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Book ; Online ; Thesis: Development and application of sediment contact bioassays for the investigation of acute and mechanism specific toxicity with Danio rerio embryos

Schiwy, Sabrina

2014

Abstract: Zs.-Fassung in dt. u. engl. ... ...

Author's details	vorgelegt von Sabrina Schiwy
Abstract	Zs.-Fassung in dt. u. engl. Sprache
Language	English
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch., Diss.--Aachen, 2014
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online ; Thesis: Development and application of sediment contact bioassays for the investigation of acute and mechanism specific toxicity with Danio rerio embryos

Schiwy, Sabrina

2014

Abstract: Zs.-Fassung in dt. u. engl. ... ...

Author's details	vorgelegt von Sabrina Schiwy
Abstract	Zs.-Fassung in dt. u. engl. Sprache
Language	English
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Techn. Hochsch., Diss.--Aachen, 2014
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Improvement of wastewater and water quality via a full-scale ozonation plant? – A comprehensive analysis of the endocrine potential using effect-based methods

Wolf, Yvonne / Oster, Sophie / Shuliakevich, Aliaksandra / Brückner, Ira / Dolny, Regina / Linnemann, Volker / Pinnekamp, Johannes / Hollert, Henner / Schiwy, Sabrina

Science of the total environment. 2022 Jan. 10, v. 803

2022

Abstract: Micropollutants (MPs), especially endocrine disrupting compounds (EDCs), are mainly released from WWTPs into surface water bodies and can subsequently lead to adverse effects in biota. Treatment with ozone proved to be a suitable method for eliminating ... ...

Abstract	Micropollutants (MPs), especially endocrine disrupting compounds (EDCs), are mainly released from WWTPs into surface water bodies and can subsequently lead to adverse effects in biota. Treatment with ozone proved to be a suitable method for eliminating such MPs. This method was implemented at the WWTP Aachen-Soers by commissioning the largest full-scale ozonation plant in Europe at the moment. Recently, effect-based methods (EBMs) have been successfully proved for compliance monitoring, e.g. estrogenic compounds. Therefore, the impact of ozone treatment on endocrine potential (agonistic and antagonistic) of treated wastewater was investigated using the ERα- and AR CALUX assays. Additionally, the impact on the receiving stream and a potential preload of the water body was assessed. Therefore, the current study could deal as a case study for small rivers being highly impacted by WWTPs.The estrogenic potential was nearly fully eliminated after ozone treatment. Contrary, the antagonistic (anti-estrogenic and anti-androgenic) potential did not show a clear elimination pattern after ozone treatment independent of the applied ozone dosage and control system. Therefore, further investigations are required regarding the antagonistic potential. Additionally, preloading of the receiving stream was found during the study period. One significant impact is a rain overflow basin (ROB) located upstream of the WWTP effluent. The highest endocrine potential was found after a ROB overflow (2.7 ng EEQ/L, 2.4 μg TMX-EQ/L, 104 μg FLU-EQ/L), suggesting that such runoff events after a heavy rainfall may act as a driver of endocrine loading to the water body. This manuscript contributes significantly to the basic understanding of the efficiency of eliminating the endocrine potential of ozone treatment by, e.g., showing that there is a further need for improving the removal efficiency of antagonistic potential. Moreover, it highlights the need to include other point sources, such as ROBs, to assess polluted surface waters comprehensively.
Keywords	basins ; case studies ; compliance ; environment ; hormone antagonists ; ozonation ; ozone ; pollutants ; rain ; runoff ; streams ; surface water ; wastewater ; water quality ; Europe
Language	English
Dates of publication	2022-0110
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.149756
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New Insights into the Toxicokinetics of 3,4-Dichloroaniline in Early Life Stages of Zebrafish (

Schiwy, Sabrina / Herber, Ann-Kathrin / Hollert, Henner / Brinkmann, Markus

Toxics

2020 Volume 8, Issue 1

Abstract: ... ...

Abstract	Abstract
Language	English
Publishing date	2020-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics8010016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Development and application of sediment contact bioassays for the investigation of acute and mechanism specific toxicity with Danio rerio embryos

Schiwy, Sabrina [Verfasser]

2014

Author's details	Sabrina Schiwy
Keywords	Biowissenschaften, Biologie ; Life Science, Biology
Subject code	sg570
Language	English
Publisher	Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen
Publishing place	Aachen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Morphological and behavioral alterations in zebrafish larvae after exposure to contaminated river sediments collected in different weather conditions.

Shuliakevich, Aliaksandra / Schröder, Katja / Nagengast, Laura / Muz, Melis / Pipal, Marek / Brückner, Ira / Hilscherova, Klara / Brack, Werner / Schiwy, Sabrina / Hollert, Henner

The Science of the total environment

2022 Volume 851, Issue Pt 1, Page(s) 157922

Abstract: Wastewater treatment plants (WWTPs) are the primary source of micropollutants in aquatic ecosystems. Many micropollutants tend to bind to sediments and persist until remobilizion by bioturbation or flood events. Advanced effluent treatment by ozonation ... ...

Abstract	Wastewater treatment plants (WWTPs) are the primary source of micropollutants in aquatic ecosystems. Many micropollutants tend to bind to sediments and persist until remobilizion by bioturbation or flood events. Advanced effluent treatment by ozonation has been proven to eliminate most micropollutants. The present study characterizes sediments' toxic potential regarding zebrafish embryo development, which highly complex nervous system is vulnerable to exposure to neurotoxic substances. Furthermore, behavioral changes can be induced even at low pollutant concentrations and do not cause acute toxicity. The study area includes stretches of the main waterbody, the Wurm River (sampling sites W1-W5), and its tributary the Haarbach River (sampling sites H1, and H2) in North-Rhine Westphalia, Germany. Both waterbodies serve as recipients of WWTPs' effluents. The effluent entering the Haarbach River is conventionally treated, while the Wurm River receives ozonated effluent from the Aachen-Soers WWTP. Seven sampling sites up- and downstream of the WWTPs were investigated in June of two subsequent years. The first sampling campaign in 2017 was characterized by prolonged dry weather. The second sampling campaign in 2018 occurred after prolonged rain events and the release of the rainwater overflow basin. Direct exposure of zebrafish embryos to native sediments using the sediment contact test represented an ecologically realistic scenario and showed no acute sublethal effects. Exposure of the zebrafish embryo to freeze-dried sediments representing the ecotoxicological status of sediments during flood events unfolded acute sublethal toxicity. Behavioral studies with zebrafish larvae were an essential part of environmental neurotoxicity testing. Zebrafish larvae exposed to sediments' concentrations causing no acute effects led to behavioral changes signalizing neurotoxic substances in sediments. Polyaromatic hydrocarbons, polychlorinated biphenyls, and nitroaromatic compounds were identified as potential toxicity drivers, whereby the rainwater overflow basin served as a possible source of pollution. Mixture toxicity, effect-directed analysis, and further sediment monitoring are needed.
MeSH term(s)	Animals ; Ecosystem ; Geologic Sediments ; Larva ; Ozone/analysis ; Polychlorinated Biphenyls/analysis ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity ; Weather ; Zebrafish
Chemical Substances	Water Pollutants, Chemical ; Ozone (66H7ZZK23N) ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2022-08-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157922
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

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Article: Short exposure to cadmium disrupts the olfactory system of zebrafish (Danio rerio) – Relating altered gene expression in the olfactory organ to behavioral deficits

Volz, Sina N / Hausen, Jonas / Nachev, Milen / Ottermanns, Richard / Schiwy, Sabrina / Hollert, Henner

Aquatic toxicology. 2020 Sept., v. 226

2020

Abstract: Fish strongly rely on olfaction as a variety of essential behaviors such as foraging and predator avoidance are mediated by the olfactory system. Cadmium (Cd) is known to impair olfaction and accumulate in the olfactory epithelium (OE) and bulb (OB) of ... ...

Abstract	Fish strongly rely on olfaction as a variety of essential behaviors such as foraging and predator avoidance are mediated by the olfactory system. Cadmium (Cd) is known to impair olfaction and accumulate in the olfactory epithelium (OE) and bulb (OB) of fishes. In the present study, the acute toxicity of Cd on olfaction in zebrafish (Danio rerio) was characterized on the molecular and behavioral level. To this end, quantitative real-time PCR was performed in order to analyze the expression of selected genes in both the OE and OB. Moreover, the response of zebrafish to an alarm cue was investigated. Following 24 h of exposure to Cd, the expression of genes associated with olfactory sensory neurons was reduced in the OE. Furthermore, the antioxidant genes peroxiredoxin 1 (prdx1) and heme oxygenase 1 (hmox1), as well as the metallothionein 2 gene (mt2) were upregulated in the OE, whereas hmox1 and the stress-inducible heat shock protein 70 gene (hsp70) were upregulated in the OB upon exposure to Cd. Following stimulation with a conspecific skin extract, zebrafish displayed a considerable disruption of the antipredator behavior with increasing Cd concentration. Taken together, Cd impaired olfaction in zebrafish, thereby disrupting the antipredator response, which is crucial for the survival of individuals. Cellular stress followed by disruption of olfactory sensory neurons may have contributed to the observed behavioral deficits.
Keywords	Danio rerio ; acute toxicity ; antioxidants ; antipredatory behavior ; bulbs ; cadmium ; conspecificity ; epithelium ; fish ; gene expression ; heat-shock protein 70 ; heme oxygenase (biliverdin-producing) ; metallothionein ; peroxiredoxin ; predator avoidance ; quantitative polymerase chain reaction ; smell ; toxicology
Language	English
Dates of publication	2020-09
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2020.105555
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3881: Show issues

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Article: Extensive rain events have a more substantial impact than advanced effluent treatment on the endocrine-disrupting activity in an effluent-dominated small river

Shuliakevich, Aliaksandra / Schroeder, Katja / Nagengast, Laura / Wolf, Yvonne / Brückner, Ira / Muz, Melis / Behnisch, Peter A. / Hollert, Henner / Schiwy, Sabrina

Science of the total environment. 2022 Feb. 10, v. 807

2022

Abstract: Wastewater treatment plants (WWTPs) remain an important primary source of emission for endocrine-disrupting compounds in the environment. As an advanced wastewater treatment process, ozonation is known to reduce endocrine-disrupting activity. However, it ...

Abstract	Wastewater treatment plants (WWTPs) remain an important primary source of emission for endocrine-disrupting compounds in the environment. As an advanced wastewater treatment process, ozonation is known to reduce endocrine-disrupting activity. However, it remains unclear to which extend improved wastewater treatment may reduce the endocrine-disrupting activity in the receiving water body. The present study investigated possible factors for the endocrine-disrupting activity in a small receiving water body, the Wurm River (North-Rhine Westphalia, Germany), up- and downstream of a local WWTP. The cell-based reporter gene CALUX® assay was applied to identify the endocrine-disrupting activity in the water, sediment, and suspended particulate matter. The water phase and the effluent sampling were primarily driven by applying the full-scale effluent ozonation (sampling campaigns in June 2017 and March 2019). In contrast, the sediment sampling aimed to compare the particle-bound endocrine-disrupting activity during dry (June 2017) and rainy summer (June 2018) seasons. The water phase showed low to moderate estrogenic/antiandrogenic activity. Advanced effluent treatment by ozonation led to a complete reduction of the endocrine-disrupting activity according to the limit of detection of the CALUX® assays. The suspended particulate matter originated from the water phase of the second sampling campaign revealed antiandrogenic activity only. Sediments at the sampling sites along the local WWTP revealed higher estrogenic and antiandrogenic activity after extensive rain events and were not affected by the ozonated effluent. Fluctuation patterns of the endocrine-disrupting activity in sediments were in line with fluctuated concentrations of polycyclic aromatic hydrocarbons. Rainwater overflow basin release was suggested as a vector for particle-bound and dissolved endocrine-disrupting activity in the receiving water body. The present study underlined the necessity for monitoring both water and sediment phases to achieve reliable profiling of the endocrine-disrupting activity. The receptor-mediated CALUX® assays were proven to be suitable for investigating the endocrine-disrupting activity distribution in different river compartments and WWTP effluents.
Keywords	advanced wastewater treatment ; basins ; detection limit ; environment ; hormone antagonists ; ozonation ; particulates ; rain ; reporter genes ; rivers ; sediments ; summer ; surface water ; Germany
Language	English
Dates of publication	2022-0210
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.150887
Database	NAL-Catalogue (AGRICOLA)

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Article: Morphological and behavioral alterations in zebrafish larvae after exposure to contaminated river sediments collected in different weather conditions

Shuliakevich, Aliaksandra / Schröder, Katja / Nagengast, Laura / Muz, Melis / Pipal, Marek / Brückner, Ira / Hilscherova, Klara / Brack, Werner / Schiwy, Sabrina / Hollert, Henner

Science of the total environment. 2022 Dec. 10, v. 851

2022

Abstract	Wastewater treatment plants (WWTPs) are the primary source of micropollutants in aquatic ecosystems. Many micropollutants tend to bind to sediments and persist until remobilizion by bioturbation or flood events. Advanced effluent treatment by ozonation has been proven to eliminate most micropollutants. The present study characterizes sediments' toxic potential regarding zebrafish embryo development, which highly complex nervous system is vulnerable to exposure to neurotoxic substances. Furthermore, behavioral changes can be induced even at low pollutant concentrations and do not cause acute toxicity. The study area includes stretches of the main waterbody, the Wurm River (sampling sites W1-W5), and its tributary the Haarbach River (sampling sites H1, and H2) in North-Rhine Westphalia, Germany. Both waterbodies serve as recipients of WWTPs' effluents. The effluent entering the Haarbach River is conventionally treated, while the Wurm River receives ozonated effluent from the Aachen-Soers WWTP. Seven sampling sites up- and downstream of the WWTPs were investigated in June of two subsequent years. The first sampling campaign in 2017 was characterized by prolonged dry weather. The second sampling campaign in 2018 occurred after prolonged rain events and the release of the rainwater overflow basin. Direct exposure of zebrafish embryos to native sediments using the sediment contact test represented an ecologically realistic scenario and showed no acute sublethal effects. Exposure of the zebrafish embryo to freeze-dried sediments representing the ecotoxicological status of sediments during flood events unfolded acute sublethal toxicity. Behavioral studies with zebrafish larvae were an essential part of environmental neurotoxicity testing. Zebrafish larvae exposed to sediments' concentrations causing no acute effects led to behavioral changes signalizing neurotoxic substances in sediments. Polyaromatic hydrocarbons, polychlorinated biphenyls, and nitroaromatic compounds were identified as potential toxicity drivers, whereby the rainwater overflow basin served as a possible source of pollution. Mixture toxicity, effect-directed analysis, and further sediment monitoring are needed.
Keywords	Danio rerio ; acute toxicity ; basins ; bioturbation ; direct contact ; ecotoxicology ; embryogenesis ; environment ; freeze drying ; nervous system ; neurotoxicity ; ozonation ; pollution ; polychlorinated biphenyls ; rain ; rivers ; sediments ; surface water ; wastewater treatment ; Germany
Language	English
Dates of publication	2022-1210
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.157922
Database	NAL-Catalogue (AGRICOLA)

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Article: Assessing the genotoxic potential of freshwater sediments after extensive rain events – Lessons learned from a case study in an effluent-dominated river in Germany

Shuliakevich, Aliaksandra / Muz, Melis / Oehlmann, Jörg / Nagengast, Laura / Schröder, Katja / Wolf, Yvonne / Brückner, Ira / Massei, Riccardo / Brack, Werner / Hollert, Henner / Schiwy, Sabrina

Water research. 2022 Feb. 01, v. 209

2022

Abstract: Wastewater treatment plant effluents and releases from rainwater overflow basins can contribute to the input of genotoxic micropollutants in aquatic ecosystems. Predominantly lipophilic genotoxic compounds tend to sorb to particulate matter, making ... ...

Abstract	Wastewater treatment plant effluents and releases from rainwater overflow basins can contribute to the input of genotoxic micropollutants in aquatic ecosystems. Predominantly lipophilic genotoxic compounds tend to sorb to particulate matter, making sediment a source and a sink of pollution. Therefore, the present study aims to investigate the genotoxic potential of freshwater sediments (i) during the dry period and (ii) after extensive rain events by collecting sediment samples in one small anthropogenically impacted river in Germany up- and downstream of the local wastewater treatment plant. The Micronucleus and Ames fluctuation assays with Salmonella typhimurium strains TA98, TA100, YG1041, and YG1042 were used to assess the genotoxic potential of organic sediment extracts. For evaluation of possible genotoxicity drivers, target analysis for 168 chemical compounds was performed. No clastogenic effects were observed, while the genotoxic potential was observed at all sampling sites primarily driven by polycyclic aromatic hydrocarbons, nitroarenes, aromatic amines, and polycyclic heteroarenes. Freshwater sediments' genotoxic potential increased after extensive rain events due to sediment perturbation and the rainwater overflow basin release. In the present study, the rainwater overflow basin was a significant source for particle-bound pollutants from untreated wastewater, suggesting its role as a possible source of genotoxic potential. The present study showed high sensitivity and applicability of the bacterial Salmonella typhimurium strains YG1041 and YG1042 to organic sediment extracts to assess the different classes of genotoxic compounds. A combination of effect-based methods and a chemical analysis was shown as a suitable tool for a genotoxic assessment of freshwater sediments.
Keywords	Salmonella Typhimurium ; basins ; case studies ; chemical analysis ; freshwater ; genotoxicity ; lipophilicity ; mutagens ; nitroaromatic compounds ; particulates ; pollution ; rain ; research ; rivers ; sediments ; wastewater ; wastewater treatment ; Germany
Language	English
Dates of publication	2022-0201
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2021.117921
Database	NAL-Catalogue (AGRICOLA)

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