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Article: Editorial: Gastrointestinal Surgery: Emerging techniques, controversies and state of art.

Pata, Francesco / Rausei, Stefano / Scabini, Stefano / Pellino, Gianluca

2022 Volume 9, Page(s) 1033757

Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1033757
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Article ; Online: I have got you under my skin.

Lupia, Tommaso / Scabini, Silvia / Stroffolini, Giacomo / Calcagno, Andrea

Infection

2020 Volume 48, Issue 2, Page(s) 315–316

MeSH term(s)	Aged ; Animals ; Dirofilaria repens/isolation & purification ; Dirofilariasis/diagnosis ; Ethiopia ; Forearm/parasitology ; Forearm/pathology ; Humans ; Male ; Pruritus/parasitology ; Skin/parasitology ; Skin/pathology ; Travel
Language	English
Publishing date	2020-01-09
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01389-5
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article: Concurrent and Subsequent Co-Infections of

Trunfio, Mattia / Scabini, Silvia / Rugge, Walter / Bonora, Stefano / Di Perri, Giovanni / Calcagno, Andrea

Microorganisms

2022 Volume 10, Issue 7

Abstract: We narratively reviewed the physiopathology, epidemiology, and management of co-infections ... ...

Abstract	We narratively reviewed the physiopathology, epidemiology, and management of co-infections in
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071275
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Article ; Online: Sentinel node biopsy in colorectal cancer: Must we believe it?

Scabini, Stefano

World journal of gastrointestinal surgery

2010 Volume 2, Issue 1, Page(s) 6–8

Abstract: Lymph node metastasis predicts survival and recurrence in colon cancer (CC), so decisions regarding adjuvant therapy are largely based on nodal status. Chemotherapy is not a routine treatment for node-negative CC because its toxicity and expense exceed ... ...

Abstract	Lymph node metastasis predicts survival and recurrence in colon cancer (CC), so decisions regarding adjuvant therapy are largely based on nodal status. Chemotherapy is not a routine treatment for node-negative CC because its toxicity and expense exceed its limited benefit in patients without evidence of nodal involvement. The sentinel lymph node (SLN) procedure is a selective sampling technique that can be used to ultrastage regional nodes. The real problem of SLN biopsy in CC is the procedure sensitivity rate. In future, studies concerning SLNs will have to consider issues such as the role of laparoscopy in colorectal resection (which cause technical difficulties in identification of SLNs) and the risk of overstaging of illness as well as the need to exclude T4 CC and, probably, rectal cancer from the studies. Is this the future of correct staging of colorectal cancer? Lymphadenectomy is at the present an integral part of colorectal surgery and surgeons must perform it correctly to improve their results. Nevertheless, for the future another "staging system" is necessary in colorectal cancer which takes into account biologic aspects of the tumor to identify patients with aggresive illness in order to treat them with more effective and less toxic therapies.
Language	English
Publishing date	2010-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573700-4
ISSN	1948-9366 ; 1948-9366
ISSN (online)	1948-9366
ISSN	1948-9366
DOI	10.4240/wjgs.v2.i1.6
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Article ; Online: Impact of formalin fixation on mismatch repair protein evaluation by immunohistochemistry.

Grillo, Federica / Ali, Murad / Paudice, Michele / Pigozzi, Simona / Anselmi, Giorgia / Scabini, Stefano / Sciallero, Stefania / Piol, Nataniele / Mastracci, Luca

Virchows Archiv : an international journal of pathology

2023 Volume 483, Issue 5, Page(s) 677–685

Abstract: Mismatch repair/microsatellite instability (MMR/MSI) status in colorectal cancer (CRC) has become fundamental as a diagnostic, prognostic, and predictive factor. MMR immunohistochemistry (IHC) is considered a simple and reliable approach; however, its ... ...

Abstract	Mismatch repair/microsatellite instability (MMR/MSI) status in colorectal cancer (CRC) has become fundamental as a diagnostic, prognostic, and predictive factor. MMR immunohistochemistry (IHC) is considered a simple and reliable approach; however, its effectiveness depends on pre-analytic factors. Aim of this study was to investigate the impact of different fixation times/protocols on MMR protein IHC quality. Left over tissue from surgically resected CRC samples (cold ischemia time < 30 min) where fixed as follows: standard formalin fixation (24-48 h); hypo-fixation (<20 h); hyper-fixation (>90 h); cold (4°C) fixation (24-48 h); standard fixation for small sample size (0.5×0.5 cm). Samples for each group were collected from 30 resected CRC and the following parameters were evaluated on 600 immunohistochemical stains: intensity of expression; patchiness of staining; presence of central artefact. Forty-six immunoreactions were inadequate (score 0 intensity), the majority regarding MLH1 or PMS2 in the hypo-fixation group (47.8%), followed by the hyper-fixation group (28.1%); cold formalin fixation showed the least inadequate cases. Patchiness and central artefact were more frequent in hypo-fixation and standard fixation group compared to the others. MLH1 (closely followed by PMS2) performed worse with regard to immunostaining intensity (p=0.0002) in the standard and in the hypo-fixation group (p< 0.00001). Using a small sample size improved patchiness/central artefacts. This is the first study specifically created to evaluate the impact of fixation on MMR protein IHC, showing that both formalin hypo- and hyper-fixation can cause problems; 24-h formalin fixation as well as cold (4°C) formalin fixation are recommended for successful IHC MMR evaluation.
MeSH term(s)	Humans ; Immunohistochemistry ; DNA Mismatch Repair ; Mismatch Repair Endonuclease PMS2 ; Microsatellite Instability ; MutL Protein Homolog 1/metabolism ; Colorectal Neoplasms/diagnosis
Chemical Substances	Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3) ; MutL Protein Homolog 1 (EC 3.6.1.3)
Language	English
Publishing date	2023-09-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-023-03661-z
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Ud III Zs.10: Show issues

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Article ; Online: The experience of the COMRE group (REctal COMmittee): can magnetic resonance imaging and endosonography really help the clinical pathway after NCRT in rectal cancer?

Scabini, Stefano / Romana, Chiara / Sartini, Marina / Attieh, Ali / Marrone, Ciro / Cristina, Maria L / Parodi, Maria C

International journal of surgery (London, England)

2023 Volume 109, Issue 10, Page(s) 2991–2995

Abstract: Background: MRI and rectal endosonography (EUS) are routinely used for preoperative tumor staging and assessment of response to therapy in patients with rectal cancer. This study aimed to evaluate the accuracy of the two techniques in predicting the ... ...

Abstract	Background: MRI and rectal endosonography (EUS) are routinely used for preoperative tumor staging and assessment of response to therapy in patients with rectal cancer. This study aimed to evaluate the accuracy of the two techniques in predicting the pathological response compared to the resected specimen and the agreement between MRI and EUS and to define the factors that could affect the ability of EUS and MRI to predict pathological responses. Materials and methods: This study included 151 adult patients with middle or low rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy, followed by curative intent elective surgery in the Oncologic Surgical Unit of a hospital in the north of Italy between January 2010 and November 2020. All patients underwent MRI and rectal EUS. Results: The accuracy of EUS to evaluate the T stage was 67.48%, and for the N stage was 75.61%; the accuracy of MRI to evaluate the T stage was 75.97%, and that for the N stage was 51.94%. The agreement in detecting the T stage between EUS and MRI was 65.14% with a Cohen's kappa of 0.4070 and that for the evaluation of the lymph nodes between EUS and MRI was 47.71% with a Cohen's kappa of 0.2680. Risk factors that affect the ability of each method to predict pathological response were also investigated using logistic regression. Conclusions: EUS and MRI are accurate tools for rectal cancer staging. However, after Radiotherapy - Chemotherapy RT-CT, neither method is reliable for establishing the T stage. EUS seems significantly better than MRI for assessing the N stage. Both methods can be used as complementary tools in the preoperative assessment and management of rectal cancer, but their role in the assessment of residual rectal tumors cannot predict the complete clinical response.
MeSH term(s)	Adult ; Humans ; Endosonography/methods ; Critical Pathways ; Magnetic Resonance Imaging ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Neoplasm Staging ; Neoadjuvant Therapy
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000579
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Article ; Online: SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation.

Costa, Delfina / Venè, Roberta / Coco, Simona / Longo, Luca / Tosetti, Francesca / Scabini, Stefano / Mastracci, Luca / Grillo, Federica / Poggi, Alessandro / Benelli, Roberto

Cells

2023 Volume 12, Issue 4

Abstract: The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 ... ...

Abstract	The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 sustaining organoid proliferation. However, the growth of some colorectal cancer (CRC)-derived organoid cultures is inhibited by this molecule via an unknown mechanism. We biochemically investigated SB202190 activity on a collection of 25 primary human CRC organoids, evaluating EGFR, Akt and Erk1-2 activation using Western blot. We found that Erk1-2 phosphorylation was induced by SB202190 in 20 organoid cultures and inhibited in 5 organoid cultures. A next-generation sequencing (NGS) analysis revealed that the inhibition of p-Erk1-2 signaling corresponded to the cultures with BRAF mutations (with four different hits, one being undescribed), while p-Erk1-2 induction was apparently unrelated to other mutations involving the EGFR pathway (Her2, KRAS and NRAS). We found that SB202190 mirrored the biochemical activity of the BRAF inhibitor Dabrafenib, known to induce the paradoxical activation of p-Erk1-2 signaling in BRAF wild-type cells. SB202190 was a more effective inhibitor of BRAF-mutated organoid growth in the long term than the specific BRAF inhibitors Dabrafenib and PLX8394. Overall, SB202190 can predict BRAF-activating mutations in patient-derived organoids, as well as allowing for the identification of new BRAF variants, preceding and enforcing NGS data.
MeSH term(s)	Humans ; Proto-Oncogene Proteins B-raf/genetics ; Protein Kinase Inhibitors/pharmacology ; Mutation ; Colorectal Neoplasms/genetics ; ErbB Receptors/genetics ; Organoids/metabolism
Chemical Substances	dabrafenib (QGP4HA4G1B) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole (PVX798P8GI) ; Protein Kinase Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; BRAF protein, human (EC 2.7.11.1)
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12040664
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Article: First case of Chryseobacterium gallinarum bloodstream infection: a diagnostic and therapeutic challenge for an emerging pathogen.

Genco, Mattia / Curtoni, Antonio / Bottino, Paolo / Scabini, Silvia / Corcione, Silvia / Vita, Davide / Guarrasi, Luisa / Bianco, Gabriele / Bondi, Alessandro / Risso, Daniela / Cavallo, Rossana / Costa, Cristina

The new microbiologica

2024 Volume 46, Issue 4, Page(s) 412–415

Abstract: Chryseobacterium spp. belongs to the Flavobacteriaceae family and is a rod-shaped gram-negative, glucose non-fermenting, non-motile bacterium ubiquitous in the environment. In humans, Chryseobacterium may be responsible for infections such as urinary ... ...

Abstract	Chryseobacterium spp. belongs to the Flavobacteriaceae family and is a rod-shaped gram-negative, glucose non-fermenting, non-motile bacterium ubiquitous in the environment. In humans, Chryseobacterium may be responsible for infections such as urinary tract infections (UTI) and ventriculitis with a pathogenic burden increasing in recent years. Chryseobacterium gallinarum was isolated for the first time in 2014 in a pharyngeal scrape sample of chicken and, until now, only one case of human UTI has been described in a pregnant 20-year-old Indian patient. Herein, we report the first case of bloodstream infection caused by C. gallinarum in a 67-year-old female burn patient, correctly identified by 16S-rRNA sequencing and successfully treated with cefepime and fosfomycin.
MeSH term(s)	Female ; Pregnancy ; Animals ; Humans ; Aged ; Young Adult ; Adult ; Chryseobacterium/genetics ; Sepsis ; Cefepime ; Chickens
Chemical Substances	Cefepime (807PW4VQE3)
Language	English
Publishing date	2024-01-19
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	756168-4
ISSN	1121-7138 ; 0391-5352
ISSN	1121-7138 ; 0391-5352
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Article ; Online: Pharmacokinetics and pharmacogenetics of high-dosage tedizolid for disseminated nocardiosis in a lung transplant patient.

Corcione, Silvia / Vita, Davide / De Nicolò, Amedeo / Scabini, Silvia / Mornese Pinna, Simone / Cusato, Jessica / Mangiapia, Mauro / D'Avolio, Antonio / De Rosa, Francesco Giuseppe

The Journal of antimicrobial chemotherapy

2024 Volume 78, Issue 12, Page(s) 3003–3004

MeSH term(s)	Humans ; Pharmacogenetics ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Oxazolidinones ; Lung Transplantation/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacokinetics
Chemical Substances	tedizolid (97HLQ82NGL) ; Oxazolidinones ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad299
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article: Real-World Experience of Ceftobiprole for Community- and Hospital-Acquired Pneumonia from a Stewardship Perspective.

Corcione, Silvia / De Benedetto, Ilaria / Carlin, Massimiliano / Pivetta, Emanuele Emilio / Scabini, Silvia / Grosso, Cecilia / Shbaklo, Nour / Porta, Massimo / Lupia, Enrico / De Rosa, Francesco Giuseppe

Microorganisms

2024 Volume 12, Issue 4

Abstract: Ceftobiprole is a fifth-generation cephalosporin approved by European and American regulatory agencies for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP). Ceftobiprole administration is useful in severe CAP as ... ...

Abstract	Ceftobiprole is a fifth-generation cephalosporin approved by European and American regulatory agencies for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP). Ceftobiprole administration is useful in severe CAP as well as HAP where the potential is to save other β-lactams including carbapenems or linezolid/vancomycin in clinical practice. The aim of this study was to report the real-world evidence of ceftobiprole in patients with CAP and HAP in a single center. In this retrospective study, we included 159 patients with CAP or HAP: 105 (66%) had CAP and 54 (34%) had HAP. The median age was 70 years (IQR 60-77), the median Charlson Comorbidity Index was 5 (IQR 3-7.5) and baseline INCREMENT ESBL score was 8 (IQR 6-11). Ceftobiprole was mostly given as a combination treatment (77%) or as a carbapenem-sparing strategy (44%). There were no differences in mortality between shorter and longer duration of treatment (<7 days compared with ≥7 days (HR 1.02, C.I. 0.58-1.77,
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12040725
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