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Article ; Online: Provision of clinical pharmacist services for individuals with chronic hepatitis C viral infection - an alternative viewpoint.

Schafer, Jason J

2015 Volume 35, Issue 4, Page(s) e37–8

MeSH term(s)	Antiviral Agents/administration & dosage ; Delivery of Health Care, Integrated ; Hepatitis C/drug therapy ; Humans ; Pharmaceutical Services/utilization
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.1564
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article ; Online: Patients Living With HIV Are Less Likely to Receive Appropriate Statin Therapy for Cardiovascular Disease Risk Reduction.

Emmons, Roshni P / Hastain, Nicholas V / Miano, Todd A / Schafer, Jason J

Journal of pharmacy practice

2021 Volume 35, Issue 4, Page(s) 568–572

Abstract: Background: Recent studies suggest that statins are underprescribed in patients living with HIV (PLWH) at risk for atherosclerotic cardiovascular disease (ASCVD), but none have assessed if eligible patients receive the correct statin and intensity ... ...

Abstract	Background: Recent studies suggest that statins are underprescribed in patients living with HIV (PLWH) at risk for atherosclerotic cardiovascular disease (ASCVD), but none have assessed if eligible patients receive the correct statin and intensity compared to uninfected controls. Objectives: The primary objective was to determine whether statin-eligible PLWH are less likely to receive appropriate statin therapy compared to patients without HIV. Methods: This retrospective study evaluated statin eligibility and prescribing among patients in both an HIV and internal medicine clinic at an urban, academic medical center from June-September 2018 using the American College of Cardiology/American Heart Association guideline on treating blood cholesterol to reduce ASCVD risk. Patients were assessed for eligibility and actual treatment with appropriate statin therapy. Characteristics of patients appropriately and not appropriately treated were compared with chi-square testing and predictors for receiving appropriate statin therapy were determined with logistic regression. Results: A total of 221/300 study subjects were statin-eligible. Fewer statin-eligible PLWH were receiving the correct statin intensity for their risk benefit group versus the uninfected control group (30.2% vs 67.0%, p < 0.001). In the multivariable logistic regression analysis, PLWH were significantly less likely to receive appropriate statin therapy, while those with polypharmacy were more likely to receive appropriate statin therapy. Conclusion: Our study reveals that PLWH may be at a disadvantage in receiving appropriate statin therapy for ASCVD risk reduction. This is important given the heightened risk for ASCVD in this population, and strategies that address this gap in care should be explored.
MeSH term(s)	Atherosclerosis/chemically induced ; Atherosclerosis/epidemiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Retrospective Studies ; Risk Factors ; Risk Reduction Behavior ; United States
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2021-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1027474-1
ISSN	1531-1937 ; 0897-1900
ISSN (online)	1531-1937
ISSN	0897-1900
DOI	10.1177/0897190021999790
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Zs.A 2893: Show issues

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Article ; Online: Weight changes in patients with sustained viral suppression switching tenofovir disoproxil fumarate to tenofovir alafenamide.

Schafer, Jason J / Zimmerman, Matty / Walshe, Ciara / Cerankowski, Jesse / Shimada, Ayako / Keith, Scott W

Obesity (Silver Spring, Md.)

2022 Volume 30, Issue 6, Page(s) 1197–1204

Abstract: Objective: Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes ... ...

Abstract	Objective: Switching from tenofovir disoproxil fumarate (TDF)- to tenofovir alafenamide (TAF)-containing antiretroviral therapy may negatively influence weight, cholesterol, and atherosclerotic cardiovascular disease risk. The extent of these changes and their association with TAF remain unclear. Methods: This retrospective cohort evaluated metabolic changes in virologically suppressed patients with HIV infection who switched from TDF to TAF without switching other antiretroviral therapy medications. Adult patients on TDF and with no HIV viral load values >200 copies/mL for ≥2 years prior to and following a TAF switch were included. Weight and other variables were collected for 2 years before and after the switch. Longitudinal linear mixed-effects models evaluated changes at 1 and 2 years after the switch. Results: In the unadjusted analysis, there were increases in weight, BMI, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, fasting glucose, and atherosclerotic cardiovascular disease risk scores 2 years after switching to TAF (each p ≤ 0.03). However, only increases in total and low-density lipoprotein cholesterol were associated with TAF and were significantly different from expected changes predicted in the adjusted longitudinal models. Conclusions: Despite observing significant unadjusted metabolic changes after switching to TAF, only changes in cholesterol were associated with TAF and were different from changes expected in time-trend adjusted models.
MeSH term(s)	Adenine/therapeutic use ; Adult ; Alanine/therapeutic use ; Anti-HIV Agents/therapeutic use ; Cardiovascular Diseases/epidemiology ; Cholesterol/blood ; Drug Substitution ; Fumarates/therapeutic use ; HIV Infections/drug therapy ; Humans ; Retrospective Studies ; Sustained Virologic Response ; Tenofovir/analogs & derivatives ; Tenofovir/therapeutic use ; Weight Gain
Chemical Substances	Anti-HIV Agents ; Fumarates ; Cholesterol (97C5T2UQ7J) ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23443
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A root cause analysis project in a medication safety course.

Schafer, Jason J

American journal of pharmaceutical education

2012 Volume 76, Issue 6, Page(s) 116

Abstract: Objective: To develop, implement, and evaluate team-based root cause analysis projects as part of a required medication safety course for second-year pharmacy students.: Design: Lectures, in-class activities, and out-of-class reading assignments were ...

Abstract	Objective: To develop, implement, and evaluate team-based root cause analysis projects as part of a required medication safety course for second-year pharmacy students. Design: Lectures, in-class activities, and out-of-class reading assignments were used to develop students' medication safety skills and introduce them to the culture of medication safety. Students applied these skills within teams by evaluating cases of medication errors using root cause analyses. Teams also developed error prevention strategies and formally presented their findings. Assessment: Student performance was assessed using a medication errors evaluation rubric. Of the 211 students who completed the course, the majority performed well on root cause analysis assignments and rated them favorably on course evaluations. Conclusion: Medication error evaluation and prevention was successfully introduced in a medication safety course using team-based root cause analysis projects.
MeSH term(s)	Clinical Competence ; Curriculum ; Drug-Related Side Effects and Adverse Reactions ; Education, Pharmacy/methods ; Humans ; Medication Errors/prevention & control ; Pharmaceutical Preparations/administration & dosage ; Root Cause Analysis ; Students, Pharmacy
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2012-07-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.5688/ajpe766116
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Zs.A 924: Show issues

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Article ; Online: The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection.

Hastain, Nicholas V / Santana, Aleena / Schafer, Jason J

The Annals of pharmacotherapy

2019 Volume 54, Issue 1, Page(s) 36–42

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Anti-Retroviral Agents/administration & dosage ; Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/pharmacokinetics ; Anti-Retroviral Agents/therapeutic use ; Drug Administration Schedule ; Drug Combinations ; Drug Interactions ; Female ; HIV Infections/drug therapy ; HIV Infections/metabolism ; Humans ; Incidence ; Male ; Medication Adherence ; Middle Aged ; Quality of Life ; Retrospective Studies ; Tablets
Chemical Substances	Anti-Retroviral Agents ; Drug Combinations ; Tablets
Language	English
Publishing date	2019-07-31
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1101370-9
ISSN	1542-6270 ; 1060-0280
ISSN (online)	1542-6270
ISSN	1060-0280
DOI	10.1177/1060028019867970
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Article ; Online: Addressing racial inequality and its effects on vaccination rate: A trial comparing a pharmacist and peer educational program (MOTIVATE) in diverse older adults.

Prioli, Katherine M / Akincigil, Ayse / Namvar, Tarlan / Mitchell-Williams, Jocelyn / Schafer, Jason J / Cunningham, Renee C / Fields-Harris, Lynn / McCoy, Megan / Vertsman, Ronald / Guesnier, Ashley / Pizzi, Laura T

Journal of managed care & specialty pharmacy

2023 Volume 29, Issue 8, Page(s) 970–980

Abstract: BACKGROUND: ...

Abstract	BACKGROUND:
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Pharmacists ; Influenza, Human/prevention & control ; Trust ; Vaccine-Preventable Diseases ; Vaccination ; Influenza Vaccines
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2376-1032
ISSN (online)	2376-1032
DOI	10.18553/jmcp.2023.29.8.970
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Article ; Online: Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.

Schafer, Jason J / Short, William R

Antiviral therapy

2012 Volume 17, Issue 8, Page(s) 1495–1502

Abstract: Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). It remains active against HIV strains harbouring mutations that affect first-generation agents. RPV is dosed once daily with food and has been coformulated ... ...

Abstract	Rilpivirine (RPV) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). It remains active against HIV strains harbouring mutations that affect first-generation agents. RPV is dosed once daily with food and has been coformulated into a single tablet containing tenofovir and emtricitabine. Two Phase III studies of treatment-naive patients found RPV and efavirenz to have similar safety and efficacy. However, suboptimal virological suppression with RPV occurred more commonly in patients with higher baseline viral loads (>100,000 copies/ml). The most common mutation that emerged during RPV therapy was E138K, which often occurred in combination with M184I. E138K is likely to cause cross-resistance to other NNRTIs thereby limiting the further utilization of this class.
MeSH term(s)	Anti-HIV Agents/adverse effects ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Benzoxazines/adverse effects ; Benzoxazines/therapeutic use ; Clinical Trials as Topic ; Drug Interactions ; Drug Resistance, Viral ; Drug Substitution ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Nitriles/adverse effects ; Nitriles/pharmacology ; Nitriles/therapeutic use ; Pyrimidines/adverse effects ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Reverse Transcriptase Inhibitors/adverse effects ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; Rilpivirine
Chemical Substances	Anti-HIV Agents ; Benzoxazines ; Nitriles ; Pyrimidines ; Reverse Transcriptase Inhibitors ; Rilpivirine (FI96A8X663) ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2012
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1339842-8
ISSN	2040-2058 ; 1359-6535
ISSN (online)	2040-2058
ISSN	1359-6535
DOI	10.3851/IMP2254
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Zs.A 4877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Hepatitis B reverse seroconversion in a patient with well controlled HIV infection: a case report and a review of the literature.

Schafer, Jason J / Formella, Danielle / Desimone, Joseph A

AIDS (London, England)

2015 Volume 29, Issue 2, Page(s) 246–248

MeSH term(s)	Aged ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Protease Inhibitors/therapeutic use ; Hepatitis B/blood ; Hepatitis B/complications ; Hepatitis B/immunology ; Hepatitis B Antibodies/blood ; Hepatitis B Antigens/blood ; Humans ; Male ; Serologic Tests
Chemical Substances	HIV Protease Inhibitors ; Hepatitis B Antibodies ; Hepatitis B Antigens
Language	English
Publishing date	2015-01-14
Publishing country	England
Document type	Case Reports ; Letter ; Review
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000000532
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Article: Once-Daily, Single-Tablet Regimens For the Treatment of HIV-1 Infection.

Truong, William R / Schafer, Jason J / Short, William R

P & T : a peer-reviewed journal for formulary management

2015 Volume 40, Issue 1, Page(s) 44–55

Abstract: Once-daily, single-tablet regimens have become integral to the management of human immunodeficiency virus type 1 infection, partly because they may improve adherence due to a lower pill burden. This article reviews the single-tablet options. ...

Abstract	Once-daily, single-tablet regimens have become integral to the management of human immunodeficiency virus type 1 infection, partly because they may improve adherence due to a lower pill burden. This article reviews the single-tablet options.
Language	English
Publishing date	2015-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036637-4
ISSN	1052-1372
ISSN	1052-1372
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Article: Incidence and Severity of Drug Interactions Before and After Switching Antiretroviral Therapy to Bictegravir/Emtricitabine/Tenofovir Alafenamide in Treatment-Experienced Patients.

Schafer, Jason J / Pandit, Neha S / Cha, Agnes / Huesgen, Emily / Badowski, Melissa / Sherman, Elizabeth M / Cocohoba, Jennifer / Shimada, Ayako / Keith, Scott W

Open forum infectious diseases

2020 Volume 8, Issue 1, Page(s) ofaa625

Abstract: Background: Switching antiretroviral therapy (ART) in people with HIV (PWH) can influence their risk for drug-drug interactions (DDIs). The purpose of this study was to assess changes in the incidence and severity of DDIs among PWH who switched their ... ...

Abstract	Background: Switching antiretroviral therapy (ART) in people with HIV (PWH) can influence their risk for drug-drug interactions (DDIs). The purpose of this study was to assess changes in the incidence and severity of DDIs among PWH who switched their ART to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). Methods: This was a multicenter retrospective cohort study of PWH on ART and at least 1 concomitant medication (CM) who switched to BIC/FTC/TAF between 3/2018 and 6/2019. Using the University of Liverpool's HIV Drug Interaction Database, 2 DDI analyses were performed for each patient. The first assessed patients' preswitch ART regimens with their CM list. The second assessed the same CM list with BIC/FTC/TAF. Each ART-CM combination was given a score of 0 (no or potential weak interaction), 1 (potential interaction), or 2 (contraindicated interaction). A paired Results: Among 411 patients, 236 (57%) had at least 1 DDI present at baseline. On average, baseline DDI scores (SD) were 1.4 (1.8) and decreased by 1 point (95% CI, -1.1 to -0.8) after patients switched to BIC/FTC/TAF ( Conclusions: Treatment-experienced PWH eligible to switch their ART may experience significant declines in number and severity of DDIs if switched to BIC/FTC/TAF.
Language	English
Publishing date	2020-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofaa625
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