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  1. Article ; Online: Welcome from the new Editor-in-Chief.

    Schaefer, Liliana

    American journal of physiology. Cell physiology

    2021  Volume 321, Issue 1, Page(s) C1–C2

    MeSH term(s) Cell Physiological Phenomena ; Editorial Policies ; Humans ; Peer Review, Research/ethics ; Peer Review, Research/methods ; Periodicals as Topic
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00181.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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  2. Article ; Online: New Year greetings from the Editor-in-Chief of the

    Schaefer, Liliana

    American journal of physiology. Cell physiology

    2021  Volume 322, Issue 1, Page(s) C122–C123

    MeSH term(s) Cell Physiological Phenomena/physiology ; Editorial Policies ; Holidays ; Humans ; Leadership ; Periodicals as Topic/trends
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00434.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cell and Molecular Physiology Section of the American Physiological Society in connection with

    Schaefer, Liliana / Pierre, Sandrine V

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 1, Page(s) C362–C363

    MeSH term(s) United States ; Cell Physiological Phenomena ; Physiology
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00033.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An

    Nyström, Alexander / Schaefer, Liliana

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 5, Page(s) C1155–C1157

    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00455.2023
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  5. Article ; Online: Decoding fibrosis: Mechanisms and translational aspects.

    Schaefer, Liliana

    Matrix biology : journal of the International Society for Matrix Biology

    2018  Volume 68-69, Page(s) 1–7

    Abstract: Fibrosis, a complex process of abnormal tissue healing which inevitably leads to loss of physiological organ structure and function, is a worldwide leading cause of death. Despite a large body of research over the last two decades, antifibrotic ... ...

    Abstract Fibrosis, a complex process of abnormal tissue healing which inevitably leads to loss of physiological organ structure and function, is a worldwide leading cause of death. Despite a large body of research over the last two decades, antifibrotic approaches are mainly limited to organ replacement therapy generating high costs of medical care. In this translational issue, a unique group of basic and clinical researchers provide meaningful answers to a desperate call of society for effective antifibrotic treatments. Fortunately, a plethora of novel fibrogenic factors and biomarkers has been identified. Noninvasive diagnostic methods and drug delivery systems have been recently developed for the management of fibrosis. Consequently, a large number of exciting clinical trials addressing comprehensive, organ and stage-specific mechanisms of fibrogenesis are ongoing. By critically addressing previously unsuccessful and novel promising therapeutic strategies, we aim to spread hope for future treatments of the various forms of organ fibrosis.
    MeSH term(s) Biomarkers/metabolism ; Clinical Trials as Topic ; Fibrosis/metabolism ; Fibrosis/therapy ; Humans ; Proteomics ; Translational Medical Research ; Wound Healing
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-04-18
    Publishing country Netherlands
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2018.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Global impact of proteoglycan science on human diseases.

    Xie, Christopher / Schaefer, Liliana / Iozzo, Renato V

    iScience

    2023  Volume 26, Issue 11, Page(s) 108095

    Abstract: In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. ...

    Abstract In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss the role of proteoglycans in selected and emerging areas of proteoglycan science, such as neurodegenerative diseases, autophagy, angiogenesis, cancer, infections and their impact on mammalian diseases.
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Autophagy: Instructions from the extracellular matrix.

    Schaefer, Liliana / Dikic, Ivan

    Matrix biology : journal of the International Society for Matrix Biology

    2021  Volume 100-101, Page(s) 1–8

    Abstract: In recent years, extensive research has uncovered crucial regulatory roles for the extracellular matrix (ECM) in regulating autophagy. Autophagy is a ubiquitous and highly conserved catabolic process that allows the selective removal and recycling of ... ...

    Abstract In recent years, extensive research has uncovered crucial regulatory roles for the extracellular matrix (ECM) in regulating autophagy. Autophagy is a ubiquitous and highly conserved catabolic process that allows the selective removal and recycling of cytosolic components via lysosomal or vacuolar degradation. Due to its pivotal role in cellular homeostasis, the impairment of autophagy is involved in the pathophysiology of numerous diseases, comprising infectious diseases, immune and neurodegenerative disorders, renal and hepatic diseases, intervertebral and cartilage disorders, as well as fibrosis and cancer. Several ECM-derived proteoglycans and proteins, including decorin, biglycan, endorepellin, endostatin, collagen VI, and plasminogen kringle 5, have been identified as strong inducers of autophagy. In contrast, laminin α2, perlecan, and lumican exert opposite function by suppressing autophagy. Importantly, by direct interaction with various receptors, which interplay with their co-receptors and adhesion molecules, the ECM is able to direct autophagy in a molecular and cell context-specific manner. Thus, vast pharmacological potential resides in translating this knowledge into the development of ECM-derived therapeutics selectively regulating autophagy.
    MeSH term(s) Autophagy ; Biglycan ; Collagen ; Decorin ; Extracellular Matrix ; Extracellular Matrix Proteins
    Chemical Substances Biglycan ; Decorin ; Extracellular Matrix Proteins ; Collagen (9007-34-5)
    Language English
    Publishing date 2021-07-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2021.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: EGFR Signaling in Lung Fibrosis.

    Schramm, Fabian / Schaefer, Liliana / Wygrecka, Malgorzata

    Cells

    2022  Volume 11, Issue 6

    Abstract: In this review article, we will first provide a brief overview of the ErbB receptor-ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and their ligands ... ...

    Abstract In this review article, we will first provide a brief overview of the ErbB receptor-ligand system and its importance in developmental and physiological processes. We will then review the literature regarding the role of ErbB receptors and their ligands in the maladaptive remodeling of lung tissue, with special emphasis on idiopathic pulmonary fibrosis (IPF). Here we will focus on the pathways and cellular processes contributing to epithelial-mesenchymal miscommunication seen in this pathology. We will also provide an overview of the in vivo studies addressing the efficacy of different ErbB signaling inhibitors in experimental models of lung injury and highlight how such studies may contribute to our understanding of ErbB biology in the lung. Finally, we will discuss what we learned from clinical applications of the ErbB1 signaling inhibitors in cancer in order to advance clinical trials in IPF.
    MeSH term(s) Antineoplastic Agents/pharmacology ; ErbB Receptors/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/pathology ; Ligands ; Lung/pathology ; Signal Transduction
    Chemical Substances Antineoplastic Agents ; Ligands ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11060986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Between life and death: Epithelial cells in lung pathologies.

    Wygrecka, Malgorzata / Schaefer, Liliana

    Cellular signalling

    2020  Volume 72, Page(s) 109652

    Abstract: Recent lineage tracing strategies, single-cell RNA sequencing approaches and high-resolution imaging identified remarkable heterogeneity of lung epithelial cells thus leaving open a question as to their specific functions in lung health and disease. ... ...

    Abstract Recent lineage tracing strategies, single-cell RNA sequencing approaches and high-resolution imaging identified remarkable heterogeneity of lung epithelial cells thus leaving open a question as to their specific functions in lung health and disease. Understanding the molecular mechanisms controlling lung epithelial cell morphogenesis and differentiation as well as communication with other cell types and extracellular matrix provides a basis for improving the outcome for patients with respiratory diseases. Although, the substantial progress has been made towards achieving this goal, we are still far away from being able to train/instruct lung epithelial cells in order to facilitate lung repair and regeneration. The special issue of the Cellular Signaling entitled "Between life and death: epithelial cells in lung pathologies" represents a blend of research articles and reviews, in which structural and functional diversities of lung epithelial cells in health and disease are discussed.
    MeSH term(s) Animals ; Cell Death ; Epithelial Cells/pathology ; Humans ; Lung/pathology ; Lung Diseases/pathology ; Phenotype ; Tumor Microenvironment
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2020.109652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online ; Conference proceedings: Proteoglycans, key regulators of cell-matrix dynamics.

    Schaefer, Liliana

    Matrix biology : journal of the International Society for Matrix Biology

    2014  Volume 35, Page(s) 1–2

    Abstract: In this special issue of Matrix Biology centered on proteoglycan biology we have assembled a blend of articles focused on the state-of-the-art of proteoglycanology. The field has greatly expanded in the past three decades and now encompasses all the ... ...

    Abstract In this special issue of Matrix Biology centered on proteoglycan biology we have assembled a blend of articles focused on the state-of-the-art of proteoglycanology. The field has greatly expanded in the past three decades and now encompasses all the areas of biology. This special issue is divided into five chapters describing hyaluronan metabolism, biosynthetic and catabolic pathways of proteoglycans and their roles in inflammation, cancer, repair and development. We hope that the new original work and the reviews from recognized leaders will stimulate investigations in this exciting and fertile field of research.
    MeSH term(s) Animals ; Extracellular Matrix/physiology ; Humans ; Inflammation/metabolism ; Neoplasms/metabolism ; Proteoglycans/chemistry ; Proteoglycans/metabolism ; Proteoglycans/physiology
    Chemical Substances Proteoglycans
    Language English
    Publishing date 2014-04
    Publishing country Netherlands
    Document type Congresses ; Editorial ; Introductory Journal Article
    ZDB-ID 1183793-7
    ISSN 1569-1802 ; 0945-053X
    ISSN (online) 1569-1802
    ISSN 0945-053X
    DOI 10.1016/j.matbio.2014.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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