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  1. AU="Schaller, Benoit"
  2. AU="Hernandez, A"
  3. AU="Nguyen, Thien H"
  4. AU="Park, Jung Wan"
  5. AU="Mahajan, Aman"
  6. AU="Hao, Yanling"
  7. AU="Eing, Lorenz"
  8. AU="Geoffroy, Pierre A"
  9. AU="Chapuis, J"
  10. AU="Berta, László"
  11. AU="Barzilay, Regina"
  12. AU="Schmidt, Michael Rahbek"
  13. AU=Tack J
  14. AU="Oh, Hye Min"
  15. AU=Gaffen Sarah L AU=Gaffen Sarah L
  16. AU="Schmitt, Christine"
  17. AU="McKay, Jackie"
  18. AU="Bellissimo, Catherine A"
  19. AU="Desai, Urja"
  20. AU="Chini, Maria Giovanna"
  21. AU="Xiao, Difei"
  22. AU="Ryan, Chris"
  23. AU="Omar Bazighifan"
  24. AU="Corominas Galbany, Jordi"
  25. AU=Fox Norma E
  26. AU="Hamilton, Shelia M"
  27. AU="Nichols, J Wylie"
  28. AU="Pesce R."
  29. AU="Gambitta, P"
  30. AU="Imran, Aqeel"
  31. AU="Sharma, Yashoda"
  32. AU="Kosai, Jordyn"
  33. AU="Aroca Ferri, María"
  34. AU="Laba, Stephanie"
  35. AU="Kim, Ye-Sel"

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  1. Artikel: Free Tissue Transfer in Head and Neck Reconstruction: A Multidisciplinary 15-Year Experience.

    Papanikolaou, Athanasios / Guarino, Laetitia / Giger, Roland / Schaller, Benoît / Constantinescu, Mihai / Olariu, Radu / Lese, Ioana

    Clinics and practice

    2023  Band 13, Heft 4, Seite(n) 820–829

    Abstract: Background: Free tissue transfer is considered the gold standard in reconstruction of extensive defects in head and neck surgery. The aim of this 15-year retrospective study is to analyze the outcomes of free tissue transfers in the head and neck area ... ...

    Abstract Background: Free tissue transfer is considered the gold standard in reconstruction of extensive defects in head and neck surgery. The aim of this 15-year retrospective study is to analyze the outcomes of free tissue transfers in the head and neck area in a tertiary referral university hospital.
    Materials and methods: A retrospective, single-center study of all patients undergoing free tissue transfers for head and neck reconstruction between 2006 and 2020 was performed. Patient demographics, comorbidities, flap characteristics, outcomes and complications were assessed.
    Results: A total of 353 free flaps were performed. The most common defect etiology was synchronous oncologic resection (74.2%). The majority of patients had at least one comorbidity (70.3%), with smoking recorded in 46.2% of the cases and alcohol consumption in 31.7%. The anterolateral thigh flap was the most commonly used flap (37.7%), followed by the osteoseptocutaneous fibula flap (26.9%). Our overall flap success rate was 97.7%, while the overall complication rate was 45.9%.
    Conclusions: Free tissue transfer in head and neck reconstruction is reliable. However, complication rates remain high due to the complexity of such cases and frequent presence of comorbidities. Nonetheless, when effectively managed within a multidisciplinary team, complications rarely jeopardize the overall reconstruction outcome.
    Sprache Englisch
    Erscheinungsdatum 2023-07-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2605724-4
    ISSN 2039-7283 ; 2039-7275
    ISSN (online) 2039-7283
    ISSN 2039-7275
    DOI 10.3390/clinpract13040074
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  2. Artikel: Prevalence of Peri-Implantitis in Implants with Turned and Rough Surfaces: a Systematic Review.

    Saulacic, Nikola / Schaller, Benoit

    Journal of oral & maxillofacial research

    2019  Band 10, Heft 1, Seite(n) e1

    Abstract: Objectives: Moderately-rough implant surface may improve implant therapy in terms of bone integration, but the increased surface roughness might affect the initiation and development of peri-implantitis. The aim of the present review was to compare the ... ...

    Abstract Objectives: Moderately-rough implant surface may improve implant therapy in terms of bone integration, but the increased surface roughness might affect the initiation and development of peri-implantitis. The aim of the present review was to compare the prevalence of peri-implantitis in implants with rough and turned (machined) implant surfaces.
    Material and methods: An electronic literature search was conducted of the MEDLINE and EMBASE databases for articles published between 1 January 1990 and 1 March 2018. Clinical human studies in the English language that had reported on prevalence of peri-implantitis in tuned and rough surface implants were searched. The initial search resulted in 690 articles.
    Results: Eight articles with 2992 implants were included in the systematic review. The incidence of peri-implantitis for two implant surfaces varied between studies. A meta-analysis was not feasible due to the heterogeneity among studies. Implant with rough surfaces were more favourable for plaque accumulation during short-term follow-up. On a long-term, turned implants surfaces were associated with more plaque and higher peri-implant bone loss. Peri-implant clinical parameters and survival rate for two implant surfaces was similar.
    Conclusions: Within the limitations of the present study, rough implant surface does not seem to increase the incidence of peri-implantitis in comparison to turned implants surface.
    Sprache Englisch
    Erscheinungsdatum 2019-03-31
    Erscheinungsland Lithuania
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2580511-3
    ISSN 2029-283X
    ISSN 2029-283X
    DOI 10.5037/jomr.2019.10101
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Pentoxifyllin und Tocopherol. Die Bedeutung in der Behandlung der Osteoradionekrose – Literaturreview und Fallbericht.

    Marjanowski, Simon David / Maldonado, Alejandra / Schaller, Benoît / Burkhard, John-Patrik Matthias

    Swiss dental journal

    2021  Band 131, Heft 9, Seite(n) 713–718

    Abstract: Osteoradionecrosis (ORN) is a serious complication after radiotherapy for head and neck cancer and is a challenging condition for both the therapist and the patient because of its difficult treatment. Different non-invasive approaches have been published ...

    Titelübersetzung Pentoxifylline and tocopherol - The importance in the treatment of osteoradionecrosis - Literature review and case report.
    Abstract Osteoradionecrosis (ORN) is a serious complication after radiotherapy for head and neck cancer and is a challenging condition for both the therapist and the patient because of its difficult treatment. Different non-invasive approaches have been published for the treatment of low-grade ORN cases without establishing a standard regimen for treatment. Based on the approach of ORN pathogenesis, the so-called radiatio-induced fibroathrophic process (RIF), a new treatment concept with pentoxifylline and tocopherol (PENTO) has been published. The results of PENTO therapy seem promising as a conservative treatment approach for mild ORN or as an alternative when surgical intervention is not possible or desired. The present study summarizes the current state of the literature and shows the effectiveness of PENTO therapy based on a case report.
    Mesh-Begriff(e) Head and Neck Neoplasms ; Humans ; Osteoradionecrosis/drug therapy ; Pentoxifylline/therapeutic use ; Tocopherols/therapeutic use
    Chemische Substanzen Tocopherols (R0ZB2556P8) ; Pentoxifylline (SD6QCT3TSU)
    Sprache Deutsch
    Erscheinungsdatum 2021-09-01
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 2754538-6
    ISSN 2296-6498
    ISSN 2296-6498
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.

    Toneatti, Daniel Jan / Graf, Ronny Roger / Burkhard, John-Patrik / Schaller, Benoît

    Clinical oral investigations

    2021  Band 25, Heft 10, Seite(n) 5579–5593

    Abstract: Objectives: This systematic review assesses dental implant survival, calculates the incidence rate of osteoradionecrosis, and evaluates risk factors in irradiated head and neck cancer patients.: Materials and methods: Various databases (e.g., Medline/ ...

    Abstract Objectives: This systematic review assesses dental implant survival, calculates the incidence rate of osteoradionecrosis, and evaluates risk factors in irradiated head and neck cancer patients.
    Materials and methods: Various databases (e.g., Medline/Embase using Ovid) and gray literature platforms were searched using a combination of keywords and subject headings. When appropriate, meta-analysis was carried out using a random effects model. Otherwise, pooled analysis was applied.
    Results: A total of 425 of the 660 included patients received radiotherapy. In total, 2602 dental implants were placed, and 1637 were placed in irradiated patients. Implant survival after an average follow-up of 37.7 months was 97% (5% confidence interval, CI 95.2%, 95% CI 98.3%) in nonirradiated patients and 91.9% (5% CI 87.7%, 95% CI: 95.3%) after an average follow-up of 39.8 months in irradiated patients. Osteoradionecrosis occurred in 11 cases, leading to an incidence of 3% (5% CI 1.6%, 95% CI 4.9%). The main factors impacting implant survival were radiation and grafting status, while factors influencing osteoradionecrosis could not be determined using meta-analysis.
    Conclusion: Our data show that implant survival in irradiated patients is lower than in nonirradiated patients, and osteoradionecrosis is-while rare-a serious complication that any OMF surgeon should be prepared for. The key to success could be a standardized patient selection and therapy to improve the standard of care, reduce risks and shorten treatment time.
    Clinical relevance: Our analysis provides further evidence that implant placement is a feasible treatment option in irradiated head and neck cancer patients with diminished oral function and good long-term cancer prognosis.
    Mesh-Begriff(e) Dental Implantation, Endosseous ; Dental Implants ; Head and Neck Neoplasms/radiotherapy ; Humans ; Osteoradionecrosis/etiology
    Chemische Substanzen Dental Implants
    Sprache Englisch
    Erscheinungsdatum 2021-08-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-021-04065-6
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  5. Artikel ; Online: Addition of Synthetic Biomaterials to Deproteinized Bovine Bone Mineral (DBBM) for Bone Augmentation-A Preclinical In Vivo Study.

    Fujioka-Kobayashi, Masako / Katagiri, Hiroki / Lang, Niklaus P / Imber, Jean-Claude / Schaller, Benoit / Saulacic, Nikola

    International journal of molecular sciences

    2022  Band 23, Heft 18

    Abstract: 1) Aim: To investigate the effect of synthetic bone substitutes, α-tricalcium phosphate (α-TCP) or bi-layered biphasic calcium-phosphate (BBCP) combined with deproteinized bovine bone mineral (DBBM), on bone formation. (2) Methods: Thirty critical size ... ...

    Abstract (1) Aim: To investigate the effect of synthetic bone substitutes, α-tricalcium phosphate (α-TCP) or bi-layered biphasic calcium-phosphate (BBCP) combined with deproteinized bovine bone mineral (DBBM), on bone formation. (2) Methods: Thirty critical size defects were randomly treated with the following five different treatment modalities: (1) negative control (NC, empty), (2) DBBM, (3) α-TCP + DBBM (1:1), (4) BBCP 3%HA/97%α-TCP + DBBM (1:1), and (5) BBCP 6%HA/94%α-TCP + DBBM (1:1). The samples, at four weeks post-surgery, were investigated by micro-CT and histological analysis. (3) Results: A similar level of new bone formation was demonstrated in the DBBM with α-TCP bone substitute groups when compared to the negative control by histomorphometry. DBBM alone showed significantly lower new bone area than the negative control (
    Mesh-Begriff(e) Animals ; Cattle ; Biocompatible Materials/pharmacology ; Biological Products ; Bone Regeneration ; Bone Substitutes/pharmacology ; Bone Substitutes/therapeutic use ; Calcium/pharmacology ; Calcium Phosphates/pharmacology ; Hydroxyapatites ; Minerals/pharmacology
    Chemische Substanzen alpha-tricalcium phosphate ; Biocompatible Materials ; Biological Products ; bone meal (TRS31EO6ZN) ; Bone Substitutes ; Calcium (SY7Q814VUP) ; Calcium Phosphates ; hydroxyapatite-beta tricalcium phosphate ; Hydroxyapatites ; Minerals
    Sprache Englisch
    Erscheinungsdatum 2022-09-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810516
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  6. Artikel ; Online: Osteoclast behaviors on the surface of deproteinized bovine bone mineral and carbonate apatite substitutes in vitro.

    Fujioka-Kobayashi, Masako / Miyamoto, Youji / Ishikawa, Kunio / Satomi, Takafumi / Schaller, Benoit

    Journal of biomedical materials research. Part A

    2022  Band 110, Heft 8, Seite(n) 1524–1532

    Abstract: The present study investigated the osteoclast differentiation potential and paracrine effects of osteoclasts on osteoblast differentiation when the cells were cultured directly on two bone substitutes (BSs): deproteinized bovine bone mineral (DBBM) and ... ...

    Abstract The present study investigated the osteoclast differentiation potential and paracrine effects of osteoclasts on osteoblast differentiation when the cells were cultured directly on two bone substitutes (BSs): deproteinized bovine bone mineral (DBBM) and carbonate apatite (CO
    Mesh-Begriff(e) Animals ; Apatites/pharmacology ; Bone Substitutes/pharmacology ; Cattle ; Cell Differentiation ; Humans ; Minerals ; Osteoblasts ; Osteoclasts ; RNA, Messenger/genetics
    Chemische Substanzen Apatites ; Bone Substitutes ; Minerals ; RNA, Messenger ; carboapatite (55326-60-8)
    Sprache Englisch
    Erscheinungsdatum 2022-04-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37392
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  7. Artikel ; Online: Reply to Potential Issues With the Use of Teriparatide After Denosumab-Related Osteonecrosis of the Jaw.

    Everts-Graber, Judith / Burkhard, John-Patrik / Schaller, Benoît / Reichenbach, Stephan / Lehmann, Thomas

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2022  Band 37, Heft 10, Seite(n) 2046–2047

    Mesh-Begriff(e) Humans ; Teriparatide/adverse effects ; Denosumab/adverse effects ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging ; Bisphosphonate-Associated Osteonecrosis of the Jaw/drug therapy ; Osteonecrosis/chemically induced ; Osteonecrosis/diagnostic imaging ; Osteonecrosis/drug therapy
    Chemische Substanzen Teriparatide (10T9CSU89I) ; Denosumab (4EQZ6YO2HI)
    Sprache Englisch
    Erscheinungsdatum 2022-08-04
    Erscheinungsland United States
    Dokumenttyp Letter ; Comment
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4656
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    Zs.A 2142: Hefte anzeigen Standort:
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  8. Artikel ; Online: The impact of the size of bone substitute granules on macrophage and osteoblast behaviors in vitro.

    Fujioka-Kobayashi, Masako / Katagiri, Hiroki / Kono, Michihide / Schaller, Benoit / Iizuka, Tateyuki / Safi, Ali-Farid

    Clinical oral investigations

    2021  Band 25, Heft 8, Seite(n) 4949–4958

    Abstract: Objective: Bone substitute (BS) size might influence the clinical outcomes of guided bone regeneration (GBR) procedures. The aim of the present study was to investigate the influence of BS size on macrophage (Mφ) and osteoblast behaviors in vitro.: ... ...

    Abstract Objective: Bone substitute (BS) size might influence the clinical outcomes of guided bone regeneration (GBR) procedures. The aim of the present study was to investigate the influence of BS size on macrophage (Mφ) and osteoblast behaviors in vitro.
    Materials and methods: Two different granule sizes (S and M/L) were assessed for four different commercial BSs: deproteinized bovine bone mineral (DBBM), biphasic calcium phosphate type 1 (BCP1), BCP type 2 (BCP2), and carbonate apatite (CO
    Results: The smaller granules showed higher material volumes and surface areas than the larger granules. Significantly higher viability of Mφs and Saos-2 cells was observed with the DBBM_L-size granules than with the DBBM_S-size granules. Gene expression experiments in Mφs revealed few differences between the two sizes of each BS, although higher CD206 mRNA levels were observed in the BCP1_L group and the CO
    Conclusions: The S-size and L-size DBBM granules exhibited clear differences in cell outcomes: cells cultured on the S-size granules exhibited lower cell viability, higher osteopromotive ability, and no noticeable Mφ polarization changes.
    Clinical relevance: A smaller granule size might be advantageous due to greater bone regeneration potential in the use of DBBM granules to treat defects.
    Mesh-Begriff(e) Animals ; Bone Regeneration ; Bone Substitutes/pharmacology ; Cattle ; Humans ; Macrophages ; Osteoblasts ; Osteogenesis
    Chemische Substanzen Bone Substitutes
    Sprache Englisch
    Erscheinungsdatum 2021-02-04
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-021-03804-z
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  9. Artikel: In Vitro Comparison of Macrophage Polarization and Osteoblast Differentiation Potentials between Granules and Block Forms of Deproteinized Bovine Bone Mineral.

    Fujioka-Kobayashi, Masako / Marjanowski, Simon D / Kono, Michihide / Katagiri, Hiroki / Miron, Richard J / Schaller, Benoit

    Materials (Basel, Switzerland)

    2020  Band 13, Heft 12

    Abstract: Deproteinized bovine bone mineral (DBBM) bone grafts are commonly utilized for guided bone regeneration (GBR) techniques in regenerative dentistry. It has been hypothesized that different forms (blocks versus particulates) might demonstrate the varying ... ...

    Abstract Deproteinized bovine bone mineral (DBBM) bone grafts are commonly utilized for guided bone regeneration (GBR) techniques in regenerative dentistry. It has been hypothesized that different forms (blocks versus particulates) might demonstrate the varying properties of cell behavior during the regenerative process. Therefore, the aim of the present study was to investigate DBBM granules and blocks for their effects on osteoblasts and macrophages (Mφs). DBBM granules and blocks were filled to the same size (φ6.4 mm in diameter × 2.0 mm in height) in cell culture wells and assessed for cell viability and cell differentiation of human osteoblast-like Saos-2 cells, and Mφs derived from human monocyte THP-1 cells. The two groups were first characterized by micro-CT analysis, which demonstrated that DBBM granules had a two-fold greater material volume and a four-fold larger surface area than the blocks. DBBM blocks showed superior viability for both osteoblasts and Mφs. Osteoblast experiments were then utilized to better characterize the influence of DBBM shapes/forms on osteoblast differentiation. Alkaline phosphatase (ALP) staining on the undecalcified frozen sections was observed throughout the DBBM granule surface, yet this staining was only observed on the upper portion of the DBBM blocks. Furthermore, DBBM blocks showed M1-Mφ polarization trends with higher IL-1 and IL-6 mRNA expression in Mφs, while the conditioned media from Mφs cultured on DBBM granules promoted osteoblast differentiation with higher mRNA levels of Runx 2, ALP and osteocalcin. In conclusion, the DBBM granules showed more regenerative effects, lower M1 marker expression, and higher osteoblast differentiation potential when compared with the blocks, which might be related to the larger material volume, higher surface area and greater ability for the cells to penetrate through the scaffold.
    Sprache Englisch
    Erscheinungsdatum 2020-06-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13122682
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Cytotoxicity and Gene Expression Changes of a Novel Homeopathic Antiseptic Oral Rinse in Comparison to Chlorhexidine in Gingival Fibroblasts.

    Fujioka-Kobayashi, Masako / Schaller, Benoit / Pikos, Michael A / Sculean, Anton / Miron, Richard J

    Materials (Basel, Switzerland)

    2020  Band 13, Heft 14

    Abstract: Most available antiseptic solutions available today have strong antibacterial effects, however most also possess major cytotoxic effects on human gingival tissues. The VEGA Oral Care Recovery Kit (StellaLife), previously evaluated in clinical studies, ... ...

    Abstract Most available antiseptic solutions available today have strong antibacterial effects, however most also possess major cytotoxic effects on human gingival tissues. The VEGA Oral Care Recovery Kit (StellaLife), previously evaluated in clinical studies, consists of 16 active ingredients that are monographed in the Homeopathic Pharmacopeia of United States (HPUS) and recognized for their accelerated healing properties (reduction in post-op pain). The aim of this study was to compare VEGA to chlorhexidine (CHX) in vitro on gingival fibroblast viability, survival at various concentrations, migration assay, proliferation activity, expression of both regenerative growth factors as well as inflammatory markers, and collagen synthesis. A 10-fold dilution of standard CHX (0.02%) led to cell death, whereas cell viability was significantly better in the VEGA group for all tested parameters. Furthermore, VEGA also induced significantly greater fibroblast migration and proliferation. CHX negatively impacted the cellular inflammatory response of gingival fibroblasts, and also led to a reduction in collagen synthesis (50% decrease). Findings from the present study provide support from basic laboratory experiments that validate the previous clinical studies supporting the use of the VEGA oral rinse on its superior biocompatibility and wound healing properties when compared to CHX.
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13143190
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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