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  1. Article ; Online: Atrial septal pouches and ridges: Morphological features and potential implications in clinical practice.

    Scagliola, Riccardo / Caponi, Domenico / Scaglione, Marco

    Trends in cardiovascular medicine

    2023  

    Abstract: Incomplete or irregular fusion of the interatrial septum may result in several anatomic variants, including atrial septal pouches and ridges, whose knowledge and recognition are still poorly widespread in clinical practice. An educational review focused ... ...

    Abstract Incomplete or irregular fusion of the interatrial septum may result in several anatomic variants, including atrial septal pouches and ridges, whose knowledge and recognition are still poorly widespread in clinical practice. An educational review focused on the definition, clinical significance and diagnostic work-up of these anatomic findings was performed using PubMed, MEDLINE, Embase and Cochrane Central databases up to June 2023. Atrial septal pouches and ridges have been associated with an increased difficulty of catheter-based interventions requiring a transseptal approach, due to procedural challenges for transseptal puncture and the restricted motion of guidewires and catheters through the transseptal access. Additionally, left atrial septal pouch may serve as a thrombogenic nidus and a source of systemic embolism, mostly in the presence of factors leading to higher left atrial pressure and/or atrial blood stasis, which increase the risk of thrombus formation and embolic events, rather than for the only presence of left atrial septal pouch itself. Further investigations are needed in order to better elucidate the implications of such anatomic findings in daily clinical practice, and to provide the most appropriate decision-making strategies.
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2023.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3419: Show issues Location:
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  2. Article ; Online: Critical aspects of dystocic delivery and neonatal outcome.

    Scaglione, Marco / Benanti, Filippo / Iatrino, Nicolò

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 6, Page(s) e2022320

    MeSH term(s) Infant, Newborn ; Female ; Humans ; Pregnancy ; Dystocia ; Delivery, Obstetric
    Language English
    Publishing date 2022-12-16
    Publishing country Italy
    Document type Letter
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i6.13758
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  3. Article ; Online: The multiple roles of inositol in fertility and newborn outcomes.

    Scaglione, Marco / Leone, Maria Clara / Mugavero, Marilena

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 6, Page(s) e2022344

    MeSH term(s) Infant, Newborn ; Humans ; Female ; Inositol ; Fertility ; Polycystic Ovary Syndrome
    Chemical Substances Inositol (4L6452S749)
    Language English
    Publishing date 2022-12-16
    Publishing country Italy
    Document type Letter
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i6.13788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Electroanatomic visualization of reentrant circuit of left fascicular ventricular tachycardia guiding a fluoroless ablation.

    Scaglione, Marco / Cerrato, Natascia / Spinoni, Enrico Guido / Battaglia, Alberto / Geuna, Francesco / Caponi, Domenico

    HeartRhythm case reports

    2023  Volume 9, Issue 10, Page(s) 745–748

    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.07.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hyperthyroidism in a 15-year-old adolescent treated with Dupilumab for severe allergic asthma and atopic dermatitis.

    Tosca, Maria Angela / Olcese, Roberta / Girosi, Donata / Casalini, Emilio / Scaglione, Marco / Ciprandi, Giorgio

    Allergologia et immunopathologia

    2023  Volume 51, Issue 3, Page(s) 181–185

    Abstract: Dupilumab is a biologic, acting on IL-4 and IL-13 pathways. Dupilumab has a pediatric indication for treating severe asthma and atopic dermatitis. We report a pediatric case concerning paucisymptomatic, transient, and self-resolving hyperthyroidism. The ... ...

    Abstract Dupilumab is a biologic, acting on IL-4 and IL-13 pathways. Dupilumab has a pediatric indication for treating severe asthma and atopic dermatitis. We report a pediatric case concerning paucisymptomatic, transient, and self-resolving hyperthyroidism. The updated literature includes the case of an adult patient who reported with hyperthyroidism, which was transient and self-resolving. Despite that these cases were transient and self-resolving, we would suggest that thyroid function assessment could be included in the follow-up of patients treated with Dupilumab. Dupilumab discontinuation is not required pending endocrinological assessment, mainly if there is an optimal clinical response to the biologic.
    MeSH term(s) Adult ; Humans ; Adolescent ; Child ; Dermatitis, Atopic/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Asthma/drug therapy ; Hypersensitivity/drug therapy ; Hyperthyroidism/drug therapy ; Severity of Illness Index ; Biological Products/therapeutic use ; Treatment Outcome
    Chemical Substances dupilumab (420K487FSG) ; Antibodies, Monoclonal ; Biological Products
    Language English
    Publishing date 2023-05-01
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v51i3.786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1165: Show issues Location:
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  6. Article: An Atypical Case of Aphasia: Transitory Ischemic Attack in a 13-Year-Old Patient with Asymptomatic SARS-CoV-2 Infection.

    Scaglione, Marco / Napoli, Flavia / Prato, Giulia / Severino, Mariasavina / Bertamino, Marta / Signa, Sara / Maghnie, Mohamad

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 7

    Abstract: We report the case of a 13-year-old patient, female, born in Northern Italy, who presented with an acute episode of aphasia, lasting about 15 min, accompanied by left arm dysesthesia. The state of consciousness remained preserved throughout the episode. ... ...

    Abstract We report the case of a 13-year-old patient, female, born in Northern Italy, who presented with an acute episode of aphasia, lasting about 15 min, accompanied by left arm dysesthesia. The state of consciousness remained preserved throughout the episode. After a first clinical evaluation at second-level hospital, the patient was sent to our institute for further investigations. Brain MRI performed at admission showed no noteworthy structural alterations. Electroencephalogram was not significant, as was the echocardiographic examination. ECG was normal, except for a corrected-QT at the upper limits of the normal range for age and gender. The neurological examination was substantially normal for the entire duration of the hospital stay. The symptomatology initially described has never reappeared. Blood tests were substantially negative, in particular thrombophilic screening excluded hereditary-familial thrombophilic diseases. Color doppler ultrasound of the supra-aortic trunks, splanchnic vessels and lower limbs were also normal. Only positivity to SARS-CoV-2 serology is reported. In the recent clinical history there were no symptoms attributable to symptomatic coronavirus infection.
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9070983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multicentric Carpo-Tarsal Osteolysis Syndrome (MCTO) and "Function Profile": a rehabilitative approach.

    Ronchetti, Anna Bruna / Usai, Marina / Savino, Valentina / Scaglione, Marco / Tacchino, Chiara Maria / Bertamino, Marta / Moretti, Paolo / Di Rocco, Maja

    Orphanet journal of rare diseases

    2023  Volume 18, Issue 1, Page(s) 392

    Abstract: Background: Multicentric Carpo-Tarsal Osteolysis Syndrome (MCTO) is an autosomal dominant disease with increased bone reabsorption in the carpus and tarsus and the elbows, knees and spine. The disease is extremely heterogeneous and secondary and ... ...

    Abstract Background: Multicentric Carpo-Tarsal Osteolysis Syndrome (MCTO) is an autosomal dominant disease with increased bone reabsorption in the carpus and tarsus and the elbows, knees and spine. The disease is extremely heterogeneous and secondary and tertiary injuries vary widely and can lead to progressive disability and severe functional limitations. In addition to the available and upcoming drug therapies, physical medicine and rehabilitation are important treatment options. Currently, the indication and plan are overlooked, nonspecific and reported only for one patient.
    Methods: We describe a case series of MCTO patients diagnosed and followed by a centre to identify functional deficit as a potential clinical marker of disease progression for future etiological therapies. In addition, we define a symptomatic treatment approach and specific clinical management, including a patient-centred rehabilitation approach. Functional assessments are performed independently by a multidisciplinary group to establish the functional abilities of patients and the relationship between residual motor skills and their degree of autonomy and participation. We suggest a way to identify a rehabilitation plan based on a specific disease using the International Classification of Functioning, Disability and Health Children and Youth (ICF-CY).
    Results: To define a reliable and reproducible "Function Profile", through age and over time, we used to value the disease status according to the ICF-CY domains. It could be used to determine the complexity of the illness, its overall impact on the complexity of the person and the burden on the caregiver, and an eventual short- and long-term rehabilitation plan for MCTO and other ultra-rare diseases.
    Conclusion: Based on the MCTO experience, we suggest a way to determine a rehabilitation plan based on a specific disease and patient needs, keeping in mind that often the final point is not recovering the full function but improving or maintaining the starting point. In all cases, each patient at the time of diagnosis requires a functional assessment that must be repeated over time to adjust the course of rehabilitation. The evaluations revealed the importance of early rehabilitation management in enhancing independence, participation and control of stress deconditioning, shrinking of muscle tendons and loss of movement to immobility.
    MeSH term(s) Child ; Adolescent ; Humans ; Osteolysis/diagnosis ; Activities of Daily Living ; Disease Progression ; Hajdu-Cheney Syndrome
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-023-02976-z
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  8. Article ; Online: Inflammatory bowel disease and infertility: analysis of literature and future perspectives.

    Carini, Francesco / Margherita Mazzola / Gagliardo, Carola / Scaglione, Marco / Giammanco, Marco / Tomasello, Giovanni

    Acta bio-medica : Atenei Parmensis

    2021  Volume 92, Issue 5, Page(s) e2021264

    Abstract: Background: inflammatory bowel diseases (IBD) are chronic disorders that affect the gastrointestinal tract but which also present extraintestinal manifestations. One of the problems related to IBD is the presence of both female and male infertility.: ... ...

    Abstract Background: inflammatory bowel diseases (IBD) are chronic disorders that affect the gastrointestinal tract but which also present extraintestinal manifestations. One of the problems related to IBD is the presence of both female and male infertility.
    Aim: determine the correlation between IBD and male and female infertility by analyzing the literature.
    Material and methods: Studies carried out in the last twenty years have been selected through the pubmed search engine. Only studies were selected that in their conclusions showed a real correlation between IBD and infertility.
    Results: the first cause of infertility in both sexes is related to the surgical interventions that patients have to face during the course of the disease, but there are also psychological causes or causes related to the use of drugs used for therapy.
    Conclusions: further studies are needed to understand what are the real mechanisms underlying infertility in subjects suffering from IBD.
    MeSH term(s) Anxiety ; Colitis ; Female ; Humans ; Infertility, Female/etiology ; Infertility, Male/epidemiology ; Infertility, Male/etiology ; Inflammatory Bowel Diseases/complications ; Male
    Language English
    Publishing date 2021-11-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92i5.11100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cell-Free Fetal DNA and Non-Invasive Prenatal Diagnosis of Chromosomopathies and Pediatric Monogenic Diseases: A Critical Appraisal and Medicolegal Remarks.

    Gullo, Giuseppe / Scaglione, Marco / Buzzaccarini, Giovanni / Laganà, Antonio Simone / Basile, Giuseppe / Chiantera, Vito / Cucinella, Gaspare / Zaami, Simona

    Journal of personalized medicine

    2022  Volume 13, Issue 1

    Abstract: Cell-free fetal DNA (cffDNA) analysis is a non-invasive prenatal diagnostic test with a fundamental role for the screening of chromosomic or monogenic pathologies of the fetus. Its administration is performed by fetal DNA detection in the mother's blood ... ...

    Abstract Cell-free fetal DNA (cffDNA) analysis is a non-invasive prenatal diagnostic test with a fundamental role for the screening of chromosomic or monogenic pathologies of the fetus. Its administration is performed by fetal DNA detection in the mother's blood from the fourth week of gestation. Given the great interest regarding its validation as a diagnostic tool, the authors have set out to undertake a critical appraisal based on a wide-ranging narrative review of 45 total studies centered around such techniques. Both chromosomopathies and monogenic diseases were taken into account and systematically discussed and elucidated. Not surprisingly, cell-free fetal DNA analysis for screening purposes is already rather well-established. At the same time, considerable interest in its diagnostic value has emerged from this literature review, which recommends the elaboration of appropriate validation studies, as well as a broad discourse, involving all stakeholders, to address the legal and ethical complexities that such techniques entail.
    Language English
    Publishing date 2022-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010001
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  10. Article ; Online: Impact of assisted reproduction techniques on the neuro-psycho-motor outcome of newborns: a critical appraisal.

    Gullo, Giuseppe / Scaglione, Marco / Cucinella, Gaspare / Perino, Antonino / Chiantera, Vito / D'Anna, Rosario / Laganà, Antonio Simone / Buzzaccarini, Giovanni

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

    2022  , Page(s) 1–5

    Abstract: Subfertility and infertility are common problems among couples of reproductive age, and they increasingly require the use of assisted reproductive techniques (ART). Understandably, doubts about the safety of such methods are increasing among future ... ...

    Abstract Subfertility and infertility are common problems among couples of reproductive age, and they increasingly require the use of assisted reproductive techniques (ART). Understandably, doubts about the safety of such methods are increasing among future parents. The purpose of this review is to analyse the real impact of ART, such as
    Language English
    Publishing date 2022-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 604639-3
    ISSN 1364-6893 ; 0144-3615
    ISSN (online) 1364-6893
    ISSN 0144-3615
    DOI 10.1080/01443615.2022.2109953
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