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Book ; Online: Cerebral Circulation

Scerrati, Alba / Ricciardi, Luca / Dones, Flavia

Updates on Models, Diagnostics and Treatments of Related Diseases

2022

Keywords	Neurology & clinical neurophysiology
Language	0\|e
Size	1 electronic resource (120 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021612962
ISBN	9781803553627 ; 1803553626
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Neurosurgical Procedures : Innovative Approaches

Scerrati, Alba / De Bonis, Pasquale

2020

Keywords	Vascular surgery ; Neurosurgery
Size	1 electronic resource (146 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021049687
ISBN	9781789851113 ; 1789851114
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Neurosurgical systematic reviews and meta-analyses for a daily practice.

Scerrati, Alba / Ricciardi, Luca

Journal of neurosurgical sciences

2022 Volume 66, Issue 5, Page(s) 389–390

MeSH term(s)	Evidence-Based Medicine ; Humans
Language	English
Publishing date	2022-10-17
Publishing country	Italy
Document type	Editorial
ZDB-ID	193139-8
ISSN	1827-1855 ; 0390-5616 ; 0026-4881
ISSN (online)	1827-1855
ISSN	0390-5616 ; 0026-4881
DOI	10.23736/S0390-5616.21.05647-2
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Article ; Online: Patient-specific cranioplasty, by direct and indirect additive manufacturing of biopolymers and implantable materials.

Flora, Barbara / Scerrati, Alba / Trovalusci, Federica / Vesco, Silvia

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 Volume 19, Issue 6, Page(s) e2568

Abstract: Background: Autologous bones are traditionally used in surgical reconstruction of skullcap. Since patients' bones are often unavailable or cause of infections, implantable synthetic materials emerged as promising alternative. These can be shaped by ... ...

Abstract	Background: Autologous bones are traditionally used in surgical reconstruction of skullcap. Since patients' bones are often unavailable or cause of infections, implantable synthetic materials emerged as promising alternative. These can be shaped by different technologies, while 3D printing offers remarkable chances in terms of flexibility, accuracy, cost-saving and customizability. Methods: This study aims to evaluate strengths and limitations of the three main strategies that imply additive manufacturing for the implementation of cranial prosthesis: (i) direct printing of PLA (polylactic acid) skullcaps, mould casting of poly(methyl methacrylate) (PMMA) prosthesis using (ii) silicone mould manufactured from a 3D printed master, (iii) 3Dprinted TPU (thermoplastic polyurethane) mould. Results: All solutions achieved good geometric accuracy and excellent mechanical resistance. Direct printing of the PLA resulted in the fastest strategy, followed by PMMA casting in a silicone mould. Conclusions: The use of silicone was overall more advantageous, due to lower costs and the possibility of sterilization by using autoclaving.
MeSH term(s)	Humans ; Polymethyl Methacrylate ; Skull/surgery ; Prostheses and Implants ; Polyesters ; Silicones ; Biopolymers
Chemical Substances	Polymethyl Methacrylate (9011-14-7) ; Polyesters ; Silicones ; Biopolymers
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2568
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Article ; Online: Perioperative interruption of antiplatelet medications for elective extradural non-instrumented spine surgery: is it really necessary?

Scerrati, Alba / DE Bonis, Pasquale

Journal of neurosurgical sciences

2021 Volume 65, Issue 5, Page(s) 542–543

MeSH term(s)	Elective Surgical Procedures ; Humans ; Platelet Aggregation Inhibitors ; Spine
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2021-03-11
Publishing country	Italy
Document type	Journal Article
ZDB-ID	193139-8
ISSN	1827-1855 ; 0390-5616 ; 0026-4881
ISSN (online)	1827-1855
ISSN	0390-5616 ; 0026-4881
DOI	10.23736/S0390-5616.21.05272-3
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Article: The effect of antiplatelet and anticoagulant therapies on clinical outcome of patients undergoing decompressive craniectomy: a systematic review.

Angelini, Chiara / Zangrossi, Pietro / Mantovani, Giorgio / Cavallo, Michele Alessandro / De Bonis, Pasquale / Scerrati, Alba

Frontiers in neurology

2024 Volume 15, Page(s) 1336760

Abstract: Objective: This systematic review aims to investigate a potential correlation between the administration of antiplatelets (APs) or anticoagulants (ACs) and perioperative complications, with a particular focus on hemorrhagic events, in patients ... ...

Abstract	Objective: This systematic review aims to investigate a potential correlation between the administration of antiplatelets (APs) or anticoagulants (ACs) and perioperative complications, with a particular focus on hemorrhagic events, in patients undergoing decompressive craniectomy (DC). Additionally, the secondary objective is to assess the neurological outcomes in patients undergoing DC while taking APs/ACs, comparing them to patients not on APs/ACs. Methods: The study utilized PubMed and Science Direct as primary online medical databases for the systematic review. Articles underwent screening based on title, abstract, and full-text review. Four studies meeting the inclusion criteria were selected for comprehensive analysis. Results: Our findings suggest that the administration of APs/ACs in patients undergoing DC does not significantly impact functional outcomes. Notably, the occurrence of rebleeding within 6 months and other complications, including infections, appears to be less frequent in patients taking APs compared to those not taking APs/ACs. Conclusion: Literature-derived data on the association between APs/ACs and DC presented considerable heterogeneity and insufficient volume for robust statistical analysis. Consequently, a definitive conclusion regarding the influence of suspending or continuing these therapies on complications and clinical outcomes cannot be confidently reached at present. To address this, a large-scale prospective study is warranted to gather substantial and precise data, facilitating a nuanced understanding of how to balance the risks and benefits associated with antiplatelet and anticoagulant agents in the context of decompressive craniectomy.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1336760
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Exoscope in Neurosurgery: An Overview of the Current Literature of Intraoperative Use in Brain and Spine Surgery.

Montemurro, Nicola / Scerrati, Alba / Ricciardi, Luca / Trevisi, Gianluca

Journal of clinical medicine

2021 Volume 11, Issue 1

Abstract: Background: Exoscopes are a safe and effective alternative or adjunct to the existing binocular surgical microscope for brain tumor, skull base surgery, aneurysm clipping and both cervical and lumbar complex spine surgery that probably will open a new ... ...

Abstract	Background: Exoscopes are a safe and effective alternative or adjunct to the existing binocular surgical microscope for brain tumor, skull base surgery, aneurysm clipping and both cervical and lumbar complex spine surgery that probably will open a new era in the field of new tools and techniques in neurosurgery. Methods: A Pubmed and Ovid EMBASE search was performed to identify papers that include surgical experiences with the exoscope in neurosurgery. PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-analyses) were followed. Results: A total of 86 articles and 1711 cases were included and analyzed in this review. Among 86 papers included in this review 74 (86%) were published in the last 5 years. Out of 1711 surgical procedures, 1534 (89.6%) were performed in the operative room, whereas 177 (10.9%) were performed in the laboratory on cadavers. In more detail, 1251 (72.7%) were reported as brain surgeries, whereas 274 (16%) and 9 (0.5%) were reported as spine and peripheral nerve surgeries, respectively. Considering only the clinical series (40 studies and 1328 patients), the overall surgical complication rate was 2.6% during the use of the exoscope. These patients experienced complication profiles similar to those that underwent the same treatments with the OM. The overall switch incidence rate from exoscope to OM during surgery was 5.8%. Conclusions: The exoscope seems to be a safe alternative compared to an operative microscope for the most common brain and spinal procedures, with several advantages that have been reached, such as an easier simplicity of use and a better 3D vision and magnification of the surgical field. Moreover, it offers the opportunity of better interaction with other members of the surgical staff. All these points set the first step for subsequent and short-term changes in the field of neurosurgery and offer new educational possibilities for young neurosurgery and medical students.
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11010223
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The neurosurgical outpatient clinic: comparison between accesses in public and private activities.

Menegatti, Marta / Del Villano, Nunzia / Scerrati, Alba / Travaglini, Francesco / Ricciardi, Luca / Lofrese, Giorgio / Cavallo, Michele Alessandro / De Bonis, Pasquale

BMC health services research

2024 Volume 24, Issue 1, Page(s) 137

Abstract: Background: Neurosurgical clinic assesses presence and extent of pathologies of central and peripheral nervous system or disorders affecting the spine, to identify most effective treatment and possible recourse to surgery. The aim of the study is to ... ...

Abstract	Background: Neurosurgical clinic assesses presence and extent of pathologies of central and peripheral nervous system or disorders affecting the spine, to identify most effective treatment and possible recourse to surgery. The aim of the study is to evaluate the appropriateness of request for a neurosurgical consult both in private and in public outpatient clinics. Materials and methods: We collected and analyzed all the reports of outpatient visits of public and private clinic over a period between January and December 2018. Results: There were 0.62% real urgent visits in the public sector and 1.19% in the private sector (p = 0.05). Peripheral pathologies represented 12.53% and 6.21% of pathologies evaluated in public and private sector respectively (p < 0.00001). In addition, 15.76% of visits in public lead to surgery, while they represented 11.45% in private (p = 0.0003). Conclusions: No study is available comparing accesses of patients in neurosurgical outpatient clinics. In public clinic, visits are booked as urgent on the prescription of the general practitioner: in reality, only 5% of these visits were really confirmed as urgent by the specialist. Peripheral pathologies are more frequent in public clinic, while cranial pathologies are more frequent in private one. Patients with cranial pathologies prefer to choose their surgeon by accessing private clinic.
MeSH term(s)	Humans ; Ambulatory Care Facilities ; Books ; General Practitioners ; Prescriptions ; Private Sector
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10571-6
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Article ; Online: Effects of a sphenopalatine ganglion block on postcraniotomy pain management: a randomized, double-blind, clinical trial.

Mantovani, Giorgio / Sgarbanti, Lorenzo / Indaimo, Antonino / Cavallo, Michele Alessandro / De Bonis, Pasquale / Flacco, Maria Elena / Scerrati, Alba

Neurosurgical focus

2024 Volume 55, Issue 6, Page(s) E13

Abstract: Objective: Postcraniotomy pain (PCP) is a common finding after neurosurgical procedures, occurring in as many 87% of patients. The sphenopalatine ganglion (SPG) has a pivotal role in several headache syndromes, and its anesthetic block is currently used ...

Abstract	Objective: Postcraniotomy pain (PCP) is a common finding after neurosurgical procedures, occurring in as many 87% of patients. The sphenopalatine ganglion (SPG) has a pivotal role in several headache syndromes, and its anesthetic block is currently used in different clinical conditions with benefit. The aim of this study was to evaluate the efficacy of an SPG block (SPGB) via a transnasal approach as adjunctive therapy in reducing pain scores during the postcraniotomy period. Methods: In this single-center, double-blind, randomized controlled trial, patients undergoing elective surgery with a supratentorial craniotomy were randomly assigned to a scalp block, local anesthetic infiltration of the wound, and systemic analgesia during the first 48 postoperative hours (standard therapy), or to standard therapy as well as an SPGB (experimental therapy). According to the available evidence, assuming a 50% reduction in the incidence of the main outcome in patients with an SPGB (vs standard treatment), 82 patients were needed to achieve 80% statistical power in an intent-to-treat analysis. Pain intensity was recorded during the first 180 postoperative days at selective time points (5 times in the hospital, 3 times by telephone interview) with different pain rating systems (a visual analog scale [VAS], numeric rating scale [NRS], and pain assessment in advanced dementia [PAINAD] scale), together with demographic, clinical, and surgical variables and complications. Heart rate and blood pressure were recorded during surgery. Differences in all variables were evaluated using a paired t-test and confirmed through Wilcoxon matched-pairs signed-rank and Kruskal-Wallis tests. Results: No complications occurred among the 83 patients enrolled. Statistically significant differences were found in the mean VAS score at postoperative days 0 (p = 0.05), 2 (p = 0.03), and 3 (p = 0.03). The PAINAD scale score showed significant differences between groups at postoperative days 1 (p = 0.006), 2 (p = 0.001), 3 (p = 0.03), and 4 (p = 0.05). The proportion of patients reporting a VAS score ≥ 3 in the first day after surgery was lower in the SPGB group than in the standard treatment group (71.9% vs 89.5%), although this difference did not reach statistical significance. At postoperative day 180, 5 patients (2 in the control group, 3 in the treatment group) had developed chronic PCP (NRS score ≥ 3). Conclusions: SPGB is a safe and effective procedure as an adjunctive treatment for PCP management in elective supratentorial craniotomy during the first 4 postoperative days compared with standard therapy. Further studies are needed to better define the clinical impact of SPGB use and its indications. Clinical trial registration no.: NCT05136625 (ClinicalTrials.gov).
MeSH term(s)	Humans ; Sphenopalatine Ganglion Block ; Pain ; Pain Management ; Anesthesia, Local ; Blood Pressure
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.9.FOCUS23549
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Article ; Online: Recurrent or junctional lumbar foraminal herniated disc in patients operated with trans pars microscopic approach.

Monticelli, Matteo / Gelmi, Clarissa Ann Elisabeth / Scerrati, Alba / Cavallo, Michele Alessandro / De Bonis, Pasquale

Neurosurgical review

2023 Volume 46, Issue 1, Page(s) 211

Abstract: This is a retrospective monocentric study. The aim of this study is to analyze the incidence of recurrent or junctional lumbar foraminal herniated disc, in patients treated with trans pars microsurgical approach. Foraminal lumbar disc herniation ... ...

Abstract	This is a retrospective monocentric study. The aim of this study is to analyze the incidence of recurrent or junctional lumbar foraminal herniated disc, in patients treated with trans pars microsurgical approach. Foraminal lumbar disc herniation represents a challenging pathology for the spinal surgeon. The appropriate surgical approach still represents a matter of debate. Several open and minimally-invasive techniques have been developed, in order to allow a proper tissue exposure and preserving the vertebral stability. The trans pars approach has already been described as a possible alternative, allowing excellent exposure of the herniated fragment with minimum bone removal. While few studies have analyzed the very low rate of post-operative instability, no articles deal with the incidence of post-operative herniated disc recurrence or junctional disc herniation in patients treated with this technique. We enrolled 160 patients operated at our institution. A univariate and multivariate analysis of possible factors influencing outcome (age, sex, level and BMI) was performed. Outcome variables were recurrent or junctional herniated disc. At the end, 135 patients were analyzed. Of the 135 patients, six presented recurrent herniated disc (4.4%) and other three developed a junctional herniation (2.2%). The occurrence of junctional herniated disc or recurrent herniated disc was not influenced by the analyzed variables, both at univariate and at multivariate analyses. The trans pars approach presents a low rate of recurrence and junctional herniation. Age, sex, level, and BMI do not influence the recurrence rate, both at same level and at junctional level.
MeSH term(s)	Humans ; Intervertebral Disc Displacement/surgery ; Retrospective Studies ; Multivariate Analysis ; Postoperative Period ; Spine
Language	English
Publishing date	2023-08-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-023-02109-x
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