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Article ; Online: Engineered human osteoarthritic cartilage organoids.

Dönges, Laura / Damle, Atharva / Mainardi, Andrea / Bock, Thomas / Schönenberger, Monica / Martin, Ivan / Barbero, Andrea

Biomaterials

2024 Volume 308, Page(s) 122549

Abstract: The availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specific inflammatory ...

Abstract	The availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main OA pathological traits such as chondrocyte hypertrophy, cartilage matrix mineralization, enhanced catabolism and mechanical stiffening. To exemplify the utility of the model, we exposed the engineered OA cartilage organoids to factors known to attenuate pathological features, including IL-1Ra, and carried out mass spectrometry-based proteomics. We identified that IL-1Ra strongly reduced production of the transcription factor CCAAT/enhancer-binding protein beta [2] and demonstrated that inhibition of the C/EBPβ-activating kinases could revert the degradative processes. Human OA cartilage organoids thus represent a relevant tool towards the discovery of new molecular drivers of cartilage degeneration and the assessment of therapeutics targeting associated pathways.
MeSH term(s)	Humans ; Organoids/metabolism ; Organoids/pathology ; Osteoarthritis/pathology ; Osteoarthritis/metabolism ; Tissue Engineering/methods ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/cytology ; Chondrogenesis ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Cartilage, Articular/pathology ; Cartilage, Articular/metabolism ; Cartilage/pathology ; Cartilage/metabolism ; CCAAT-Enhancer-Binding Protein-beta/metabolism ; Proteomics
Chemical Substances	CCAAT-Enhancer-Binding Protein-beta
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2024.122549
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Article: [Interferon].

SCHOENENBERGER, M

Blut

2003 Volume 8, Page(s) 1–4

MeSH term(s)	Humans ; Interferons ; Viruses
Chemical Substances	Interferons (9008-11-1)
Language	German
Publishing date	2003-08-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	213648-x
ISSN	0006-5242
ISSN	0006-5242
DOI	10.1007/bf01570365
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Article: Planetary Probe Entry Atmosphere Estimation Using Synthetic Air Data System.

Karlgaard, Christopher D / Schoenenberger, Mark

Journal of spacecraft and rockets

2017 Volume 55, Issue 3, Page(s) 599–610

Abstract: This paper develops an atmospheric state estimator based on inertial acceleration and angular rate measurements combined with a vehicle aerodynamic model. The approach utilizes the navigation state of the vehicle to recast the vehicle aerodynamic model ... ...

Abstract	This paper develops an atmospheric state estimator based on inertial acceleration and angular rate measurements combined with a vehicle aerodynamic model. The approach utilizes the navigation state of the vehicle to recast the vehicle aerodynamic model to be a function solely of the atmospheric state. Force and moment measurements are based on vehicle sensed accelerations and angular rates. These measurements are combined with an aerodynamic model and a Kalman-Schmidt filter to estimate the atmospheric conditions. The method is applied to data from the Mars Science Laboratory mission, which landed the Curiosity rover on the surface of Mars in August 2012. The results of the estimation algorithm are compared with results from a Flush Air Data Sensing algorithm based on onboard pressure measurements on the vehicle forebody. The comparison indicates that the proposed method provides estimates consistent with the air data measurements, without the use of pressure transducers. Implications for future missions such as the Mars 2020 entry capsule are described.
Language	English
Publishing date	2017-12-15
Publishing country	United States
Document type	Journal Article
ISSN	0022-4650
ISSN	0022-4650
DOI	10.2514/1.A34115
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Article: Opioide bei Patienten mit Niereninsuffizienz.

Pfefferkorn, Florian / Harings-Kaim, Annette / Schönenberger, Melanie / Leuppi-Taegtmeyer, Anne

Therapeutische Umschau. Revue therapeutique

2020 Volume 77, Issue 1, Page(s) 10–13

Abstract: Opioids in patients with renal ... ...

Title translation	Opioids in patients with renal impairment.
Abstract	Opioids in patients with renal impairment
MeSH term(s)	Analgesics, Opioid/adverse effects ; Fentanyl ; Humans ; Hydromorphone ; Oxycodone ; Tramadol
Chemical Substances	Analgesics, Opioid ; Tramadol (39J1LGJ30J) ; Oxycodone (CD35PMG570) ; Hydromorphone (Q812464R06) ; Fentanyl (UF599785JZ)
Language	German
Publishing date	2020-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	82044-1
ISSN	1664-2864 ; 0040-5930
ISSN (online)	1664-2864
ISSN	0040-5930
DOI	10.1024/0040-5930/a001144
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Article: Strategisches Management im Krankenhaus

Schönenberger, M.

Schweizerische Ärztezeitung

2005 Volume 86, Issue 9, Page(s) 562

Language	German
Document type	Article
ZDB-ID	507697-3
ISSN	0036-7486
Database	Current Contents Medicine

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Book ; Thesis: Gesundheitsförderung und Prävention im Familienkontext. Untersuchung zur Wirksamkeit des Projekts "Eltern und Schule stärken Kinder" in Abhängigkeit von der erzieherischen Kompetenz der Eltern

Schönenberger, Michaela

2012

Abstract: Das Projekt "Eltern und Schule stärken Kinder" (ESSKI) ist ein Forschungs- und Entwicklungsprojekt, das die Förderung und Stärkung der personalen und sozialen Kompetenzen bei Kindern, Lehrpersonen und Eltern mittels international erprobter ... ...

Title translation	Health promotion and prevention in families: Evaluation of the project "Eltern und Schule stärken Kinder" with special regard to parenting skills
Abstract	Das Projekt "Eltern und Schule stärken Kinder" (ESSKI) ist ein Forschungs- und Entwicklungsprojekt, das die Förderung und Stärkung der personalen und sozialen Kompetenzen bei Kindern, Lehrpersonen und Eltern mittels international erprobter Interventionsprogramme zum Ziel hatte. Das Projekt wurde im Rahmen eines randomisierten, experimentellen Kontrollgruppendesigns mit drei Messzeitpunkten (Pretest, Posttest, Follow-up) evaluiert, Die vorliegende Dissertation nimmt eine Detailanalyse der ESSKI-Daten vor und analysiert einerseits Unterschiede zwischen teilnehmenden Familien und Familien, die nicht an ESSKI teilgenommen haben (Kinddaten) und prüft andererseits die Wirkweisen der Interventionsprogramme in Abhängigkeit unterschiedlicher Familienkontexte (Eltern- und Kinddaten). Wesentliche Ergebnisse waren: Die Kinder und Jugendlichen der an ESSKI teilnehmenden Familien unterschieden sich in ihren Stärken und Schwächen nicht signifikant von den Kindern der nicht teilnehmenden Familien (N=l409; SDQ-Einschätzung Lehrpersonen). Eine Clusteranalyse zeigt beim Pretest signifikante Unterschiede zwischen den drei gebildeten Erziehungskontexten (POSITIV, N=205; MITTEL, N=300; NEGATIV, N=I83) in den folgenden Dimensionen: (1) elterliche psychische Gesundheit und Widerstandsfähigkeit, (2) Elternzufriedenheit sowie (3) kindliche Stärken und Schwachen. Mit zunehmender Erziehungskompetenz stieg auch das selbstberichtete Wohlbefinden in den Familien an. Die Eltern mit dem nachteiligsten Erziehungsverhalten schienen im Vergleich zu den anderen beiden Elterngruppen bezüglich ihrer psychischen Gesundheit und Widerstandsfähigkeit signifikant mehr vom Projekt ESSKI zu profitieren scheinen. In der Detailanalyse der Interventionsgruppen (Kontroll- und Experimentalgruppen) auf Elnzelclusterebene konnten diese Ergebnisse allerdings nicht mehr bestätigt werden.
Keywords	Elternfertigkeiten ; Elterntraining ; Evaluation ; Gesundheitsförderung ; Health Promotion ; Parent Training ; Parenting Skills ; Prevention ; Prävention ; Social Skills ; Social Skills Training ; Soziale Fertigkeiten ; Training sozialer Fertigkeiten
Language	German
Size	188 S.
Publisher	Universität, Philosophische Fakultät
Publishing place	Zürich
Document type	Book ; Thesis
Note	Elektronische Publikation im Internet
Database	PSYNDEX

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Article ; Online: Temperature-Induced Surface Effects on Drug Nanosuspensions.

Aleandri, Simone / Schönenberger, Monica / Niederquell, Andres / Kuentz, Martin

Pharmaceutical research

2018 Volume 35, Issue 3, Page(s) 69

Abstract: Purpose: The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are commonly employed. Clearly ... ...

Abstract	Purpose: The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are commonly employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug nanosuspensions were to be studied for temperatures of 25 and 37°C by using complementary surface analytical methods. Methods: Atomic force microscopy, inverse gas chromatography and UV surface dissolution imaging were used together for the first time to assess pharmaceutical nanosuspensions that were obtained by wet milling. Fenofibrate and bezafibrate were selected as model drugs in presence of sodium dodecyl sulfate and hydroxypropyl cellulose as anionic and steric stabilizer, respectively. Results: It was demonstrated that in case of bezafibrate nanosuspension, a surface modification occurred at 37°C compared to 25°C, which notably affected dissolution rate. By contrast, no similar effect was observed in case of fenofibrate nanoparticles. Conclusions: The combined usage of analytical surface methods provides the basis for a better understanding of phenomena that take place on drug surfaces. Such understanding is of importance for pharmaceutical development to achieve desirable quality attributes of nanosuspensions.
MeSH term(s)	Bezafibrate/chemistry ; Bezafibrate/pharmacokinetics ; Cellulose/analogs & derivatives ; Cellulose/chemistry ; Chemistry, Pharmaceutical ; Drug Compounding/methods ; Drug Liberation ; Drug Stability ; Drug Storage ; Excipients/chemistry ; Fenofibrate/chemistry ; Fenofibrate/pharmacokinetics ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/pharmacokinetics ; Microscopy, Atomic Force ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Sodium Dodecyl Sulfate/chemistry ; Solubility ; Suspensions ; Temperature
Chemical Substances	Excipients ; Hypolipidemic Agents ; Suspensions ; Sodium Dodecyl Sulfate (368GB5141J) ; Cellulose (9004-34-6) ; hydroxypropylcellulose (9XZ8H6N6OH) ; Fenofibrate (U202363UOS) ; Bezafibrate (Y9449Q51XH)
Language	English
Publishing date	2018-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-017-2300-6
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Article ; Online: Bidirectional reflectance measurement of tungsten samples to assess reflection model in WEST tokamak.

Ben Yaala, M / Aumeunier, M-H / Steiner, R / Schönenberger, M / Martin, C / Le Bohec, M / Talatizi, C / Marot, L / Meyer, E

The Review of scientific instruments

2021 Volume 92, Issue 9, Page(s) 93501

Abstract: This paper presents the measurement of the bidirectional reflectance distribution function of tungsten (W) samples and the resulting reflection models in the nuclear fusion device WEST (tokamak). For this, an experimental gonio-spectrophotometer was ... ...

Abstract	This paper presents the measurement of the bidirectional reflectance distribution function of tungsten (W) samples and the resulting reflection models in the nuclear fusion device WEST (tokamak). For this, an experimental gonio-spectrophotometer was developed to fully characterize the material's optical and thermal-radiative properties of metallic samples with different roughnesses. Ray-tracing photonic simulation was then carried out to predict the photon behavior in a fully metallic environment as a function of reflectance measurement. Low emissivity (0.1 at 4 μm) and highly specular reflectance (fitting with a Gaussian distribution around the specular direction with a small width lower than 10°) are found for W samples. These measurements have been used as input for the photonic simulation, and the resulting synthetic image reproduced the reflection features well on the upper divertor, detected in WEST infrared experimental images.
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0046140
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Article ; Online: Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer.

Ditzinger, Felix / Scherer, Uta / Schönenberger, Monica / Holm, René / Kuentz, Martin

Molecular pharmaceutics

2018 Volume 16, Issue 1, Page(s) 141–150

Abstract: Hot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable amorphous solid dispersions (ASD). ... ...

Abstract	Hot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable amorphous solid dispersions (ASD). Considerations of miscibility, stability, and biopharmaceutical performance narrow the selection of excipients, and further technical constraints arise from needed pharmaceutical processing. The present work introduces the concept of molecularly targeted interactions of a coformer with a polymer to design a new matrix for HME. Model systems of dimethylaminoethyl methacrylate copolymer, Eudragit E (EE), and bicarboxylic acids were studied, and pronounced molecular interactions were demonstrated by
MeSH term(s)	Drug Compounding ; Magnetic Resonance Spectroscopy ; Malates/chemistry ; Microscopy, Atomic Force ; Polymers/chemistry ; Solubility ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Malates ; Polymers ; malic acid (817L1N4CKP)
Language	English
Publishing date	2018-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.8b00920
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Article ; Online: Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging.

Abreu-Villela, Renata / Schönenberger, Monica / Caraballo, Isidoro / Kuentz, Martin

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2018 Volume 133, Page(s) 122–130

Abstract: Early stages of crystallization from amorphous solid dispersion (ASD) are typically not detected by means of standard methods like powder X-ray diffraction (XRPD). The aim of this study is therefore to evaluate if fractal analysis based on energy ... ...

Abstract	Early stages of crystallization from amorphous solid dispersion (ASD) are typically not detected by means of standard methods like powder X-ray diffraction (XRPD). The aim of this study is therefore to evaluate if fractal analysis based on energy dispersive X-ray imaging can provide the means to identify early signs of physical instability. ASDs of the poorly water-soluble compound, felodipine (FEL) were prepared by solvent evaporation using different grades of HPMCAS, at 50 wt% drug loading. Samples were stored at accelerated conditions of 40 °C. Scanning electron microscopy equipped with an energy-dispersive X-ray spectroscopy (SEM-EDS) was used for elemental mapping of tablet surfaces. Comparative data were generated with a standard XRPD and with more sensitive methods for detection of early instability, i.e. laser scanning confocal microscopy (LSM) and atomic force microscopy (AFM). The SEM-EDS identified changes of drug-rich domains that were confirmed by LSM and AFM. Early changes in drug clusters were also revealed by a multifractal analysis that indicated a beginning phase separation and drug crystallization. Therefore, the presented fractal cluster analysis based on chemical imaging bears much promise as a new method to detect early signs of physical instability in ASD, which is of great relevance for pharmaceutical development.
MeSH term(s)	Cluster Analysis ; Crystallization/methods ; Felodipine/chemistry ; Fractals ; Microscopy, Atomic Force/methods ; Microscopy, Confocal/methods ; Microscopy, Electron, Scanning/methods ; Pharmaceutical Preparations/chemistry ; Powders/chemistry ; Solubility ; Solvents/chemistry ; Tablets/chemistry ; Water/chemistry ; X-Ray Diffraction/methods
Chemical Substances	Pharmaceutical Preparations ; Powders ; Solvents ; Tablets ; Water (059QF0KO0R) ; Felodipine (OL961R6O2C)
Language	English
Publishing date	2018-10-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2018.10.007
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