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  1. Article ; Online: MRI and Trouillas' grading system of pituitary tumors: the usefulness of T2 signal intensity volumetric values.

    Calandrelli, Rosalinda / Pilato, Fabio / D'Apolito, Gabriella / Schiavetto, Stefano / Gessi, Marco / D'Alessandris, Quintino Giorgio / Lauretti, Liverana / Gaudino, Simona

    Neuroradiology

    2023  Volume 65, Issue 11, Page(s) 1567–1578

    Abstract: Purpose: To classify pituitary macroadenomas according to the Trouillas' grading system; to compare this grading system with T2 values of volumetric signal intensity to determine T2 values able to predict the final grade.: Methods: A total of 106 ... ...

    Abstract Purpose: To classify pituitary macroadenomas according to the Trouillas' grading system; to compare this grading system with T2 values of volumetric signal intensity to determine T2 values able to predict the final grade.
    Methods: A total of 106 patients with macroadenomas were grouped according to the grading system score combining proliferation and invasiveness criteria of Trouillas' classification. Normalized volumetric signal intensity values were extracted from coronal T2-weighted images (nT2mean, nT2Max, nT2min) and were compared with the final grading score system.
    Results: Thirty-three patients were in grade 1a (non-invasive, non-proliferative tumors), 17 patients in grade 1b (non-invasive, proliferative tumors), 36 patients in grade 2a (invasive, non-proliferative tumors), and 20 patients in grade 2b (invasive, proliferative tumors). No patient was in grade 3 (metastatic tumors). nT2Max and nT2min were the best quantitative values to discriminate invasive from non-invasive grades; in invasive grades, nT2Max intensity values were higher, and nT2min intensity values were lower than in non-invasive grades. Receiver operating characteristic analysis of nT2 values showed that nT2min values had a better diagnostic performance than nT2Max values because they allowed differentiating with a moderate accuracy invasive tumors (2a or 2b grades) from both non-invasive proliferative tumors (1b) and non-invasive-non proliferative tumors (1a) (2a vs 1b: AUC
    Conclusion: Volumetric nT2Max and nT2min values of MRI might be practical and non-invasive markers for assessing tumor invasiveness although nT2 min signal intensity values have more effects in discriminating tumor's invasive behavior.
    MeSH term(s) Humans ; Pituitary Neoplasms/diagnostic imaging ; Pituitary Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; ROC Curve ; Neoplasm Grading ; Retrospective Studies
    Language English
    Publishing date 2023-05-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-023-03162-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Contrast-Induced Acute Kidney Injury and Endothelial Dysfunction: The Role of Vascular and Biochemical Parameters.

    Perrotta, Adolfo Marco / Gigante, Antonietta / Rotondi, Silverio / Menè, Paolo / Notturni, Adriano / Schiavetto, Stefano / Tanzilli, Gaetano / Pellicano, Chiara / Guaglianone, Giuseppe / Tinti, Francesca / Palange, Paolo / Mazzaferro, Sandro / Cianci, Rosario / Lai, Silvia

    Journal of personalized medicine

    2023  Volume 13, Issue 4

    Abstract: Introduction: Contrast-induced acute kidney injury (CIAKI) is one of the main causes of acute renal failure in hospitalized patients, following the administration of iodinated contrast medium used for CT scans and angiographic procedures. CIAKI ... ...

    Abstract Introduction: Contrast-induced acute kidney injury (CIAKI) is one of the main causes of acute renal failure in hospitalized patients, following the administration of iodinated contrast medium used for CT scans and angiographic procedures. CIAKI determines a high cardiovascular risk and appears to be one of the most feared complications of coronary angiography, causing a notable worsening of the prognosis with high morbidity and mortality.
    Aim: To evaluate a possible association between the renal resistive index (RRI) and the development of CIAKI, as well as an association with the main subclinical markers of atherosclerosis and the main cardiovascular risk factors.
    Materials and methods: We enrolled 101 patients with an indication for coronary angiography. Patients underwent an assessment of renal function (serum nitrogen and basal creatinine, 48 and 72 h after administration of contrast medium), inflammation (C reactive protein (CRP), serum calcium and phosphorus, intact parathormone (iPTH), 25-hydroxyvitaminD (25-OH-VitD), serum uric acid (SUA), total cholesterol, serum triglycerides, serum glucose and insulin). All patients also carried out an evaluation of RRI, intima-media thickness (IMT), interventricular septum (IVS) and the ankle-brachial index (ABI).
    Results: 101 patients (68 male), with a mean age of 73.0 ± 15.0 years, were enrolled for the study; 35 are affected by type 2 diabetes mellitus. A total of 19 cases of CIAKI were reported (19%), while among diabetic patients we reported an incidence of 23% (8 patients). In our study, patients with CIAKI had significantly higher RRI (
    Conclusions: We showed a significant difference in RRI, IMT, SUA and CRP values between the population developing CIAKI and patients without CIAKI. This data appears relevant considering that RRI and IMT are low-cost, non-invasive and easily reproducible markers of endothelial dysfunction and atherosclerosis.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13040701
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  3. Article ; Online: Effects of Lumacaftor/Ivacaftor on physical activity and exercise tolerance in three adults with cystic fibrosis.

    Savi, Daniela / Schiavetto, Stefano / Simmonds, Nicholas J / Righelli, Dario / Palange, Paolo

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2019  Volume 18, Issue 3, Page(s) 420–424

    Abstract: The combination of the corrector lumacaftor with the potentiator ivacaftor has been approved for treatment of cystic fibrosis (CF) patients homozygous for the Phe508del CFTR mutation. There are no reports detailing the effect of lumacaftor-ivacaftor on ... ...

    Abstract The combination of the corrector lumacaftor with the potentiator ivacaftor has been approved for treatment of cystic fibrosis (CF) patients homozygous for the Phe508del CFTR mutation. There are no reports detailing the effect of lumacaftor-ivacaftor on physical activity (PA) and exercise tolerance. We performed incremental cardiopulmonary exercise testing (CPET) and we assessed PA pre- and post 2 years initiation of lumacaftor-ivacaftor in three CF adults. PA of mild intensity improved by +13% in patient 1, + 84% in patients 2 and + 89% in patient 3. Oxygen uptake increased both at anaerobic threshold and at peak exercise (patient 1 + 33%, patient 2 + 42% and patient 3 + 20%). Daily physical activities and exercise tolerance improved after two years of lumacaftor-ivacaftor therapy.
    MeSH term(s) Activities of Daily Living ; Adult ; Aminophenols/administration & dosage ; Aminopyridines/administration & dosage ; Benzodioxoles/administration & dosage ; Chloride Channel Agonists/administration & dosage ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Drug Combinations ; Drug Monitoring/methods ; Exercise ; Exercise Tolerance/drug effects ; Exercise Tolerance/physiology ; Forced Expiratory Volume/drug effects ; Humans ; Male ; Middle Aged ; Mutation ; Oxygen Consumption/drug effects ; Quinolones/administration & dosage ; Treatment Outcome
    Chemical Substances Aminophenols ; Aminopyridines ; Benzodioxoles ; Chloride Channel Agonists ; Drug Combinations ; Quinolones ; lumacaftor, ivacaftor drug combination ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2019-03-14
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2091075-7
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2019.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New strategies of physical activity assessment in cystic fibrosis: a pilot study.

    Savi, Daniela / Graziano, Luigi / Giordani, Barbara / Schiavetto, Stefano / Vito, Corrado De / Migliara, Giuseppe / Simmonds, Nicholas J / Palange, Paolo / Elborn, J Stuart

    BMC pulmonary medicine

    2020  Volume 20, Issue 1, Page(s) 285

    Abstract: Background: Regular physical activity (PA) is a valued part of cystic fibrosis (CF) care. Although the accelerometer, SenseWear Armband (SWA), accurately measures habitual PA in CF, it is mostly used for research purposes. For the first time, we ... ...

    Abstract Background: Regular physical activity (PA) is a valued part of cystic fibrosis (CF) care. Although the accelerometer, SenseWear Armband (SWA), accurately measures habitual PA in CF, it is mostly used for research purposes. For the first time, we analyzed different methods of measuring PA in daily life by the use of smartphones and other electronic devices such as smartwatch and Fitbit.
    Methods: Twenty-four stable adults with CF (mean age 37.5 ± 11.5SD yrs.; FEV
    Results: There was a good agreement between SWA and Fitbit for number of steps (p = 0.605) and energy expenditure (p = 0.143). iOS smartphones were similar to SWA in monitoring the number of steps (p = 0.911). Significant differences were found between SWA and both Smartwatch and Android smartphones.
    Conclusions: Fitbit and iOS smartphones seem to be a valuable approach to monitor daily PA. They provide a good performance to measure step number compared to SWA.
    MeSH term(s) Accelerometry ; Activities of Daily Living ; Adult ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis/psychology ; Energy Metabolism ; Exercise ; Female ; Humans ; Male ; Middle Aged ; Monitoring, Ambulatory/instrumentation ; Pilot Projects ; Respiratory Function Tests ; Surveys and Questionnaires ; Telemedicine
    Language English
    Publishing date 2020-10-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-020-01313-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mycophenolate Mofetil Improves Exercise Tolerance in Systemic Sclerosis Patients with Interstitial Lung Disease: A Pilot Study.

    Vaiarello, Valentina / Schiavetto, Stefano / Foti, Federica / Gigante, Antonietta / Iannazzo, Francesco / Paone, Gregorino / Palange, Paolo / Rosato, Edoardo

    Rheumatology and therapy

    2020  Volume 7, Issue 4, Page(s) 1037–1044

    Abstract: Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by the overproduction of collagen leading to fibrosis of the skin and internal organs. Interstitial lung disease (ILD) is one of the major causes of death in patients with SSc. ...

    Abstract Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by the overproduction of collagen leading to fibrosis of the skin and internal organs. Interstitial lung disease (ILD) is one of the major causes of death in patients with SSc. Exercise tolerance can be investigated by cardio-pulmonary exercise testing (CPET). First-line therapies in patients with SSc associated with ILD (SSc-ILD) include cyclophosphamide and mycophenolate mofetil (MMF). The aim of this study was to evaluate the response of patients with SSc-ILD to MMF by means of CPET.
    Methods: Ten consecutive SSc patients were enrolled in this study. All SSc patients underwent clinical evaluation, echocardiography, pulmonary function tests, high-resolution computed tomography (HRCT) and CPET at baseline and after 2 years of therapy with MMF.
    Results: After 24 months of treatment with MMF (target dose 1500 mg twice daily), forced vitality capacity, diffusing capacity of the lungs for carbon monoxide and systolic pulmonary arterial pressure had not improved significantly and there were no significant differences in HRCT findigns. In addition, peak oxygen uptake (V'O
    Conclusion: These data from our pilot study on a small cohort of SSc patients are the first to demonstrate that treatment with MMF can improves exercise tolerance and leg discomfort in patients with SSc-ILD. These preliminary results need to be confirmed in large randomized studies.
    Language English
    Publishing date 2020-08-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2783278-8
    ISSN 2198-6584 ; 2198-6576
    ISSN (online) 2198-6584
    ISSN 2198-6576
    DOI 10.1007/s40744-020-00232-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Governmental Response to the COVID-19 Pandemic:A Quantitative Ethnographic Comparison of Public Health Authorities' Communication in Denmark, Norway, and Sweden

    Schnaider, Karoline / Schiavetto, Stefano / Meier, Florian Maximilian / Wasson, Barbara / Brink Allsopp, Benjamin / Spikol , Daniel

    Schnaider , K , Schiavetto , S , Meier , F M , Wasson , B , Brink Allsopp , B & Spikol , D 2020 , Governmental Response to the COVID-19 Pandemic : A Quantitative Ethnographic Comparison of Public Health Authorities' Communication in Denmark, Norway, and Sweden . in ICQE: International Conference on Quantitative Ethnography 2020 . ICQE: International Conference on Quantitative Ethnography 2020 .

    2020  

    Abstract: The Scandinavian countries are often seen as a unity. However, during the COVID-19 pandemic striking differences on how the countries approached the crisis became evident. This quantitative-ethnographic (QE) study aimed to understand political and ... ...

    Abstract The Scandinavian countries are often seen as a unity. However, during the COVID-19 pandemic striking differences on how the countries approached the crisis became evident. This quantitative-ethnographic (QE) study aimed to understand political and cultural similarities and differences between the three Scandinavian countries -Denmark, Norway and Sweden - through their crisis communications during the COVID-19 pandemic. Specifically, we focused on how the health authorities of the three countries, in their press releases, treated information about COVID-19 and acted in four fields: reorganization of population behavior, containment of viral transmission, preparation of health systems, and management of socioeconomic impacts. As a methodology, the QE tools nCoder and ENA were applied, respectively: to code the press releases and to correlate the treatment of information with the four fields of action.
    Keywords COVID-19 ; Pandemic ; Crisis communication ; Quantitative ethnography ; covid19
    Subject code 306
    Language English
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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