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  1. Article ; Online: AOA Critical Issues: Perceptions on the State of Diversity, Equity, and Inclusion in Orthopaedic Surgery: A Survey of the AOA Membership.

    Tabaie, Sean A / Schermerhorn, Janse T / Baird, Michael / Lattanza, Lisa / Ode, Gabriella / Mesfin, Addisu

    The Journal of bone and joint surgery. American volume

    2023  Volume 105, Issue 23, Page(s) 1920–1926

    Abstract: Background: Orthopaedic surgery continues to trail other specialties in increasing diversity among its physician workforce. Various efforts have been and are currently being made to not only increase diversity, but also promote equity and inclusion in ... ...

    Abstract Background: Orthopaedic surgery continues to trail other specialties in increasing diversity among its physician workforce. Various efforts have been and are currently being made to not only increase diversity, but also promote equity and inclusion in the field. The purpose of this study was to survey members of the American Orthopaedic Association (AOA) to determine how leaders in orthopaedics view diversity, equity, and inclusion (DEI) at the present time and to understand their perspective while moving into the future.
    Methods: An anonymous 11-question survey was disseminated online to AOA members in May 2022. These individuals were identified by the AOA membership directory and the email ListServe. The survey included free-response and multiple-choice questions. Demographic information was self-identified, and both qualitative and quantitative data were collected.
    Results: Of the 1,657 AOA members who were provided the survey, 262 (15.8%) responded. Approximately 29.5% (77) and 45.6% (119) of the surveyed population ranked "retention of underrepresented populations in orthopaedic residency (women, URiM)" as "very important" or "absolutely essential," respectively. The answers to the free-response questions identified multiple core themes that responders were passionate about, namely resident and attending physician recruitment and retention, as well as resident selection.
    Conclusions: Leaders in the field of orthopaedic surgery desire for action to be taken in the field of DEI. The findings of this survey denote positive attitudes even though many inequalities still pervade the field of orthopaedics. Through mentorship, objective evaluation, transparency, and continued intentional action, orthopaedic surgery is well-positioned to continue to move forward with DEI.
    MeSH term(s) Humans ; Female ; United States ; Orthopedics/education ; Internship and Residency ; Diversity, Equity, Inclusion ; Orthopedic Procedures ; Surveys and Questionnaires
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.23.00392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Case of Periprosthetic Joint Infection Because of Rothia Mucilaginosa.

    Schermerhorn, Janse T / Colantonio, Donald F / Larson, Derek T / McGill, Robert J

    Military medicine

    2021  Volume 188, Issue 3-4, Page(s) e894–e897

    Abstract: Periprosthetic joint infection (PJI) is a rare but devastating complication of total joint arthroplasty. Identifying the offending infectious agent is essential to appropriate treatment, and uncommon pathogens often lead to a diagnostic delay. This case ... ...

    Abstract Periprosthetic joint infection (PJI) is a rare but devastating complication of total joint arthroplasty. Identifying the offending infectious agent is essential to appropriate treatment, and uncommon pathogens often lead to a diagnostic delay. This case describes the first known instance of a total knee arthroplasty (TKA) with Rothia mucilaginosa, a typical respiratory tract organism. This report aims to provide insight into the treatment of this atypical PJI, as there are only six previously published cases of Rothia species PJI septic arthritis. The patient is a 64-year-old diabetic male who underwent a right TKA and left TKA ∼6 months later. Approximately 3 weeks status post-left TKA, he showed evidence of left PJI. One year after treatment and recovery from his left PJI, he presented with several months of right knee pain and fatigue. Subsequent labs and imaging revealed right PJI. No recent history of dental disease or work was observed. He then underwent two-stage revision right knee arthroplasty and microbial cultures yielded Rothia mucilaginosa. After initial empiric treatment, antibiotic therapy was narrowed to 6 weeks of vancomycin. Following negative aspiration cultures the patient underwent reimplantation of right TKA components. One year following treatment, the patient was fully recovered with no evidence of infection. This case emphasizes the possibility of microbial persistence despite various antibiotic treatment regimens for the patient's contralateral knee arthroplasty and PJI. Additionally, this case demonstrates the importance of two-stage revision in patients with PJI, and the viability of treating Rothia species PJIs with vancomycin.
    MeSH term(s) Humans ; Male ; Middle Aged ; Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Diabetes Mellitus/epidemiology ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/microbiology ; Reoperation ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Case Reports
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usab203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thermal stability and structure of glyceraldehyde-3-phosphate dehydrogenase from the coral

    Perez, Astrid M / Wolfe, Jacob A / Schermerhorn, Janse T / Qian, Yiwen / Cela, Bekim A / Kalinowski, Cody R / Largoza, Garrett E / Fields, Peter A / Brandt, Gabriel S

    RSC advances

    2021  Volume 11, Issue 17, Page(s) 10364–10374

    Abstract: Corals are vulnerable to increasing ocean temperatures. It is known that elevated temperatures lead to the breakdown of an essential mutualistic relationship with photosynthetic algae. The molecular mechanisms of this temperature-dependent loss of ... ...

    Abstract Corals are vulnerable to increasing ocean temperatures. It is known that elevated temperatures lead to the breakdown of an essential mutualistic relationship with photosynthetic algae. The molecular mechanisms of this temperature-dependent loss of symbiosis are less well understood. Here, the thermal stability of a critical metabolic enzyme, glyceraldehyde-3-phosphate dehydrogenase, from the stony coral
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d0ra10119b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors.

    Lin, Benjamin C / Harris, Darcy R / Kirkman, Lucy M D / Perez, Astrid M / Qian, Yiwen / Schermerhorn, Janse T / Hong, Min Y / Winston, Dennis S / Xu, Lingyin / Brandt, Gabriel S

    ACS omega

    2017  Volume 2, Issue 10, Page(s) 6605–6612

    Abstract: A relatively high-affinity inhibitor of FIKK kinase from the malaria ... ...

    Abstract A relatively high-affinity inhibitor of FIKK kinase from the malaria parasite
    Language English
    Publishing date 2017-10-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN 2470-1343
    DOI 10.1021/acsomega.7b00997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum.

    Lin, Benjamin C / Harris, Darcy R / Kirkman, Lucy M D / Perez, Astrid M / Qian, Yiwen / Schermerhorn, Janse T / Hong, Min Y / Winston, Dennis S / Xu, Lingyin / Lieber, Alexander M / Hamilton, Matthew / Brandt, Gabriel S

    Bioorganic chemistry

    2017  Volume 75, Page(s) 217–223

    Abstract: The FIKK family of kinases is unique to parasites of the Apicomplexan order, which includes all malaria parasites. Plasmodium falciparum, the most virulent form of human malaria, has a family of 19 FIKK kinases, most of which are exported into the host ... ...

    Abstract The FIKK family of kinases is unique to parasites of the Apicomplexan order, which includes all malaria parasites. Plasmodium falciparum, the most virulent form of human malaria, has a family of 19 FIKK kinases, most of which are exported into the host red blood cell during malaria infection. Here, we confirm that FIKK 8 is a non-exported member of the FIKK kinase family. Through expression and purification of the recombinant kinase domain, we establish that emodin is a relatively high-affinity (IC
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2017.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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