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  1. Book: Frontiers in viral hepatitis

    Schinazi, Raymond F.

    2003  

    Author's details ed. by Raymond F. Schinazi
    Keywords Hepatitis B ; Hepatitis C ; Hepatitis B / drug therapy ; Hepatitis C / drug therapy ; Drug Resistance, Viral ; Carcinoma, Hepatocellular / prevention & control ; Hepatitis, Viral ; Hepatitis, Viral/Chemotherapy ; Hepatitis viruses ; Virushepatitis
    Subject code 616.3623
    Language English
    Size XXVIII, 569 S. : zahlr. Ill.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes index
    HBZ-ID HT013912960
    ISBN 0-444-50986-0 ; 978-0-444-50986-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 659 order for loan Magazin

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  2. Article ; Online: Lethal mutagenesis as an antiviral strategy.

    Swanstrom, Ronald / Schinazi, Raymond F

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6580, Page(s) 497–498

    Abstract: Figure: see text]. ...

    Abstract [Figure: see text].
    MeSH term(s) Animals ; Antiviral Agents/adverse effects ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/virology ; Cytidine/adverse effects ; Cytidine/analogs & derivatives ; Cytidine/metabolism ; Cytidine/pharmacology ; Cytidine/therapeutic use ; Cytidine/toxicity ; DNA/biosynthesis ; Evolution, Molecular ; Genome, Viral ; Humans ; Hydroxylamines/adverse effects ; Hydroxylamines/metabolism ; Hydroxylamines/pharmacology ; Hydroxylamines/therapeutic use ; Mutagenesis ; Mutagenicity Tests ; Phosphorylation ; RNA Virus Infections/drug therapy ; RNA Virus Infections/virology ; RNA Viruses/drug effects ; RNA Viruses/genetics ; RNA, Viral/biosynthesis ; RNA, Viral/genetics ; Ribonucleosides/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics
    Chemical Substances Antiviral Agents ; Hydroxylamines ; RNA, Viral ; Ribonucleosides ; Cytidine (5CSZ8459RP) ; DNA (9007-49-2) ; N(4)-hydroxycytidine (C3D11PV2O4) ; molnupiravir (YA84KI1VEW)
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn0048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  3. Book ; Conference proceedings: Third International Conference on Therapies for Viral Hepatitis

    Schinazi, Raymond F.

    12 - 16 December, 1999, Maui, USA

    (Antiviral therapy ; 4, Suppl. 4)

    1999  

    Event/congress International Conference on Therapies for Viral Hepatitis (3, 1999, MauiHawaii)
    Author's details co-chairs: Raymond Schinazi
    Series title Antiviral therapy ; 4, Suppl. 4
    Collection
    Language English
    Size 48 S.
    Publisher Internat. Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT011230179
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4877 -4,Suppl.4- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Conference proceedings: Second International Conference on Therapies for Viral Hepatitis

    Schinazi, Raymond F.

    Kona, Big Island, Hawaii, USA, 15 - 19 December 1997

    (Antiviral therapy ; 3, Suppl. 3)

    1998  

    Event/congress International Conference on Therapies for Viral Hepatitis (2, 1997, KailuaKonaHawaii)
    Author's details co-chairs: Raymond F. Schinazi
    Series title Antiviral therapy ; 3, Suppl. 3
    Collection
    Language English
    Size IX, 146 S. : Ill.
    Publisher Internat. Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT010404280
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4877 -3,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  5. Book: Therapies for viral hepatitis

    Schinazi, Raymond F.

    1998  

    Author's details ed. by Raymond F. Schinazi
    Keywords Virushepatitis ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung
    Language English
    Size XXII, 451 S. : Ill., graph. Darst.
    Publisher Internat. Med. Press
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT010725057
    ISBN 1-901769-01-1 ; 978-1-901769-01-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 3983 order for loan Magazin

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  6. Book ; Conference proceedings: Therapies for viral hepatitis / 2

    Schinazi, Raymond F.

    1st International Conference [on Therapies for Viral Hepatitis], 11 - 15 December 1995, Kauai, Hawaii ; proceedings

    (... ; 1, Suppl. 4)

    1996  

    Event/congress International Conference on Therapies for Viral Hepatitis (1, 1995, KauaiHawaii)
    Author's details chairs: Raymond F. Schinazi
    Series title ... ; 1, Suppl. 4
    Therapies for viral hepatitis
    Antiviral therapy
    Collection Therapies for viral hepatitis
    Antiviral therapy
    Language English
    Size 99 S. : Ill., graph. Darst.
    Publisher Internat. Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT010091316
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 4877 -1,Suppl.4- not available for loan Zeitschriften-Lesesaal

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  7. Book ; Conference proceedings: Therapies for viral hepatitis / 1

    Schinazi, Raymond F.

    1st International Conference [on Therapies for Viral Hepatitis], 11 - 15 December 1995, Kauai, Hawaii ; proceedings

    (... ; 1, Suppl. 3)

    1996  

    Event/congress International Conference on Therapies for Viral Hepatitis (1, 1995, KauaiHawaii)
    Author's details chairs: Raymond F. Schinazi
    Series title ... ; 1, Suppl. 3
    Antiviral therapy
    Therapies for viral hepatitis
    Collection Antiviral therapy
    Therapies for viral hepatitis
    Language English
    Size 69 S. : Ill., graph. Darst., Kt.
    Publisher Internat. Med. Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT010091281
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4877 -1,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  8. Article ; Online: The best backbone for HIV prevention, treatment, and elimination: Emtricitabine+tenofovir.

    Schinazi, Raymond F / Patel, Dharmeshkumar / Ehteshami, Maryam

    Antiviral therapy

    2022  Volume 27, Issue 2, Page(s) 13596535211067599

    Abstract: The advent of antiretroviral combination therapy has significantly impacted the HIV/AIDS epidemic. No longer a death sentence, HIV infection can be controlled and suppressed using cocktail therapies that contain two or more small molecule drugs. This ... ...

    Abstract The advent of antiretroviral combination therapy has significantly impacted the HIV/AIDS epidemic. No longer a death sentence, HIV infection can be controlled and suppressed using cocktail therapies that contain two or more small molecule drugs. This review aims to highlight the discovery, development, and impact of one such molecule, namely, emtricitabine (FTC, emtriva), which is one of the most successful drugs in the fight against HIV/AIDS and has been taken by over 94% of individuals infected with HIV in the USA. We also pay tribute to Dr. John C. Martin, former CEO and Chairman of Gilead Sciences, who unexpectedly passed away in 2021. A true visionary, he was instrumental in delivering FTC, as part of combination therapy with TDF (tenofovir, viread) to the global stage. As the fight to eradicate HIV marches on, we honor Dr. Martin's legacy of collaboration, achievement, and hope.
    MeSH term(s) Acquired Immunodeficiency Syndrome/drug therapy ; Anti-HIV Agents/therapeutic use ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; HIV-1 ; Humans ; Male ; Tenofovir/therapeutic use
    Chemical Substances Anti-HIV Agents ; Tenofovir (99YXE507IL) ; Emtricitabine (G70B4ETF4S)
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.1177/13596535211067599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 174: Show issues

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  9. Article ; Online: Direct Synthesis of Aryloxy Phosphonamidate Nucleotide Prodrugs Using the Cross Metathesis Assisted by Ultrasonic Irradiation.

    Choi, Se Myeong / Nam, Ye Eun / An, Yeon Jin / Choi, Eun Rang / Park, Hyejin / Schinazi, Raymond F / Cho, Jong Hyun

    Organic letters

    2024  

    Abstract: A direct synthetic strategy of aryloxy phosphonamidate nucleotide prodrugs (A, G, C, and U) was developed with the CM reaction assisted by ultrasonic irradiation and partitioned addition of 12 mol % of Hoveyda-Grubbs (H-G) II catalyst in 61-82% yields as ...

    Abstract A direct synthetic strategy of aryloxy phosphonamidate nucleotide prodrugs (A, G, C, and U) was developed with the CM reaction assisted by ultrasonic irradiation and partitioned addition of 12 mol % of Hoveyda-Grubbs (H-G) II catalyst in 61-82% yields as a mixture of
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Moving Fast Toward Hepatitis B Virus Elimination.

    Bassit, Leda / Ono, Suzane Kioko / Schinazi, Raymond F

    Advances in experimental medicine and biology

    2021  Volume 1322, Page(s) 115–138

    Abstract: Currently, there are two safe and effective therapeutic strategies for chronic hepatitis B treatment, namely, nucleoside analogs and interferon alpha (pegylated or non-pegylated). These treatments can control viral replication and improve survival; ... ...

    Abstract Currently, there are two safe and effective therapeutic strategies for chronic hepatitis B treatment, namely, nucleoside analogs and interferon alpha (pegylated or non-pegylated). These treatments can control viral replication and improve survival; however, they do not eliminate the virus and therefore require long-term continued therapy. In addition, there are significant concerns about virus rebound on discontinuation of therapy and the development of fibrosis and hepatocellular carcinoma despite therapy. Therefore, the search for new, more effective, and safer antiviral agents that can cure hepatitis B virus (HBV) continues. Anti-HBV drug discovery and development is fundamentally impacted by our current understanding of HBV replication, disease physiopathology, and persistence of HBV covalently closed circular DNA (cccDNA). Several HBV replication targets are the basis for novel anti-HBV drug development strategies. Many of them are already in clinical trial phase 1 or 2, while others with promising results are still in preclinical stages. As research intensifies, potential HBV curative therapies and modalities in the pipeline are now on the horizon.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; DNA, Circular/genetics ; DNA, Circular/pharmacology ; DNA, Circular/therapeutic use ; DNA, Viral/genetics ; Hepatitis B/drug therapy ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/drug therapy ; Humans ; Virus Replication
    Chemical Substances Antiviral Agents ; DNA, Circular ; DNA, Viral
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-16-0267-2_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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