risk includes young (< 10 years) B cell precursor ALL (BCP-ALL) patients with low presentation leucocyte count (< 50 × 109/L) and no high-risk features. Intermediate risk includes BCP-ALL patients with no high-risk features but are older and have high presentation leucocyte counts and/or bulky disease. High risk includes BCP-ALL patients with any high-risk feature, including high-risk genetics, central nervous system leukaemia, poor prednisolone response at treatment day 8 and high MRD (≥ 0·01%) at the end of induction. Patients with T-lineage ALL constitute the fourth risk group. All patients receive four intensive treatment blocks (induction, consolidation, interim maintenance, delayed intensification) followed by 96 weeks of maintenance. Treatment intensity varies by risk group. Clinical data management is based on a web-based remote data capture system. The first randomisation examines the toxicity impact of a shorter induction schedule of prednisolone (3 vs 5 weeks) in young non-high-risk BCP-ALL. The second randomisation examines the survival benefit of substituting doxorubicin with mitoxantrone in delayed intensification for all patients. Primary outcome measures include event-free survival (overall, by risk groups), sepsis rates in induction ...
    Schlagwörter Acute lymphoblastic leukaemia ; Childhood ; Randomised trial ; Risk stratification ; Open label ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Purification of native histidine-rich protein 2 (nHRP2) from Plasmodium falciparum culture supernatant, infected RBCs, and parasite lysate

    Balwan Singh / Jessica N. McCaffery / Amy Kong / Yong Ah / Scott Wilson / Sayan Chatterjee / Deepak Tomar / Michael Aidoo / Venkatachalam Udhayakumar / Eric Rogier

    Malaria Journal, Vol 20, Iss 1, Pp 1-

    2021  Band 13

    Abstract: Abstract Background Despite the widespread use of histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs), purified native HRP2 antigen is not standardly used in research applications or assessment of RDTs used in the field. Methods This ... ...

    Abstract Abstract Background Despite the widespread use of histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs), purified native HRP2 antigen is not standardly used in research applications or assessment of RDTs used in the field. Methods This report describes the purification of native HRP2 (nHRP2) from the HB3 Plasmodium falciparum culture strain. As this culture strain lacks pfhrp3 from its genome, it is an excellent source of HRP2 protein only and does not produce the closely-related HRP3. The nHRP2 protein was isolated from culture supernatant, infected red blood cells (iRBCs), and whole parasite lysate using nickel-metal chelate chromatography. Biochemical characterization of nHRP2 from HB3 culture was conducted by SDS-PAGE and western blotting, and nHRP2 was assayed by RDT, ELISA, and bead-based immunoassay. Results Purified nHRP2 was identified by SDS-PAGE and western blot as a − 60 kDa protein that bound anti-HRP-2 monoclonal antibodies. Mouse anti-HRP2 monoclonal antibody was found to produce high optical density readings between dilutions of 1:100 and 1:3,200 by ELISA with assay signal observed up to a 1:200,000 dilution. nHRP2 yield from HB3 culture by bead-based immunoassay revealed that both culture supernatant and iRBC lysate were practical sources of large quantities of this antigen, producing a total yield of 292.4 µg of nHRP2 from two pooled culture preparations. Assessment of nHRP2 recognition by RDTs revealed that Carestart Pf HRP2 and HRP2/pLDH RDTs detected purified nHRP2 when applied at concentrations between 20.6 and 2060 ng/mL, performing within a log-fold dilution of commercially-available recombinant HRP2. The band intensity observed for the nHRP2 dilutions was equivalent to that observed for P. falciparum culture strain dilutions of 3D7 and US06 F Nigeria XII between 12.5 and 1000 parasites/µL. Conclusions Purified nHRP2 could be a valuable reagent for laboratory applications as well as assessment of new and existing RDTs prior to their use in clinical settings. These results ...
    Schlagwörter Plasmodium falciparum ; Antigen ; Histidine-rich protein 2 (HRP2) ; Protein purification ; Arctic medicine. Tropical medicine ; RC955-962 ; Infectious and parasitic diseases ; RC109-216
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Cor pulmonale in a case of infantile Gaucher′s disease

    Soumya Patra / Sayan Chatterjee / Shilpi Singhla / Bijoy Patra / Anu Maheswari / Anju Seth

    Indian Journal of Endocrinology and Metabolism, Vol 15, Iss 2, Pp 134-

    2011  Band 136

    Abstract: Infantile Gaucher′s disease presenting as cor pulmonale is rarely reported in pediatric literature. We report a 3.3 year old boy with infantile Gaucher′s disease who presented to us as interstitial lung disease, pulmonary hypertension along with features ...

    Abstract Infantile Gaucher′s disease presenting as cor pulmonale is rarely reported in pediatric literature. We report a 3.3 year old boy with infantile Gaucher′s disease who presented to us as interstitial lung disease, pulmonary hypertension along with features of cor pulmonale. The high resolution CT findings were typical of interstitial and airspace disease. Cor pulmonale in this patient was a result of severe pulmonary hypertension.
    Schlagwörter Cor-pulmonale ; Gaucher′s disease ; infant ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2011-01-01T00:00:00Z
    Verlag Endocrine Society of India
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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