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  1. Book ; Thesis: Die phototherapeutische Keratektomie bei Erkrankungen im Bereich der Hornhaut- und Skleraoberfläche mittels Excimer-Laser

    Scharf, Maria

    1993  

    Author's details vorgelegt von Scharf Maria
    Language German
    Size V, 92 Bl. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 1994
    HBZ-ID HT006521112
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    95 E 339 order for loan Magazin

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  2. Thesis ; Online: Investigations on the effects of conjugated linoleic acids and dietary concentrate proportion on performance and various physiological parameters of periparturient dairy cows and their calves

    Scharf, Maria

    2014  

    Abstract: Milchkühe unterliegen in der Frühlaktation einem Energiedefizit, das durch Körperfettmobilisierung kompensiert wird. Die milchfettreduzierenden Eigenschaften von trans-10,cis-12 CLA versprechen Energieeinsparungseffekte. Beobachtete CLA Effekte auf den ... ...

    Abstract Milchkühe unterliegen in der Frühlaktation einem Energiedefizit, das durch Körperfettmobilisierung kompensiert wird. Die milchfettreduzierenden Eigenschaften von trans-10,cis-12 CLA versprechen Energieeinsparungseffekte. Beobachtete CLA Effekte auf den Energie- und Fettstoffwechsel von Kühen sind uneinheitlich, wobei die Kombination einer CLA-Gabe in einer hoch konzentrierten im Vergleich zu einer angepassten Ration antepartum (ap) noch nicht untersucht wurde. Außerdem ist wenig über Effekte auf den Pansenstoffwechsel und einer mütterlichen CLA-Gabe auf Kälber bekannt. Es wurde eine Studie mit 64 trächtigen Kühen durchgeführt, um die genannten Parameter um die Abkalbung zu untersuchen. Der CLA-Zusatz in einer hochkonzentrierten Diät ap milderte das postpartale Energiedefizit durch erhöhte Futteraufnahmen, hatte aber keinen Effekt auf den Leber- und Fettstoffwechsel von peripartalen Kühen. CLA hatte einen minimalen Effekt auf den Pansenstoffwechsel und keinen Effekt auf die Kälber.

    Dairy cows are physiological subjected to an energy deficit during early lactation, which were compensated by the use of body fat reserves. The milk fat reducing properties of trans-10,cis-12 CLA suggests an energy-saving effect in cows. Observed CLA effects on energy and lipid metabolism of cows were contradictory, whereby a CLA addition in a high compared to an adequate concentrate proportion in the diet antepartum (ap) has not been investigated. Also less is known about CLA effects on rumen metabolism and maternal CLA effects on their offspring. A trial with 64 pregnant cows was conducted to study the mentioned topics around calving. Supplemented CLA in a high concentrate diet ap could alleviate the negative energy balance during early lactation via increasing dry matter intakes but seems to have no effect on metabolic situation, liver and lipid metabolism of periparturient cows. CLA had a minor effect on rumen metabolism. Maternal CLA supplementation did not have effects on calves.
    Keywords ddc:630 ; Konjugierte Linolsäuren; Konzentrat; Milchkuh; Kälber; Stoffwechsel; Energiebilanz; Fettstoffwechsel; Pansenfermentation ; Conjugated linoleic acids; concentrates; dairy cows; calves; metabolism; energy balance; lipid metabolism; rumen fermentation
    Language English
    Publishing date 2014-08-01
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Thesis ; Online: Investigations on the effects of conjugated linoleic acids and dietary concentrate proportion on performance and various physiological parameters of periparturient dairy cows and their calves

    Scharf, Maria

    2014  

    Abstract: Milchkühe unterliegen in der Frühlaktation einem Energiedefizit, das durch Körperfettmobilisierung kompensiert wird. Die milchfettreduzierenden Eigenschaften von trans-10,cis-12 CLA versprechen Energieeinsparungseffekte. Beobachtete CLA Effekte auf den ... ...

    Abstract Milchkühe unterliegen in der Frühlaktation einem Energiedefizit, das durch Körperfettmobilisierung kompensiert wird. Die milchfettreduzierenden Eigenschaften von trans-10,cis-12 CLA versprechen Energieeinsparungseffekte. Beobachtete CLA Effekte auf den Energie- und Fettstoffwechsel von Kühen sind uneinheitlich, wobei die Kombination einer CLA-Gabe in einer hoch konzentrierten im Vergleich zu einer angepassten Ration antepartum (ap) noch nicht untersucht wurde. Außerdem ist wenig über Effekte auf den Pansenstoffwechsel und einer mütterlichen CLA-Gabe auf Kälber bekannt. Es wurde eine Studie mit 64 trächtigen Kühen durchgeführt, um die genannten Parameter um die Abkalbung zu untersuchen. Der CLA-Zusatz in einer hochkonzentrierten Diät ap milderte das postpartale Energiedefizit durch erhöhte Futteraufnahmen, hatte aber keinen Effekt auf den Leber- und Fettstoffwechsel von peripartalen Kühen. CLA hatte einen minimalen Effekt auf den Pansenstoffwechsel und keinen Effekt auf die Kälber.

    Dairy cows are physiological subjected to an energy deficit during early lactation, which were compensated by the use of body fat reserves. The milk fat reducing properties of trans-10,cis-12 CLA suggests an energy-saving effect in cows. Observed CLA effects on energy and lipid metabolism of cows were contradictory, whereby a CLA addition in a high compared to an adequate concentrate proportion in the diet antepartum (ap) has not been investigated. Also less is known about CLA effects on rumen metabolism and maternal CLA effects on their offspring. A trial with 64 pregnant cows was conducted to study the mentioned topics around calving. Supplemented CLA in a high concentrate diet ap could alleviate the negative energy balance during early lactation via increasing dry matter intakes but seems to have no effect on metabolic situation, liver and lipid metabolism of periparturient cows. CLA had a minor effect on rumen metabolism. Maternal CLA supplementation did not have effects on calves.
    Keywords Text ; ddc:630 ; Konjugierte Linolsäuren ; Konzentrat ; Milchkuh ; Kälber ; Stoffwechsel ; Energiebilanz ; Fettstoffwechsel ; Pansenfermentation ; Conjugated linoleic acids ; concentrates ; dairy cows ; calves ; metabolism ; energy balance ; lipid metabolism ; rumen fermentation
    Language English
    Publishing date 2014-08-01
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Impact of an Online Training Program About Cancer Clinical Trials on Primary Care Physicians' Knowledge, Attitudes and Beliefs, and Behavior.

    Bylund, Carma L / Michaels, Margo / Weiss, Elisa S / Patel, Shilpa / D'Agostino, Thomas A / Binz-Scharf, Maria Christina / McKee, Diane

    Journal of cancer education : the official journal of the American Association for Cancer Education

    2020  Volume 36, Issue 5, Page(s) 1039–1044

    Abstract: Participation in cancer clinical trials (CCTs) is critical to improving cancer treatments and quality of care. However, rates of patient participation remain low. Research has shown that a trusted physician recommendation is an important influence on ... ...

    Abstract Participation in cancer clinical trials (CCTs) is critical to improving cancer treatments and quality of care. However, rates of patient participation remain low. Research has shown that a trusted physician recommendation is an important influence on patients' decisions to enroll in a CCT. Improving primary care providers' (PCPs') knowledge, attitudes, and beliefs about CCTs is a promising potential path for improving CCT participation. The aim of this pilot study was to test the effect of an online educational course for PCPs about clinical trials on primary care providers' knowledge, attitudes and beliefs, and behavior. Forty-one PCPs in the New York City area participated in a 1-h online training session on cancer clinical trials. These PCPs had self-selected to complete the training in a previous survey. The objectives of the training module were to (1) educate the PCPs about clinical trials, with a focus on overcoming misconceptions; and (2) discuss roles of PCPs in partnering with oncologists to help patients gain access to clinical trials. The training module included didactics, audio excerpts, and case descriptions. Participants completed a pre-test immediately before taking the course, a post-test immediately after taking the course, and a 3-month post-course survey. All three assessments included a general T/F knowledge test, a 7-item attitude/belief scale, and a knowledge test focused specifically on local resources and access for clinical trials. Forty-one PCPs completed the module and the pre-post course surveys. Eighty percent (33/41) also completed the 3-month post-course survey. General knowledge and local knowledge increased significantly (p < .05) from pre- to post-course. At 3 months post-training, both general and local knowledge scores remained significantly increased from baseline. For those who completed the 3-month post-course survey, attitudes and beliefs increased significantly from pre- to post-course, but this change was not sustained at 3 months post-training. At 3 months post-training, 52% of the PCPs who had an interaction with a recently diagnosed cancer patient reported speaking with patients about CCTs as a result of the training. A brief online course showed significant and sustained improvement in PCPs' general and local knowledge about cancer clinical trials, which translated into self-reported behavior change. Future dissemination of the course and further research into its impact are important next steps.
    MeSH term(s) Attitude of Health Personnel ; Health Knowledge, Attitudes, Practice ; Humans ; Neoplasms/therapy ; Physicians, Primary Care ; Pilot Projects ; Surveys and Questionnaires
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632898-2
    ISSN 1543-0154 ; 0885-8195 ; 1543-1154
    ISSN (online) 1543-0154
    ISSN 0885-8195 ; 1543-1154
    DOI 10.1007/s13187-020-01731-3
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    Zs.A 2185: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Online ; Thesis: Exploration and exploitation

    Binz-Scharf, Maria Christina

    toward a theory of knowledge sharing in digital government projects

    2003  

    Institution Universität St. Gallen
    Author's details vorgelegt von Maria Christina Binz-Scharf
    Keywords E-Government ; Neues Steuerungsmodell ; Öffentliche Verwaltung ; Internet ; E-Business ; Organisatorischer Wandel ; Verwaltungsreform ; Deutschland ; Wissensmanagement
    Language English
    Size Online-Ressource, XI, 183, text, 30 cm
    Edition [Elektronische Ressource]
    Publisher Univ., Hochschule für Wirtschafts-, Rechts- und Sozialwiss. (HSG)
    Publishing place St. Gallen
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis @St. Gallen, Univ., Diss., 2003
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  6. Book ; Online: A new order of things

    Binz-Scharf, Maria Christina / Lazer, David

    managing novelty and cooperation in e-government projects

    (Faculty research working paper series / John F. Kennedy School of Government, Harvard University ; 08,048)

    2008  

    Author's details Maria Christina Binz-Scharf; David Lazer
    Series title Faculty research working paper series / John F. Kennedy School of Government, Harvard University ; 08,048
    Language English
    Size Online-Ressource (38 S.), graph. Darst.
    Publisher Harvard Univ., John F. Kennedy School of Government
    Publishing place Cambridge, Mass
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  7. Article: Making Science

    Binz-Scharf, Maria C / Kalish, Yuval / Paik, Leslie

    American behavioral scientist. , v. 59, no. 5

    New Generations of Collaborative Knowledge Production

    2015  

    Abstract: Research scientists have become increasingly dependent on collaborations across laboratories and organizations to maintain their productivity. However, the increased specialization of individual laboratories works against the current drive toward ... ...

    Abstract Research scientists have become increasingly dependent on collaborations across laboratories and organizations to maintain their productivity. However, the increased specialization of individual laboratories works against the current drive toward understanding systems in the sciences. Consequently, there is a tension between the rising importance of collaborative efforts and the practical and structural challenges in establishing and managing such collaborations. Combining ethnographic case studies of three biology research labs with network data of their larger scientific community, we explore the changing process of scientific knowledge production in the age of Big Science. We find that virtual technologies open up the knowledge process as scientists have easier access to data, publications, and each other. At the same time, we find that these technologies—specifically scientific databases—do not eradicate the social aspects of scientific knowledge production as collaborative structures in science remain relatively unchanged. We discuss the implications for theory and practice of this seemingly contradictory character of scientific knowledge production.
    Keywords anthropology ; case studies ; scientists
    Language English
    Dates of publication 2015-05
    Size p. 531-547.
    Publishing place SAGE Publications
    Document type Article
    ISSN 1552-3381
    DOI 10.1177/0002764214556805
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Effects of dietary CLA supplementation, parity and different concentrate levels before calving on immunoglobulin G1, G2 and M concentrations in dairy cows.

    Eger, Melanie / Horn, Jana / Hussen, Jamal / Schuberth, Hans-Joachim / Scharf, Maria / Meyer, Ulrich / Dänicke, Sven / Bostedt, Hartwig / Breves, Gerhard

    Research in veterinary science

    2017  Volume 114, Page(s) 287–293

    Abstract: Peripartal dairy cows exhibit a higher susceptibility for infectious diseases, which might be linked to the negative energy balance occurring at the onset of lactation. A dietary supplementation of conjugated linoleic acids (CLA) may reduce milk fat ... ...

    Abstract Peripartal dairy cows exhibit a higher susceptibility for infectious diseases, which might be linked to the negative energy balance occurring at the onset of lactation. A dietary supplementation of conjugated linoleic acids (CLA) may reduce milk fat yield and subsequently lower the energy deficit. The utilization of immunoglobulins (Ig) for colostrogenesis might impair humoral immunity in peripartal dairy cows; therefore this study investigated the effects of a CLA supplement, parity and different dietary energy levels on plasma and colostrum IgG1, IgG2 and IgM levels in dairy cows and their calves. Blood samples were collected from 64 cows from 21days before until 56days after parturition and colostrum samples for the first 3days of lactation. Plasma immunoglobulin concentrations of 19 calves were determined before colostrum uptake. Neither plasma IgG1, nor IgG2 levels were affected by CLA or dietary energy level. However, immunoglobulin levels were affected by parity. Heifers possessed the lowest IgG1 concentrations. IgG2 concentrations were highest in cows with 2 lactations prior to parturition and in heifers after parturition. Plasma IgM levels were characterized by a sharp decrease 3days prior to parturition and were scarcely affected by the feeding regimen or parity. Generally, immunoglobulin levels appear to be mostly independent from the peripartal energy balance of the cows and are not influenced by dietary CLA. However, pronounced differences among parities for IgG1 and IgG2 were revealed which should be further evaluated.
    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2017.05.026
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    Zs.B 673: Show issues Location:
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  9. Article: Lending a helping hand

    Mergel, Ines / Binz-Scharf, Maria Christina / Lazer, David

    International journal of learning and change : IJLC Vol. 3, No. 1 (2008/09), p. 5-22

    voluntary engagement in knowledge sharing

    2008  Volume 3, Issue 1, Page(s) 5–22

    Author's details Ines Mergel and David Lazer; Maria Christina Binz-Scharf
    Keywords Polizei ; Wissenstransfer ; Soziales Netzwerk ; Social Web ; USA
    Language English
    Size graph. Darst.
    Publisher Inderscience Enterprises
    Publishing place [Olney, Bucks.]
    Document type Article
    ZDB-ID 2219338-8
    Database ECONomics Information System

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  10. Book ; Online: Searching for answers

    Binz-Scharf, Maria Christina / Lazer, David / Mergel, Ines

    networks of practice among public administrators

    (Faculty research working paper series / John F. Kennedy School of Government, Harvard University ; 08,046)

    2008  

    Author's details Maria Christina Binz-Scharf; David Lazer; Ines Mergel
    Series title Faculty research working paper series / John F. Kennedy School of Government, Harvard University ; 08,046
    Language English
    Size Online-Ressource (32 S.), graph. Darst.
    Publisher Harvard Univ., John F. Kennedy School of Government
    Publishing place Cambridge, Mass
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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