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  1. Article ; Online: Re: The FRCR 2B examination: a survey of candidate perceptions and experiences.

    Craig, Alistair / Schembri, Nicola

    Clinical radiology

    2012  Volume 67, Issue 1, Page(s) 89–92; author reply 92–93

    MeSH term(s) Educational Measurement ; Female ; Humans ; Male ; Radiology/education
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2011.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Automated data capture from free-text radiology reports to enhance accuracy of hospital inpatient stroke codes.

    Flynn, Robert W V / Macdonald, Thomas M / Schembri, Nicola / Murray, Gordon D / Doney, Alexander S F

    Pharmacoepidemiology and drug safety

    2010  Volume 19, Issue 8, Page(s) 843–847

    Abstract: Purpose: Much potentially useful clinical information for pharmacoepidemiological research is contained in unstructured free-text documents and is not readily available for analysis. Routine health data such as Scottish Morbidity Records (SMR01) ... ...

    Abstract Purpose: Much potentially useful clinical information for pharmacoepidemiological research is contained in unstructured free-text documents and is not readily available for analysis. Routine health data such as Scottish Morbidity Records (SMR01) frequently use generic 'stroke' codes. Free-text Computerised Radiology Information System (CRIS) reports have potential to provide this missing detail. We aimed to increase the number of stroke-type-specific diagnoses by augmenting SMR01 with data derived from CRIS reports and to assess the accuracy of this methodology.
    Methods: SMR01 codes describing first-ever-stroke admissions in Tayside, Scotland from 1994 to 2005 were linked to CRIS CT-brain scan reports occurring with 14 days of admission. Software was developed to parse the text and elicit details of stroke type using keyword matching. An algorithm was iteratively developed to differentiate intracerebral haemorrhage (ICH) from ischaemic stroke (IS) against a training set of reports with pathophysiologically precise SMR01 codes. This algorithm was then applied to CRIS reports associated with generic SMR01 codes. To establish the accuracy of the algorithm a sample of 150 ICH and 150 IS reports were independently classified by a stroke physician.
    Results: There were 8419 SMR01 coded first-ever strokes. The proportion of patients with pathophysiologically clear diagnoses doubled from 2745 (32.6%) to 5614 (66.7%). The positive predictive value was 94.7% (95%CI 89.8-97.3) for IS and 76.7% (95%CI 69.3-82.7) for haemorrhagic stroke.
    Conclusions: A free-text processing approach was acceptably accurate at identifying IS, but not ICH. This approach could be adapted to other studies where radiology reports may be informative.
    MeSH term(s) Algorithms ; Cerebral Hemorrhage/diagnosis ; Electronic Health Records ; Female ; Hospitals ; Humans ; Inpatients ; Male ; Radiology ; Radiology Information Systems ; Stroke/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2010-07-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099748-9
    ISSN 1099-1557 ; 1053-8569
    ISSN (online) 1099-1557
    ISSN 1053-8569
    DOI 10.1002/pds.1981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: T1 characteristics of interstitial pulmonary fibrosis on 3T MRI-a predictor of early interstitial change?

    Mirsadraee, Saeed / Tse, Matthew / Kershaw, Lucy / Semple, Scott / Schembri, Nicola / Chin, Calvin / Murchison, John T / Hirani, Nik / van Beek, Edwin J R

    Quantitative imaging in medicine and surgery

    2015  Volume 6, Issue 1, Page(s) 42–49

    Abstract: Background: Computed tomography (CT) is routinely used for diagnosis and characterisation of idiopathic pulmonary fibrosis (IPF). The technique however has limited sensitivity in detection and monitoring of early fibrotic changes. The aim of this study ... ...

    Abstract Background: Computed tomography (CT) is routinely used for diagnosis and characterisation of idiopathic pulmonary fibrosis (IPF). The technique however has limited sensitivity in detection and monitoring of early fibrotic changes. The aim of this study was to evaluate T1 characteristics in the radiologically diseased lung parenchyma in IPF patient compared to apparently normal parenchyma in both interstitial lung disease (ILD) patients and healthy volunteers and to investigate the feasibility of the technique in prediction of early fibrotic lung changes that may not be visible on CT.
    Methods: Ten patients with IPF underwent high resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) on the same day of attendance. 3T MRI was repeated in seven patients with IPF to test the reproducibility of results. The control group included healthy volunteers (n=10). A modified look-locker inversion-recovery (MOLLI) sequence (124×192 acquisition matrix; 8 mm slice) was performed during a 15-20 s breathhold in a single slice. The position of MR slice was pre-selected where there was CT evidence of normal and fibrotic lung. MOLLI imaging was performed prior to the contrast administration, and at 15, 25, 30 and 35 min post Gadolinium. The imaging data were then processed with a curve-fitting technique to estimate T1 values. T1 values of the apparent fibrotic and normal lung in IPF patients and normal lung were compared.
    Results: Fibrotic lung had a higher pre-contrast T1 than either morphologically normal lung in ILD patients or control lung (P=0.02) in healthy volunteers (1309±123, 1069±71, and 1011±172 ms, respectively). Morphologically normal lung T1 and control lung T1 were not significantly different pre-contrast, however, at 10 min after administration of Gadolinium, control lung had a significantly shorter T1 than either fibrotic or morphologically normal lung (494±34, 670±63, and 619±41 ms, respectively; P=0.001). T1 for fibrotic lung continued to decrease until 20 min after contrast agent administration (P≤0.0001), whereas morphologically normal lung T1 did not significantly change after 10 min (P>0.3). This indicates delayed uptake of contrast agent in the fibrotic lung compared with morphologically normal lung.
    Conclusions: T1 mapping of patients with IPF at 3T is feasible and demonstrates a significant difference between fibrotic lung tissue and morphologically normal lung tissue both before Gadolinium administration and at 10 min delayed post-contrast images. The technique is able to evaluate early fibrosis in patients with apparently morphologically normal lung.
    Language English
    Publishing date 2015-11-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.3978/j.issn.2223-4292.2016.02.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The BRICS (Bronchiectasis Radiologically Indexed CT Score): A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis.

    Bedi, Pallavi / Chalmers, James D / Goeminne, Pieter C / Mai, Cindy / Saravanamuthu, Pira / Velu, Prasad Palani / Cartlidge, Manjit K / Loebinger, Michael R / Jacob, Joe / Kamal, Faisal / Schembri, Nicola / Aliberti, Stefano / Hill, Uta / Harrison, Mike / Johnson, Christopher / Screaton, Nicholas / Haworth, Charles / Polverino, Eva / Rosales, Edmundo /
    Torres, Antoni / Benegas, Michael N / Rossi, Adriano G / Patel, Dilip / Hill, Adam T

    Chest

    2017  Volume 153, Issue 5, Page(s) 1177–1186

    Abstract: Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.: Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable ...

    Abstract Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.
    Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients.
    Results: A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV
    Conclusions: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.
    MeSH term(s) Aged ; Bronchiectasis/diagnosis ; Bronchiectasis/etiology ; Cohort Studies ; Female ; Hospitalization ; Humans ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Respiratory Function Tests ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-12-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2017.11.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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