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  1. Article: "LONG COVID WIRD EIN PROBLEM BLEIBEN". Eine Corona-Infektion hinterlässt bei vielen Menschen langfristig Spuren. Long-Covid-Experte Bernhard Schieffer plädiert für eine frühzeitige, sektorenübergreifende Behandlung der Patienten

    Schieffer, Bernhard

    Gesundheit und Gesellschaft

    2022  Volume 25, Issue 9, Page(s) 34

    Language German
    Document type Article
    ZDB-ID 1435511-5
    ISSN 1436-1728
    Database Current Contents Medicine

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  2. Article: Corrigendum: The rationale for the treatment of long-COVID esymptoms-a cardiologist's view.

    Schieffer, Elisabeth / Schieffer, Bernhard

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1244340

    Abstract: This corrects the article DOI: 10.3389/fcvm.2022.992686.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcvm.2022.992686.].
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1244340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The rationale for the treatment of long-Covid symptoms - A cardiologist's view.

    Schieffer, Elisabeth / Schieffer, Bernhard

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 992686

    Abstract: The ongoing coronavirus disease 2019 pandemic left us with thousands of patients suffering from neurological, cardiovascular, and psychiatric disorders named post-acute sequelae of COVID-19 or ... ...

    Abstract The ongoing coronavirus disease 2019 pandemic left us with thousands of patients suffering from neurological, cardiovascular, and psychiatric disorders named post-acute sequelae of COVID-19 or just
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.992686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Race for ACE: Targeting Angiotensin-Converting Enzymes (ACE) in SARS-CoV-2 Infection.

    Schieffer, Elisabeth / Schieffer, Bernhard

    Journal of the renin-angiotensin-aldosterone system : JRAAS

    2022  Volume 2022, Page(s) 2549063

    Abstract: The SARS-CoV-2 virus is spreading around the world, and its clinical manifestation COVID-19 is challenging medical, economic, and social systems. With more and more scientific and social media reports on the COVID-19 pandemic appearing, differences in ... ...

    Abstract The SARS-CoV-2 virus is spreading around the world, and its clinical manifestation COVID-19 is challenging medical, economic, and social systems. With more and more scientific and social media reports on the COVID-19 pandemic appearing, differences in geographical presentations and clinical management occur. Since ACE2 (angiotensin-converting enzyme 2) is the gatekeeper receptor for the SARS-CoV-2 virus in the upper bronchial system, we here focus on the central role of the renin-angiotensin aldosterone system (RAAS) in the SARS-CoV-2 virus infection, the role of pharmacological RAAS inhibitors, and specific genetic aspects, i.e., single nucleotide polymorphisms (SNP) for the clinical outcome of COVID-19. We aimed to bring together clinical, epidemiological, molecular, and pathophysiological and pharmacological data/observations on cardiovascular aspects in the actual SARS-CoV-2 virus pandemic. In detail, we will report controversies about the Yin-Yan between ACE2 and ACE1 and potential implications for the treatment of hypertension, coronary artery disease, and heart failure. Here, we summarize the encouraging and dynamic global effort of multiple biomedical disciplines resulted in astonishing fight against COVID-19 targeting the renin-angiotensin-aldosterone system, yet the race for ACE just begun.
    MeSH term(s) Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensins ; COVID-19/drug therapy ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; SARS-CoV-2
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensins ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2086948-4
    ISSN 1752-8976 ; 1470-3203
    ISSN (online) 1752-8976
    ISSN 1470-3203
    DOI 10.1155/2022/2549063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Monitoring a Mystery: The Unknown Right Ventricle during Left Ventricular Unloading with Impella in Patients with Cardiogenic Shock.

    Markus, Birgit / Kreutz, Julian / Chatzis, Giorgios / Syntila, Styliani / Choukeir, Maryana / Schieffer, Bernhard / Patsalis, Nikolaos

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051265
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  6. Article ; Online: Was ist neu bei Perikard-Erkrankungen?

    Divchev, Dimitar / Schnurbus, Mareike / Schieffer, Bernhard

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 11, Page(s) 704–710

    Abstract: Pericardial disease represents a large diversity of inflammation related injury of the pericardium. Multifactorial causes may contribute to acute and recurrent pericarditis, pericardial effusion without major hemodynamic compromise, cardiac tamponade or ... ...

    Title translation What's new in pericardial disease?
    Abstract Pericardial disease represents a large diversity of inflammation related injury of the pericardium. Multifactorial causes may contribute to acute and recurrent pericarditis, pericardial effusion without major hemodynamic compromise, cardiac tamponade or constrictive pericarditis. Currently, inflammatory pericardial pathologies are observed in cases of SARS-CoV-2-infection or after vaccination. Beside established anti-inflammatory therapeutic strategies with NSAID, corticosteroids and colchicine, auto-inflammation and inflammasomes seam to offer more specific targets for advanced treatment options.
    MeSH term(s) COVID-19 ; Cardiac Tamponade/diagnosis ; Cardiac Tamponade/etiology ; Cardiac Tamponade/therapy ; Humans ; Inflammation/complications ; Pericardial Effusion/therapy ; SARS-CoV-2
    Language German
    Publishing date 2022-05-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1593-9470
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  7. Article: Prähospitaler Kreislaufstillstand im Lockdown: Auswirkungen der übergreifenden Infektionspräventionsmaßnahmen während der ersten SARS-CoV-2-Welle.

    Grübl, T / Plöger, B / Sassen, M C / Jerrentrup, A / Schieffer, B / Betz, S

    Notfall & rettungsmedizin

    2021  , Page(s) 1–6

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Consequences of infection prevention measures during such contagion events can cause disadvantages especially for patients in out-of-hospital cardiac arrest ( ... ...

    Title translation Out-of-hospital cardiac arrest during lockdown.
    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Consequences of infection prevention measures during such contagion events can cause disadvantages especially for patients in out-of-hospital cardiac arrest (OHCA).
    Methods: Retrospective analysis of OHCAs in one county from January-May in 2018, 2019 and 2020, with the first appearance of the SARS-CoV‑2 pandemic in 2020 and a high incidence of the influenza virus in 2018.
    Results: A total of 497 OHCAs were investigated (2018
    Discussion: The lockdown during the first wave of SARS-CoV‑2 pandemic does not seem to have affected the outcome of OHCA patients without coronavirus disease 2019 (COVID-19) in the end.
    Language German
    Publishing date 2021-08-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1424737-9
    ISSN 1436-0578 ; 1434-6222
    ISSN (online) 1436-0578
    ISSN 1434-6222
    DOI 10.1007/s10049-021-00932-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Impact of Positive Inotropic Therapy on Hemodynamics and Organ Function in Acute Heart Failure: A Differentiated View.

    Cheko, Juan / Patsalis, Nikolaos / Kreutz, Julian / Divchev, Dimitar / Chatzis, Georgios / Schieffer, Bernhard / Markus, Birgit

    Journal of personalized medicine

    2023  Volume 14, Issue 1

    Abstract: Background: Little is known about the impact of treatment with inotropic drugs on the interaction of hemodynamics, biomarkers, and end-organ function in patients with acute decompensated heart failure (HF) of different origins and heart rhythms.: ... ...

    Abstract Background: Little is known about the impact of treatment with inotropic drugs on the interaction of hemodynamics, biomarkers, and end-organ function in patients with acute decompensated heart failure (HF) of different origins and heart rhythms.
    Methods: Fifty patients with different causes of acute decompensated HF (dilated cardiomyopathy DCM, ischemic cardiomyopathy ICM, atrial fibrillation AF, sinus rhythm/pacemaker lead rhythm SR/PM) were treated with dobutamine or levosimendan. Non-invasive hemodynamics, biomarkers, and parameters of renal organ function were evaluated at hospital admission and after myocardial recompensation (day 5 to 7).
    Results: Twenty-seven patients with ICM and twenty-three patients with DCM were included. Thirty-nine patients were treated with dobutamine and eleven with levosimendan. Sixteen were accompanied by persistent AF and thirty-four presented either with SR or PM. In the overall cohort, body weight and biomarkers (NT-proBNP/ST2) significantly decreased. GFR significantly increased during therapy with either dobutamine or levosimendan. However, hemodynamic parameters seem to be only improved in patients with DCM, in the levosimendan sub-group, and in patients with SR/PM.
    Conclusion: Patients with acute decompensated HF benefit from positive inotropic therapy during short-term follow-ups. In particular, patients with DCM, those after levosimendan therapy and those with SR/PM, seem to benefit most from inotropic therapy.
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010017
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  9. Article ; Online: Hemoadsorption as part of a multimodal therapy concept to treat Capnocytophaga sepsis with thrombocytopenia and multiple organ failure.

    Kreutz, Julian / Choukeir, Maryana / Chatzis, Georgios / Schieffer, Bernhard / Markus, Birgit

    The International journal of artificial organs

    2022  Volume 46, Issue 1, Page(s) 52–57

    Abstract: Background: Capnocytophaga, a: Case presentation: We report on a 68-year-old male who was hospitalized with fever, oliguria and repeated vomiting after suffering a minor bite by his dog. On admission, he was diagnosed with sepsis. In addition, his ... ...

    Abstract Background: Capnocytophaga, a
    Case presentation: We report on a 68-year-old male who was hospitalized with fever, oliguria and repeated vomiting after suffering a minor bite by his dog. On admission, he was diagnosed with sepsis. In addition, his coagulation status was markedly deranged resulting in the administration of mass transfusions to stabilize his coagulative status. Following detection of
    Conclusions: This case supports the clinical recognition of severe Capnocytophaga infection that can lead to critical conditions even in immunocompetent patients. Combined broad spectrum antibiotic therapy, mass transfusions, CRRT, and CytoSorb hemoadsorption therapy resulted in a control of the critical situation. However, further research is needed to fully elucidate the role of hemoadsorption in this rare but life-threatening setting.
    MeSH term(s) Aged ; Animals ; Male ; Capnocytophaga ; Multiple Organ Failure/microbiology ; Multiple Organ Failure/therapy ; Sepsis/microbiology ; Sepsis/therapy ; Thrombocytopenia ; Bites and Stings/complications ; Bites and Stings/microbiology ; Hemadsorption ; Humans
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988221132575
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  10. Article ; Online: Herz-Kreislauf-Erkrankungen und COVID-19 : Pathophysiologie, Komplikationen und Therapien.

    Schieffer, Elisabeth / Schieffer, Bernhard / Hilfiker-Kleiner, Denise

    Herz

    2021  Volume 46, Issue 2, Page(s) 107–114

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is a challenge for our healthcare system but at the same time is one of the excellent catalyzers and promoters of successful translational research. The COVID-19 is not only a simple viral infection of the ...

    Title translation Cardiovascular diseases and COVID-19 : Pathophysiology, complications and treatment.
    Abstract The coronavirus disease 2019 (COVID-19) pandemic is a challenge for our healthcare system but at the same time is one of the excellent catalyzers and promoters of successful translational research. The COVID-19 is not only a simple viral infection of the bronchial system but is also a pandemic hyperinflammatory multiorgan disease. The cardiovascular system plays a causal role in this context, as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells via the angiotensin-converting enzyme 2 (ACE-2), an enzyme in the renin-angiotensin system. Furthermore, cardiovascular comorbidities and risk factors, such as hypertension, diabetes and obesity play an important role in the severity of the course of the disease. Additional risk factors, such as gender, age, genetics and air pollution modulate both the severity of the SARS-CoV‑2 infection as well as cardiovascular diseases. As sequelae of COVID-19, increased thrombosis, myocardial infarction, myocardial inflammation and vasculitis occur, which directly damage the cardiovascular system and substantially contribute to the high morbidity and mortality. Knowledge gained from many studies on the course of the disease in patients infected with SARS-CoV‑2 has led to improved treatment possibilities, which now in the second wave are partly standardized and were, and are, in particular adapted to complications of the cardiovascular system. In this review we provide a short overview on the pathophysiology of the SARS-CoV‑2 in general and also specifically on the cardiovascular system. Furthermore, we summarize the current treatment approaches and their pathophysiological principles (status November 2020).
    MeSH term(s) COVID-19 ; Cardiovascular Diseases/therapy ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language German
    Publishing date 2021-01-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-020-05013-y
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