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  1. Article ; Online: Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in

    Mack, Andrew R / Kumar, Vijay / Taracila, Magdalena A / Mojica, Maria F / O'Shea, Margaret / Schinabeck, William / Silver, Galen / Hujer, Andrea M / Papp-Wallace, Krisztina M / Chen, Shuang / Haider, Shozeb / Caselli, Emilia / Prati, Fabio / van den Akker, Focco / Bonomo, Robert A

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 11, Page(s) e0079123

    Abstract: A wide variety of clinically observed single amino acid substitutions in the Ω-loop region have been associated with increased minimum inhibitory concentrations and resistance to ceftazidime (CAZ) and ceftolozane (TOL) ... ...

    Abstract A wide variety of clinically observed single amino acid substitutions in the Ω-loop region have been associated with increased minimum inhibitory concentrations and resistance to ceftazidime (CAZ) and ceftolozane (TOL) in
    MeSH term(s) Ceftazidime/pharmacology ; Cephalosporinase/metabolism ; Pseudomonas/genetics ; Molecular Docking Simulation ; beta-Lactamases/metabolism ; Protein Engineering ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Azabicyclo Compounds/pharmacology ; Pseudomonas aeruginosa/metabolism ; Drug Combinations
    Chemical Substances Ceftazidime (9M416Z9QNR) ; ceftolozane (37A4IES95Q) ; Cephalosporinase (EC 3.5.2.-) ; S02030 ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00791-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action.

    Dousa, Khalid M / Nguyen, David C / Kurz, Sebastian G / Taracila, Magdalena A / Bethel, Christopher R / Schinabeck, William / Kreiswirth, Barry N / Brown, Sheldon T / Boom, W Henry / Hotchkiss, Richard S / Remy, Kenneth E / Jacono, Frank J / Daley, Charles L / Holland, Steven M / Miller, Alita A / Bonomo, Robert A

    mBio

    2022  Volume 13, Issue 1, Page(s) e0352921

    Abstract: Mycobacterium abscessus ( ...

    Abstract Mycobacterium abscessus (
    MeSH term(s) Humans ; beta-Lactams/pharmacology ; beta-Lactamase Inhibitors/pharmacology ; Anti-Bacterial Agents/pharmacology ; Mycobacterium abscessus ; Cefuroxime/pharmacology ; Microbial Sensitivity Tests ; Imipenem/pharmacology ; Amoxicillin/pharmacology ; Amoxicillin/therapeutic use ; beta-Lactamases
    Chemical Substances beta-Lactams ; beta-Lactamase Inhibitors ; Anti-Bacterial Agents ; durlobactam (PSA33KO9WA) ; Cefuroxime (O1R9FJ93ED) ; Imipenem (71OTZ9ZE0A) ; Amoxicillin (804826J2HU) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03529-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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