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  1. AU="Sayed Masoud Hosseini"
  2. AU="Pathania, Deepak"
  3. AU=Xu Yuzhong AU=Xu Yuzhong
  4. AU="Mehmood, Huzaifa"
  5. AU="Etcheverry, Amandine"
  6. AU="Sein, Andrea M"
  7. AU="Vo, Thi-Phi-Giao"
  8. AU="Allan, Alasdair"
  9. AU="Thurlow, Lance R"
  10. AU="Lum, Krystal"
  11. AU="Wilms, Miriam"
  12. AU="Russell, Michael H"
  13. AU="Bedoya-Arias, Hugo A"
  14. AU="Hijri, Mohamed"
  15. AU="Priscilla Gates"
  16. AU="Reiber, Matthew"
  17. AU="Bauer-Rowe, Khristian E"
  18. AU="Tanner, Martin E"
  19. AU="Creech, Gardner S"
  20. AU="José P. Oliveira-Filho"
  21. AU="Munt, Jennifer E"
  22. AU="Whiley, Phillip J"
  23. AU="V.Sudhir, "
  24. AU="Chatow, Lior"
  25. AU=Xue Zhe
  26. AU="Peter D. Yurchenco"
  27. AU="Várbíró, Gábor"
  28. AU="Sheleg, Dmitriy"
  29. AU="Panzirer, David"

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  1. Artikel ; Online: Bidirectional Association Between COVID-19 and Mental Health Disorders

    Haleh Talaie / Sayed Masoud Hosseini / Maryam Nazari / Farzad Nazemi

    International Journal of Medical Toxicology and Forensic Medicine, Vol 11, Iss 3, p

    A Narrative Review

    2021  Band 34101

    Abstract: Background: Fear, anxiety, and stress are natural reactions of the human body to unpredictable and potentially threatening conditions. Currently, individuals are encountering Coronavirus Disease 2019 (COVID-19) pandemic; it is caused by a virulent, ... ...

    Abstract Background: Fear, anxiety, and stress are natural reactions of the human body to unpredictable and potentially threatening conditions. Currently, individuals are encountering Coronavirus Disease 2019 (COVID-19) pandemic; it is caused by a virulent, partially unknown pathogen with high transmissibility, recognized as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is conceivable to experience anxiety, stress, and subsequent mental health disorders during the pandemic. This narrative review provided a brief overview of mechanisms involved in COVID-19 and mental health disorders as well as the bidirectional association between them. Methods: Scientific electronic databases, such as PubMed, Scopus, Web of Science, and Google Scholar were thoroughly searched, based on different keywords in this study. Results: Lifestyle changes and isolation for breaking the chain of infection facilitate mental health disorders development more than before. Since the onset of the pandemic, the prevalence of mental health disorders has significantly increased. Moreover, studies suggested that the incidence of COVID-19 and the progression of the disease to a severe and life-threatening stage is higher in individuals with a history of mental health disorders. Inflammation is caused by, also may cause mental health disorders. Besides, COVID-19 is associated with cytokine storm and subsequent inflammation. Conclusion: There seems to be a bidirectional association between COVID-19 and mental health disorders, in which inflammation acts as an adaptor.
    Schlagwörter coronavirus disease 2019 (covid-19) ; severe acute respiratory syndrome coronavirus 2 (sars-cov- 2) ; mental disorders ; cytokine release syndrome ; inflammation ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag Shaheed Beheshti University of Medical Sciences
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Hepatotoxicity Among Poisoned Patients

    Arezou Mahdavinejad / Haleh Talaie / Ali Saffaei / Mitra Rahimi / Sayed Masoud Hosseini

    International Journal of Medical Toxicology and Forensic Medicine, Vol 12, Iss 4, Pp 38931-

    A Cross-sectional Study

    2022  Band 38931

    Abstract: Background: Drug-induced liver injury is a major cause of hepatitis worldwide. In patients diagnosed with acute poisoning, drug-induced liver injury is a critical challenge. This study aims to evaluate the pattern of hepatotoxicity in poisoned patients ... ...

    Abstract Background: Drug-induced liver injury is a major cause of hepatitis worldwide. In patients diagnosed with acute poisoning, drug-induced liver injury is a critical challenge. This study aims to evaluate the pattern of hepatotoxicity in poisoned patients admitted to Loghman Hakim Hospital. Methods: In this cross-sectional study that was conducted at Loghman Hakim hospital, the clinical records of poisoned patients were evaluated and patients with hepatotoxicity were selected for final analysis. The clinical and para-clinical information of these patients was recorded. The SPSS software, version 23. was used for statistical analysis. Results: A total of 260 cases were included in this study. The Mean±SD age of patients was 38.24±16.29 years and most of them were male (79.2%). Patients with narcotics poisoning had the highest prevalence (38.5%), especially when they were taken together with acetaminophen or benzodiazepine. In addition, among the patients studied, those with underlying cardiovascular disease are more likely to develop hepatotoxicity. Conclusion: In conclusion, among people with various types of poisoning, it seems that narcotics (opium, heroin, methadone, etc.), particularly when taken together with acetaminophen or benzodiazepines, cause hepatotoxicity and increase serum levels of liver aminotransferases. Also, in the study population, patients with underlying cardiovascular disease had a higher chance of liver injury. Therefore, clinicians are recommended to accurately monitor the sign and symptoms of hepatotoxicity in these populations.
    Schlagwörter drug-induced hepatotoxicity ; poisoning ; overdose ; liver ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag Shaheed Beheshti University of Medical Sciences
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Risk Factors of Hospital-acquired Thrombocytopenia in Toxicological Intensive Care Unit

    Haleh Talaie / Sayed Masoud Hosseini / Maryam Nazari / Mehdi Salavati Esfahani / Behjat Barari

    International Journal of Medical Toxicology and Forensic Medicine, Vol 10, Iss

    2020  Band 3

    Abstract: Background: Platelet count is a readily available biomarker predicting disease severity and risk of mortality in the intensive care units (ICU). This study aims to describe the frequency, to assess the risk factors, and to evaluate the impact of ... ...

    Abstract Background: Platelet count is a readily available biomarker predicting disease severity and risk of mortality in the intensive care units (ICU). This study aims to describe the frequency, to assess the risk factors, and to evaluate the impact of thrombocytopenia on patient outcomes in a Toxicological ICU (TICU). Methods: In this prospective observational Cohort study, we enrolled 184 patients admitted to our TICU from October 1st, 2019, to August 23rd, 2020. Mild/moderate and severe thrombocytopenia were defined as at least one platelet counts less than 150×103/µL and 50×103/µL during the ICU stay, respectively. Results: Of 184 enrolled patients, 45.7% had mild to moderate thrombocytopenia and 5.4% had severe thrombocytopenia. Old age (OR: 1.042, 95%CI: 1.01-1.075, P=0.01), male gender (OR: 4.348, 95%CI: 1.33-14.22, P=0.015), increased international normalized ratio (INR) levels (OR: 3.72, 95%CI: 1.15-112, P=0.028), and administration of some medications including heparin (OR: 3.553, 95%CI: 1.11-11.36, P=0.033), antihypertensive drugs (OR: 2.841, 95%CI: 1.081-7.471, P=0.034), linezolid (OR: 13.46, 95%CI: 4.75-38.13, P<0.001), erythromycin (OR: 19.58, 95%CI: 3.23-118.86, P=0.001), and colistin (OR: 10.29, 95% CI 1.44-73.69, P=0.02) were the risk factors of hospital-acquired thrombocytopenia. The outcomes of patients with normal platelet count were significantly better than those who developed thrombocytopenia (P<0.001). Conclusion: We found that thrombocytopenia could develop in almost 50% of patients admitted to TICU, which is associated with poor prognosis. Additionally, the platelet counts should be closely monitored to administer some medications (heparin, antihypertensive drug, and linezolid), especially in old patients.
    Schlagwörter thrombocytopenia ; poisoning ; intensive care unit (icu) ; patient outcome assessment ; risk factors ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-09-01T00:00:00Z
    Verlag Shaheed Beheshti University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats

    Sayed Masoud Hosseini / Elahe Taghiabadi / Khalil Abnous / Alireza Timcheh Hariri / Hamed Pourbakhsh / Hossein Hosseinzadeh

    Iranian Journal of Basic Medical Sciences, Vol 20, Iss 8, Pp 927-

    2017  Band 939

    Abstract: Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous ... ...

    Abstract Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologically dangerous reactive oxygen species. This experiment was planned to evaluate the protective effect of thymoquinone against subchronic ethanol toxicity in rats. Materials and Methods: Experiments were performed on six groups. Each group consisted of six animals, including control group (saline, gavage), ethanol-receiving group (3 g/kg/day, gavage), thymoquinone (2.5, 5, 10 mg/Kg/day, intraperitoneally (IP)) plus ethanol and thymoquinone (10 mg/Kg/day, IP) groups. Treatments were carried out in four weeks. Results: Thymoquinone reduced the ethanol-induced increase in the lipid peroxidation and severity of histopathological alteration in liver and kidney tissues. In addition it improved the levels of proinflammatory cytokines in liver tissue. Furthermore, thymoquinone corrected the liver enzymes level including alanine transaminase, aspartate transaminase and alkaline phosphatase in serum and glutathione content in liver and kidney tissues. Other experiments such as Western blot analysis and quantitative real-time RT-PCR revealed that thymoquinone suppressed the expression of Bax/Bcl-2 ratio (both protein and mRNA level), and caspases activation pursuant to ethanol toxicity. Conclusion: This study indicates that thymoquinone may have preventive effects against ethanol toxicity in the liver and kidney tissue through reduction in lipid peroxidation and inflammation, and also interrupting apoptosis.
    Schlagwörter Apoptosis ; Ethanol toxicity ; GSH content ; Lipid peroxidation ; Nigella sativa ; Thymoquinone ; Medicine ; R
    Thema/Rubrik (Code) 660 ; 590
    Sprache Englisch
    Erscheinungsdatum 2017-08-01T00:00:00Z
    Verlag Mashhad University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Insecticidal effects of essential oils from two medicinal plants against Aleuroclava jasmini (Hemiptera

    Saeid Javadi Khederi / Mehdi Khoobdel / Mohammad Khanjani / Asghar Hosseininia / Behzad Sadeghi Sorkhe Dizaji / Sayed Masoud Hosseini / Hosein Sobati

    Journal of Crop Protection, Vol 8, Iss 1, Pp 57-

    Aleyrodidae)

    2019  Band 67

    Abstract: The whitefly, Aleuroclava jasmini Takahashi (Hemiptera: Aleyrodidae) is an important pest on paper mulberry Brousson etiapapyrifera (L.) Vent. (Moraceae) plants in the green space of Tehran, Iran. Considering the importance of essential oils in the ... ...

    Abstract The whitefly, Aleuroclava jasmini Takahashi (Hemiptera: Aleyrodidae) is an important pest on paper mulberry Brousson etiapapyrifera (L.) Vent. (Moraceae) plants in the green space of Tehran, Iran. Considering the importance of essential oils in the integrated management program of pests, the present survey were carried out to assess the insecticidal effects of essential oils extracted from garden thyme, Thymus vulgaris L. (Lamiaceae), and neem seed, Azadirachta indica A. Juss (Meliaceae) on mortality of immature stages of A. jasmini including eggs, first-instar nymphs, and pupae, and adult repellency. Three doses of the above mentioned essential oils consisting of 0.125%, 0.25% and 0.5% (v/v), were tested in contact toxicity assays. Separately, various essential oils (0.5%), as well as Tween-20 (0.5%) were applied as treated and control for adult repellency. Responses differed according to the type and concentration of oils, as well as growth stage of A. jasmini. The highest mortality was detected with increasing concentration of assayed essential oils. The results showed that younger nymphs were more sensitive to treatments than other growth stages. Essential oil derived from T. vulgaris was the most effective, decreasing the survival rate of eggs, nymphs and pupae 64%, 76% and 50%, respectively, as compared with controls. In free-choice assays, the mean numbers of eggs laid on 0.5% A. indica and T. vulgaris oil-treated plants were 80.98% and 58.57% lower than on control plants, respectively. In conclusion, extracted oils from T. vulgaris and A. indica represented the highest contact toxicity, and repellency to A. jasmini respectively. Finally, the assayed essential oils show promise for inclusion in integrated A. jasmini management programs in green space of Tehran, Iran.
    Schlagwörter insecticide ; repellency ; essential oil ; paper mulberry ; whitefly ; Agriculture ; S
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag University of Tarbiat Modares
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Effect of Nigella sativa fixed oil on ethanol toxicity in rats

    Hamed Pourbakhsh / Elahe Taghiabadi / Khalil Abnous / Alireza Timcheh Hariri / Sayed Masoud Hosseini / Hossein Hosseinzadeh

    Iranian Journal of Basic Medical Sciences, Vol 17, Iss 12, Pp 1020-

    2015  Band 1031

    Abstract: Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including ... ...

    Abstract Objective(s):This study was planned to appraise the protective effect of Nigella sativa fixed oil (NSO) against subchronic ethanol induced toxicity in rats. Materials and Methods: Studies were carried out on six groups of six animals each, including control (normal saline, gavage), ethanol (3 g/kg/day, gavage), NSO (0.125, 0.25 and 0.5 ml/Kg/day, IP) plus ethanol and NSO (0.5 ml/Kg/day, IP) groups. Treatments were continued for 4 weeks. Results: According to data, treatment with NSO attenuated ethanol-induced increased levels of malondialdehyde (MDA), tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6), as well as histopathological changes in liver and kidney tissues. Moreover, NSO improved the level of serum liver enzymes (including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and glutathione (GSH) content in liver and kidney tissues in ethanol-treated rats. Western blot analysis and quantitative real time RT-PCR showed that NSO treatment inhibited apoptosis stimulated by ethanol through decreasing the Bax/Bcl-2 ratio (both protein and mRNA levels), cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9 level in liver and kidney. Conclusion: This study showed that NSO may have protective effects against hepatotoxicity and renal toxicity of ethanol by decreasing lipid peroxidation and inflammation and preventing apoptosis.
    Schlagwörter Apoptosis Ethanol toxicity Lipid peroxidation Nigella sativa Oxidative stress Alcohol ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2015-12-01T00:00:00Z
    Verlag Mashhad University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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