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  1. Article ; Online: Applications of PET and SPECT in Patients with Autism Spectrum Disorder.

    Martini, Anna Lisa / Quartuccio, Natale / Schiera, Irene Giovanna / Berti, Valentina / Burroni, Luca / Cistaro, Angelina

    Current medical imaging

    2024  Volume 20, Page(s) 1–11

    Abstract: Autism spectrum disorder (ASD) consists of neurological development disorders that manifest before three years of age and affect social interactions, markedly restricting range of interests and activities, often associated with some degree of ... ...

    Abstract Autism spectrum disorder (ASD) consists of neurological development disorders that manifest before three years of age and affect social interactions, markedly restricting range of interests and activities, often associated with some degree of intellectual disability. Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are non-invasive imaging tools to investigate the function of the brain in vivo. SPECT and PET studies exploring rCBF and brain glucose metabolism in patients with ASD have been performed, providing important insights into the brain regions involved in ASD. Abnormalities in serotonergic, dopaminergic, GABAergic, cholinergic, and glutamatergic systems have been suggested to contribute to the observed distorted brain circuitry associated with ASD. However, the specificity of such abnormalities needs to be fully clarified because schizophrenia and other psychiatric diseases have been shown to present with comparable changes in neurotransmitter systems. Neuroinflammation could also play a role in the development of autism. Therefore, ASD is a complicated process involving a number of factors. It is mandatory to perform more research studies to determine the molecular cornerstone of ASD and to improve our comprehension of the clinical correlates of ASD.
    MeSH term(s) Humans ; Autism Spectrum Disorder/diagnostic imaging ; Tomography, X-Ray Computed ; Positron-Emission Tomography ; Tomography, Emission-Computed, Single-Photon/methods ; Brain/diagnostic imaging ; Brain/metabolism
    Language English
    Publishing date 2024-02-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1573-4056
    ISSN (online) 1573-4056
    DOI 10.2174/0115734056232408230927072959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Esophageal Cancer with Early Onset in a Patient with Cri du Chat Syndrome.

    Danesino, Cesare / Gualtierotti, Monica / Origi, Matteo / Cistaro, Angelina / Malacarne, Michela / Massidda, Matteo / Bencardino, Katia / Coviello, Domenico / Albani, Giovanni / Schiera, Irene Giovanna / Liava, Alexandra / Guala, Andrea

    Diseases (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Background: In Cri du Chat (CdC), cancer as comorbidity is extremely rare. In databases from Denmark, Spain, Australia, New Zealand, and Japan, no cancer was reported; in Italy and Germany, four cancers were identified out of 321 CdCs.: Methods: In a ...

    Abstract Background: In Cri du Chat (CdC), cancer as comorbidity is extremely rare. In databases from Denmark, Spain, Australia, New Zealand, and Japan, no cancer was reported; in Italy and Germany, four cancers were identified out of 321 CdCs.
    Methods: In a 29-year-old CdC patient, clinical investigations following hematemesis led to the diagnosis of esophageal adenocarcinoma (EAC). A high pain threshold was also observed. Conventional and molecular cytogenetic defined the size of the deletion, and exome analysis on the trio completed the molecular work.
    Results: Cytogenetic analysis showed a de novo chromosomal alteration: 46,XY,ishdel(5)(p14.3)(D5S28-) and arr[GRCh37] 5p15.33p14.3(1498180_19955760)x1. A quantitative sensory test demonstrated a high heat threshold. A 18f-fluorodeoxyglucose PET/TC scan of the brain failed to detect reduction of metabolism in the somatosensory area or insular cortex. Exome analysis in the trio (patient and parents) failed to identify variants to be interpreted as a likely risk factor for EAC.
    Conclusion: We conclude that the presence of well-known risk factors (maleness, obesity, gastroesophageal reflux, and Barrett's metaplasia) in a patient with very limited capability of expressing discomfort or referring clinical symptoms have been the main risk factors for developing EAC. At present, based on the available data, there is no evidence of any increased risk of developing cancer in CdC patients.
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720869-2
    ISSN 2079-9721
    ISSN 2079-9721
    DOI 10.3390/diseases12010009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Brain positron emission tomography in idiopathic normal-pressure hydrocephalus: new 18 F-fluorodeoxyglucose pattern in a long-known syndrome.

    Cistaro, Angelina / Quartuccio, Natale / Piccardo, Arnoldo / Meo, Giuseppe / Gandoglia, Ilaria / Schiera, Irene Giovanna / Fania, Piercarlo / Lupidi, Francesco / Bottoni, Gianluca / Massollo, Michela / Altrinetti, Vania / Pestarino, Emanuela / Iacozzi, Massimiliano / Iantorno, Massimiliano / Del Sette, Massimo

    Nuclear medicine communications

    2023  Volume 44, Issue 12, Page(s) 1163–1167

    Abstract: Aim: Patients with idiopathic normal-pressure hydrocephalus (iNPH) can show a global reduction in cerebral glucose metabolism at [ 18 F]Fluorodeoxyglucose (FDG) PET. The presence of caudate hypometabolism has been identified as a potential biomarker in ... ...

    Abstract Aim: Patients with idiopathic normal-pressure hydrocephalus (iNPH) can show a global reduction in cerebral glucose metabolism at [ 18 F]Fluorodeoxyglucose (FDG) PET. The presence of caudate hypometabolism has been identified as a potential biomarker in iNPH, yet there is limited evidence of hypermetabolic findings in patients with iNPH so far.
    Methods: We retrieved retrospectively patients with iNPH and normal cognitive assessment, evaluated before surgery undergoing brain [ 18 F]FDG-PET. The 18 F-FDG-PET brain scans were compared to those of a control group of healthy subjects, matched for age and sex, by statistical parametric mapping (SPM) to identify areas of relative hypo- and hypermetabolism. Furthermore, the existence of a correlation between areas of hypo- and hypermetabolism in the patient group was tested.
    Results: Seven iNPH patients (mean age 74 ± 6 years) were found in the hospital database. SPM group analysis revealed clusters of significant hypometabolism ( P  = 0.001) in the iNPH group in the dorsal striatum, involving caudate and putamen bilaterally. Clusters of significant hypermetabolism ( P  = 0.001) were revealed in the bilateral superior and precentral frontal gyrus (BA 4, 6). A significant inverse correlation between striatal hypometabolism and bilateral superior and precentral frontal gyrus hypermetabolism was revealed ( P  < 0.001 corrected for multiple comparisons).
    Conclusion: In this cohort, patients with iNPH showed subcortical hypometabolism, including bilateral dorsal striatum. To the best of our knowledge, this is the first report demonstrating a hypermetabolic pattern in the primary motor and premotor areas, and showing an inverse correlation between the striatum and motor cortex in patients with iNPH.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Fluorodeoxyglucose F18/metabolism ; Retrospective Studies ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Brain/metabolism ; Hydrocephalus/metabolism
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: 18F-FDG-PET brain imaging may highlight brain metabolic alterations in dysautonomic syndrome after human papilloma virus vaccination.

    Vadalà, Maria / Cistaro, Angelina / Quartuccio, Natale / Calcagni, Maria Lucia / Fania, Piercarlo / Margotti, Simone / Schiera, Irene Giovanna / Laurino, Carmen / Palmieri, Beniamino

    Nuclear medicine communications

    2020  Volume 41, Issue 12, Page(s) 1275–1282

    Abstract: Aim: The aim of this study was to evaluate brain glucose metabolism by means of [18F]-fluoro-deoxygluycose (F-FDG) PET in a group of patients presenting dysautonomic syndrome after human papilloma virus (HPV) immunization.: Methods: Medical records ... ...

    Abstract Aim: The aim of this study was to evaluate brain glucose metabolism by means of [18F]-fluoro-deoxygluycose (F-FDG) PET in a group of patients presenting dysautonomic syndrome after human papilloma virus (HPV) immunization.
    Methods: Medical records of patients, referred to the 'Second Opinion Medical Consulting Network' Medical Centre (Modena, Italy) diagnosed with dysautonomic syndrome were searched. Inclusion criteria were presence in the medical history of adverse drug reactions following HPV vaccine; a Montreal Cognitive Assessment score <25 and good quality of a F-FDG-PET brain scan performed within 12 months from the diagnosis of dysautonomic syndrome. F-FDG-PET images of patients (HPV-group) were compared to a control group, matched for age and sex, using statistical parametric mapping (SPM).
    Results: The F-FDG-PET study was available for five female patients. The SPM-group analysis revealed significant hypometabolism (P < 0.05 false discovery rate corrected) in the right superior and medial temporal gyrus (Brodmann areas 22, 21) and insula (Brodmann area 13). At a threshold of P < 0.001 (uncorrected), further hypometabolic regions were revealed in the right superior temporal gyrus (Brodmann area 42) and caudate head and in the left superior temporal gyrus (Brodmann area 22), frontal subcallosal gyrus (Brodmann area 47) and insula (Brodmann area 13). Relative hypermetabolism (P = 0.001) was revealed in the right premotor cortex (Brodmann area 6).
    Conclusion: This study revealed the possibility of altered brain glucose metabolism in subjects with dysautonomic syndrome post-immunization with HPV vaccine. These results could reinforce the hypothesis of a causal relationship between HPV vaccine, or some component included in the vaccine and the development of clinical manifestations.
    MeSH term(s) Adult ; Autonomic Nervous System Diseases/diagnostic imaging ; Autonomic Nervous System Diseases/etiology ; Autonomic Nervous System Diseases/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Female ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Humans ; Male ; Middle Aged ; Papillomavirus Vaccines/adverse effects ; Positron-Emission Tomography
    Chemical Substances Papillomavirus Vaccines ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2020-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 18F-FDG PET brain findings in disease-discordant monozygotic mosaic twins with Cri du Chat (5p-) syndrome.

    Cistaro, Angelina / Schiera, Irene Giovanna / Fania, Piercarlo / Tognon, Fabio / Liava, Alexandra / Danesino, Cesare / Albani, Giovanni / Guala, Andrea / Vogrig, Alberto / Quartuccio, Natale

    Neurocase

    2021  Volume 27, Issue 3, Page(s) 319–322

    Abstract: We describe the first report on the genotype-phenotype patterns and [18F] fluoro-deoxygluycose ( ...

    Abstract We describe the first report on the genotype-phenotype patterns and [18F] fluoro-deoxygluycose (
    MeSH term(s) Cerebellum ; Cri-du-Chat Syndrome ; Fluorodeoxyglucose F18 ; Humans ; Positron-Emission Tomography ; Twins, Monozygotic
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1302651-3
    ISSN 1465-3656 ; 1355-4794
    ISSN (online) 1465-3656
    ISSN 1355-4794
    DOI 10.1080/13554794.2021.1957118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4412: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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