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  1. Article ; Online: Lymphatics and The Intestinal Stem Cell Niche: An Ultrastructural and 3D-Immunofluorescence Study.

    Pasolli, Hilda Amalia / Niec, Rachel E / Schernthanner, Marina / Gur-Cohen, Shiri / Fuchs, Elaine

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 1080

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.

    Reis, Bernardo S / Darcy, Patrick W / Khan, Iasha Z / Moon, Christine S / Kornberg, Adam E / Schneider, Vanessa S / Alvarez, Yelina / Eleso, Olawale / Zhu, Caixia / Schernthanner, Marina / Lockhart, Ainsley / Reed, Aubrey / Bortolatto, Juliana / Castro, Tiago B R / Bilate, Angelina M / Grivennikov, Sergei / Han, Arnold S / Mucida, Daniel

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6603, Page(s) 276–284

    Abstract: γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression ... ...

    Abstract γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC models, we found that most γδ T cells in premalignant or nontumor colons exhibit cytotoxic markers, whereas tumor-infiltrating γδ T cells express a protumorigenic profile. These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vγδ gene usage in both humans and mice. Longitudinal intersectional genetics and antibody-dependent strategies targeting murine γδ T cells enriched in the epithelium at steady state led to heightened tumor development, whereas targeting γδ subsets that accumulate during CRC resulted in reduced tumor growth. Our results uncover temporal pro- and antitumor roles for γδ T cell subsets.
    MeSH term(s) Animals ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Cytotoxicity, Immunologic ; Humans ; Intestines/immunology ; Intraepithelial Lymphocytes/immunology ; Mice ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/physiology
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj8695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  3. Article ; Online: Lymphatics act as a signaling hub to regulate intestinal stem cell activity.

    Niec, Rachel E / Chu, Tinyi / Schernthanner, Marina / Gur-Cohen, Shiri / Hidalgo, Lynette / Pasolli, Hilda Amalia / Luckett, Kathleen A / Wang, Zhong / Bhalla, Sohni R / Cambuli, Francesco / Kataru, Raghu P / Ganesh, Karuna / Mehrara, Babak J / Pe'er, Dana / Fuchs, Elaine

    Cell stem cell

    2022  Volume 29, Issue 7, Page(s) 1067–1082.e18

    Abstract: Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. The ... ...

    Abstract Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. The complexity of these niches and underlying communication pathways are not fully known. Here, we report a lymphatic network at the intestinal crypt base that intimately associates with ISCs. Employing in vivo loss of function and lymphatic:organoid cocultures, we show that crypt lymphatics maintain ISCs and inhibit their precocious differentiation. Pairing single-cell and spatial transcriptomics, we apply BayesPrism to deconvolve expression within spatial features and develop SpaceFold to robustly map the niche at high resolution, exposing lymphatics as a central signaling hub for the crypt in general and ISCs in particular. We identify WNT-signaling factors (WNT2, R-SPONDIN-3) and a hitherto unappreciated extracellular matrix protein, REELIN, as crypt lymphatic signals that directly govern the regenerative potential of ISCs.
    MeSH term(s) Cell Proliferation ; Intestinal Mucosa/metabolism ; Intestines ; Organoids ; Signal Transduction ; Stem Cells ; Wnt Proteins/metabolism
    Chemical Substances Wnt Proteins
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6589: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 75: Show issues

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  4. Article ; Online: Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.

    Roulis, Manolis / Kaklamanos, Aimilios / Schernthanner, Marina / Bielecki, Piotr / Zhao, Jun / Kaffe, Eleanna / Frommelt, Laura-Sophie / Qu, Rihao / Knapp, Marlene S / Henriques, Ana / Chalkidi, Niki / Koliaraki, Vasiliki / Jiao, Jing / Brewer, J Richard / Bacher, Maren / Blackburn, Holly N / Zhao, Xiaoyun / Breyer, Richard M / Aidinis, Vassilis /
    Jain, Dhanpat / Su, Bing / Herschman, Harvey R / Kluger, Yuval / Kollias, George / Flavell, Richard A

    Nature

    2020  Volume 580, Issue 7804, Page(s) 524–529

    Abstract: The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in ... ...

    Abstract The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Antigens, Ly/metabolism ; Arachidonic Acid/metabolism ; Carcinogenesis ; Cell Cycle Proteins/metabolism ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestines/pathology ; Male ; Membrane Proteins/metabolism ; Mesoderm/metabolism ; Mesoderm/pathology ; Mice ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Organoids/metabolism ; Organoids/pathology ; Paracrine Communication ; Receptors, Prostaglandin E, EP4 Subtype/metabolism ; Single-Cell Analysis ; Stem Cell Niche ; YAP-Signaling Proteins
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antigens, Ly ; Cell Cycle Proteins ; Ly6a protein, mouse ; Membrane Proteins ; PTGER4 protein, human ; Ptger4 protein, mouse ; Receptors, Prostaglandin E, EP4 Subtype ; YAP-Signaling Proteins ; Yap1 protein, mouse ; Arachidonic Acid (27YG812J1I) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2020-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2166-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  5. Article ; Online: IDO1

    Pflügler, Sandra / Svinka, Jasmin / Scharf, Irene / Crncec, Ilija / Filipits, Martin / Charoentong, Pornpimol / Tschurtschenthaler, Markus / Kenner, Lukas / Awad, Monira / Stift, Judith / Schernthanner, Marina / Bischl, Romana / Herndler-Brandstetter, Dietmar / Glitzner, Elisabeth / Moll, Herwig P / Casanova, Emilio / Timelthaler, Gerald / Sibilia, Maria / Gnant, Michael /
    Lax, Sigurd / Thaler, Josef / Müller, Mathias / Strobl, Birgit / Mohr, Thomas / Kaser, Arthur / Trajanoski, Zlatko / Heller, Gerwin / Eferl, Robert

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 252

    Abstract: Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to ... ...

    Abstract Tumors have evolved mechanisms to escape anti-tumor immunosurveillance. They limit humoral and cellular immune activities in the stroma and render tumors resistant to immunotherapy. Sensitizing tumor cells to immune attack is an important strategy to revert immunosuppression. However, the underlying mechanisms of immune escape are still poorly understood. Here we discover Indoleamine-2,3-dioxygenase-1 (IDO1)
    MeSH term(s) Animals ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Immune Tolerance/immunology ; Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Intestinal Neoplasms/immunology ; Intestinal Neoplasms/metabolism ; Intestinal Neoplasms/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Paneth Cells/immunology ; STAT1 Transcription Factor/physiology
    Chemical Substances Indoleamine-Pyrrole 2,3,-Dioxygenase ; STAT1 Transcription Factor
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0989-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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