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  1. Article ; Online: Precautionary Allergen Labeling: Avoidance for All?

    Schaible, Allison / Kabourek, Jamie / Elverson, Wendy / Venter, Carina / Cox, Amanda / Groetch, Marion

    Current allergy and asthma reports

    2024  Volume 24, Issue 3, Page(s) 81–94

    Abstract: Purpose of review: Precautionary allergen labeling (PAL) suggests the risk of unintended allergen presence (UAP) in food but is unregulated in most countries and inconsistently applied by food manufacturers. This review evaluates the current use of PAL, ...

    Abstract Purpose of review: Precautionary allergen labeling (PAL) suggests the risk of unintended allergen presence (UAP) in food but is unregulated in most countries and inconsistently applied by food manufacturers. This review evaluates the current use of PAL, its relevance to allergic consumers, and weighs possible advantages and disadvantages of avoiding products with PAL.
    Recent findings: In most countries, manufacturers are free to decide whether, when, and how to apply PAL resulting in inconsistencies and consumer confusion. Patients with food allergy often interpret PAL incorrectly and without guidance from their health care providers. Health care providers are also prone to misinterpreting PAL, indicating a need for better education. Consumers desire guidance on whether to avoid products with PAL or not. Until further regulatory guidance is available, shared decision-making between patient and provider is required to offer individualized, rather than one-size-fits-all, approaches to PAL.
    MeSH term(s) Humans ; Food Labeling ; Allergens ; Food Hypersensitivity/prevention & control ; Food ; Health Personnel
    Chemical Substances Allergens
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-024-01129-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5548: Show issues Location:
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  2. Article ; Online: Experience transitioning post-food allergy clinical trial participants to daily ingestion of retail food equivalents.

    Baker, Mary Grace / Cox, Amanda / Kattan, Jacob D / Oriel, Roxanne C / Tsuang, Angela / Agyemang, Amanda / Nowak-Wegrzyn, Anna / Flom, Julie D / Schaible, Allison / Groetch, Marion / Wang, Julie / Sicherer, Scott H

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 3, Page(s) 783–785.e2

    MeSH term(s) Humans ; Food Hypersensitivity ; Food ; Allergens ; Eating
    Chemical Substances Allergens
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.11.010
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    Zs.A 7086: Show issues Location:
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  3. Article ; Online: Successful baked egg and baked milk oral immunotherapy in a pediatric cohort.

    Zhang, Shouling / Kattan, Jacob D / Baker, Mary Grace / Oriel, Roxanne C / Tsuang, Angela J / Sicherer, Scott H / Schaible, Allison M / Groetch, Marion E / Cox, Amanda L

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 2, Page(s) 661–663.e3

    MeSH term(s) Child ; Humans ; Animals ; Milk ; Egg Hypersensitivity/therapy ; Cooking ; Immunotherapy ; Milk Hypersensitivity/therapy ; Allergens/therapeutic use
    Chemical Substances Allergens
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.039
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  4. Article ; Online: Retail Food Equivalents for Post-Oral Immunotherapy Dosing in the Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy in Food-Allergic Children and Adults (OUtMATCH) Clinical Trial.

    Groetch, Marion / Mudd, Kim / Woch, Margaret / Schaible, Allison / Gray, Brianna E / Babineau, Denise C / Bird, J Andrew / Jones, Stacie / Kim, Edwin H / Lanser, Bruce J / Poyser, Julian / Rogers, Nicole / Shreffler, Wayne / Sicherer, Scott / Spergel, Amanda K Rudman / Spergel, Jonathan / Vickery, Brian P / Chinthrajah, R Sharon / Wood, Robert

    The journal of allergy and clinical immunology. In practice

    2022  Volume 11, Issue 2, Page(s) 572–580.e2

    Abstract: Background: Patients with food allergy may be advised to introduce specific foods into their diets, both to increase tolerance gradually and as next steps after completing oral immunotherapy or other therapeutic interventions. However, the safe use of ... ...

    Abstract Background: Patients with food allergy may be advised to introduce specific foods into their diets, both to increase tolerance gradually and as next steps after completing oral immunotherapy or other therapeutic interventions. However, the safe use of retail foods depends on the ability to establish the specific allergen protein content of these foods.
    Objective: To develop a systematic approach to estimate the protein content of peanut, milk, egg, wheat, cashew, hazelnut, and walnut in a variety of retail food equivalents for each allergen and associated patient education materials.
    Method: We created an algorithm that used a multistep process with information from product food labels, nutrient databases, independent weighing and measuring of foods, and information provided by manufacturers, including certificates of analysis, and e-mail communication to estimate the allergen protein content of multiple retail foods for each of seven allergens. Once a variety of retail food equivalents for each allergen and allergen serving size was determined, we developed participant education handouts, which were reviewed by study teams at 10 food allergy centers, the National Institute of Allergy and Infectious Diseases, and the Consortium for Food Allergy Research coordinating center. After 1 year of use, multiple queries were addressed and the retail food equivalents and educational materials were reviewed and edited.
    Results: We identified a variety of retail food equivalents for seven allergens at six serving sizes, and created 48 unique patient education materials.
    Conclusion: Our results provide extensive guidance on a variety of retail equivalents for seven foods, and a method to estimate retail food protein equivalents systematically with ongoing reassessment.
    MeSH term(s) Adult ; Child ; Humans ; Allergens/therapeutic use ; Desensitization, Immunologic/methods ; Food Hypersensitivity/drug therapy ; Nuts ; Omalizumab/therapeutic use
    Chemical Substances Allergens ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.022
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  5. Article ; Online: Educational resources received by families after successful baked egg/baked milk oral food challenge: An international survey.

    Hicks, Allison G / Pickett, Kaci / Casale, Thomas B / Cassimos, Dimitrios / Elverson, Wendy / Gerdts, Jennifer / Gray, Sarah / Jones, Carla / LeBovidge, Jennifer / Levin, Michael / Mack, Douglas P / Minshall, Eleanor / Nowak-Wegrzyn, Anna / Pistiner, Michael / Protudjer, Jennifer L P / Said, Maria / Schaible, Allison / Smith, Pete / Vassilopoulou, Emilia /
    Venter, Carina

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 12, Page(s) 3328–3332.e2

    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.08.055
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  6. Article ; Online: Cord blood units with low CD34+ cell viability have a low probability of engraftment after double unit transplantation.

    Scaradavou, Andromachi / Smith, Katherine M / Hawke, Rebecca / Schaible, Allison / Abboud, Michelle / Kernan, Nancy A / Young, James W / Barker, Juliet N

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2009  Volume 16, Issue 4, Page(s) 500–508

    Abstract: Double unit cord blood (CB) transplantation (CBT) appears to augment engraftment despite only one unit engrafting in most patients. We hypothesized that superior unit quality, as measured by a higher percentage of viable cells postthaw, would determine ... ...

    Abstract Double unit cord blood (CB) transplantation (CBT) appears to augment engraftment despite only one unit engrafting in most patients. We hypothesized that superior unit quality, as measured by a higher percentage of viable cells postthaw, would determine the engrafting unit. Therefore, we prospectively analyzed 46 double-unit transplants postthaw using flow cytometry with modified gating that included all dead cells. Using a 75% threshold (mean viability minus 2 SD), 20% of units had low CD34+ cell viability, with viability varying according to the bank of origin. Further, in the 44 patients with single unit engraftment, CD34+ cell viability was higher in engrafting units (P=.0016). Although either unit engrafted if both had high CD34+ viability, units with <75% viability were very unlikely to engraft: in 16 patients who received one high and one low CD34+ viability unit, only 1 of 16 units with viability <75% engrafted (P=.0006). Further, in the single patient without engraftment of either unit, both had CD34+ viability <75%. Finally, poor CD34+ viability correlated with lower colony forming units (CFUs) (P=.02). Our data suggests one mechanism by which double unit CBT can improve engraftment is by increasing the probability of transplanting at least one unit with adequate viability and the potential to engraft.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antigens, CD34/blood ; Antigens, CD34/immunology ; Blood Preservation ; Cell Survival/immunology ; Child ; Cord Blood Stem Cell Transplantation/methods ; Female ; Fetal Blood/cytology ; Fetal Blood/immunology ; Flow Cytometry ; Humans ; Leukemia/blood ; Leukemia/therapy ; Lymphoma/blood ; Lymphoma/therapy ; Male ; Middle Aged ; Postoperative Complications ; Prospective Studies ; Transplantation Conditioning ; Transplantation, Homologous ; Treatment Outcome ; Young Adult
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2009-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2009.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  7. Article ; Online: A "no-wash" albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactions.

    Barker, Juliet N / Abboud, Michelle / Rice, Robert D / Hawke, Rebecca / Schaible, Allison / Heller, Glenn / La Russa, Vincent / Scaradavou, Andromachi

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2009  Volume 15, Issue 12, Page(s) 1596–1602

    Abstract: Preparation of cord blood (CB) units for infusion by albumin-dextran dilution without centrifugation may be advantageous for adult patients to minimize cell loss and, unlike a bedside thaw, is still conducted in the controlled laboratory environment. ... ...

    Abstract Preparation of cord blood (CB) units for infusion by albumin-dextran dilution without centrifugation may be advantageous for adult patients to minimize cell loss and, unlike a bedside thaw, is still conducted in the controlled laboratory environment. Therefore, we studied CB transplantation (CBT) using this technique in 54 consecutive CBT recipients >20 kg. Patients (median age=42 years [range: 7-66 years]; median weight=71 kg [range: 24-109]) were transplanted for high-risk hematologic malignancies with myeloablative (n=35) or nonmyeloablative (n=19) conditioning and 4-6/6 human leukocyte antigen (HLA)-matched double-unit grafts. One hundred seven units were thawed with dilution, whereas 1 red blood cell (RBC)-replete unit was washed. A 5:1 dextran 40%/25% albumin solution was used. RBC-depleted units (n=104) were diluted >or=5.5-fold (median final volume 200 mL [range: 200-500]), whereas RBC-replete units (n=3) were diluted >or=4-fold (median final volume 400 mL [range: 400-535]). Total nucleated cell (TNC) recovery was 86%; the median infused TNC dose was 2.17x10(7)/kg/unit. Although 35 patients (65%) had a total of 45 infusion reactions (6 nausea, 31 hypertension, 3 pain, 1 rigors/fever, 2 transient hypoxia, 2 renal impairment) requiring additional therapy, there were no infusion-related serious adverse events, and reactions were not related to dimethyl sulfoxide (DMSO) dose/kg. Cumulative incidence of sustained donor engraftment was 94% (95% cumulative incidence [CI]: 87-100) with neutrophil recovery occurring at a median of 25 days (range: 13-43) in myeloablative and 10 days (range: 7-36) in nonmyeloablative recipients. CB thaw with albumin-dextran dilution reduces unit manipulation, and minimizes cell loss, speeds time to infusion, is associated with a tolerable infusion reaction profile, and a high rate of sustained engraftment in CBT recipients >or=20 kg.
    MeSH term(s) Adolescent ; Adult ; Aged ; Albumins ; Blood Preservation/methods ; Child ; Cord Blood Stem Cell Transplantation/adverse effects ; Cord Blood Stem Cell Transplantation/methods ; Cryopreservation/methods ; Dextrans ; Dimethyl Sulfoxide ; Female ; Fetal Blood ; Humans ; Male ; Middle Aged ; Prospective Studies ; Young Adult
    Chemical Substances Albumins ; Dextrans ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2009-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2009.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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