Article: Psikhicheskie rasstroistva, assotsiirovannye s ostroi fazoi techeniya COVID-19: klinika, podkhody k terapii.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2023 Volume 123, Issue 4. Vyp. 2, Page(s) 52–59
Abstract: Background: The purpose is to study the structure of clinical manifestations of mental disorders in the acute period of COVID-19 among patients, who were hospitalized with a new coronavirus infection and their relations with the severity of the immune ... ...
| Title translation | Mental disorders associated with acute COVID-19: clinical picture, therapy approaches. | ||||||||||
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| Abstract | Background: The purpose is to study the structure of clinical manifestations of mental disorders in the acute period of COVID-19 among patients, who were hospitalized with a new coronavirus infection and their relations with the severity of the immune response, to assess the efficacy and safety profile of the spectrum of used psychopharmacotherapy. Material and methods: A study was conducted of patients, hospitalized to the department of infectious diseases and repurposed for COVID-19 clinical departments with a diagnosis of COVID-19 (compliance with the criteria for ICD-10: U07.1) from September 2020 to March 2021. Study design: single center opened retrospective cohort study. The main group is consisted of 72 patients, average age - 71 [56.0; 81.0] years, the part of women - 64.0%. The control group ( Results: In the following range of mental disorders were identified: a depressive episode (ICD-10 F32) by 31 patients, by 22 - a disorder of adaptive reactions (ICD-10 F43.2), by 5 - delirium not caused by alcohol or other psychoactive substances (ICD-10 F05), by 14 - mild cognitive impairment caused by damage and disfunction of the brain or somatic diseases (ICD-10 F06.7). In comparison with the control group, these patients showed a statistically significant ( Conclusion: The results of the study confirm the heterogeneity of the structure of mental disorders in the acute form of coronavirus infection, revealing the relations between the clinical picture and laboratory parameters of the immune response to systemic inflammation. Recommendations are given for the choice of psychopharmacotherapy, in conformity with the peculiarities of pharmacokinetics and interaction with somatotropic therapy. |
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| MeSH term(s) | Humans ; Female ; Aged ; Middle Aged ; COVID-19/complications ; Retrospective Studies ; Mental Disorders ; Antipsychotic Agents ; Inflammation | ||||||||||
| Chemical Substances | Antipsychotic Agents | ||||||||||
| Language | Russian | ||||||||||
| Publishing date | 2023-05-04 | ||||||||||
| Publishing country | Russia (Federation) | ||||||||||
| Document type | English Abstract ; Journal Article | ||||||||||
| ZDB-ID | 1201462-x | ||||||||||
| ISSN | 2309-4729 ; 1997-7298 ; 0044-4588 | ||||||||||
| ISSN (online) | 2309-4729 | ||||||||||
| ISSN | 1997-7298 ; 0044-4588 | ||||||||||
| DOI | 10.17116/jnevro202312304252 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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