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Book ; Thesis: Vergleichende Untersuchung der nicht-invasiven Flussmessung im Truncus pulmonalis zwischen Probanden, Leistungssportlern und Patienten mit pulmonal-arterieller Hypertonie

Schindler, Tobias

2008

Author's details	vorgelegt von Tobias Schindler
Language	German
Size	104 S., graph. Darst., 29 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dresden, Techn. Univ., Diss., 2008
HBZ-ID	HT016131602
Database	Catalogue ZB MED Medicine, Health

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2010 E 478	order for loan	Magazin

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Book ; Thesis: Marknagelungstechniken an den großen Röhrenknochen der unteren Extremität im Klinikum Hof

Schindler, Tobias

eine Analyse des Krankengutes der Jahre 1994 - 1997

2000

Author's details	vorgelegt von Tobias Schindler
Language	German
Size	72 Bl., Ill., graph. Darst.
Edition	[Mikrofiche-Ausg.]
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Erlangen, Nürnberg, Univ., Diss., 2000
HBZ-ID	HT013240074
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: PHARE: a bioinformatics pipeline for compositional profiling of multiclonal Plasmodium falciparum infections from long-read Nanopore sequencing data.

Hosch, Salome / Wagner, Philipp / Giger, Johanna Nouria / Dubach, Nina / Saavedra, Elis / Perno, Carlo Federico / Gody, Jean-Chrysostome / Pagonendji, Marilou Sonia / Ngoagouni, Carine / Ndoua, Christophe / Nsanzabana, Christian / Vickos, Ulrich / Daubenberger, Claudia / Schindler, Tobias

The Journal of antimicrobial chemotherapy

2024 Volume 79, Issue 5, Page(s) 987–996

Abstract: Background: The emergence of drug-resistant clones of Plasmodium falciparum is a major public health concern, and the ability to detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic ... ...

Abstract	Background: The emergence of drug-resistant clones of Plasmodium falciparum is a major public health concern, and the ability to detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic settings, malaria infected people often carry multiple P. falciparum clones simultaneously making it likely to miss drug-resistant clones using traditional molecular typing methods. Objectives: Our goal was to develop a bioinformatics pipeline for compositional profiling in multiclonal P. falciparum samples, sequenced using the Oxford Nanopore Technologies MinION platform. Methods: We developed the 'Finding P. falciparum haplotypes with resistance mutations in polyclonal infections' (PHARE) pipeline using existing bioinformatics tools and custom scripts written in python. PHARE was validated on three control datasets containing P. falciparum DNA of four laboratory strains at varying mixing ratios. Additionally, the pipeline was tested on clinical samples from children admitted to a paediatric hospital in the Central African Republic. Results: The PHARE pipeline achieved high recall and accuracy rates in all control datasets. The pipeline can be used on any gene and was tested with amplicons of the P. falciparum drug resistance marker genes pfdhps, pfdhfr and pfK13. Conclusions: The PHARE pipeline helps to provide a more complete picture of drug resistance in the circulating P. falciparum population and can help to guide treatment recommendations. PHARE is freely available under the GNU Lesser General Public License v.3.0 on GitHub: https://github.com/Fippu/PHARE.
MeSH term(s)	Plasmodium falciparum/genetics ; Plasmodium falciparum/drug effects ; Humans ; Computational Biology/methods ; Nanopore Sequencing/methods ; Malaria, Falciparum/parasitology ; Drug Resistance/genetics ; Antimalarials/pharmacology ; Mutation
Chemical Substances	Antimalarials
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkae060
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Article: Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation

Keller, Ladina / Patel, Chandni / Welsche, Sophie / Schindler, Tobias / Hürlimann, Eveline / Keiser, Jennifer

Parasites & vectors. 2020 Dec., v. 13, no. 1

2020

Abstract: BACKGROUND: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy ... ...

Abstract	BACKGROUND: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy comparing traditional microscopic to newly emerging molecular approaches such as quantitative Polymerase Chain Reaction (qPCR) are scarce and hampered partly by lack of an established diagnostic gold standard. METHODS: We compared the performance of the copromicroscopic Kato-Katz method to qPCR in the framework of a randomized controlled trial on Pemba Island, Tanzania, evaluating treatment efficacy based on cure rates of albendazole monotherapy versus ivermectin-albendazole against Trichuris trichiura and concomitant STH infections. Day-to-day variability of both diagnostic methods was assessed to elucidate reproducibility of test results by analysing two stool samples before and two stool samples after treatment of 160 T. trichiura Kato-Katz positive participants, partially co-infected with Ascaris lumbricoides and hookworm, per treatment arm (n = 320). As negative controls, two faecal samples of 180 Kato-Katz helminth negative participants were analysed. RESULTS: Fair to moderate correlation between microscopic egg count and DNA copy number for the different STH species was observed at baseline and follow-up. Results indicated higher sensitivity of qPCR for all three STH species across all time points; however, we found lower test result reproducibility compared to Kato-Katz. When assessed with two samples from consecutive days by qPCR, cure rates were significantly lower for T. trichiura (23.2 vs 46.8%), A. lumbricoides (75.3 vs 100%) and hookworm (52.4 vs 78.3%) in the ivermectin-albendazole treatment arm, when compared to Kato-Katz. CONCLUSIONS: qPCR diagnosis showed lower reproducibility of test results compared to Kato-Katz, hence multiple samples per participant should be analysed to achieve a reliable diagnosis of STH infection. Our study confirms that cure rates are overestimated using Kato-Katz alone. Our findings emphasize that standardized and accurate molecular diagnostic tools are urgently needed for future monitoring within STH control and/or elimination programmes.
Keywords	Ascaris lumbricoides ; DNA ; Trichuris trichiura ; albendazole ; eggs ; helminthiasis ; hookworms ; mixed infection ; quantitative polymerase chain reaction ; randomized clinical trials ; Tanzania
Language	English
Dates of publication	2020-12
Size	p. 517.
Publishing place	BioMed Central
Document type	Article
Note	NAL-light
ZDB-ID	2409480-8
ISSN	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-020-04401-x
Database	NAL-Catalogue (AGRICOLA)

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Article: Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi₃ complex with a macrocyclic tris(salen)-ligand

Nagae, Haruki / Sakamoto, Kazutaka / Fujiwara, Sakiko / Schindler, Tobias / Kon, Yoshihiro / Sato, Kazuhiko / Okuda, Jun / Mashima, Kazushi

Chemical communications. 2021 Oct. 26, v. 57, no. 85

2021

Abstract: A hetero-tetranuclear CeNi₃ complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis ... ...

Abstract	A hetero-tetranuclear CeNi₃ complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce–O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.
Keywords	homolytic cleavage ; ligands ; light
Language	English
Dates of publication	2021-1026
Size	p. 11169-11172.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d1cc04540g
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Article ; Online: Gene Coverage Count and Classification (GC

Stabler, Thomas C / Dwivedi, Ankit / Shrestha, Biraj / Joshi, Sudhaunshu / Schindler, Tobias / Ouattara, Amed / García, Guillermo A / Daubenberger, Claudia / Silva, Joana C

Malaria journal

2022 Volume 21, Issue 1, Page(s) 357

Abstract: Background: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly ... ...

Abstract	Background: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly targeted in diagnostics for Plasmodium falciparum detection. The presence of such deletions can be determined in publically available P. falciparum whole genome sequencing (WGS) datasets. A computational approach was developed and validated, termed Gene Coverage Count and Classification (GC Methods: GC Results: GC Conclusions: The GC
MeSH term(s)	Histidine ; Plasmodium falciparum/genetics ; Tool Use Behavior ; Whole Genome Sequencing ; Genotype
Chemical Substances	Histidine (4QD397987E)
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2091229-8
ISSN	1475-2875 ; 1475-2875
ISSN (online)	1475-2875
ISSN	1475-2875
DOI	10.1186/s12936-022-04376-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence and molecular identification of zoonotic Anisakis and Pseudoterranova species in fish destined to human consumption in Chile

Muñoz-Caro, Tamara / Machuca, Alvaro / Morales, Pamela / Verdugo, Javiera / Reyes, Rodrigo / García, Macarena / Rutaihwa, Liliana / Schindler, Tobias / Poppert, Sven / Taubert, Anja / Hermosilla, Carlos

Parasitology research. 2022 May, v. 121, no. 5

2022

Abstract: Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional ... ...

Abstract	Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional preparations. In the present study, a total of 180 fish specimens representing three different fish species, i.e., Chilean hake (Merluccius gayi), snoek (Thyrsites atun), and sea bream (Brama australis), were caught at central coast of Chile. Parasitological examination was performed on musculature and abdominal cavity for subsequent extraction and quantification of anisakid larvae. Estimation of infection parameters, such as prevalence, was performed indicating 100% (CI: 0.94–1.0) prevalence of anisakid L3 in Chilean hakes and snoeks. Moreover, sea breams reached a prevalence of 35% (CI: 0.23–0.48). Prevalence of anisakid larvae in muscle was also analyzed showing values of 18.6% (CI: 0.097–0.309) in Chilean hakes, 15% (CI: 0.07–0.26) in snoeks, and 1.7% (CI: 0–0.089) in sea breams. Meanwhile, prevalence of anisakid larvae in internal organs showed highest values for peritoneum (100% and 83.3%) for snoeks and Chilean hakes, respectively, for liver (96.7%) and gonads (86.6%) in Chilean hakes, and for intestine (98.3%) in snoeks. Molecular analysis of collected anisakid L3 unveiled presence of two potentially zoonotic nematode species, i.e., Pseudoterranova cattani and Anisakis pegreffii. P. cattani was found in Chilean hakes and snoeks being the first molecular host species report for Chilean snoeks. Besides, A. pegreffii was also identified in these species being the first molecular report on this regard. These findings are relevant for better understanding of epidemiology of anisakiasis in Chilean coasts and for public health issues considering potential risk of human population due to its culinary preferences in eating raw fish.
Keywords	Anisakis pegreffii ; Brama ; Merluccius gayi ; Pseudoterranova ; Sparidae ; Thyrsites atun ; abdominal cavity ; anisakiasis ; coasts ; epidemiology ; hosts ; human population ; humans ; intestines ; liver ; muscles ; parasitology ; peritoneum ; public health ; raw fish ; research ; risk ; Chile
Language	English
Dates of publication	2022-05
Size	p. 1295-1304.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-022-07459-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Draft Genome Sequences of Seven Streptococcus agalactiae Strains Isolated from Camelus dromedarius at the Horn of Africa

Rothen, Julian / Schindler, Tobias / Pothier, Joël F. / Younan, Mario / Certa, Ulrich / Daubenberger, Claudia A. / Pflüger, Valentin / Jores, Joerg

Genome Announcements

2023

Abstract: We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the ... ...

Abstract	We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the underlying mechanisms of pathogenicity and antibiotic resistance of camel GBS.
Keywords	africa ; strains ; camelus dromedarius ; streptococcus
Publishing date	2023-03-10T14:33:15Z
Publisher	American Society for Microbiology
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation.

Keller, Ladina / Patel, Chandni / Welsche, Sophie / Schindler, Tobias / Hürlimann, Eveline / Keiser, Jennifer

Parasites & vectors

2020 Volume 13, Issue 1, Page(s) 517

Abstract: Background: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy ... ...

Abstract	Background: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy comparing traditional microscopic to newly emerging molecular approaches such as quantitative Polymerase Chain Reaction (qPCR) are scarce and hampered partly by lack of an established diagnostic gold standard. Methods: We compared the performance of the copromicroscopic Kato-Katz method to qPCR in the framework of a randomized controlled trial on Pemba Island, Tanzania, evaluating treatment efficacy based on cure rates of albendazole monotherapy versus ivermectin-albendazole against Trichuris trichiura and concomitant STH infections. Day-to-day variability of both diagnostic methods was assessed to elucidate reproducibility of test results by analysing two stool samples before and two stool samples after treatment of 160 T. trichiura Kato-Katz positive participants, partially co-infected with Ascaris lumbricoides and hookworm, per treatment arm (n = 320). As negative controls, two faecal samples of 180 Kato-Katz helminth negative participants were analysed. Results: Fair to moderate correlation between microscopic egg count and DNA copy number for the different STH species was observed at baseline and follow-up. Results indicated higher sensitivity of qPCR for all three STH species across all time points; however, we found lower test result reproducibility compared to Kato-Katz. When assessed with two samples from consecutive days by qPCR, cure rates were significantly lower for T. trichiura (23.2 vs 46.8%), A. lumbricoides (75.3 vs 100%) and hookworm (52.4 vs 78.3%) in the ivermectin-albendazole treatment arm, when compared to Kato-Katz. Conclusions: qPCR diagnosis showed lower reproducibility of test results compared to Kato-Katz, hence multiple samples per participant should be analysed to achieve a reliable diagnosis of STH infection. Our study confirms that cure rates are overestimated using Kato-Katz alone. Our findings emphasize that standardized and accurate molecular diagnostic tools are urgently needed for future monitoring within STH control and/or elimination programmes.
MeSH term(s)	Animals ; Albendazole/therapeutic use ; Anthelmintics/therapeutic use ; Ascaris lumbricoides/isolation & purification ; Clinical Laboratory Techniques/methods ; Drug Combinations ; Feces/parasitology ; Helminthiasis/diagnosis ; Helminthiasis/drug therapy ; Helminths/isolation & purification ; Indian Ocean Islands/epidemiology ; Ivermectin/therapeutic use ; Parasite Egg Count/methods ; Pathology, Molecular/methods ; Prevalence ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Sensitivity and Specificity ; Soil/parasitology ; Tanzania/epidemiology ; Treatment Outcome ; Trichuris/isolation & purification ; Humans
Chemical Substances	Albendazole (F4216019LN) ; Anthelmintics ; Drug Combinations ; Ivermectin (70288-86-7) ; Soil
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-020-04401-x
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Article ; Online: Whole-genome sequencing for One Health surveillance of antimicrobial resistance in conflict zones: a case study of

Abukhattab, Said / Hosch, Salome / Abu-Rmeileh, Niveen M E / Hasan, Shadi / Vonaesch, Pascale / Crump, Lisa / Hattendorf, Jan / Daubenberger, Claudia / Zinsstag, Jakob / Schindler, Tobias

Applied and environmental microbiology

2023 Volume 89, Issue 9, Page(s) e0065823

Abstract: Antimicrobial resistance (AMR) is a critical global concern driven by the overuse, misuse, and/or usage of inadequate antibiotics on humans, animals' agriculture, and as a result of contaminated environments. This study is the first One Health survey in ... ...

Abstract	Antimicrobial resistance (AMR) is a critical global concern driven by the overuse, misuse, and/or usage of inadequate antibiotics on humans, animals' agriculture, and as a result of contaminated environments. This study is the first One Health survey in the Middle East that incorporated whole-genome sequencing (WGS) to examine the spread of AMR in
MeSH term(s)	Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; One Health ; Drug Resistance, Bacterial ; Chickens/microbiology ; Salmonella ; Salmonella enterica/genetics ; Campylobacter/genetics ; Microbial Sensitivity Tests ; Drug Resistance, Multiple, Bacterial/genetics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.00658-23
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