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Book ; Online: Therapeutic Landscapes in Colorectal Carcinoma

Scanu, Antonio M / De Miglio, Maria Rosaria

2023

Keywords	Medicine ; Oncology ; colorectal cancer ; inflammatory pathways ; NFKB ; RIPK2 ; MSI ; dMMR ; colorectal ; cancer ; immunotherapy ; Romania ; incidence ; PCR ; IHC ; drug development ; targeted therapies ; preclinical candidates ; databases ; cancer therapeutics ; TGF-b ; regorafenib ; colorectal carcinoma ; intratumor heterogeneity ; single-cell next-generation sequencing ; precision medicine ; metastatic colorectal cancer ; BRAF mutation ; triple target therapy ; colorectal cancer screening ; COVID-19 ; SARS-CoV-2 ; colon cancer ; cell line models ; dependencies ; targeted therapy ; signal transduction ; neoadjuvant chemotherapy (NAC) ; locally advanced colon cancer (LACC) ; preoperative treatment ; propensity score matching ; survival ; liver transplantation ; de novo malignancy ; immunosuppression ; uracil-tegafur ; chemotherapy ; adjuvant therapy ; stage IIA ; n/a
Language	English
Size	1 electronic resource (142 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030646168
ISBN	9783036594408 ; 303659440X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Therapeutic Landscapes in Colorectal Carcinoma.

Scanu, Antonio Mario / De Miglio, Maria Rosaria

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: Colorectal cancer (CRC) is a disease of major public health and socioeconomic concern [ ... ]. ...

Abstract	Colorectal cancer (CRC) is a disease of major public health and socioeconomic concern [...].
MeSH term(s)	Humans ; Colorectal Neoplasms/therapy ; Colorectal Neoplasms/pathology ; Public Health
Language	English
Publishing date	2023-04-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050821
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current management of incidental gallbladder cancer: A review.

Feo, Claudio F / Ginesu, Giorgio C / Fancellu, Alessandro / Perra, Teresa / Ninniri, Chiara / Deiana, Giulia / Scanu, Antonio M / Porcu, Alberto

International journal of surgery (London, England)

2022 Volume 98, Page(s) 106234

Abstract: Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The ... ...

Abstract	Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The majority of patients with GBC remain asymptomatic for a long time and diagnosis is usually late when the disease is at an advanced stage. Radical surgery consisting in resection of the gallbladder liver bed and regional lymph nodes seems to be the best treatment option for incidental GBC. However, recurrence rates after salvage surgery are still high and the addition of neoadjuvant/adjuvant chemotherapy may improve outcomes. The aim of the present review is to evaluate current literature for advances in management of incidental GBC, with particular focus on staging techniques and surgical options.
MeSH term(s)	Cholecystectomy ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/epidemiology ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Lymph Node Excision ; Neoplasm Staging
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2022.106234
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harnessing Minimal Residual Disease as a Predictor for Colorectal Cancer: Promising Horizons Amidst Challenges.

Wen, Xiaofen / Coradduzza, Donatella / Shen, Jiaxin / Scanu, Antonio Mario / Muroni, Maria Rosaria / Massidda, Matteo / Rallo, Vincenzo / Carru, Ciriaco / Angius, Andrea / De Miglio, Maria Rosaria

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 10

Abstract: Minimal Residual Disease (MRD) detection has emerged as an independent factor in clinical and pathological cancer assessment offering a highly effective method for predicting recurrence in colorectal cancer (CRC). The ongoing research initiatives such as ...

Abstract	Minimal Residual Disease (MRD) detection has emerged as an independent factor in clinical and pathological cancer assessment offering a highly effective method for predicting recurrence in colorectal cancer (CRC). The ongoing research initiatives such as the DYNAMIC and CIRCULATE-Japan studies, have revealed the potential of MRD detection based on circulating tumor DNA (ctDNA) to revolutionize management for CRC patients. MRD detection represents an opportunity for risk stratification, treatment guidance, and early relapse monitoring. Here we overviewed the evolving landscape of MRD technology and its promising applications through the most up-to-date research and reviews, underscoring the transformative potential of this approach. Our primary focus is to provide a point-to-point perspective and address key challenges relating to the adoption of ctDNA-based MRD detection in the clinical setting. By identifying critical areas of interest and hurdles surrounding clinical significance, detection criteria, and potential applications of basic research, this article offers insights into the advancements needed to evaluate the role of ctDNA in CRC MRD detection, contributing to favorable clinical options and improved outcomes in the management of CRC.
MeSH term(s)	Humans ; Neoplasm, Residual/diagnosis ; Clinical Relevance ; Japan ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Biomarkers, Tumor/genetics
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-10-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59101886
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Portrait of Intratumoral Genomic and Transcriptomic Heterogeneity at Single-Cell Level in Colorectal Cancer.

Angius, Andrea / Scanu, Antonio Mario / Arru, Caterina / Muroni, Maria Rosaria / Carru, Ciriaco / Porcu, Alberto / Cossu-Rocca, Paolo / De Miglio, Maria Rosaria

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 11

Abstract: In the study of cancer, omics technologies are supporting the transition from traditional clinical approaches to precision medicine. Intra-tumoral heterogeneity (ITH) is detectable within a single tumor in which cancer cell subpopulations with different ... ...

Abstract	In the study of cancer, omics technologies are supporting the transition from traditional clinical approaches to precision medicine. Intra-tumoral heterogeneity (ITH) is detectable within a single tumor in which cancer cell subpopulations with different genome features coexist in a patient in different tumor areas or may evolve/differ over time. Colorectal carcinoma (CRC) is characterized by heterogeneous features involving genomic, epigenomic, and transcriptomic alterations. The study of ITH is a promising new frontier to lay the foundation towards successful CRC diagnosis and treatment. Genome and transcriptome sequencing together with editing technologies are revolutionizing biomedical research, representing the most promising tools for overcoming unmet clinical and research challenges. Rapid advances in both bulk and single-cell next-generation sequencing (NGS) are identifying primary and metastatic intratumoral genomic and transcriptional heterogeneity. They provide critical insight in the origin and spatiotemporal evolution of genomic clones responsible for early and late therapeutic resistance and relapse. Single-cell technologies can be used to define subpopulations within a known cell type by searching for differential gene expression within the cell population of interest and/or effectively isolating signal from rare cell populations that would not be detectable by other methods. Each single-cell sequencing analysis is driven by clustering of cells based on their differentially expressed genes. Genes that drive clustering can be used as unique markers for a specific cell population. In this review we analyzed, starting from published data, the possible achievement of a transition from clinical CRC research to precision medicine with an emphasis on new single-cell based techniques; at the same time, we focused on all approaches and issues related to this promising technology. This transition might enable noninvasive screening for early diagnosis, individualized prediction of therapeutic response, and discovery of additional novel drug targets.
MeSH term(s)	Colorectal Neoplasms/genetics ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Precision Medicine ; Transcriptome/genetics
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57111257
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lipoprotein(a): Looking ahead.

Scanu, Angelo M

Nutrition, metabolism, and cardiovascular diseases : NMCD

2005 Volume 15, Issue 5, Page(s) 331–333

MeSH term(s)	Apolipoprotein B-100 ; Apolipoproteins A/blood ; Apolipoproteins A/chemistry ; Apolipoproteins B/chemistry ; Cardiovascular Diseases ; Humans ; Lipoprotein(a)/blood ; Lipoprotein(a)/chemistry ; Lipoprotein(a)/genetics ; Lipoproteins, LDL/blood ; Lipoproteins, LDL/chemistry
Chemical Substances	Apolipoprotein B-100 ; Apolipoproteins A ; Apolipoproteins B ; Lipoprotein(a) ; Lipoproteins, LDL
Language	English
Publishing date	2005-10
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2005.07.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metaproteomic Profile of the Colonic Luminal Microbiota From Patients With Colon Cancer.

Tanca, Alessandro / Abbondio, Marcello / Fiorito, Giovanni / Pira, Giovanna / Sau, Rosangela / Manca, Alessandra / Muroni, Maria Rosaria / Porcu, Alberto / Scanu, Antonio Mario / Cossu-Rocca, Paolo / De Miglio, Maria Rosaria / Uzzau, Sergio

Frontiers in microbiology

2022 Volume 13, Page(s) 869523

Abstract: Recent studies have provided evidence of interactions among the gut microbiota (GM), local host immune cells, and intestinal tissues in colon carcinogenesis. However, little is known regarding the functions exerted by the GM in colon cancer (CC), ... ...

Abstract	Recent studies have provided evidence of interactions among the gut microbiota (GM), local host immune cells, and intestinal tissues in colon carcinogenesis. However, little is known regarding the functions exerted by the GM in colon cancer (CC), particularly with respect to tumor clinical classification and lymphocyte infiltration. In addition, stool, usually employed as a proxy of the GM, cannot fully represent the original complexity of CC microenvironment. Here, we present a pilot study aimed at characterizing the metaproteome of CC-associated colonic luminal contents and identifying its possible associations with CC clinicopathological features. Colonic luminal contents were collected from 24 CC tissue specimens immediately after surgery. Samples were analyzed by shotgun metaproteomics. Almost 30,000 microbial peptides were quantified in the samples, enabling the achievement of the taxonomic and functional profile of the tumor-associated colonic luminal metaproteome. Upon sample aggregation based on tumor stage, grade, or tumor-infiltrating lymphocytes (TILs), peptide sets enabling discrimination of sample groups were identified through discriminant analysis (DA). As a result,
Language	English
Publishing date	2022-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.869523
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inflammatory Indexes as Predictive Biomarkers of Postoperative Complications in Oncological Thoracic Surgery.

Ginesu, Giorgio Carlo / Paliogiannis, Panagiotis / Feo, Claudio F / Cossu, Maria Laura / Scanu, Antonio Mario / Fancellu, Alessandro / Fois, Alessandro Giuseppe / Zinellu, Angelo / Perra, Teresa / Veneroni, Simone / Porcu, Alberto

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 5, Page(s) 3425–3432

Abstract: The role of inflammatory responses in predicting outcomes in oncological thoracic surgery is still unclear. The aim of this study was to evaluate a series of blood count inflammation indexes as predicting factors for postoperative complications. We ... ...

Abstract	The role of inflammatory responses in predicting outcomes in oncological thoracic surgery is still unclear. The aim of this study was to evaluate a series of blood count inflammation indexes as predicting factors for postoperative complications. We retrospectively studied 249 patients undergoing elective thoracic surgery in our institution between 2008 and 2020. A total of 184 patients underwent open surgery, and 65 underwent VATS. The neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) ratios, Systemic Inflammation Response Index (SIRI) were calculated preoperatively and on the first and fourth postoperative days, as well as a new derivative index, the Aggregate Inflammation Systemic Index (AISI). Univariate correlations evidenced a statistically significant association between the NLR at the fourth postoperative day and the occurrence of surgical complications in the global cohort (rho = 0.15,
MeSH term(s)	Biomarkers ; Humans ; Inflammation ; Postoperative Complications/etiology ; Prospective Studies ; Retrospective Studies ; Thoracic Surgery
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-05-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29050276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Perianal mucinous adenocarcinoma with dysplastic polyps of the colon: A case report.

Feo, Claudio F / Veneroni, Simone / Santoru, Antonio / Cossu, Maria Laura / Scanu, Antonio M / Ginesu, Giorgio C / Porcu, Alberto

International journal of surgery case reports

2020 Volume 78, Page(s) 99–102

Abstract: Introduction: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines.: ... ...

Abstract	Introduction: Perianal mucinous adenocarcinoma is rarely encountered in the setting of anal neoplasms. The rarity of the disease and the paucity of publications on this topic are responsible for a lack of diagnostic and therapeutic guidelines. Presentation of case: An 80-year-old man with mucinous adenocarcinoma of the anal canal associated with dysplastic polyps of the colon was treated by multiple endoscopic polypectomies and abdomino-perineal resection of the rectum. We discuss the management of this rare case from the diagnosis up to one-year follow-up. Discussion: Perianal mucinous adenocarcinoma is a very rare entity frequently combined with chronic fistulas. Inflammatory symptoms may mislead its diagnosis, which is often delayed. The unique association between perianal mucinous adenocarcinoma and dysplastic polyps of the colon, that we have reported, may suggest a secondary etiology. High clinical suspicion is important for early and correct diagnosis, which should be based on endoanal ultrasound and/or magnetic resonance imaging followed by deep tissue biopsies. Conclusion: We stress the importance of accumulating such cases in the literature. The understanding of the etiopathogenic mechanisms may lead to the development of novel diagnostic and therapeutic protocols.
Language	English
Publishing date	2020-12-05
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2020.12.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lipoprotein(a) and the atherothrombotic process: mechanistic insights and clinical implications.

Scanu, Angelo M

Current atherosclerosis reports

2003 Volume 5, Issue 2, Page(s) 106–113

Abstract: Although many epidemiologic studies have pointed at an association between plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular risk, the data obtained have been conflicting because of a number of factors, particularly those dealing with plasma ... ...

Abstract	Although many epidemiologic studies have pointed at an association between plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular risk, the data obtained have been conflicting because of a number of factors, particularly those dealing with plasma storage, lack of assay standardization, population sample size, age, gender, ethnic variations, and variable disease endpoints. Moreover, the attention has been primarily focused on whole Lp(a), with relatively less emphasis on its constituent apolipoprotein(a) and on the apolipoprotein B100-containing lipoprotein, mainly low-density lipoprotein (LDL), to which apolipoprotein(a) is linked. According to recent studies, small-size apolipoprotein(a) isoforms may represent a cardiovascular risk factor either by themselves or synergistically with plasma Lp(a) concentration. Moreover, the density properties of the LDL moiety may have an impact on Lp(a) pathogenicity. It has also become apparent that Lp(a) can be modified by oxidative events and by the action of lipolytic and proteolytic enzymes with the generation of products that exhibit atherothrombogenic potential. The role of the O-glycans linked to the inter-kringle linkers of apolipoprotein(a) is also emerging. This information is raising the awareness of the pleiotropic functions of Lp(a) and is opening new vistas on pathogenetic mechanisms whose knowledge is essential for developing rational therapies against this complex cardiovascular pathogen.
MeSH term(s)	Biomarkers/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/genetics ; Coronary Vessels/metabolism ; Humans ; Lipoprotein(a)/blood ; Lipoprotein(a)/genetics ; Lipoprotein(a)/metabolism ; Models, Animal ; Oxidation-Reduction ; Polymorphism, Genetic ; Tunica Intima/metabolism
Chemical Substances	Biomarkers ; Lipoprotein(a)
Language	English
Publishing date	2003-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	2057369-8
ISSN	1523-3804
ISSN	1523-3804
DOI	10.1007/s11883-003-0081-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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