Article ; Online: Controling the cytoskeleton during CEACAM3-mediated phagocytosis.
European journal of cell biology
2024 Volume 103, Issue 1, Page(s) 151384
Abstract: Phagocytosis, an innate defense mechanism of multicellular animals, is initiated by specialized surface receptors. A phagocytic receptor expressed by human polymorphonuclear granulocytes, the major professional phagocytes in our body, is one of the ... ...
| Abstract | Phagocytosis, an innate defense mechanism of multicellular animals, is initiated by specialized surface receptors. A phagocytic receptor expressed by human polymorphonuclear granulocytes, the major professional phagocytes in our body, is one of the fastest evolving human proteins implying a special role in human biology. This receptor, CEACAM3, is a member of the CarcinoEmbryonic Antigen-related Cell Adhesion Molecule (CEACAM) family and dedicated to the immediate recognition and rapid internalization of human-restricted pathogens. In this focused contribution, we will review the special adaptations of this protein, which co-evolves with different species of mucosa-colonizing bacteria. While the extracellular Immunoglobulin-variable (Ig |
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| MeSH term(s) | Animals ; Humans ; Phagocytosis ; Cell Adhesion Molecules ; Cytoskeleton ; Signal Transduction ; Phosphorylation ; Carcinoembryonic Antigen | |||||
| Chemical Substances | Cell Adhesion Molecules ; CEACAM3 protein, human ; Carcinoembryonic Antigen | |||||
| Language | English | |||||
| Publishing date | 2024-01-05 | |||||
| Publishing country | Germany | |||||
| Document type | Review ; Journal Article | |||||
| ZDB-ID | 391967-5 | |||||
| ISSN | 1618-1298 ; 0070-2463 ; 0171-9335 | |||||
| ISSN (online) | 1618-1298 | |||||
| ISSN | 0070-2463 ; 0171-9335 | |||||
| DOI | 10.1016/j.ejcb.2024.151384 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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