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  1. Article ; Online: GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses.

    Krieg, Paula F / Sonner, Jana K / Kurelic, Roberta / Engler, Jan Broder / Scharenberg, Marlena F / Bauer, Simone / Nikolaev, Viacheslav O / Friese, Manuel A

    Frontiers in immunology

    2023  Volume 13, Page(s) 1113348

    Abstract: G-protein coupled receptors (GPCR) regulate 3',5'-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T cell (Teff) function as well as ... ...

    Abstract G-protein coupled receptors (GPCR) regulate 3',5'-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T cell (Teff) function as well as regulatory T cell (Treg)-mediated immunosuppression. Several GPCRs have been identified to be crucial for Teff and Treg function. However, the role of the orphan, constitutively active Gs-coupled GPCR GPR52 is unknown. Here we show that GPR52 regulates cAMP levels in T cells but does not affect T cell function. We found that stimulation of transfected HEK cells or primary T cells with a GPR52 agonist results in a rise of intracellular cAMP. However, neither
    MeSH term(s) Animals ; Cell Differentiation ; Cyclic AMP ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/agonists ; T-Lymphocytes, Regulatory ; Humans
    Chemical Substances Cyclic AMP (E0399OZS9N) ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1113348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: Characterization of incidence, prevalence, and treatment patterns of chronic lymphocytic leukemia based on German healthcare claims data

    Wartmann, Hannes / Schneller, Susanne / Scharenberg, Marlena / Struck, Karolin / Deiters, Barthold / Heidler, Tobias / Schmitz, Norbert / Volmer, Timm

    2022  , Page(s) 22gaa03

    Event/congress 29. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie; Münster; Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA); 2022
    Keywords Medizin, Gesundheit
    Publishing date 2022-11-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22gaa03
    Database German Medical Science

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  3. Article ; Online: Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.

    Brownlie, Demi / Scharenberg, Marlena / Mold, Jeff E / Hård, Joanna / Kekäläinen, Eliisa / Buggert, Marcus / Nguyen, Son / Wilson, Jennifer N / Al-Ameri, Mamdoh / Ljunggren, Hans-Gustaf / Marquardt, Nicole / Michaëlsson, Jakob

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 11

    Abstract: Human adaptive-like "memory" ... ...

    Abstract Human adaptive-like "memory" CD56
    MeSH term(s) Adaptation, Physiological/immunology ; Flow Cytometry ; Humans ; Immunophenotyping ; Integrin alpha1/immunology ; Killer Cells, Natural/immunology ; Lung/immunology ; Lung Neoplasms/immunology ; Lung Neoplasms/therapy
    Chemical Substances Integrin alpha1
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2016580118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

    Marquardt, Nicole / Kekäläinen, Eliisa / Chen, Puran / Lourda, Magda / Wilson, Jennifer N / Scharenberg, Marlena / Bergman, Per / Al-Ameri, Mamdoh / Hård, Joanna / Mold, Jeffrey E / Ljunggren, Hans-Gustaf / Michaëlsson, Jakob

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 3841

    Abstract: Human lung tissue-resident NK cells (trNK cells) are likely to play an important role in host responses towards viral infections, inflammatory conditions and cancer. However, detailed insights into these cells are still largely lacking. Here we show, ... ...

    Abstract Human lung tissue-resident NK cells (trNK cells) are likely to play an important role in host responses towards viral infections, inflammatory conditions and cancer. However, detailed insights into these cells are still largely lacking. Here we show, using RNA sequencing and flow cytometry-based analyses, that subsets of human lung CD69
    MeSH term(s) Aged ; Aged, 80 and over ; Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Datasets as Topic ; Female ; Humans ; Immunity, Mucosal ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lung/cytology ; Lung/immunology ; Lung/surgery ; Lung Diseases/immunology ; Lung Diseases/pathology ; Lung Diseases/surgery ; Male ; Middle Aged ; Pneumonectomy ; RNA-Seq ; Respiratory Mucosa/cytology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Transcriptome/immunology
    Language English
    Publishing date 2019-08-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-11632-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells.

    Scharenberg, Marlena / Vangeti, Sindhu / Kekäläinen, Eliisa / Bergman, Per / Al-Ameri, Mamdoh / Johansson, Niclas / Sondén, Klara / Falck-Jones, Sara / Färnert, Anna / Ljunggren, Hans-Gustaf / Michaëlsson, Jakob / Smed-Sörensen, Anna / Marquardt, Nicole

    Frontiers in immunology

    2019  Volume 10, Page(s) 1116

    Abstract: NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections. Here, we ... ...

    Abstract NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections. Here, we investigated the effects of IAV infection on human lung and peripheral blood NK cells
    MeSH term(s) Antigen Presentation ; Blood Circulation ; Bronchial Hyperreactivity/metabolism ; Cytotoxicity, Immunologic ; Humans ; Influenza A virus/physiology ; Influenza, Human/immunology ; K562 Cells ; Killer Cells, Natural/immunology ; Lung/physiology ; Lymphocyte Activation
    Language English
    Publishing date 2019-05-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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