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  1. Article ; Online: Author Response to Comment on "Plasma calcitonin gene-related peptide and nerve growth factor as headache and pain biomarkers in recently deployed soldiers with and without a recent concussion".

    Scher, Ann I / Chai, Xiyun / Johnson, Kirk W

    Headache

    2024  Volume 64, Issue 1, Page(s) 121

    MeSH term(s) Humans ; Calcitonin Gene-Related Peptide/metabolism ; Military Personnel ; Headache/diagnosis ; Headache/metabolism ; Pain ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Nerve Growth Factors ; Biomarkers
    Chemical Substances Calcitonin Gene-Related Peptide (JHB2QIZ69Z) ; Nerve Growth Factors ; Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Letter
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patient-Centered Treatment of Chronic Migraine With Medication Overuse: More Is Not Always Better.

    Scher, Ann I / Bendtsen, Lars

    Neurology

    2022  Volume 98, Issue 14, Page(s) 563–564

    MeSH term(s) Analgesics/therapeutic use ; Chronic Disease ; Headache Disorders, Secondary/therapy ; Humans ; Migraine Disorders/drug therapy ; Patient-Centered Care ; Prescription Drug Overuse
    Chemical Substances Analgesics
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000200252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Assessing mean corpuscular volume as a screening tool for gestational vitamin B12 deficiency based on NHANES.

    Fideli, Ülgen S / Scher, Ann I / Olsen, Cara / Hisle-Gorman, Elizabeth

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    2023  

    Abstract: Vitamin B12 can lead to neurological deficits. We assessed whether the mean corpuscular volume (MCV) could be a sufficiently sensitive measurement for abnormal serum methylmalonic Acid (MMA) and total plasma homocysteine (tHCY) (biomarkers of vitamin B12 ...

    Abstract Vitamin B12 can lead to neurological deficits. We assessed whether the mean corpuscular volume (MCV) could be a sufficiently sensitive measurement for abnormal serum methylmalonic Acid (MMA) and total plasma homocysteine (tHCY) (biomarkers of vitamin B12 or folate deficiency) and if so, at what cutoff value. A total of 26,397 participants (12,730 males and 13,667 females) were included in the analysis. Weighted analysis was performed using NHANES data to calculate crude/adjusted associations between MCV-MMA/tHCY, using linear regression. Unadjusted odds ratios (OR) 95% CIs were estimated from logistic regression models. Receiver Operating Curve and the Youden Index were used to identify the MCV level that most accurately distinguished those with abnormal MMA and tHCY (dependent variables) from those without. A positive and significant correlation between MCV-MMA/tHCY was found in the general population between ages 18-85, 0.95 (95% C.I. 0.75-1.17) and 2.61 (95% C.I. 2.15-3.08). In pregnant women, for every unit increase in MCV there was a 19% increase in odds of abnormal MMA, OR 1.19 (95% C.I. 1.08-1.31), p=0.001 and the Area Under the Curve for MCV as a test for abnormal MMA was 78%. An MCV cutoff of 93.1 correctly identified abnormal MMA in pregnant women with 81% sensitivity and 77% specificity. In the general population the MCV test performed poorly in identifying abnormal MMA/tHCY. MCV is an inexpensive measurement that may be useful to screen asymptomatic pregnant women for vitamin B12 abnormalities. This may have a significant impact on reducing adverse neurological outcomes in their children.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    DOI 10.1024/0300-9831/a000788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Medication overuse headache: The trouble with prevalence estimates.

    Loder, Elizabeth W / Scher, Ann I

    Cephalalgia : an international journal of headache

    2019  Volume 40, Issue 1, Page(s) 3–5

    MeSH term(s) Denmark ; Headache ; Headache Disorders ; Headache Disorders, Secondary ; Humans ; Prevalence
    Language English
    Publishing date 2019-09-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102419876907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The relationship between prior psychiatric diagnosis and brain cancer diagnosis in the U.S. military health system.

    Bytnar, Julie A / Lin, Jie / Theeler, Brett J / Scher, Ann I / Shriver, Craig D / Zhu, Kangmin

    Cancer causes & control : CCC

    2022  Volume 33, Issue 9, Page(s) 1135–1144

    Abstract: Purpose: Prior research suggested the increased likelihood of brain cancer diagnosis following certain psychiatric diagnoses. This association may result from detection bias or suggest an early sign for brain cancer. This study investigated whether ... ...

    Abstract Purpose: Prior research suggested the increased likelihood of brain cancer diagnosis following certain psychiatric diagnoses. This association may result from detection bias or suggest an early sign for brain cancer. This study investigated whether psychiatric illness may be an early manifestation of brain cancer while considering potential effects of detection bias.
    Methods: This case-control study used the data from the Department of Defense's Central Cancer Registry and the Military Health System Data Repository. Four cancer-free controls and one negative-outcome control (cancers not associated with psychiatric illness) were matched to each brain cancer case diagnosed from 1998 to 2013 by age, sex, race, and military status. The groups were compared in the likelihood of having a pre-existing psychiatric diagnosis using conditional logistic regression.
    Results: We found a significant association of psychiatric illnesses with brain cancer (Odds Ratio (OR) = 2.63, 95% confidence interval (CI) = 2.18-3.16) and other cancers (OR = 1.80, 95% CI = 1.49-2.19), compared to non-cancer controls. The association was stronger for psychiatric diagnoses within three months before cancer (brain cancer: OR = 26.77, 95% CI = 15.40-46.53; other cancers: OR = 4.12, 95% CI = 1.96-8.65). The association with psychiatric disorders within 3 months were higher for small brain tumors (OR = 128.32, 95% CI = 17.28-952.92 compared to non-cancer controls) while the OR was 2.79 for other cancers (95% CI = 0.86-8.99 compared to non-cancer controls).
    Conclusion: Our findings suggest an association between diagnosed psychiatric illnesses and subsequent brain cancer diagnosis, which may not be solely explained by detection bias. Psychiatric illness might be a sign for early detection of brain cancer beyond the potential effects of detection bias.
    MeSH term(s) Brain Neoplasms/diagnosis ; Brain Neoplasms/epidemiology ; Case-Control Studies ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Military Health Services ; Military Personnel ; Odds Ratio
    Language English
    Publishing date 2022-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-022-01608-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Migraine research comes of age in the 21st century.

    Moskowitz, Michael A / Dodick, David W / Scher, Ann I / van den Maagdenberg, Arn M J M

    The Lancet. Neurology

    2022  Volume 21, Issue 11, Page(s) 955–958

    MeSH term(s) Humans ; History, 21st Century ; History, 20th Century ; Migraine Disorders/therapy ; Migraine Disorders/history
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00398-2
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  7. Article ; Online: Comment on "Paranasal sinus opacification in headache sufferers: A population-based imaging study (the HUNT study-MRI)".

    Lal, Devyani / Scher, Ann I

    Cephalalgia : an international journal of headache

    2017  Volume 37, Issue 6, Page(s) 507–508

    MeSH term(s) Headache ; Humans ; Magnetic Resonance Imaging ; Paranasal Sinuses ; Research Design
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102416651452
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  8. Article ; Online: Guidelines of the International Headache Society for controlled trials of pharmacological preventive treatment for persistent post-traumatic headache attributed to mild traumatic brain injury.

    Ashina, Håkan / Diener, Hans-Christoph / Tassorelli, Cristina / Scher, Ann I / Lipton, Richard B / Pozo-Rosich, Patricia / Sinclair, Alexandra J / Chong, Catherine D / Finkel, Alan G / Ashina, Messoud / Schwedt, Todd J / Dodick, David W / Terwindt, Gisela M

    Cephalalgia : an international journal of headache

    2024  Volume 44, Issue 3, Page(s) 3331024241234068

    Abstract: Background: Persistent headache attributed to traumatic injury to the head is divided into two subtypes, one attributed to moderate or severe traumatic injury and another attributed to mild traumatic injury (i.e., concussion). The latter is much more ... ...

    Abstract Background: Persistent headache attributed to traumatic injury to the head is divided into two subtypes, one attributed to moderate or severe traumatic injury and another attributed to mild traumatic injury (i.e., concussion). The latter is much more prevalent, in part because more than 90% of cases with traumatic brain injury are classified as mild. The pathophysiology of persistent post-traumatic headache is poorly understood and the underlying mechanisms are likely multifactorial. There is currently no approved treatment specifically for persistent post-traumatic headache, and management strategies rely on medications used for migraine or tension-type headache. Therefore, high-quality trials are urgently needed to support clinical decision-making and optimize management strategies. International guidelines can facilitate appropriate trial design and ensure the acquisition of high-quality data evaluating the efficacy, tolerability, and safety of available and novel pharmacological therapies for the preventive treatment of persistent post-traumatic headache.
    Methods: The development of this guideline was based on a literature review of available studies in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials, along with a review of previously published guidelines for controlled trials of preventive treatment for episodic and chronic migraine. The identified literature was critically appraised, and due to the scarcity of scientific evidence, recommendations were primarily based on the consensus of experts in the field.
    Objective: To provide guidelines for designing state-of-the-art controlled clinical trials aimed at evaluating the effectiveness of preventive treatments for persistent post-traumatic headache attributed to mild traumatic brain injury.
    MeSH term(s) Humans ; Brain Concussion/drug therapy ; Post-Traumatic Headache/etiology ; Post-Traumatic Headache/prevention & control ; Tension-Type Headache/complications ; Headache/complications ; Migraine Disorders ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/03331024241234068
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  9. Article ; Online: Suicide risk is elevated in migraineurs who have comorbid fibromyalgia.

    Kurth, Tobias / Scher, Ann I

    Neurology

    2015  Volume 85, Issue 12, Page(s) 1012–1013

    MeSH term(s) Female ; Fibromyalgia/diagnosis ; Fibromyalgia/epidemiology ; Humans ; Male ; Migraine Disorders/diagnosis ; Migraine Disorders/epidemiology ; Suicidal Ideation ; Suicide, Attempted
    Language English
    Publishing date 2015-09-22
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000001960
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  10. Article ; Online: Epidemiology and classification of post-traumatic headache: what do we know and how do we move forward? Comment on Lucas et al., "Prevalence and characterization of headache following mild TBI".

    Scher, Ann I / Monteith, Teshamae S

    Cephalalgia : an international journal of headache

    2014  Volume 34, Issue 2, Page(s) 83–85

    MeSH term(s) Brain Injuries/diagnosis ; Brain Injuries/epidemiology ; Female ; Headache/diagnosis ; Headache/epidemiology ; Humans ; Male
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 604567-4
    ISSN 1468-2982 ; 0333-1024
    ISSN (online) 1468-2982
    ISSN 0333-1024
    DOI 10.1177/0333102413499644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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