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  1. Book: BASICS Chirurgie

    Schiergens, Tobias

    (Basics)

    2023  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Series title Basics
    Keywords Hardcover, Softcover / Medizin/Klinische Fächer ; Chirurgie
    Subject Surgery
    Language German
    Size IX, 198 Seiten, Illustrationen, 29.7 cm x 21 cm, 620 g
    Edition 5. Auflage
    Publisher Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT030068467
    ISBN 978-3-437-42509-7 ; 3-437-42509-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 A 864 available for loan (reading room) Lesesaal EG

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  2. Book: BASICS Chirurgie

    Schiergens, Tobias

    (BASICS)

    2019  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Series title BASICS
    Keywords Operation ; operative Therapie ; Transplantation ; Kinderchirurgie ; Viszeralchirurgie ; Visceralchirugie ; Chirurgie
    Subject Surgery
    Subject code 610
    Language German
    Size IX, 198 Seiten, Illustrationen, 29.7 cm x 21 cm
    Edition 4. Auflage
    Publisher Elsevier
    Publishing place München
    Publishing country Germany
    Document type Book
    Old title Vorangegangen ist
    HBZ-ID HT019853046
    ISBN 978-3-437-42519-6 ; 3-437-42519-6 ; 9783437058707 ; 3437058703
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1837 on loan 0 Vormerkungen

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  3. Book ; Online ; E-Book: Basics Chirurgie

    Schiergens, Tobias

    2015  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Keywords Chirurgie
    Subject Surgery
    Subject code 617
    Language German
    Size X, 198 S. : zahlr. Ill. ; Online-Ressource, 300 farb. Ill.
    Edition 3. Aufl.
    Publisher Urban & Fischer Verlag/Elsevier GmbH
    Publishing place München
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Note Lizenzpflichtig
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018974132
    ISBN 978-3-437-29889-9 ; 978-3-437-42518-9 ; 3-437-29889-5 ; 3-437-42518-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book: Basics Chirurgie

    Schiergens, Tobias

    (Basics)

    2012  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Series title Basics
    Keywords Chirurgie
    Subject Surgery
    Language German
    Size VIII, 198 S. : Ill., graph. Darst.
    Edition 2. Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT017322574
    ISBN 978-3-437-42517-2 ; 3-437-42517-X ; 9783437591792 ; 3437591797
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 10559 order for loan Magazin
    2012 A 3302 order for loan Magazin

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  5. Book: Basics Chirurgie

    Schiergens, Tobias

    (Basics)

    2009  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Series title Basics
    Keywords Chirurgie
    Subject Surgery
    Language German
    Size XI, 193 S. : zahlr. Ill.
    Edition 1. Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT016067061
    ISBN 978-3-437-42516-5 ; 3-437-42516-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4724 order for loan Magazin

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book: BASICS Chirurgie

    Schiergens, Tobias

    (Basics)

    2015  

    Title variant Chirurgie
    Author's details Tobias Schiergens
    Series title Basics
    Keywords Chirurgie
    Language German
    Size VIII, 198 S., zahlr. Ill., graph. Darst., 30 cm
    Edition 3. Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München
    Document type Book
    ISBN 3437425188 ; 9783437298899 ; 9783437425189 ; 3437298895
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article ; Online: Implementierung neuer Technologien unter ökonomischen Gesichtspunkten im DRG-System.

    Schiergens, T S / Sienel, W G R / Werner, J

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2020  Volume 91, Issue 7, Page(s) 561–566

    Abstract: The implementation of technological innovations in surgery, such as robotic-assisted procedures, novel implants, navigation or modern visualization techniques, pose an economic challenge for institutions, as they are rarely cost-covering per se. In the ... ...

    Title translation Implementation of new technologies in the DRG system under economic aspects.
    Abstract The implementation of technological innovations in surgery, such as robotic-assisted procedures, novel implants, navigation or modern visualization techniques, pose an economic challenge for institutions, as they are rarely cost-covering per se. In the German diagnosis-related groups (DRG) system, the costs of numerous novel technologies and innovations in surgery are not or not sufficiently covered in the short term and even less in the middle and long term. This review article describes the economic aspects of surgical innovations and outlines possible ways for hospitals to cover costs. A simulated case study illustrates the extent to which the current German DRG tariff system reflects the costs of minimally invasive techniques (laparoscopic, robot-assisted) in the context of an elective sigmoid colon resection with benign indications.
    MeSH term(s) Colectomy ; Colon, Sigmoid ; Diagnosis-Related Groups ; Elective Surgical Procedures ; Laparoscopy ; Robotic Surgical Procedures
    Language German
    Publishing date 2020-05-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-020-01184-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.97: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Conference proceedings: Genetische und klinische Risikofaktoren für postoperative Komplikationen nach Ileozökalresektion bei Morbus Crohn

    Schardey, J / Kappenberger, A / Zimmermann, P / Beigel, F / Schiergens, T / Kasparek, M / Kühn, F / Wirth, U

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 08

    Event/congress Viszeralmedizin 2022 76. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie 13. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV, Erst online. Dann Hamburg., 2022-09-12
    Language German
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1754611
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 111/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil.

    Schöckel, Leah / Woischke, Christine / Surendran, Sai Agash / Michl, Marlies / Schiergens, Tobias / Hölscher, Andreas / Glass, Florian / Kreissl, Peter / Klauschen, Frederick / Günther, Michael / Ormanns, Steffen / Neumann, Jens

    BMC cancer

    2024  Volume 24, Issue 1, Page(s) 234

    Abstract: Background: Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation. In addition, ...

    Abstract Background: Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation. In addition, PPARG agonists, known as thiazolidinediones, are well established in the treatment of type 2 diabetes mellitus. PPARGs role in cancer is a matter of debate, as pro- and anti-tumour properties have been described in various tumour entities. Currently, the specific role of PPARG in patients with colorectal cancer (CRC) is not fully understood.
    Material and methods: The prognostic impact of PPARG expression was investigated by immunohistochemistry in a case-control study using a matched pair selection of CRC tumours (n = 246) with either distant metastases to the liver (n = 82), lung (n = 82) or without distant metastases (n = 82). Its effect on proliferation as well as the sensitivity to the chemotherapeutic drug 5-fluorouracil (5-FU) was examined after activation, inhibition, and transient gene knockdown of PPARG in the CRC cell lines SW403 and HT29.
    Results: High PPARG expression was significantly associated with pulmonary metastasis (p = 0.019). Patients without distant metastases had a significantly longer overall survival with low PPARG expression in their tumours compared to patients with high PPARG expression (p = 0.045). In the pulmonary metastasis cohort instead, a trend towards longer survival was observed for patients with high PPARG expression in their tumour (p = 0.059). Activation of PPARG by pioglitazone and rosiglitazone resulted in a significant dose-dependent increase in proliferation of CRC cell lines. Inhibition of PPARG by its specific inhibitor GW9662 and siRNA-mediated knockdown of PPARG significantly decreased proliferation. Activating PPARG significantly increased the CRC cell lines sensitivity to 5-FU while its inhibition decreased it.
    Conclusion: The prognostic effect of PPARG expression depends on the metastasis localization in advanced CRC patients. Activation of PPARG increased malignancy associated traits such as proliferation in CRC cell lines but also increases sensitivity towards the chemotherapeutic agent 5-FU. Based on this finding, a combination therapy of PPARG agonists and 5-FU-based chemotherapy constitutes a promising strategy which should be further investigated.
    MeSH term(s) Humans ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; PPAR gamma/agonists ; Diabetes Mellitus, Type 2/drug therapy ; Case-Control Studies ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Cell Proliferation ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic
    Chemical Substances Fluorouracil (U3P01618RT) ; PPAR gamma
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-024-11985-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Operationsindikation bei Colitis ulcerosa. Indication for surgical therapy in ulcerative colitis

    Rentsch, M. / Kühn, F. / Sint, A. / Ganschow, P. / Werner, J. / Schiergens, T.

    Pädiatrische Praxis

    2020  Volume 94, Issue 2, Page(s) 323

    Language German
    Document type Article
    ZDB-ID 123435-3
    ISSN 0030-9346
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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