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  1. Book ; Thesis: Morphologische Veränderungen bei Patienten mit einseitiger Lippen-Kiefer-Gaumen-Segel-Spalte bis zur 1. Dentition nach Gingivoperiostalplastik

    Schiefer, Andrea

    eine multizentrische Pilotstudie

    2016  

    Author's details vorgelegt von Andrea Schiefer
    Language German
    Size 57 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Fakultät der Universität zu Köln, 2016
    HBZ-ID HT018948447
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 D 415 order for loan Magazin

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  2. Book ; Thesis: Die horizontale Segmentdistraktion

    Schiefer, Andrea

    eine mögliche Alternative zur autologen Knochentransplantation

    2004  

    Author's details vorgelegt von Andrea Schiefer
    Language German
    Size 97 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Diss., 200x
    HBZ-ID HT014044154
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 MB 252 order for loan Magazin

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  3. Book ; Thesis: Einzelkanal-Untersuchungen am Ryanodin-Rezeptor-Kanal unter den Bedingungen der Ca 2+ -Konzentrationsklemme

    Schiefer, Alfred

    1995  

    Author's details vorgelegt von Alfred Schiefer
    Keywords Calcium Channels / physiology ; Muscle Proteins ; Calcium / metabolism
    Language German
    Size 58 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 1995
    HBZ-ID HT006763012
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    95 D 3645 order for loan Magazin

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  4. Book ; Thesis: Aktivitätsmarker bei Morbus Crohn

    Schiefer, Anna

    1999  

    Author's details vorgelegt von Anna Schiefer, geb. Pismennaja
    Language German
    Size 46 Bl., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Halle, Univ., Diss., 1999
    HBZ-ID HT012901461
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 80 order for loan Magazin

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  5. Article: Organic Acid to Nitrile: A Chemoenzymatic Three-Step Route.

    Winkler, Margit / Horvat, Melissa / Schiefer, Astrid / Weilch, Victoria / Rudroff, Florian / Pátek, Miroslav / Martínková, Ludmila

    Advanced synthesis & catalysis

    2022  Volume 365, Issue 1, Page(s) 37–42

    Abstract: Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for a whole range of different reactions. We report a cyanide free chemoenzymatic cascade for nitrile synthesis. The reaction pathway starts with ...

    Abstract Various widely applied compounds contain cyano-groups, and this functional group serves as a chemical handle for a whole range of different reactions. We report a cyanide free chemoenzymatic cascade for nitrile synthesis. The reaction pathway starts with a reduction of carboxylic acid to aldehyde by carboxylate reductase enzymes (CARs) applied as living cell biocatalysts. The second - chemical - step includes
    Language English
    Publishing date 2022-12-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2041384-1
    ISSN 1615-4169 ; 1615-4150
    ISSN (online) 1615-4169
    ISSN 1615-4150
    DOI 10.1002/adsc.202201053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Accuracy of fetal middle cerebral artery Doppler ultrasound for moderate to severe fetal anemia prior to 24 weeks gestation.

    Miller, Katherine / Green, Sophie / Schiefer, Allyson / Tuuli, Methodius G / Shanks, Anthony

    Journal of perinatology : official journal of the California Perinatal Association

    2022  Volume 43, Issue 2, Page(s) 231–232

    MeSH term(s) Female ; Pregnancy ; Humans ; Middle Cerebral Artery/diagnostic imaging ; Fetal Diseases/diagnostic imaging ; Anemia/diagnostic imaging ; Ultrasonography ; Ultrasonography, Doppler ; Ultrasonography, Prenatal ; Blood Flow Velocity ; Gestational Age ; Umbilical Arteries/diagnostic imaging
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-022-01444-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2412: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity.

    Hecko, Sebastian / Schiefer, Astrid / Badenhorst, Christoffel P S / Fink, Michael J / Mihovilovic, Marko D / Bornscheuer, Uwe T / Rudroff, Florian

    Chemical reviews

    2023  Volume 123, Issue 6, Page(s) 2832–2901

    Abstract: Many successful stories in enzyme engineering are based on the creation of randomized diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods that enabled their evaluation with high throughput are dominated by ... ...

    Abstract Many successful stories in enzyme engineering are based on the creation of randomized diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods that enabled their evaluation with high throughput are dominated by spectroscopic techniques due to their high speed and sensitivity. A large proportion of studies relies on fluorogenic substrates that mimic the chemical properties of the target or coupled enzymatic assays with an optical read-out that assesses the desired catalytic efficiency indirectly. The most reliable hits, however, are achieved by screening for conversions of the starting material to the desired product. For this purpose, functional group assays offer a general approach to achieve a fast, optical read-out. They use the chemoselectivity, differences in electronic and steric properties of various functional groups, to reduce the number of false-positive results and the analytical noise stemming from enzymatic background activities. This review summarizes the developments and use of functional group probes for chemoselective derivatizations, with a clear focus on screening for enzymatic activity in protein engineering.
    MeSH term(s) High-Throughput Screening Assays/methods ; Protein Engineering/methods
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.2c00304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/78: Show issues
    Z 4.4: Show issues

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  8. Article ; Online: A laboratory-based predictive pathway for the development of

    Balthazar, Jacqueline T / Golparian, Daniel / Unemo, Magnus / Read, Timothy D / Grosse, Miriam / Stadler, Marc / Pfarr, Kenneth / Schiefer, Andrea / Hoerauf, Achim / Edwards, Jennifer L / Vassylyev, Dmitry G / Shafer, William M

    Microbiology spectrum

    2024  , Page(s) e0056024

    Abstract: The continued emergence of : Importance: The continued emergence of multi-antibiotic-resistant strains ... ...

    Abstract The continued emergence of
    Importance: The continued emergence of multi-antibiotic-resistant strains of
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00560-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations.

    Becker, Tim / Heitkötter, Jan / Krome, Anna K / Schiefer, Andrea / Pfarr, Kenneth / Ehrens, Alexandra / Grosse, Miriam / Sandargo, Birthe / Stammberger, Ingo / Stadler, Marc / Hübner, Marc P / Kehraus, Stefan / Hoerauf, Achim / Wagner, Karl G

    Pharmaceutics

    2024  Volume 16, Issue 3

    Abstract: Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for oral ... ...

    Abstract Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for oral administration since non-aqueous solvents are often not tolerable. In the case of the anti-infective corallopyronin A, currently undergoing preclinical investigation for filarial nematode and bacterial infections, commonly used vehicles such as polyethylene glycol 200, aqueous solutions combined with cosolvents or solubilizers, or aqueous suspension have failed due to insufficient tolerability, solubility, or the generation of a non-homogeneous suspension. To this end, the aim of the study was to establish an alternative approach which offers suitable tolerability, dissolution, and ease of handling. Thus, a corallopyronin A-mesoporous silica formulation was successfully processed and tested in a seven-day toxicology study focused on Beagle dogs, including a toxicokinetic investigation on day one. Sufficient tolerability was confirmed by the vehicle control group. The vehicle enabled high-dose levels resulting in a low-, middle-, and high-dose of 150, 450, and 750 mg/kg. Overall, it was possible to achieve high plasma concentrations and exposures, leading to a valuable outcome of the toxicology study and establishing mesoporous silica as a valuable contender for challenging drug candidates.
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16030386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: On the Convergence of Modeling and Simulation.

    Augsdrfer, Ursula H / Riffnaller-Schiefer, Andreas

    IEEE computer graphics and applications

    2017  Volume 37, Issue 4, Page(s) 8–13

    Abstract: Product development consists of two stages: geometrical modeling to define the product's shape, followed by mechanical simulation to verify the design specification and ensure the product's structural integrity. New demands on product design cannot be ... ...

    Abstract Product development consists of two stages: geometrical modeling to define the product's shape, followed by mechanical simulation to verify the design specification and ensure the product's structural integrity. New demands on product design cannot be met using this traditional approach to product development where these two stages remain distinct. Thus, making simulation and analysis pervasive throughout the modeling stage has become a critical goal. This article discusses how far we have come in merging design and analysis and what challenges lie ahead.
    Language English
    Publishing date 2017-08-21
    Publishing country United States
    Document type Journal Article
    ISSN 1558-1756
    ISSN (online) 1558-1756
    DOI 10.1109/MCG.2017.3271469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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