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  1. Article: Übergang in einen sekundär progredienten Verlauf als Indikation zur schubprophylaktischen Basistherapie mit Interferon β-1b

    Schenk, L. K.

    Aktuelle Neurologie

    (Dieses Supplement ist entstanden mit freundlicher Unterstützung von Bayer HealthCare)

    2012  Volume 39, Issue S 01, Page(s) S29–S30

    Abstract: Eine heute 41-jährige Patientin wird vorgestellt, deren schubprophylaktische Basismedikation aufgrund der Entwicklung eines chronisch progredienten Verlaufs der Multiplen Sklerose von Glatirameracetat auf Interferon β-1b umgestellt wurde. Die Multiple ... ...

    Series title Dieses Supplement ist entstanden mit freundlicher Unterstützung von Bayer HealthCare
    Abstract Eine heute 41-jährige Patientin wird vorgestellt, deren schubprophylaktische Basismedikation aufgrund der Entwicklung eines chronisch progredienten Verlaufs der Multiplen Sklerose von Glatirameracetat auf Interferon β-1b umgestellt wurde. Die Multiple Sklerose der Patientin war im Rahmen einer unter Kortikoidstoßtherapie regredienten Optikusneuritis diagnostiziert worden. Wegen eines Kinderwunsches hatte die Patientin zunächst auf die angeratene Schubprophylaxe verzichtet, begann diese jedoch nach ihrem 2. Schub 3 Jahre später mit Glatirameracetat (20 mg/d s. c.). Nach dem Übergang in einen chronisch rezidivierenden Verlauf stellten wir sie vor 4 Jahren auf eine Basistherapie mit Interferon β-1b um.
    Keywords Multiple Sklerose ; sekundär progredienter Verlauf ; Kinderwunsch ; Glatiramer ; Interferon β-1b ; multiple sclerosis ; secondary progressive course ; desire to become pregnant ; glatiramer acetate ; interferon β-1b
    Language German
    Publishing date 2012-05-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 124980-0
    ISSN 1438-9428 ; 0302-4350 ; 1431-4886
    ISSN (online) 1438-9428
    ISSN 0302-4350 ; 1431-4886
    DOI 10.1055/s-0032-1304866
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 970: Show issues Location:
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    Zs.MO 141: Show issues

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  2. Article: Ionenleitfähigkeit und mehr: TMEM16-Proteine regulieren calciumabhängige Signalwege im Nephron

    Henke, S. F. / Pavenstädt, H. / Schenk, L. K.

    Nieren- und Hochdruckkrankheiten

    2018  Volume 47, Issue 3, Page(s) 151–156

    Language German
    Document type Article
    ZDB-ID 184315-1
    ISSN 0300-5224
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Neonatal ethical decision making: where does the NNP fit in?

    Waltman, P A / Schenk, L K

    Neonatal network : NN

    1999  Volume 18, Issue 8, Page(s) 27–32

    Abstract: Neonatal nurse practitioners are frequently confronted with ethical dilemmas in the NICU. This article reflects on the historical basis of ethical decision making and the issues some novice NNPs face today regarding their participation in the decision- ... ...

    Abstract Neonatal nurse practitioners are frequently confronted with ethical dilemmas in the NICU. This article reflects on the historical basis of ethical decision making and the issues some novice NNPs face today regarding their participation in the decision-making process. It examines various educational strategies that can be used to help NNPs to develop the skills they need to participate collaboratively in ethical decision making in the NICU. It concludes with recommendations for further research.
    MeSH term(s) Decision Making ; Ethics, Nursing ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal/standards ; Neonatal Nursing/standards ; Nurse Practitioners/standards ; Nurse's Role ; United States
    Language English
    Publishing date 1999-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639300-7
    ISSN 1539-2880 ; 0730-0832
    ISSN (online) 1539-2880
    ISSN 0730-0832
    DOI 10.1891/0730-0832.18.8.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3186: Show issues Location:
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  4. Article ; Online: The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes.

    Wennmann, D O / Vollenbröker, B / Eckart, A K / Bonse, J / Erdmann, F / Wolters, D A / Schenk, L K / Schulze, U / Kremerskothen, J / Weide, T / Pavenstädt, H

    Cell death & disease

    2014  Volume 5, Page(s) e1519

    Abstract: The Hippo pathway fulfills a crucial function in controlling the balance between proliferation, differentiation and apoptosis in cells. Recent studies showed that G protein-coupled receptors (GPCRs) serve as upstream regulators of Hippo signaling, that ... ...

    Abstract The Hippo pathway fulfills a crucial function in controlling the balance between proliferation, differentiation and apoptosis in cells. Recent studies showed that G protein-coupled receptors (GPCRs) serve as upstream regulators of Hippo signaling, that either activate or inactivate the Hippo pathway via the large tumor suppressor kinase (LATS) and its substrate, the co-transcription factor Yes-associated protein (YAP). In this study, we focused on the Angiotensin II type 1 receptor (AT1R), which belongs to the GPCR family and has an essential role in the control of blood pressure and water homeostasis. We found that Angiotensin II (Ang II) inactivates the pathway by decreasing the activity of LATS kinase; therefore, leading to an enhanced nuclear shuttling of unphosphorylated YAP in HEK293T cells. This shuttling of YAP is actin-dependent as disruption of the actin cytoskeleton inhibited dephosphorylation of LATS and YAP. Interestingly, in contrast to HEK293T cells, podocytes, which are a crucial component of the glomerular filtration barrier, display a predominant nuclear YAP localization in vivo and in vitro. Moreover, stimulation with Ang II did not alter Hippo pathway activity in podocytes, which show a deactivated pathway. Reactivation of the LATS kinase activity in podocytes resulted in an increased cytoplasmic YAP localization accompanied by a strong induction of apoptosis. Thus, our work indicates that the control of LATS activation and subsequent YAP localization is important for podocyte homeostasis and survival.
    MeSH term(s) Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Angiotensin II/pharmacology ; Animals ; Apoptosis/genetics ; Cell Line, Transformed ; Cell Survival ; Gene Expression Regulation ; HEK293 Cells ; Homeostasis ; Humans ; Mice ; Mice, Transgenic ; Organ Specificity ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Phosphorylation ; Podocytes/cytology ; Podocytes/metabolism ; Primary Cell Culture ; Protein Transport ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Receptor, Angiotensin, Type 1/genetics ; Receptor, Angiotensin, Type 1/metabolism ; Signal Transduction ; Transcription Factors
    Chemical Substances Adaptor Proteins, Signal Transducing ; Phosphoproteins ; Receptor, Angiotensin, Type 1 ; Transcription Factors ; YAP1 protein, human ; Angiotensin II (11128-99-7) ; LATS1 protein, human (EC 2.7.1.-) ; Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2014-11-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/cddis.2014.476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Caring as perceived during the birth experience.

    Propst, M G / Schenk, L K / Clairain, S

    NLN publications

    1994  , Issue 14-2607, Page(s) 252–264

    MeSH term(s) Female ; Humans ; Labor, Obstetric/psychology ; Models, Theoretical ; Nurse-Patient Relations ; Obstetric Nursing ; Pregnancy
    Language English
    Publishing date 1994-05
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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