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  1. Article ; Online: "Training immunity" against nosocomial pathogens.

    Schäfer, Alexandra / Martinez, David R

    Science immunology

    2023  Volume 8, Issue 89, Page(s) eadl5685

    Abstract: Non-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens. ...

    Abstract Non-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens.
    MeSH term(s) Humans ; Trained Immunity ; Cross Infection ; Vaccines ; Immunity, Innate ; Hospitals
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.adl5685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Die Rolle des Herpesvirus saimiri orf73-LANA als Mediator der viralen Latenz und Persistenz

    Schäfer, Alexandra

    2003  

    Author's details vorgelegt von Alexandra Schäfer
    Language German
    Size 75 S. : Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2003
    HBZ-ID HT013821003
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 D 1839 order for loan Magazin

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  3. Book ; Thesis: Verlaufsuntersuchungen nach neonatalem sonographischem Screening des Harntraktes

    Schäfer, Alexandra

    1999  

    Author's details vorgelegt von Alexandra Schäfer
    Language German
    Size 90 Bl., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1999
    HBZ-ID HT013069203
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 MB 88 order for loan Magazin

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  4. Article ; Online: Cell and animal models of SARS-CoV-2 pathogenesis and immunity.

    Leist, Sarah R / Schäfer, Alexandra / Martinez, David R

    Disease models & mechanisms

    2020  Volume 13, Issue 9

    Abstract: The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans ... ...

    Abstract The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Vaccines ; Cells, Cultured ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/virology ; Disease Models, Animal ; Host Microbial Interactions ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Species Specificity ; Tissue Culture Techniques ; Viral Vaccines/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.046581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Epigenetic Landscape during Coronavirus Infection.

    Schäfer, Alexandra / Baric, Ralph S

    Pathogens (Basel, Switzerland)

    2017  Volume 6, Issue 1

    Abstract: Coronaviruses (CoV) comprise a large group of emerging human and animal pathogens, including the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) strains. The molecular ...

    Abstract Coronaviruses (CoV) comprise a large group of emerging human and animal pathogens, including the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) strains. The molecular mechanisms regulating emerging coronavirus pathogenesis are complex and include virus-host interactions associated with entry, replication, egress and innate immune control. Epigenetics research investigates the genetic and non-genetic factors that regulate phenotypic variation, usually caused by external and environmental factors that alter host expression patterns and performance without any change in the underlying genotype. Epigenetic modifications, such as histone modifications, DNA methylation, chromatin remodeling, and non-coding RNAs, function as important regulators that remodel host chromatin, altering host expression patterns and networks in a highly flexible manner. For most of the past two and a half decades, research has focused on the molecular mechanisms by which RNA viruses antagonize the signaling and sensing components that regulate induction of the host innate immune and antiviral defense programs upon infection. More recently, a growing body of evidence supports the hypothesis that viruses, even lytic RNA viruses that replicate in the cytoplasm, have developed intricate, highly evolved, and well-coordinated processes that are designed to regulate the host epigenome, and control host innate immune antiviral defense processes, thereby promoting robust virus replication and pathogenesis. In this article, we discuss the strategies that are used to evaluate the mechanisms by which viruses regulate the host epigenome, especially focusing on highly pathogenic respiratory RNA virus infections as a model. By combining measures of epigenome reorganization with RNA and proteomic datasets, we articulate a spatial-temporal data integration approach to identify regulatory genomic clusters and regions that play a crucial role in the host's innate immune response, thereby defining a new viral antagonism mechanism following emerging coronavirus infection.
    Keywords covid19
    Language English
    Publishing date 2017-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens6010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Establishing a Mouse Model for Sexual Transmission and Male Reproductive Tract Persistence of Ebola Virus.

    Clancy, Chad S / Smart, Gabrielle / Rhoderick, J Fred / O'Donnell, Kyle L / Rosenke, Rebecca / Schäfer, Alexandra / Marzi, Andrea

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 7, Page(s) S554–S558

    Abstract: Ebola virus disease (EVD) has resulted in the death of over 15 000 people since its discovery in 1976. At least 1 incident of re-emergence of EVD has been associated with persistent male reproductive tract infection in a patient surviving EVD greater ... ...

    Abstract Ebola virus disease (EVD) has resulted in the death of over 15 000 people since its discovery in 1976. At least 1 incident of re-emergence of EVD has been associated with persistent male reproductive tract infection in a patient surviving EVD greater than 500 days prior. To date, animal models of Ebola virus (EBOV) infection have failed to fully characterize the pathogenesis of reproductive tract infection. Furthermore, no animal model of sexual transmission of EBOV exists. In this study, we describe a roadmap to modeling sexual transmission of EBOV using a mouse-adapted EBOV isolate in immunocompetent male mice and female Ifnar-/- mice.
    MeSH term(s) Animals ; Humans ; Male ; Female ; Ebolavirus ; Hemorrhagic Fever, Ebola ; Reproductive Tract Infections ; Disease Models, Animal
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  7. Article ; Online: Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection.

    Graham, Jessica B / Swarts, Jessica L / Leist, Sarah R / Schäfer, Alexandra / Bell, Timothy A / Hock, Pablo / Farrington, Joe / Shaw, Ginger D / Ferris, Martin T / Pardo-Manuel de Villena, Fernando / Baric, Ralph S / Lund, Jennifer M

    iScience

    2024  Volume 27, Issue 3, Page(s) 109103

    Abstract: The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address the role of host genetics on immune phenotypes and ... ...

    Abstract The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a diverse range of symptoms. Here, we address the role of host genetics on immune phenotypes and clinical outcomes following viral infection by studying genetically diverse mice from the Collaborative Cross (CC), allowing for use of a small animal model with controlled genetic diversity while maintaining genetic replicates. We demonstrate variation by deeply profiling a broad range of innate and adaptive immune cell phenotypes at steady-state in 63 genetically distinct CC mouse strains and link baseline immune signatures with virologic and clinical disease outcomes following infection of mice with herpes simplex virus 2 (HSV-2) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This work serves as a resource for CC strain selection based on steady-state immune phenotypes or disease presentation upon viral infection, and further, points to possible pre-infection immune correlates of survival and early viral clearance upon infection.
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: St. Leonhards Garten

    Hornung, Klaus / Schäfer, Alexandra

    Idee 2005 - 2006, Konzeption 2007 - 2008, Realisation 2009 - 2013 ; [stilvoll urban leben]

    2012  

    Title variant Sankt Leonhards
    Institution Braunschweig / Fachbereich Stadtplanung und Umweltschutz
    Author's details [Hrsg. Stadt Braunschweig, Fachbereich Stadtplanung und Umweltschutz. Verantw.: Alexandra Schäfer; Klaus Hornung]
    Keywords Sankt Leonhards Garten
    Language German
    Size 143 S., zahlr. Ill., graph. Darst., 26 cm, 750 g
    Publisher Appelhans
    Publishing place Braunschweig
    Document type Book
    Note Literaturverz. S. [40] - 41
    ISBN 9783941737679 ; 3941737678
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Article: Cell and animal models of SARS-CoV-2 pathogenesis and immunity

    Leist, Sarah R / Schäfer, Alexandra / Martinez, David R

    Dis. model. mech. (Print)

    Abstract: The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans ... ...

    Abstract The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #745043
    Database COVID19

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  10. Article: A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.

    Lee, Jimin / Stewart, Cameron / Schaefer, Alexandra / Leaf, Elizabeth M / Park, Young-Jun / Asarnow, Daniel / Powers, John M / Treichel, Catherine / Corti, Davide / Baric, Ralph / King, Neil P / Veesler, David

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Continuous evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and monoclonal antibody therapies. To overcome this challenge, we set out to ... ...

    Abstract Continuous evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and monoclonal antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.12.571160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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