Article ; Online: Characteristics and Clinical Outcomes of Children With Wilms' Tumour: A 15-year Experience in a Single Centre in Nigeria.
2023 Volume 59, Issue 5, Page(s) 1009–1014
Abstract: Background: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment ... ...
| Abstract | Background: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment abandonment and infrastructure deficit. The purpose of this study was to analyze the clinical outcome of children with Wilms tumour managed in a Nigerian referral centre over a 15-year period. Methods: This is a retrospective study of children with WT (nephroblastoma) who were treated at our institution between January 2006 and December 2020. Clinical characteristics, treatments, and outcomes were analyzed. Results: Thirty-five patients were identified. The median age at diagnosis was 36 months including 22 (62.9 %) females. Twenty-six (74.3 %) had advanced (stage III & IV) disease. Confirmatory histology was available for 16 patients ((45.7 %) among which 10 (62.5 %) were mixed type. The right kidney was affected in 18 patients (51.4 %), left in 15 (42.9 %) and 2 were not documented. Preoperative chemotherapy was given in 22 (62.9 %) patients and 13 (37.1) patients had primary nephrectomy. Eight (22.9 %) patients died during treatment (from disease or treatment related causes), and one abandoned treatment. A total of 26 patients completed treatment. Out of these, 8 (30.8 %) were lost to follow up, four patients died and 14 (53.8 %) patients survived at a median follow-up period of 18 months. The survival decreased with advancing stages of the disease, p = 0.002. Conclusions: Majority of children with Wilms tumour in our practice presented with advanced disease. Death during treatment, treatment abandonment and lost to follow up were common. Level of evidence: Level II. Type of study: Retrospective Study. |
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| MeSH term(s) | Child ; Female ; Humans ; Infant ; Child, Preschool ; Male ; Retrospective Studies ; Nigeria/epidemiology ; Wilms Tumor/pathology ; Kidney Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Treatment Outcome | |||||
| Language | English | |||||
| Publishing date | 2023-12-16 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 80165-3 | |||||
| ISSN | 1531-5037 ; 0022-3468 | |||||
| ISSN (online) | 1531-5037 | |||||
| ISSN | 0022-3468 | |||||
| DOI | 10.1016/j.jpedsurg.2023.12.018 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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