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  1. Article ; Online: Intestinal erosion rate following transabdominal preperitoneal (TAPP) and totally extraperitoneal (TEP) inguinal hernia repair: does the surgical approach matter?

    Apostolou, K / Schizas, D

    Hernia : the journal of hernias and abdominal wall surgery

    2021  Volume 25, Issue 5, Page(s) 1389–1390

    MeSH term(s) Hernia, Inguinal/surgery ; Herniorrhaphy/adverse effects ; Humans ; Laparoscopy ; Surgical Mesh/adverse effects
    Language English
    Publishing date 2021-01-11
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1388125-5
    ISSN 1248-9204 ; 1265-4906
    ISSN (online) 1248-9204
    ISSN 1265-4906
    DOI 10.1007/s10029-020-02356-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5390: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Transverse colon diverticulitis mimicking acute appendicitis.

    Vagios, Ilias / Vailas, Michail / Vergadis, Chrysovalantis / Schizas, Dimitrios

    BMJ case reports

    2024  Volume 17, Issue 1

    Abstract: Diverticulitis in a solitary transverse colon diverticulum is uncommon, with only a handful of cases documented in the literature. There are various clinical manifestations of the disease, which make clinical and radiological diagnosis rather challenging. ...

    Abstract Diverticulitis in a solitary transverse colon diverticulum is uncommon, with only a handful of cases documented in the literature. There are various clinical manifestations of the disease, which make clinical and radiological diagnosis rather challenging. Herein, we present a case of a premenopausal female patient in her late 40s who presented to the emergency department, complaining of right lower quadrant abdominal pain, nausea, anorexia and fever. Following clinical, biochemical and radiological tests, the patient was prepared for surgical operation, with the presumed diagnosis of acute appendicitis. An appendicectomy was planned via a McBurney incision. Notably, no inflammation of the appendix was discovered. However, on further exploration, an inflammatory mass was identified in the transverse colon, which was subsequently excised and sent for histological examination. The histology results confirmed the presence of a ruptured solitary transverse colon diverticulum, accompanied by an adjacent mesenteric abscess. The patient's postoperative recovery was uneventful.
    MeSH term(s) Female ; Humans ; Appendicitis/diagnosis ; Appendicitis/surgery ; Appendicitis/complications ; Colon, Transverse/diagnostic imaging ; Colon, Transverse/surgery ; Diverticulum, Colon/complications ; Diverticulitis/complications ; Appendix/pathology ; Diverticulitis, Colonic/diagnostic imaging ; Diverticulitis, Colonic/surgery ; Acute Disease ; Diagnosis, Differential
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-254703
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  3. Article ; Online: Prediction of remaining surgery duration in laparoscopic videos based on visual saliency and the transformer network.

    Loukas, Constantinos / Seimenis, Ioannis / Prevezanou, Konstantina / Schizas, Dimitrios

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2024  Volume 20, Issue 2, Page(s) e2632

    Abstract: Background: Real-time prediction of the remaining surgery duration (RSD) is important for optimal scheduling of resources in the operating room.: Methods: We focus on the intraoperative prediction of RSD from laparoscopic video. An extensive ... ...

    Abstract Background: Real-time prediction of the remaining surgery duration (RSD) is important for optimal scheduling of resources in the operating room.
    Methods: We focus on the intraoperative prediction of RSD from laparoscopic video. An extensive evaluation of seven common deep learning models, a proposed one based on the Transformer architecture (TransLocal) and four baseline approaches, is presented. The proposed pipeline includes a CNN-LSTM for feature extraction from salient regions within short video segments and a Transformer with local attention mechanisms.
    Results: Using the Cholec80 dataset, TransLocal yielded the best performance (mean absolute error (MAE) = 7.1 min). For long and short surgeries, the MAE was 10.6 and 4.4 min, respectively. Thirty minutes before the end of surgery MAE = 6.2 min, 7.2 and 5.5 min for all long and short surgeries, respectively.
    Conclusions: The proposed technique achieves state-of-the-art results. In the future, we aim to incorporate intraoperative indicators and pre-operative data.
    MeSH term(s) Humans ; Laparoscopy ; Operating Rooms ; Electric Power Supplies
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.2632
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    Zs.A 6382: Show issues Location:
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  4. Article ; Online: Author's Reply: Management of Morgagni's Hernia in the Adult Population: A Systematic Review of the Literature.

    Katsaros, Ioannis / Schizas, Dimitrios

    World journal of surgery

    2022  Volume 46, Issue 3, Page(s) 727–728

    MeSH term(s) Adult ; Hernias, Diaphragmatic, Congenital/diagnostic imaging ; Hernias, Diaphragmatic, Congenital/surgery ; Humans
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-021-06365-0
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    Zs.A 1336: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Response to 'Re: Bochdalek hernias in adult population: a systematic review of the literature'.

    Katsaros, Ioannis / Schizas, Dimitrios

    ANZ journal of surgery

    2022  Volume 92, Issue 12, Page(s) 3406

    Language English
    Publishing date 2022-12-17
    Publishing country Australia
    Document type Letter
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18087
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 180: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: The Impact of Trophoblast Cell-Surface Antigen 2 Expression on the Survival of Patients with Gastrointestinal Tumors: A Systematic Review.

    Liatsou, Efstathia / Schizas, Dimitrios / Frountzas, Maximos

    Journal of personalized medicine

    2023  Volume 13, Issue 10

    Abstract: Background: Trophoblast cell-surface antigen 2 (TROP-2) is a transmembrane glycoprotein expressed in epithelial cells that has been associated with malignant progression in most carcinomas. Accordingly, the genetic complexity of gastrointestinal tumors ... ...

    Abstract Background: Trophoblast cell-surface antigen 2 (TROP-2) is a transmembrane glycoprotein expressed in epithelial cells that has been associated with malignant progression in most carcinomas. Accordingly, the genetic complexity of gastrointestinal tumors necessitates the investigation of new biomarkers with potential prognostic value. The aim of this systematic review is to assess the effect of TROP-2 on the overall survival of patients who underwent surgery for gastrointestinal malignancy.
    Methods: The present systematic review was designed using the PRISMA and AMSTAR guidelines. We searched the Pubmed, EMBASE and CENTRAL databases from their inception to September 2023.
    Results: Ten studies that enrolled 2293 patients were included for qualitative analysis. Six studies evaluated patients with colorectal cancer, two studies included patients with gastric carcinoma, patients with pancreatic cancer were included in one study and one study included hepatobiliary cancer patients. TROP-2 was positive in 1005/2293 samples of the immunohistochemically evaluated biopsies and was associated with poor overall survival in all studies. High intensity was also associated with more aggressive histopathological characteristics, such us deep tissue invasion, lymph node metastasis and cell atypia. The prognostic value of TROP-2 was shown to be enhanced in patients with advanced disease and poor histological differentiation.
    Conclusion: TROP-2 was expressed at high levels in gastrointestinal tumors, which was associated with both tumor development and pathological aggressiveness. Therefore, TROP-2 could be used as a biomarker to determine clinical prognosis and as a potential therapeutic target in malignancies of the gastrointestinal tract, but further studies need to validate it.
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13101445
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  7. Article ; Online: Extranodal Extension in Esophageal Cancer: Does It Belong in the TNM System?

    Mylonas, Konstantinos S / Schizas, Dimitrios

    Journal of investigative surgery : the official journal of the Academy of Surgical Research

    2021  Volume 35, Issue 3, Page(s) 707–708

    MeSH term(s) Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Extranodal Extension ; Humans ; Neoplasm Staging
    Language English
    Publishing date 2021-05-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639444-9
    ISSN 1521-0553 ; 0894-1939
    ISSN (online) 1521-0553
    ISSN 0894-1939
    DOI 10.1080/08941939.2021.1928342
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: A case report of a forgotten Christmas gift.

    Mulita, Francesk / Vailas, Michail / Kapiris, Stylianos / Mavrodimitraki, Elena / Kyriakopoulos, Georgios / Schizas, Dimitrios / Sotiropoulou, Maria

    Przeglad gastroenterologiczny

    2024  Volume 19, Issue 1, Page(s) 99–100

    Language English
    Publishing date 2024-03-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596134-2
    ISSN 1897-4317 ; 1895-5770
    ISSN (online) 1897-4317
    ISSN 1895-5770
    DOI 10.5114/pg.2024.136324
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  9. Article ; Online: Significance of TP53, CDKN2A, SMAD4 and KRAS in Pancreatic Cancer.

    Stefanoudakis, Dimitrios / Frountzas, Maximos / Schizas, Dimitrios / Michalopoulos, Nikolaos V / Drakaki, Alexandra / Toutouzas, Konstantinos G

    Current issues in molecular biology

    2024  Volume 46, Issue 4, Page(s) 2827–2844

    Abstract: The present review demonstrates the major tumor suppressor genes, including TP53, CDKN2A and SMAD4, associated with pancreatic cancer. Each gene's role, prevalence and impact on tumor development and progression are analyzed, focusing on the intricate ... ...

    Abstract The present review demonstrates the major tumor suppressor genes, including TP53, CDKN2A and SMAD4, associated with pancreatic cancer. Each gene's role, prevalence and impact on tumor development and progression are analyzed, focusing on the intricate molecular landscape of pancreatic cancer. In addition, this review underscores the prognostic significance of specific mutations, such as loss of TP53, and explores some potential targeted therapies tailored to these molecular signatures. The findings highlight the importance of genomic analyses for risk assessment, early detection and the design of personalized treatment approaches in pancreatic cancer. Overall, this review provides a comprehensive analysis of the molecular intricacies of pancreatic tumors, paving the way for more effective and tailored therapeutic interventions.
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46040177
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    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: MYD88 and Proinflammatory Chemokines in Aortic Atheromatosis: Exploring Novel Statin Effects.

    Mylonas, Konstantinos S / Peroulis, Michail / Schizas, Dimitrios / Kapelouzou, Alkistis

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Atherosclerosis is driven by a diverse range of cellular and molecular processes. In the present study, we sought to better understand how statins mitigate proatherogenic inflammation. 48 male New Zealand rabbits were divided into eight groups, each ... ...

    Abstract Atherosclerosis is driven by a diverse range of cellular and molecular processes. In the present study, we sought to better understand how statins mitigate proatherogenic inflammation. 48 male New Zealand rabbits were divided into eight groups, each including 6 animals. The control groups received normal chow for 90 and 120 days. Three groups underwent a hypercholesterolemic diet (HCD) for 30, 60, and 90 days. Another three groups underwent HCD for 3 months, followed by normal chow for one month, with or without rosuvastatin or fluvastatin. The cytokine and chemokine expressions were assessed in the samples of thoracic and abdominal aorta. Rosuvastatin significantly reduced MYD88, CCL4, CCL20, CCR2, TNF-α, IFN-β, IL-1b, IL-2, IL-4, IL-8, and IL-10, both in the thoracic and abdominal aorta. Fluvastatin also downregulated MYD88, CCR2, IFN-β, IFN-γ, IL-1b, IL-2, IL-4, and IL-10 in both aortic segments. Rosuvastatin curtailed the expression of CCL4, IFN-β, IL-2, IL-4, and IL-10 more effectively than fluvastatin in both types of tissue. MYD88, TNF-α, IL-1b, and IL-8 showed a stronger downregulation with rosuvastatin compared to fluvastatin only in the thoracic aorta. The CCL20 and CCR2 levels reduced more extensively with rosuvastatin treatment only in abdominal aortic tissue. In conclusion, statin therapy can halt proatherogenic inflammation in hyperlipidemic animals. Rosuvastatin may be more effective in downregulating MYD88 in atherosclerotic thoracic aortas.
    MeSH term(s) Male ; Animals ; Rabbits ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Rosuvastatin Calcium/pharmacology ; Rosuvastatin Calcium/therapeutic use ; Interleukin-10/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Fluvastatin/pharmacology ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-2/metabolism ; Interleukin-4/metabolism ; Interleukin-8/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Aortic Diseases/metabolism ; Aorta, Abdominal/metabolism ; Inflammation/drug therapy ; Chemokines/metabolism
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Rosuvastatin Calcium (83MVU38M7Q) ; Interleukin-10 (130068-27-8) ; Myeloid Differentiation Factor 88 ; Fluvastatin (4L066368AS) ; Tumor Necrosis Factor-alpha ; Interleukin-2 ; Interleukin-4 (207137-56-2) ; Interleukin-8 ; Chemokines
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119248
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