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  1. Article ; Online: D-dimer and C-reactive Protein Blood Levels Over Time Used to Predict Pulmonary Embolism in Two COVID-19 Patients.

    Becher, Yael / Goldman, Leonid / Schacham, Nadav / Gringauz, Irina / Justo, Dan

    European journal of case reports in internal medicine

    2020  Volume 7, Issue 6, Page(s) 1725

    Abstract: The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present ... ...

    Abstract The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present two COVID-19 patients in whom pulmonary embolism was suspected (and diagnosed) due to a discrepancy between an increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time. We believe that an opposite change in the blood levels of both biomarkers over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Learning points: The diagnosis of pulmonary embolism is challenging in COVID-19 patients since symptoms, signs and high D-dimer blood levels might be similar in both diseases.An increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Italy
    Document type Journal Article
    ISSN 2284-2594
    ISSN (online) 2284-2594
    DOI 10.12890/2020_001725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Screening for Asymptomatic Urinary Retention in Older Adult Men at Admission to the Internal Medicine Department: A Prospective Study.

    Schacham, Nadav Yehoshua / Schwarzman, Arkady / Brom, Adi / Gilboa, Mayan / Groutz, Asnat / Justo, Dan

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 7, Page(s) 432–436

    Abstract: Background: Screening for asymptomatic urinary retention (AUR) in older adult men at hospital admission to the internal medicine department has never been studied.: Objectives: To assess the incidence of AUR in older adult men at hospital admission, ... ...

    Abstract Background: Screening for asymptomatic urinary retention (AUR) in older adult men at hospital admission to the internal medicine department has never been studied.
    Objectives: To assess the incidence of AUR in older adult men at hospital admission, its risk factors, and its outcome.
    Methods: The study comprised 111 older adult men aged ≥ 75 years who were admitted to three internal medicine departments. All men underwent post-void residual (PVR) urine volume measurement on the morning following admission by using a portable ultrasound bladder scan. AUR was defined as a PVR urine volume of ≥ 200 ml without symptoms. Men with AUR had a follow-up phone call concerning symptoms and urinary catheter status30 days following hospitalization.
    Results: Seven (6.3%) men had AUR. Relative to the 104 men without AUR, they had significantly higher prevalence of severe dependency (6/7 vs. 33/104, 85.7% vs. 31.7%, (P = 0.007), cognitive impairment (5/7 vs. 19/104, 71.4% vs. 18.3%, P = 0.005), and use of anticholinergic agents (4/7 vs. 19/104, 57.1% vs. 18.3%, P = 0.033). A urinary catheter was inserted in one man (14.3%), but it was removed later during hospitalization. No symptoms were reported and no urinary catheter was inserted following hospitalization in men with AUR.
    Conclusions: AUR in older adult men at hospital admission is uncommon and has a favorable outcome. Hence, screening for AUR in all older adult men at admission is not recommended, but it may be considered in severely dependent older adult men with cognitive impairment who use anticholinergic agents.
    MeSH term(s) Aged, 80 and over ; Asymptomatic Diseases/epidemiology ; Asymptomatic Diseases/therapy ; Cholinergic Antagonists/therapeutic use ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Functional Status ; Humans ; Incidence ; Male ; Mass Screening/methods ; Outcome Assessment, Health Care ; Patient Admission/statistics & numerical data ; Patients' Rooms ; Point-of-Care Testing ; Prostatic Hyperplasia/diagnosis ; Prostatic Hyperplasia/epidemiology ; Risk Factors ; Ultrasonography/methods ; Urinary Bladder/diagnostic imaging ; Urinary Retention/diagnosis ; Urinary Retention/epidemiology ; Urinary Retention/etiology ; Urinary Retention/therapy
    Chemical Substances Cholinergic Antagonists
    Language English
    Publishing date 2021-08-02
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: D-dimer and C-reactive protein blood levels over time used to predict pulmonary embolism in two covid-19 patients

    Becher, Yael / Goldman, Leonid / Schacham, Nadav / Gringauz, Irina / Justo, Dan

    Eur. J. Case Rep. Intern. Med.

    Abstract: The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present ... ...

    Abstract The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. We present two COVID-19 patients in whom pulmonary embolism was suspected (and diagnosed) due to a discrepancy between an increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time. We believe that an opposite change in the blood levels of both biomarkers over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #596645
    Database COVID19

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  4. Article ; Online: Intraoperative Hypotension and Acute Kidney Injury after Noncardiac Surgery in Infants and Children: A Retrospective Cohort Analysis.

    Schacham, Nadav Y / Chhabada, Surendrasingh / Efune, Proshad N / Pu, Xuan / Liu, Liu / Yang, Dongsheng / Raza, Praneeta C / Szmuk, Peter / Sessler, Daniel I

    Anesthesiology

    2021  Volume 136, Issue 1, Page(s) 93–103

    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/physiopathology ; Adolescent ; Blood Pressure/physiology ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Hypotension/diagnosis ; Hypotension/physiopathology ; Infant ; Intraoperative Complications/diagnosis ; Intraoperative Complications/physiopathology ; Male ; Monitoring, Intraoperative/methods ; Retrospective Studies
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.133: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  5. Article ; Online: Incidence of adverse events attributable to bupivacaine liposome injectable suspension or plain bupivacaine for postoperative pain in pediatric surgical patients: A retrospective matched cohort analysis.

    Cohen, Barak / Glosser, Logan / Saab, Remie / Walters, Michael / Salih, Ahmed / Zafeer-Khan, Mohammad / Rivas, Eva / Zhang, Kan / Schacham, Nadav Y / Chodavarapu, Praneeta / Essber, Hani / Chelnick, David / Raza, Syed / Hanline, CeCelia / Khoshknabi, Dilara / Yang, Dongsheng / Seif, John / Chhabada, Surendrasingh / Turan, Alparslan

    Paediatric anaesthesia

    2018  Volume 29, Issue 2, Page(s) 169–174

    Abstract: Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by ... ...

    Abstract Background: Surgical wound infiltration with local anesthetics is common as part of multimodal analgesia and enhanced recovery pathways in pediatric surgical patients. Liposomal bupivacaine can provide up to 92 hours of pain relief, and was approved by the U.S Food and Drug Administration for local infiltration in adults. It is also commonly used by pediatric surgeons, but its safety profile in this age group has not been described.
    Aims: The aim of this study was to describe the incidence of local anesthetic systemic toxicity syndrome in pediatric surgical patients receiving liposomal bupivacaine compared to plain bupivacaine for surgical wound infiltration.
    Methods: We conducted a retrospective, single center, assessor blinded cohort study of pediatric surgical inpatients having open or laparoscopic surgery in the Cleveland Clinic between 2013 and 2017 and receiving wound infiltration with local anesthetics. We compared the incidence of local anesthetic systemic toxicity among those who received any dose of liposomal bupivacaine and those who received plain bupivacaine. Groups were matched 1:2 according to procedure type, age, and physical status score. Local anesthetic systemic toxicity was primarily defined as at least two signs or symptoms possibly related to anesthetic toxicity, as judged by two independent adjudicators blinded to the type of local anesthetic. A sensitivity analysis compared the incidence of a single sign/symptom possibly related to anesthetic toxicity.
    Results: A total of 924 surgical cases were included in the final analysis (356 liposomal bupivacaine and 568 plain bupivacaine cases). The primary outcome did not occur in any patient. The sensitivity analysis found three cases in the liposomal bupivacaine group and two cases in the plain bupivacaine group having a single sign/symptom possibly related to local anesthetic administration (relative risk 2.4, 95% CI 0.4-14.0, P = 0.38).
    Conclusion: In a cohort of pediatric surgical patients receiving wound infiltration with either plain or liposomal bupivacaine, we identified no cases of local anesthetic systemic toxicity syndrome, and only few patients with any sign or symptom that could potentially be related to local anesthetic toxicity.
    MeSH term(s) Adolescent ; Anesthesia, Local/adverse effects ; Anesthesia, Local/methods ; Anesthetics, Local/administration & dosage ; Anesthetics, Local/adverse effects ; Bupivacaine/administration & dosage ; Bupivacaine/adverse effects ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Incidence ; Infant ; Laparoscopy ; Liposomes/administration & dosage ; Male ; Pain Management/methods ; Pain, Postoperative/drug therapy ; Retrospective Studies ; Suspensions/administration & dosage
    Chemical Substances Anesthetics, Local ; Liposomes ; Suspensions ; Bupivacaine (Y8335394RO)
    Language English
    Publishing date 2018-12-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.13561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3306: Show issues Location:
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