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  1. Book: The management of Parkinson's disease - what is new?

    Schapira, Anthony H. V.

    (European journal of neurology ; 18, Suppl. 1)

    2011  

    Author's details guest ed.: A. H. V. Schapira
    Series title European journal of neurology ; 18, Suppl. 1
    Collection
    Language English
    Size 21 S. : graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016743519
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4738 -18,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: The Gut Microbiota in Parkinson Disease: Interactions with Drugs and Potential for Therapeutic Applications.

    Menozzi, Elisa / Schapira, Anthony H V

    CNS drugs

    2024  Volume 38, Issue 5, Page(s) 315–331

    Abstract: The concept of a 'microbiota-gut-brain axis' has recently emerged as an important player in the pathophysiology of Parkinson disease (PD), not least because of the reciprocal interaction between gut bacteria and medications. The gut microbiota can ... ...

    Abstract The concept of a 'microbiota-gut-brain axis' has recently emerged as an important player in the pathophysiology of Parkinson disease (PD), not least because of the reciprocal interaction between gut bacteria and medications. The gut microbiota can influence levodopa kinetics, and conversely, drugs administered for PD can influence gut microbiota composition. Through a two-step enzymatic pathway, gut microbes can decarboxylate levodopa to dopamine in the small intestine and then dehydroxylate it to m-tyramine, thus reducing availability. Inhibition of bacterial decarboxylation pathways could therefore represent a strategy to increase levodopa absorption. Other bacterial perturbations common in PD, such as small intestinal bacterial overgrowth and Helicobacter pylori infection, can also modulate levodopa metabolism, and eradication therapies may improve levodopa absorption. Interventions targeting the gut microbiota offer a novel opportunity to manage disabling motor complications and dopa-unresponsive symptoms. Mediterranean diet-induced changes in gut microbiota composition might improve a range of non-motor symptoms. Prebiotics can increase levels of short-chain fatty acid-producing bacteria and decrease pro-inflammatory species, with positive effects on clinical symptoms and levodopa kinetics. Different formulations of probiotics showed beneficial outcomes on constipation, with some of them improving dopamine levels; however, the most effective dosage and duration and long-term effects of these treatments remain unknown. Data from faecal microbiota transplantation studies are preliminary, but show encouraging trends towards improvement in both motor and non-motor outcomes.This article summarises the most up-to-date knowledge in pharmacomicrobiomics in PD, and discusses how the manipulation of gut microbiota represents a potential new therapeutic avenue for PD.
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Gastrointestinal Microbiome/physiology ; Levodopa/pharmacology ; Dopamine ; Helicobacter Infections ; Helicobacter pylori
    Chemical Substances Levodopa (46627O600J) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-04-03
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.1007/s40263-024-01073-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4083: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Parkinsonian disorders in clinical practice

    Schapira, Anthony H. V.

    2009  

    Author's details ed. by Anthony H. V. Schapira
    Keywords Parkinson Disease / physiopathology ; Parkinson Disease / therapy ; Antiparkinson Agents / therapeutic use
    Language English
    Size XII, 196 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016039974
    ISBN 978-1-4051-9601-7 ; 1-4051-9601-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 3918 order for loan Magazin

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  4. Book: The scientific and clinical basis for future therapies in Parkinson´s disease

    Schapira, Anthony H. V.

    (European journal of neurology ; 15, Suppl. 1)

    2008  

    Author's details guest ed.: Anthony H. V. Schapira
    Series title European journal of neurology ; 15, Suppl. 1
    Collection
    Language English
    Size 25 S.
    Publisher Blackwell Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015500991
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4738 -15,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  5. Book: Neurology and clinical neuroscience

    Schapira, Anthony H. V.

    2007  

    Author's details ed. Anthony H. V. Schapira
    Keywords Nervous System Diseases ; Neurology
    Language English
    Size XXVI, 1626 S. : Ill., graph. Darst.
    Publisher Mosby Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note Systemvoraussetzungen: Windows: 800 x 600 pixels screen resolution; 256 colors; 128 MB RAM; Windows 98SE, 2000 or XP operating system; Internet Explorer 6.0, Netscape 7 or later and Firefox 1.x. - Macintosh: 800 x 600 pixels screen resolution; 256 colors; 128 MB RAM; MAC OS 10.2 or later operating system; Safari 1.x or later and Firefox 1.x
    Accompanying material 1 CD-ROM (12 cm) + Begleith. (6 S.)
    HBZ-ID HT014975322
    ISBN 0-323-03354-7 ; 978-0-323-03354-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 1784 order for loan Magazin
    2007 MO 162 <<[Begleitmaterial]>> order for loan Magazin

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  6. Book: Restless legs syndrome

    Schapira, Anthony H. V.

    (European journal of neurology ; 13, Suppl. 3)

    2006  

    Author's details guest ed.: Anthony H. V. Schapira
    Series title European journal of neurology ; 13, Suppl. 3
    Collection
    Language English
    Size 30 S. : Ill., graph. Darst.
    Publisher Blackwell Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014878697
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4738 -13,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  7. Book: Progress in Parkinson's disease

    Schapira, Anthony H. V.

    (Neurology ; 61,6, Suppl. 3)

    2003  

    Author's details A. H. V. Schapira, guest ed
    Series title Neurology ; 61,6, Suppl. 3
    Collection
    Language English
    Size S63 S. : graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT013810435
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 153 -61,Suppl.3- verfügbar in Königswinter Königswinter

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  8. Article ; Online: GBA

    Smith, Laura / Schapira, Anthony H V

    Cells

    2022  Volume 11, Issue 8

    Abstract: ... ...

    Abstract The
    MeSH term(s) Endoplasmic Reticulum/metabolism ; Glucosylceramidase/genetics ; Humans ; Lysosomes/metabolism ; Mutation/genetics ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Parkinson Disease/therapy ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
    Chemical Substances alpha-Synuclein ; GBA protein, human (EC 3.2.1.45) ; Glucosylceramidase (EC 3.2.1.45)
    Language English
    Publishing date 2022-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11081261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Conference proceedings: Current advances in Parkinson's disease

    Schapira, Anthony H. V.

    proceedings of a Meeting Current Advances in Parkinson's Disease: Challenges and Developments, Bath, UK, 9 - 10 March 2002

    (European journal of neurology ; 9, Suppl. 3)

    2002  

    Event/congress Meeting Current Advances in Parkinson's Disease: Challenges and Developments (2002, Bath)
    Author's details guest ed.: A. H. V. Schapira
    Series title European journal of neurology ; 9, Suppl. 3
    Collection
    Language English
    Size 67 S. : Ill., graph. Darst.
    Publisher Blackwell Science
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013545546
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4738 -9,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  10. Book: Mitochondrial disorders in neurology / 2

    Schapira, Anthony H. V.

    (Blue books of practical neurology ; 26)

    2002  

    Author's details ed. by Anthony H. V. Schapira
    Series title Blue books of practical neurology ; 26
    Mitochondrial disorders in neurology
    Collection Mitochondrial disorders in neurology
    Keywords Mitochondriopathie ; Nervensystem
    Subject Mitochondrium ; Mitochondriale Störung ; Systema nervosum ; NS
    Language English
    Size XV, 304 S. : Ill., graph. Darst.
    Publisher Butterworth Heinemann
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013359779
    ISBN 0-7506-7288-9 ; 978-0-7506-7288-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 2660 order for loan Magazin

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