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  1. Article ; Online: Dual Infection of Hepatitis A Virus and Hepatitis E Virus- What Is Known?

    Sayed, Ibrahim M

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Viral hepatitis is an infection of human hepatocytes resulting in liver damage. Dual infection of two hepatotropic viruses affects disease outcomes. The hepatitis A virus (HAV) and hepatitis E virus (HEV) are two enterically transmitted viruses; they are ...

    Abstract Viral hepatitis is an infection of human hepatocytes resulting in liver damage. Dual infection of two hepatotropic viruses affects disease outcomes. The hepatitis A virus (HAV) and hepatitis E virus (HEV) are two enterically transmitted viruses; they are single-stranded RNA viruses and have common modes of transmission. They are transmitted mainly by the fecal-oral route and ingestion of contaminated food, though the HAV has no animal reservoirs. The HAV and HEV cause acute self-limiting disease; however, the HEV, but not HAV, can progress to chronic and extrahepatic infections. The HAV/HEV dual infection was reported among acute hepatitis patients present in developing countries. The impact of the HAV/HEV on the prognosis for acute hepatitis is not completely understood. Studies showed that the HAV/HEV dual infection increased abnormalities in the liver leading to fulminant hepatic failure (FHF) with a higher mortality rate compared to infection with a single virus. On the other hand, other reports showed that the clinical symptoms of the HAV/HEV dual infection were comparable to symptoms associated with the HAV or HEV monoinfection. This review highlights the modes of transmission, the prevalence of the HAV/HEV dual infection in various countries and among several study subjects, the possible outcomes of this dual infection, potential model systems for studying this dual infection, and methods of prevention of this dual infection and its associated complications.
    MeSH term(s) Humans ; Hepatitis E virus ; Hepatitis A virus ; Hepatitis A/complications ; Hepatitis A/epidemiology ; Hepatitis E/complications ; Hepatitis E/epidemiology
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

    Sayed, Ibrahim M / Abdelwahab, Sayed F

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: Though Egypt ranks among the top countries for viral hepatitis and death-related liver disease, Hepatitis E virus (HEV) is a neglected pathogen. Living in villages and rural communities with low sanitation, use of underground well water and contact with ... ...

    Abstract Though Egypt ranks among the top countries for viral hepatitis and death-related liver disease, Hepatitis E virus (HEV) is a neglected pathogen. Living in villages and rural communities with low sanitation, use of underground well water and contact with animals are the main risk factors for HEV infection. Domestic animals, especially ruminants and their edible products, are one source of infection. Contamination of water by either human or animal stools is the main route of infection. In addition, HEV either alone or in coinfection with other hepatotropic viruses has been recorded in Egyptian blood donors. HEV seropositivity among Egyptian villagers was 60-80%, especially in the first decade of life. Though HEV seropositivity is the highest among Egyptians, HEV infection is not routinely diagnosed in Egyptian hospitals. The initial manifestations of HEV among Egyptians is a subclinical infection, although progression to fulminant hepatic failure has been recorded. With the improvement in serological and molecular approaches and increasing research on HEV, it is becoming clear that HEV represents a threat for Egyptians and preventive measures should be considered to reduce the infection rate and possible complications.
    Language English
    Publishing date 2022-11-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11111337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hepatic Immune Response Against Hepatitis E Virus Genotype 1 Infection Among Animal Models.

    Sayed, Ibrahim M

    The Journal of infectious diseases

    2019  Volume 220, Issue 6, Page(s) 1082–1083

    MeSH term(s) Animals ; Genotype ; Hepatitis E ; Hepatitis E virus/immunology ; Immunoglobulin G ; Macaca mulatta ; Models, Animal
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2019-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiz233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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  4. Article ; Online: A comment on "Current status of hepatitis E virus infection at a rhesus monkey farm in China".

    Sayed, Ibrahim M

    Veterinary microbiology

    2019  Volume 237, Page(s) 108379

    MeSH term(s) Animals ; China ; Farms ; Hepatitis E ; Hepatitis E virus ; Macaca mulatta
    Language English
    Publishing date 2019-08-09
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2019.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Assays with Patient-Derived Organoids to Evaluate the Impact of Microbial Infection on Base Excision Repair (BER) Enzymes.

    Sayed, Ibrahim M / Chakraborty, Anirban / Das, Soumita

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2701, Page(s) 157–172

    Abstract: Microbes play an important role in regulating cellular responses and the induction of chronic diseases. Infection and chronic inflammation can cause DNA damage, and the accumulation of mutations leads to cancer development. The well-known examples of ... ...

    Abstract Microbes play an important role in regulating cellular responses and the induction of chronic diseases. Infection and chronic inflammation can cause DNA damage, and the accumulation of mutations leads to cancer development. The well-known examples of cancer-associated microbes are Helicobacter pylori in gastric cancer and Fusobacterium nucleatum (Fn), Bacteroides fragilis, and E.coli NC101 in colorectal cancer (CRC). These carcinopathogens modify the expressions of the base excision repair enzymes and cause DNA damage. This chapter will show how Fn can initiate CRC through the downregulation of a critical enzyme of the base excision repair (BER) pathway that subsequently causes accumulation of DNA damage. We used the stem cell-based organoid model and enteroid-derived monolayer (EDM) from the murine and human colon to assess the impact of infection on the expression of BER enzymes on the transcriptional and translational levels and to develop other functional assays. For example, we used this EDM model to assess the inflammatory response, DNA damage response, and physiological responses, where we correlated the level of these parameters to BER enzyme levels.
    MeSH term(s) Humans ; Animals ; Mice ; DNA Repair ; DNA Damage ; Mutation ; Neoplasms/genetics ; Organoids
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3373-1_10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Emerging Pathogens Causing Acute Hepatitis.

    Sayed, Ibrahim M / El-Shamy, Ahmed / Abdelwahab, Sayed F

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: Acute hepatitis is defined as an inflammation or injury in the hepatocytes that continues for a short period of time (less than 6 months) [ ... ]. ...

    Abstract Acute hepatitis is defined as an inflammation or injury in the hepatocytes that continues for a short period of time (less than 6 months) [...].
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Isolation of RNA from the Murine Colonic Tissue and qRT-PCR for Inflammatory Cytokines.

    Sayed, Ibrahim M / Inouye, Kaili / Das, Soumita / Alexander, Laura Crotty

    Bio-protocol

    2023  Volume 13, Issue 6, Page(s) e4634

    Abstract: E-cigarette (E-cig) inhalation affects health status by modulating inflammation profiles in several organs, including the brain, lung, heart, and colon. The effect of flavored fourth-generation pod-based E-cigs (JUUL) on murine gut inflammation is ... ...

    Abstract E-cigarette (E-cig) inhalation affects health status by modulating inflammation profiles in several organs, including the brain, lung, heart, and colon. The effect of flavored fourth-generation pod-based E-cigs (JUUL) on murine gut inflammation is modulated by both flavor and exposure period. Exposure of mice to JUUL mango and JUUL mint for one month upregulated inflammatory cytokines, particularly TNF-α, IL-6, and Cxcl-1 (IL-8). JUUL Mango effects were more prominent than those incurred by JUUL Mint after one month of exposure. However, JUUL Mango reduced the expression of colonic inflammatory cytokines after three months of exposure. In this protocol, we detail the process of RNA isolation from the mouse colon and the use of extracted RNA in profiling the inflammatory milieu. Efficient RNA extraction from the murine colon is the most important step in the evaluation of inflammatory transcripts in the colon.
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Microbial sensing to control host immune responses.

    Sayed, Ibrahim M / Bhattacharyya, Asima / Das, Soumita

    Frontiers in microbiology

    2022  Volume 13, Page(s) 1054640

    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1054640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The WxxxE proteins in microbial pathogenesis

    Achi, Sajan Chandrangadhan / Karimilangi, Sareh / Lie, Dominique / Sayed, Ibrahim M. / Das, Soumita

    Critical Reviews in Microbiology. 2023 Mar. 4, v. 49, no. 2 p.197-213

    2023  

    Abstract: Effector proteins secreted by pathogens modulate various host cellular processes and help in bacterial pathogenesis. Some of these proteins, injected by enteric pathogens via Type Three Secretion System (T3SS) were grouped together based on a conserved ... ...

    Abstract Effector proteins secreted by pathogens modulate various host cellular processes and help in bacterial pathogenesis. Some of these proteins, injected by enteric pathogens via Type Three Secretion System (T3SS) were grouped together based on a conserved signature motif (WxxxE) present in them. The presence of WxxxE motif is not limited to effectors released by enteric pathogens or the T3SS but has been detected in non-enteric pathogens, plant pathogens and in association with Type II and Type IV secretion systems. WxxxE effectors are involved in actin organization, inflammation regulation, vacuole or tubule formation, endolysosomal signalling regulation, tight junction disruption, and apoptosis. The WxxxE sequence has also been identified in TIR [Toll/interleukin-1 (IL-1) receptor] domains of bacteria and host. In the present review, we have focussed on the established and predicted functions of WxxxE effectors secreted by several pathogens, including enteric, non-enteric, and plant pathogens.
    Keywords actin ; apoptosis ; inflammation ; interleukin-1 ; microbiology ; pathogenesis ; secretion ; tight junctions ; type III secretion system ; vacuoles ; WxxxE motif ; effectors ; pathogens ; function ; TIR domains
    Language English
    Dates of publication 2023-0304
    Size p. 197-213.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1053620-6
    ISSN 1549-7828 ; 1040-841X
    ISSN (online) 1549-7828
    ISSN 1040-841X
    DOI 10.1080/1040841X.2022.2046546
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 84/701: Show issues

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  10. Article ; Online: Role of ELMO1 in inflammation and cancer-clinical implications.

    Tocci, Stefania / Ibeawuchi, Stella-Rita / Das, Soumita / Sayed, Ibrahim M

    Cellular oncology (Dordrecht)

    2022  Volume 45, Issue 4, Page(s) 505–525

    Abstract: Background: Engulfment and cell motility protein 1 (ELMO1) is a key protein for innate immunity since it is required for the clearance of apoptotic cells and pathogenic bacteria as well as for the control of inflammatory responses. ELMO1, through ... ...

    Abstract Background: Engulfment and cell motility protein 1 (ELMO1) is a key protein for innate immunity since it is required for the clearance of apoptotic cells and pathogenic bacteria as well as for the control of inflammatory responses. ELMO1, through binding with Dock180 and activation of the Rac1 signaling pathway, plays a significant role in cellular shaping and motility. Rac-mediated actin cytoskeletal rearrangement is essential for bacterial phagocytosis, but also plays a crucial role in processes such as cancer cell invasion and metastasis. While the role of ELMO1 in bacterial infection and inflammatory responses is well established, its implication in cancer is not widely explored yet. Molecular changes or epigenetic alterations such as DNA methylation, which ultimately leads to alterations in gene expression and deregulation of cellular signaling, has been reported for ELMO1 in different cancer types.
    Conclusions: In this review, we provide an updated and comprehensive summary of the roles of ELMO1 in infection, inflammatory diseases and cancer. We highlight the possible mechanisms regulated by ELMO1 that are relevant for cancer development and progression and provide insight into the possible use of ELMO1 as a diagnostic biomarker and therapeutic target.
    MeSH term(s) Actins/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Inflammation ; Neoplasms/genetics ; Signal Transduction
    Chemical Substances Actins ; Adaptor Proteins, Signal Transducing ; ELMO1 protein, human
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2595109-9
    ISSN 2211-3436 ; 1875-8606 ; 2211-3428
    ISSN (online) 2211-3436
    ISSN 1875-8606 ; 2211-3428
    DOI 10.1007/s13402-022-00680-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6908: Show issues Location:
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