Article ; Online: Daratumumab Use Prior to Kidney Transplant and T Cell-Mediated Rejection: A Case Report.
American journal of kidney diseases : the official journal of the National Kidney Foundation
2023 Volume 81, Issue 5, Page(s) 616–620
Abstract: There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest ...
| Abstract | There is growing interest in daratumumab in the solid organ transplant realm owing to the potential immunomodulatory effects on CD38-expressing cells, primarily plasma cells, as they have a key role in antibody production. In particular there is interest in use of daratumumab for desensitization and potential treatment for antibody-mediated rejection. However, ongoing investigation with daratumumab has shown potential immunologic concerns in vitro, with a significant increase in populations of CD4-positive cytotoxic T cells and CD8-positive helper T cells in both peripheral blood and bone marrow that could lead to acute T cell-mediated rejection in the solid organ transplant patient. To date, there are no published reports of an association with daratumumab use and T cell-mediated rejection in vivo. In this case report we present what is to our knowledge the first documented case of an early severe T cell-mediated rejection in a low-immunologic-risk living-donor kidney transplant recipient who received daratumumab for multiple myeloma maintenance prior to transplant. |
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| MeSH term(s) | Humans ; Kidney Transplantation ; ADP-ribosyl Cyclase 1 ; Antibodies, Monoclonal/therapeutic use ; Multiple Myeloma/therapy ; T-Lymphocytes | ||||||||||
| Chemical Substances | daratumumab (4Z63YK6E0E) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Antibodies, Monoclonal | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2023-01-06 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Case Reports ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 604539-x | ||||||||||
| ISSN | 1523-6838 ; 0272-6386 | ||||||||||
| ISSN (online) | 1523-6838 | ||||||||||
| ISSN | 0272-6386 | ||||||||||
| DOI | 10.1053/j.ajkd.2022.11.010 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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