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  1. Article ; Online: Low Yield, High Costs: The Futility of Blood Cultures in Pneumonia.

    Huber, Lars C / Schibli, Adrian

    Chest

    2020  Volume 158, Issue 3, Page(s) 1284

    MeSH term(s) Bacteremia ; Blood Culture ; Community-Acquired Infections ; Humans ; Medical Futility ; Pneumonia/diagnosis
    Language English
    Publishing date 2020-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.04.014
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  2. Article ; Online: Assessment of a novel, easy-to-implement, aerosolized H

    Novák, Martin / Gloor, Christian / Wicki, Esther / Herb, Dorothea / Schibli, Adrian / Richner, Gilles

    Journal of occupational and environmental hygiene

    2022  Volume 19, Issue 10-11, Page(s) 663–675

    Abstract: The COVID-19 pandemic has affected the world and caused a supply shortage of personal protection equipment, especially filtering facepiece respirators (FFP). This has increased the risk of many healthcare workers contracting SARS-CoV-2. Various ... ...

    Abstract The COVID-19 pandemic has affected the world and caused a supply shortage of personal protection equipment, especially filtering facepiece respirators (FFP). This has increased the risk of many healthcare workers contracting SARS-CoV-2. Various strategies have been assessed to tackle these supply issues. In critical shortage scenarios, reusing single-use-designed respirators may be required. Thus, an easily applicable and reliable FFP2 (or alike) respirator decontamination method, allowing safe re-use of FFP2 respirators by healthcare personnel, has been developed and is presented in this study. A potent and gentle aerosolized hydrogen peroxide (12% wt) method was applied over 4 hr to decontaminate various brands of FFP2 respirators within a small common room, followed by adequate aeration and storage overnight. The microbial efficacy was tested on unused respirator pieces using spores of
    MeSH term(s) Humans ; SARS-CoV-2 ; Pandemics/prevention & control ; COVID-19/prevention & control ; Decontamination/methods ; Equipment Reuse ; Ventilators, Mechanical
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131820-7
    ISSN 1545-9632 ; 1545-9624
    ISSN (online) 1545-9632
    ISSN 1545-9624
    DOI 10.1080/15459624.2022.2125519
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    Zs.A 5821: Show issues Location:
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  3. Article: Cohort Profile: The Zurich Primary HIV Infection Study.

    Freind, Matt C / Tallón de Lara, Carmen / Kouyos, Roger D / Wimmersberger, David / Kuster, Hebert / Aceto, Leonardo / Kovari, Helen / Flepp, Markus / Schibli, Adrian / Hampel, Benjamin / Grube, Christina / Braun, Dominique L / Günthard, Huldrych F

    Microorganisms

    2024  Volume 12, Issue 2

    Abstract: The Zurich Primary HIV Infection (ZPHI) study is a longitudinal cohort study established in 2002, aiming to study the clinical, epidemiological, and biological characteristics of primary HIV infection. The ZPHI enrolls individuals with documented primary ...

    Abstract The Zurich Primary HIV Infection (ZPHI) study is a longitudinal cohort study established in 2002, aiming to study the clinical, epidemiological, and biological characteristics of primary HIV infection. The ZPHI enrolls individuals with documented primary HIV-1 infection. At the baseline and thereafter, the socio-demographic, clinical, and laboratory data are systematically collected, and regular blood sampling is performed for biobanking. By the end of December 2022, 486 people were enrolled, of which 353 were still undergoing active follow-up. Of the 486 participants, 86% had an acute infection, and 14% a recent HIV-1 infection. Men who have sex with men accounted for 74% of the study population. The median time from the estimated date of infection to diagnosis was 32 days. The median time from diagnosis to the initiation of antiretroviral therapy was 11 days, and this has consistently decreased over the last two decades. During the seroconversion phase, 447 (92%) patients reported having symptoms, of which only 73% of the patients were classified as having typical acute retroviral syndrome. The ZPHI study is a well-characterized cohort belonging to the most extensively studied primary HIV infection cohort. Its findings contribute to advancing our understanding of the early stages of HIV infection and pathogenesis, and it is paving the way to further improve HIV translational research and HIV medicine.
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020302
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  4. Article: CME: Typhus abdominalis – Klinik, Diagnostik, Therapie und Prävention.

    Moser-van der Geest, Noëlle / Schibli, Adrian / Huber, Lars C

    Praxis

    2019  Volume 108, Issue 14, Page(s) 937–943

    Abstract: CME: Typhoid Fever - Clinical Manifestation, Diagnosis, Therapy and ... ...

    Title translation CME: Typhoid Fever - Clinical Manifestation, Diagnosis, Therapy and Prevention.
    Abstract CME: Typhoid Fever - Clinical Manifestation, Diagnosis, Therapy and Prevention
    MeSH term(s) Africa South of the Sahara ; Humans ; Travel ; Typhoid Fever/diagnosis ; Typhoid Fever/prevention & control ; Typhoid Fever/therapy ; Vaccination
    Language German
    Publishing date 2019-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a003319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 12: Show issues

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  5. Article ; Online: COVID-19

    Bieri-Brning, Gabriela / Beck, Sacha / Schibli, Adrian / Gschwindner, Heike

    Schweizerische Ärztezeitung ; ISSN 0036-7486 1424-4004

    Erfahrungen aus den Pflegezentren der Stadt Zrich

    2020  

    Keywords covid19
    Language German
    Publisher EMH Swiss Medical Publishers, Ltd.
    Publishing country ch
    Document type Article ; Online
    DOI 10.4414/saez.2020.18943
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19

    Bieri-Brning, Gabriela / Beck, Sacha / Schibli, Adrian / Gschwindner, Heike

    Bulletin des Médecins Suisses ; ISSN 1424-4012

    Erfahrungen aus den Pflegezentren der Stadt Zrich

    2020  

    Keywords covid19
    Language French
    Publisher EMH Swiss Medical Publishers, Ltd.
    Publishing country ch
    Document type Article ; Online
    DOI 10.4414/bms.2020.18943
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015.

    Osthoff, Michael / Schibli, Adrian / Fadini, Davide / Lardelli, Pietro / Goldenberger, Daniel

    BMC infectious diseases

    2016  Volume 16, Page(s) 210

    Abstract: Background: Louse-borne relapsing fever (LBRF) is a neglected disease that has been restricted to East Africa for many decades. Several cases in refugees from the Horn of Africa have been recently diagnosed in four European countries.: Case ... ...

    Abstract Background: Louse-borne relapsing fever (LBRF) is a neglected disease that has been restricted to East Africa for many decades. Several cases in refugees from the Horn of Africa have been recently diagnosed in four European countries.
    Case presentation: We report four additional cases of LBRF in asylum seekers from Somalia and Eritrea who presented with fever shortly after arriving in Switzerland during a seven-month period. Multiple spirochetes were visualized on stained blood films which were identified as Borrelia recurrentis by 16S rRNA gene sequencing. All patients recovered after antibiotic treatment with ceftriaxone and/or doxycycline. Concurrent infections (malaria and tuberculosis) were diagnosed in half of our patients. Possible modes of transmission and preventive measures are discussed.
    Conclusions: These reported cases highlight the ongoing transmission of LBRF in migrants from East Africa. Diagnosis of LBRF cases and prevention of autochthonous transmission in asylum seeker camps are important steps for the near future.
    MeSH term(s) Adolescent ; Adult ; Africa ; Animals ; Anti-Bacterial Agents/administration & dosage ; Borrelia/classification ; Borrelia/drug effects ; Borrelia/genetics ; Borrelia/isolation & purification ; Ceftriaxone/administration & dosage ; Doxycycline/administration & dosage ; Female ; Humans ; Male ; Pediculus/microbiology ; RNA, Ribosomal, 16S/genetics ; Refugees/statistics & numerical data ; Relapsing Fever/diagnosis ; Relapsing Fever/drug therapy ; Relapsing Fever/microbiology ; Relapsing Fever/transmission ; Switzerland ; Transients and Migrants ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; RNA, Ribosomal, 16S ; Ceftriaxone (75J73V1629) ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2016-05-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-016-1541-z
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  8. Article ; Online: Painless swelling of the forefoot and recurrent subcutaneous abscesses of the lower leg-Two distinct presentations illustrating the spectrum of eumycetoma in a nonendemic country.

    Schibli, Adrian / Goldenberger, Daniel / Krieg, Andreas / Hirschmann, Anna / Bruder, Elisabeth / Osthoff, Michael

    PLoS neglected tropical diseases

    2017  Volume 11, Issue 4, Page(s) e0005360

    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0005360
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  9. Article ; Online: Universal Admission Screening for SARS-CoV-2 Infections among Hospitalized Patients, Switzerland, 2020.

    Scheier, Thomas / Schibli, Adrian / Eich, Geri / Rüegg, Christian / Kube, Frank / Schmid, Adrian / Karrer, Urs / Wolfensberger, Aline / Sax, Hugo / Schreiber, Peter W

    Emerging infectious diseases

    2021  Volume 27, Issue 2, Page(s) 404–410

    Abstract: Switzerland began a national lockdown on March 16, 2020, in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the prevalence of SARS-CoV-2 infection among patients admitted to 4 hospitals in the ... ...

    Abstract Switzerland began a national lockdown on March 16, 2020, in response to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the prevalence of SARS-CoV-2 infection among patients admitted to 4 hospitals in the canton of Zurich, Switzerland, in April 2020. These 4 acute care hospitals screened 2,807 patients, including 2,278 (81.2%) who did not have symptoms of coronavirus disease (COVID-19). Overall, 529 (18.8%) persons had >1 symptom of COVID-19, of whom 60 (11.3%) tested positive for SARS-CoV-2. Eight asymptomatic persons (0.4%) also tested positive for SARS-CoV-2. Our findings indicate that screening on the basis of COVID-19 symptoms, regardless of clinical suspicion, can identify most SARS-CoV-2-positive persons in a low-prevalence setting.
    MeSH term(s) Adult ; Aged ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Testing/methods ; COVID-19 Testing/statistics & numerical data ; Diagnostic Tests, Routine/methods ; Diagnostic Tests, Routine/statistics & numerical data ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Patient Admission/statistics & numerical data ; Prevalence ; SARS-CoV-2 ; Switzerland/epidemiology ; Universal Precautions/methods ; Universal Precautions/statistics & numerical data
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2702.202318
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    Zs.A 4778: Show issues Location:
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  10. Article ; Online: Molecular epidemiology of invasive Group A Streptococcal infections before and after the COVID-19 pandemic in Switzerland

    Andrianaki, Angeliki M. / Franz, Jessica / Andreoni, Federica / Bergada-Pijuan, Judith / Scheier, Thomas C. / Duwe, Tanja / Pfister, Marc / Seth-Smith, Helena / Roloff, Tim / Kolesnik-Goldmann, Natalia / Burkhard, Sara H. / Cusini, Alexia / Karrer, Urs / Rüegg, Christian / Schibli, Adrian / Schrenzel, Jacques / Musumeci, Stefano / Kouyos, Roger D. / Egli, Adrian /
    Brugger, Silvio D. / Zinkernagel, Annelies S.

    medRxiv

    Abstract: Group A Streptococcus (GAS, aka Streptococcus pyogenes) poses a significant public health concern, causing a diverse spectrum of infections with high mortality rates. Following the COVID-19 pandemic, a resurgence of invasive GAS (iGAS) infections has ... ...

    Abstract Group A Streptococcus (GAS, aka Streptococcus pyogenes) poses a significant public health concern, causing a diverse spectrum of infections with high mortality rates. Following the COVID-19 pandemic, a resurgence of invasive GAS (iGAS) infections has been documented, necessitating efficient outbreak detection methods. Whole genome sequencing (WGS) serves as the gold standard for GAS molecular typing, albeit constrained by time and costs. This study aimed to characterize the postpandemic increased prevalence of iGAS on the molecular epidemiological level in order to assess whether new, more virulent variants have emerged, as well as to assess the performance of the rapid and cost-effective Fourier-transform infrared (FTIR) spectroscopy as an alternative to WGS for detecting and characterizing GAS transmission routes. A total of 66 iGAS strains isolated from nine Swiss hospitals during the COVID-19 post-pandemic increased GAS prevalence were evaluated and compared to 15 strains collected before and 12 during the COVID-19 pandemic. FT-IR measurements and WGS were conducted for network analysis. Demographic, clinical, and epidemiological data were collected. Skin and soft tissue infection was the most common diagnosis, followed by primary bacteremia and pneumonia. Viral co-infections were found in 25% of cases and were significantly associated with more severe disease requiring intensive care unit admission. WGS analysis did not reveal emerging GAS genetic distinct variants after the COVID-19 pandemic, indicating the absence of a pandemic-induced shift. FT-IR spectroscopy exhibited limitations in differentiating genetically distant GAS strains, yielding poor overlap with WGS-derived clusters. The emm1/ST28 gebotype was predominant in our cohort and was associated with five of the seven deaths recorded, in accordance with the molecular epidemiological data before the pandemic. Additionally, no notable shift in antibiotic susceptibility patterns was observed. Our data suggest that mainly non-pathogen related factors contributed to the recent increased prevalence of iGAS.
    Keywords covid19
    Language English
    Publishing date 2024-04-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2024.04.03.24305261
    Database COVID19

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